LDLRAD3 (low density lipoprotein receptor class A domain containing 3)

Gene

• Entrez ID: 143458
• Gene name: Low density lipoprotein receptor class A domain containing 3
• Gene symbol: LDLRAD3
• Synonyms (NCBI Gene): LRAD3
• Chromosome: 11
• Chromosome location: 11p13

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT037641	hsa-miR-744-5p	CLASH	23622248
MIRT1106744	hsa-miR-105	CLIP-seq
MIRT1106745	hsa-miR-106a	CLIP-seq
MIRT1106746	hsa-miR-106b	CLIP-seq
MIRT1106747	hsa-miR-1205	CLIP-seq
MIRT1106748	hsa-miR-1231	CLIP-seq
MIRT1106749	hsa-miR-1262	CLIP-seq
MIRT1106750	hsa-miR-1273d	CLIP-seq
MIRT1106751	hsa-miR-1275	CLIP-seq
MIRT1106752	hsa-miR-129-5p	CLIP-seq
MIRT1106753	hsa-miR-130a	CLIP-seq
MIRT1106754	hsa-miR-130b	CLIP-seq
MIRT1106755	hsa-miR-17	CLIP-seq
MIRT1106756	hsa-miR-1912	CLIP-seq
MIRT1106757	hsa-miR-194	CLIP-seq
MIRT1106758	hsa-miR-199a-5p	CLIP-seq
MIRT1106759	hsa-miR-199b-5p	CLIP-seq
MIRT1106760	hsa-miR-20a	CLIP-seq
MIRT1106761	hsa-miR-20b	CLIP-seq
MIRT1106762	hsa-miR-22	CLIP-seq
MIRT1106763	hsa-miR-2277-3p	CLIP-seq
MIRT1106764	hsa-miR-301a	CLIP-seq
MIRT1106765	hsa-miR-301b	CLIP-seq
MIRT1106766	hsa-miR-3128	CLIP-seq
MIRT1106767	hsa-miR-3130-5p	CLIP-seq
MIRT1106768	hsa-miR-3150a-5p	CLIP-seq
MIRT1106769	hsa-miR-3150b-5p	CLIP-seq
MIRT1106770	hsa-miR-3155	CLIP-seq
MIRT1106771	hsa-miR-3155b	CLIP-seq
MIRT1106772	hsa-miR-3161	CLIP-seq
MIRT1106773	hsa-miR-3607-3p	CLIP-seq
MIRT1106774	hsa-miR-3612	CLIP-seq
MIRT1106775	hsa-miR-3666	CLIP-seq
MIRT1106776	hsa-miR-3686	CLIP-seq
MIRT1106777	hsa-miR-3973	CLIP-seq
MIRT1106778	hsa-miR-4260	CLIP-seq
MIRT1106779	hsa-miR-4295	CLIP-seq
MIRT1106780	hsa-miR-4427	CLIP-seq
MIRT1106781	hsa-miR-4443	CLIP-seq
MIRT1106782	hsa-miR-4471	CLIP-seq
MIRT1106783	hsa-miR-4474-5p	CLIP-seq
MIRT1106784	hsa-miR-4482	CLIP-seq
MIRT1106785	hsa-miR-4506	CLIP-seq
MIRT1106786	hsa-miR-4530	CLIP-seq
MIRT1106787	hsa-miR-454	CLIP-seq
MIRT1106788	hsa-miR-4652-3p	CLIP-seq
MIRT1106789	hsa-miR-4665-5p	CLIP-seq
MIRT1106790	hsa-miR-4680-3p	CLIP-seq
MIRT1106791	hsa-miR-4694-3p	CLIP-seq
MIRT1106792	hsa-miR-4701-3p	CLIP-seq
MIRT1106793	hsa-miR-4719	CLIP-seq
MIRT1106794	hsa-miR-4720-5p	CLIP-seq
MIRT1106795	hsa-miR-4757-5p	CLIP-seq
MIRT1106796	hsa-miR-4790-3p	CLIP-seq
MIRT1106797	hsa-miR-4799-3p	CLIP-seq
MIRT1106798	hsa-miR-484	CLIP-seq
MIRT1106799	hsa-miR-516b	CLIP-seq
MIRT1106800	hsa-miR-519a	CLIP-seq
MIRT1106801	hsa-miR-519b-3p	CLIP-seq
MIRT1106802	hsa-miR-519c-3p	CLIP-seq
MIRT1106803	hsa-miR-519d	CLIP-seq
MIRT1106804	hsa-miR-520g	CLIP-seq
MIRT1106805	hsa-miR-520h	CLIP-seq
MIRT1106806	hsa-miR-542-3p	CLIP-seq
MIRT1106807	hsa-miR-548ag	CLIP-seq
MIRT1106808	hsa-miR-548ai	CLIP-seq
MIRT1106809	hsa-miR-591	CLIP-seq
MIRT1106810	hsa-miR-605	CLIP-seq
MIRT1106811	hsa-miR-606	CLIP-seq
MIRT1106812	hsa-miR-650	CLIP-seq
MIRT1106813	hsa-miR-654-3p	CLIP-seq
MIRT1106814	hsa-miR-760	CLIP-seq
MIRT1106815	hsa-miR-922	CLIP-seq
MIRT1106816	hsa-miR-93	CLIP-seq
MIRT1106744	hsa-miR-105	CLIP-seq
MIRT2029436	hsa-miR-1207-3p	CLIP-seq
MIRT2029437	hsa-miR-122	CLIP-seq
MIRT2029438	hsa-miR-1302	CLIP-seq
MIRT2029439	hsa-miR-198	CLIP-seq
MIRT2029440	hsa-miR-2053	CLIP-seq
MIRT2029441	hsa-miR-24	CLIP-seq
MIRT2029442	hsa-miR-3121-3p	CLIP-seq
MIRT2029443	hsa-miR-3122	CLIP-seq
MIRT2029444	hsa-miR-3164	CLIP-seq
MIRT2029445	hsa-miR-3189-3p	CLIP-seq
MIRT2029446	hsa-miR-3649	CLIP-seq
MIRT2029447	hsa-miR-3913-5p	CLIP-seq
MIRT2029448	hsa-miR-4283	CLIP-seq
MIRT2029449	hsa-miR-4298	CLIP-seq
MIRT2029450	hsa-miR-4437	CLIP-seq
MIRT2029451	hsa-miR-4455	CLIP-seq
MIRT1106783	hsa-miR-4474-5p	CLIP-seq
MIRT2029452	hsa-miR-4508	CLIP-seq
MIRT2029453	hsa-miR-4520b-3p	CLIP-seq
MIRT2029454	hsa-miR-4529-3p	CLIP-seq
MIRT2029455	hsa-miR-4535	CLIP-seq
MIRT2029456	hsa-miR-455-3p	CLIP-seq
MIRT2029457	hsa-miR-4645-3p	CLIP-seq
MIRT2029458	hsa-miR-4659a-3p	CLIP-seq
MIRT2029459	hsa-miR-4659b-3p	CLIP-seq
MIRT1106791	hsa-miR-4694-3p	CLIP-seq
MIRT2029460	hsa-miR-4747-5p	CLIP-seq
MIRT2029461	hsa-miR-4774-5p	CLIP-seq
MIRT2029462	hsa-miR-4776-5p	CLIP-seq
MIRT2029463	hsa-miR-4781-5p	CLIP-seq
MIRT2029464	hsa-miR-492	CLIP-seq
MIRT1106799	hsa-miR-516b	CLIP-seq
MIRT2029465	hsa-miR-744	CLIP-seq
MIRT2029466	hsa-miR-9	CLIP-seq
MIRT1106744	hsa-miR-105	CLIP-seq
MIRT2029437	hsa-miR-122	CLIP-seq
MIRT2029438	hsa-miR-1302	CLIP-seq
MIRT2260348	hsa-miR-1304	CLIP-seq
MIRT1106758	hsa-miR-199a-5p	CLIP-seq
MIRT1106759	hsa-miR-199b-5p	CLIP-seq
MIRT2260349	hsa-miR-205	CLIP-seq
MIRT2029441	hsa-miR-24	CLIP-seq
MIRT2260350	hsa-miR-2467-5p	CLIP-seq
MIRT2029443	hsa-miR-3122	CLIP-seq
MIRT2029444	hsa-miR-3164	CLIP-seq
MIRT2260351	hsa-miR-3187-3p	CLIP-seq
MIRT2260352	hsa-miR-3188	CLIP-seq
MIRT2029445	hsa-miR-3189-3p	CLIP-seq
MIRT2260353	hsa-miR-345	CLIP-seq
MIRT2260354	hsa-miR-3545-3p	CLIP-seq
MIRT2029446	hsa-miR-3649	CLIP-seq
MIRT2029447	hsa-miR-3913-5p	CLIP-seq
MIRT2260355	hsa-miR-3975	CLIP-seq
MIRT2260356	hsa-miR-4252	CLIP-seq
MIRT2029448	hsa-miR-4283	CLIP-seq
MIRT2029449	hsa-miR-4298	CLIP-seq
MIRT2260357	hsa-miR-4435	CLIP-seq
MIRT2029450	hsa-miR-4437	CLIP-seq
MIRT2029451	hsa-miR-4455	CLIP-seq
MIRT1106783	hsa-miR-4474-5p	CLIP-seq
MIRT2029452	hsa-miR-4508	CLIP-seq
MIRT2260358	hsa-miR-4522	CLIP-seq
MIRT2260359	hsa-miR-4539	CLIP-seq
MIRT2260360	hsa-miR-4701-5p	CLIP-seq
MIRT2029460	hsa-miR-4747-5p	CLIP-seq
MIRT2029461	hsa-miR-4774-5p	CLIP-seq
MIRT2029463	hsa-miR-4781-5p	CLIP-seq
MIRT2260361	hsa-miR-485-5p	CLIP-seq
MIRT1106799	hsa-miR-516b	CLIP-seq
MIRT2260362	hsa-miR-548s	CLIP-seq
MIRT2260363	hsa-miR-588	CLIP-seq
MIRT2029437	hsa-miR-122	CLIP-seq
MIRT2029441	hsa-miR-24	CLIP-seq
MIRT2029444	hsa-miR-3164	CLIP-seq
MIRT2029448	hsa-miR-4283	CLIP-seq
MIRT2029450	hsa-miR-4437	CLIP-seq
MIRT2029451	hsa-miR-4455	CLIP-seq
MIRT2029452	hsa-miR-4508	CLIP-seq
MIRT2390081	hsa-miR-450b-5p	CLIP-seq
MIRT2029453	hsa-miR-4520b-3p	CLIP-seq
MIRT2029454	hsa-miR-4529-3p	CLIP-seq
MIRT2029455	hsa-miR-4535	CLIP-seq
MIRT2390082	hsa-miR-4695-3p	CLIP-seq
MIRT2029462	hsa-miR-4776-5p	CLIP-seq
MIRT2029463	hsa-miR-4781-5p	CLIP-seq
MIRT2029464	hsa-miR-492	CLIP-seq
MIRT2390083	hsa-miR-507	CLIP-seq
MIRT1106799	hsa-miR-516b	CLIP-seq
MIRT2390084	hsa-miR-557	CLIP-seq
MIRT2029465	hsa-miR-744	CLIP-seq
MIRT2029466	hsa-miR-9	CLIP-seq
MIRT2029437	hsa-miR-122	CLIP-seq
MIRT2029440	hsa-miR-2053	CLIP-seq
MIRT2029441	hsa-miR-24	CLIP-seq
MIRT2029444	hsa-miR-3164	CLIP-seq
MIRT2029448	hsa-miR-4283	CLIP-seq
MIRT2029450	hsa-miR-4437	CLIP-seq
MIRT2029451	hsa-miR-4455	CLIP-seq
MIRT1106783	hsa-miR-4474-5p	CLIP-seq
MIRT2029452	hsa-miR-4508	CLIP-seq
MIRT2390081	hsa-miR-450b-5p	CLIP-seq
MIRT2029453	hsa-miR-4520b-3p	CLIP-seq
MIRT2029454	hsa-miR-4529-3p	CLIP-seq
MIRT2029455	hsa-miR-4535	CLIP-seq
MIRT2390082	hsa-miR-4695-3p	CLIP-seq
MIRT2029462	hsa-miR-4776-5p	CLIP-seq
MIRT2029463	hsa-miR-4781-5p	CLIP-seq
MIRT2029464	hsa-miR-492	CLIP-seq
MIRT2390083	hsa-miR-507	CLIP-seq
MIRT1106799	hsa-miR-516b	CLIP-seq
MIRT2390084	hsa-miR-557	CLIP-seq
MIRT2029465	hsa-miR-744	CLIP-seq
MIRT2029466	hsa-miR-9	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001540	Function	Amyloid-beta binding	IEA
GO:0005515	Function	Protein binding	IPI	26854353
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0006898	Process	Receptor-mediated endocytosis	IBA
GO:0006898	Process	Receptor-mediated endocytosis	IEA
GO:0016020	Component	Membrane	IEA
GO:0016192	Process	Vesicle-mediated transport	IEA
GO:0070613	Process	Regulation of protein processing	IEA

Other IDs

• MIM: 617986
• HGNC: 27046
• e!Ensembl: ENSG00000179241

Protein

• UniProt ID: Q86YD5
• Protein name: Low-density lipoprotein receptor class A domain-containing protein 3 (LDLR class A domain-containing protein 3)
• Protein function: May influence APP processing, resulting in a decrease in sAPP-alpha production and increased amyloidogenic P3 peptide production. May regulate ITCH and NEDD4 E3 ligase activity and degradation (PubMed:26854353). {ECO:0000250, ECO:0000269|PubMed:
• PDB: 7FFF, 7FFL, 7FFN
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00057	Ldl_recept_a	27 → 64	Low-density lipoprotein receptor domain class A	Repeat
  PF00057	Ldl_recept_a	69 → 106	Low-density lipoprotein receptor domain class A	Repeat
  PF00057	Ldl_recept_a	111 → 147	Low-density lipoprotein receptor domain class A	Repeat

• Tissue specificity: TISSUE SPECIFICITY: Expressed at high levels in brain, lung, skeletal muscle, and pancreas. Expressed at moderate levels in heart, placenta, and kidney but not detected in the liver. {ECO:0000269|PubMed:21795536}.
• Sequence:

  MWLLGPLCLLLSSAAESQLLPGNNFTNECNIPGNFMCSNGRCIPGAWQCDGLPDCFDKSD
  EKECPKAKSKCGPTFFPCASGIHCIIGRFRCNGFEDCPDGSDEENCTANPLLCSTARYHC
  KNGLCIDKSFICDGQNNCQDNSDEESCESSQEPGSGQVFVTSENQLVYYPSITYAIIGSS
  VIFVLVVALLALVLHHQRKRNNLMTLPVHRLQHPVLLSRLVVLDHPHHCNVTYNVNNGIQ
  YVASQAEQNASEVGSPPSYSEALLDQRPAWYDLPPPPYSSDTESLNQADLPPYRSRSGSA
  NSASSQAASSLLSVEDTSHSPGQPGPQEGTAEPRDSEPSQGTEEV

• Sequence length: 345

Associated diseases

Unknown
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
EBV-positive nodal T- and NK-cell lymphoma	Likely benign	rs1158579811	RCV004557774

Associations from Text Mining
Disease Name	Relationship Type	References
Anxiety	Associate	35577822
Carcinoma Non Small Cell Lung	Stimulate	32658600
Carcinoma Non Small Cell Lung	Associate	36817452
Colorectal Neoplasms	Associate	37587156
COVID 19	Associate	34431042
Infections	Associate	34431042
Lymphatic Metastasis	Stimulate	29307994
Motor Disorders	Associate	35577822
Neoplasm Metastasis	Associate	29307994
Neoplasms	Associate	35035814, 35975639
Neurodegenerative Diseases	Associate	35577822
Pancreatic Neoplasms	Associate	29307994
Stomach Neoplasms	Associate	35975639