Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	143425
Gene name Gene Name - the full gene name approved by the HGNC.	Synaptotagmin 9
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	SYT9
Synonyms (NCBI Gene) Gene synonyms aliases	-
Chromosome Chromosome number	11
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	11p15.4

Show/Hide all(100)

miRTarBase ID	miRNA	Experiments	Reference
MIRT026062	hsa-miR-196a-5p	Sequencing	20371350
MIRT571234	hsa-miR-651-3p	PAR-CLIP	20371350
MIRT571233	hsa-miR-511-3p	PAR-CLIP	20371350
MIRT571232	hsa-miR-1252-5p	PAR-CLIP	20371350
MIRT571231	hsa-miR-4795-5p	PAR-CLIP	20371350
MIRT571230	hsa-miR-1253	PAR-CLIP	20371350
MIRT571229	hsa-miR-6770-5p	PAR-CLIP	20371350
MIRT571228	hsa-miR-3171	PAR-CLIP	20371350
MIRT571227	hsa-miR-567	PAR-CLIP	20371350
MIRT571225	hsa-miR-4711-3p	PAR-CLIP	20371350
MIRT571226	hsa-miR-3616-5p	PAR-CLIP	20371350
MIRT571224	hsa-miR-573	PAR-CLIP	20371350
MIRT571223	hsa-miR-297	PAR-CLIP	20371350
MIRT571234	hsa-miR-651-3p	PAR-CLIP	20371350
MIRT571233	hsa-miR-511-3p	PAR-CLIP	20371350
MIRT571232	hsa-miR-1252-5p	PAR-CLIP	20371350
MIRT571231	hsa-miR-4795-5p	PAR-CLIP	20371350
MIRT571230	hsa-miR-1253	PAR-CLIP	20371350
MIRT571229	hsa-miR-6770-5p	PAR-CLIP	20371350
MIRT571228	hsa-miR-3171	PAR-CLIP	20371350
MIRT571227	hsa-miR-567	PAR-CLIP	20371350
MIRT571225	hsa-miR-4711-3p	PAR-CLIP	20371350
MIRT571226	hsa-miR-3616-5p	PAR-CLIP	20371350
MIRT571224	hsa-miR-573	PAR-CLIP	20371350
MIRT571223	hsa-miR-297	PAR-CLIP	20371350
MIRT450067	hsa-miR-100-3p	PAR-CLIP	22100165
MIRT450065	hsa-miR-3919	PAR-CLIP	22100165
MIRT450066	hsa-miR-4756-3p	PAR-CLIP	22100165
MIRT450064	hsa-miR-3928-5p	PAR-CLIP	22100165
MIRT450063	hsa-miR-6806-3p	PAR-CLIP	22100165
MIRT450062	hsa-miR-127-5p	PAR-CLIP	22100165
MIRT571234	hsa-miR-651-3p	PAR-CLIP	20371350
MIRT571233	hsa-miR-511-3p	PAR-CLIP	20371350
MIRT571232	hsa-miR-1252-5p	PAR-CLIP	20371350
MIRT571231	hsa-miR-4795-5p	PAR-CLIP	20371350
MIRT571230	hsa-miR-1253	PAR-CLIP	20371350
MIRT571229	hsa-miR-6770-5p	PAR-CLIP	20371350
MIRT571228	hsa-miR-3171	PAR-CLIP	20371350
MIRT571227	hsa-miR-567	PAR-CLIP	20371350
MIRT571225	hsa-miR-4711-3p	PAR-CLIP	20371350
MIRT571226	hsa-miR-3616-5p	PAR-CLIP	20371350
MIRT571224	hsa-miR-573	PAR-CLIP	20371350
MIRT571223	hsa-miR-297	PAR-CLIP	20371350
MIRT571234	hsa-miR-651-3p	PAR-CLIP	20371350
MIRT571233	hsa-miR-511-3p	PAR-CLIP	20371350
MIRT571232	hsa-miR-1252-5p	PAR-CLIP	20371350
MIRT571231	hsa-miR-4795-5p	PAR-CLIP	20371350
MIRT571230	hsa-miR-1253	PAR-CLIP	20371350
MIRT571229	hsa-miR-6770-5p	PAR-CLIP	20371350
MIRT571228	hsa-miR-3171	PAR-CLIP	20371350
MIRT571227	hsa-miR-567	PAR-CLIP	20371350
MIRT571225	hsa-miR-4711-3p	PAR-CLIP	20371350
MIRT571226	hsa-miR-3616-5p	PAR-CLIP	20371350
MIRT571224	hsa-miR-573	PAR-CLIP	20371350
MIRT571223	hsa-miR-297	PAR-CLIP	20371350
MIRT450067	hsa-miR-100-3p	PAR-CLIP	22100165
MIRT450065	hsa-miR-3919	PAR-CLIP	22100165
MIRT450066	hsa-miR-4756-3p	PAR-CLIP	22100165
MIRT450064	hsa-miR-3928-5p	PAR-CLIP	22100165
MIRT450063	hsa-miR-6806-3p	PAR-CLIP	22100165
MIRT450062	hsa-miR-127-5p	PAR-CLIP	22100165
MIRT1407780	hsa-miR-1229	CLIP-seq
MIRT1407781	hsa-miR-1257	CLIP-seq
MIRT1407782	hsa-miR-136	CLIP-seq
MIRT1407783	hsa-miR-141	CLIP-seq
MIRT1407784	hsa-miR-196a	CLIP-seq
MIRT1407785	hsa-miR-196b	CLIP-seq
MIRT1407786	hsa-miR-200a	CLIP-seq
MIRT1407787	hsa-miR-2052	CLIP-seq
MIRT1407788	hsa-miR-219-2-3p	CLIP-seq
MIRT1407789	hsa-miR-2964a-3p	CLIP-seq
MIRT1407790	hsa-miR-3117-5p	CLIP-seq
MIRT1407791	hsa-miR-324-5p	CLIP-seq
MIRT1407792	hsa-miR-3607-5p	CLIP-seq
MIRT1407793	hsa-miR-3622b-5p	CLIP-seq
MIRT1407794	hsa-miR-380	CLIP-seq
MIRT1407795	hsa-miR-3977	CLIP-seq
MIRT1407796	hsa-miR-425	CLIP-seq
MIRT1407797	hsa-miR-4642	CLIP-seq
MIRT1407798	hsa-miR-4676-5p	CLIP-seq
MIRT1407799	hsa-miR-4695-3p	CLIP-seq
MIRT1407800	hsa-miR-4712-3p	CLIP-seq
MIRT1407801	hsa-miR-4774-5p	CLIP-seq
MIRT1407802	hsa-miR-4799-5p	CLIP-seq
MIRT1407803	hsa-miR-548m	CLIP-seq
MIRT1407804	hsa-miR-575	CLIP-seq
MIRT1407805	hsa-miR-659	CLIP-seq
MIRT1554386	hsa-miR-676	CLIP-seq
MIRT2122248	hsa-miR-1972	CLIP-seq
MIRT2122249	hsa-miR-2467-3p	CLIP-seq
MIRT2122250	hsa-miR-3619-3p	CLIP-seq
MIRT2122251	hsa-miR-4468	CLIP-seq
MIRT2122252	hsa-miR-4650-5p	CLIP-seq
MIRT2122253	hsa-miR-4782-5p	CLIP-seq
MIRT2637896	hsa-miR-1252	CLIP-seq
MIRT2637897	hsa-miR-3647-5p	CLIP-seq
MIRT2637898	hsa-miR-4496	CLIP-seq
MIRT2637896	hsa-miR-1252	CLIP-seq
MIRT2637897	hsa-miR-3647-5p	CLIP-seq
MIRT2637898	hsa-miR-4496	CLIP-seq

Show/Hide all(26)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000149	Function	SNARE binding	IBA	21873635
GO:0001786	Function	Phosphatidylserine binding	IBA	21873635
GO:0005509	Function	Calcium ion binding	IBA	21873635
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005544	Function	Calcium-dependent phospholipid binding	IBA	21873635
GO:0005546	Function	Phosphatidylinositol-4,5-bisphosphate binding	IEA
GO:0005886	Component	Plasma membrane	IBA	21873635
GO:0005886	Component	Plasma membrane	TAS
GO:0014059	Process	Regulation of dopamine secretion	IBA	21873635
GO:0016192	Process	Vesicle-mediated transport	IBA	21873635
GO:0017156	Process	Calcium-ion regulated exocytosis	IBA	21873635
GO:0017158	Process	Regulation of calcium ion-dependent exocytosis	IBA	21873635
GO:0019905	Function	Syntaxin binding	IBA	21873635
GO:0030276	Function	Clathrin binding	IBA	21873635
GO:0030285	Component	Integral component of synaptic vesicle membrane	IEA
GO:0030665	Component	Clathrin-coated vesicle membrane	TAS
GO:0030667	Component	Secretory granule membrane	IEA
GO:0031045	Component	Dense core granule	IBA	21873635
GO:0042802	Function	Identical protein binding	IEA
GO:0045956	Process	Positive regulation of calcium ion-dependent exocytosis	IEA
GO:0050796	Process	Regulation of insulin secretion	IEA
GO:0061024	Process	Membrane organization	TAS
GO:0070382	Component	Exocytic vesicle	IBA	21873635
GO:0071277	Process	Cellular response to calcium ion	IBA	21873635
GO:0098686	Component	Hippocampal mossy fiber to CA3 synapse	IEA
GO:0099502	Process	Calcium-dependent activation of synaptic vesicle fusion	IEA

MIM	HGNC	e!Ensembl
613528	19265	ENSG00000170743

Protein

UniProt ID

Q86SS6

Protein name

Synaptotagmin-9 (Synaptotagmin IX) (SytIX)

Protein function

May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00168	C2	235 → 333	C2 domain	Domain
PF00168	C2	367 → 476	C2 domain	Domain

Sequence

MPGARDALCHQALQLLAELCARGALEHDSCQDFIYHLRDRARPRLRDPDISVSLLTLVVT
ACGLALFGVSLFVSWKLCWVPWRERGLPSGSKDNNQEPLNYMDTETNEQENSEDFLDPPT
PCPDSSMKISHTSPDIPLSTQTGIQENCAHGVRVQRQVTEPTSSARHNSIRRQLNLSNPD
FNIQQLQKQEQLTGIGRIKPELYKQRSLDNDDGRRSNSKACGKLNFILKYDCDLEQLIVK
IHKAVNLPAKDFSGTSDPYVKIYLLPDRKTKHQTKVHRKTLNPVFDEVFLFPVPYNDLEA
RKLHFSVYDFDRFSRHDLIGQVVVDHFLDLADFPRECILWKDIEYVTNDNVDLGELMFSL
CYLPTAGRLTITIIKARNLKAMDITGASDPYVKVSLMCDGRRLKKRKTSTKRNTLNPVYN
EAIVFDVPPENIDQIHLSIAVMDYDRVGHNEIIGVCQVGNEAERLGRDHWSEMLSYPRKP
IAHWHSLVEKR

Sequence length

491

Interactions

View interactions

	Reactome
			Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis

Show/Hide Causal Diseases (1)

Disease term	Disease name	dbSNP ID	References
Causal
Colorectal cancer	Colorectal Carcinoma	rs137854568, rs137854573, rs137854575, rs387906234, rs121908380, rs121908702, rs267606674, rs794729661, rs121909055, rs281865417, rs267606884, rs28934575, rs587776769, rs104893815, rs587776800 View all (467 more)

Show/Hide Unknown Diseases (1)

Disease term	Disease name	Evidence	References	Source
Unknown
Breast Cancer	Breast Cancer	Importantly, breast cancer patients bearing PRC2 LOF mutations displayed significantly worse prognosis compared with PRC2 wild-type patients		GWAS, CBGDA

Show/Hide Text Mining Associations (4)

Disease Name	Relationship Type	References
Associations from Text Mining
Cockayne Syndrome	Associate	26972010
Heart Septal Defects	Associate	28834160
Pancreatic Neoplasms	Associate	23334854
Stomach Neoplasms	Associate	34229539

SYT9 (synaptotagmin 9)