Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	143425
Gene name	Synaptotagmin 9
Gene symbol	SYT9
Synonyms (NCBI Gene)	-
Chromosome	11
Chromosome location	11p15.4

100

Show/Hide all (100)

miRTarBase ID	miRNA	Experiments	Reference
MIRT026062	hsa-miR-196a-5p	Sequencing	20371350
MIRT571234	hsa-miR-651-3p	PAR-CLIP	20371350
MIRT571233	hsa-miR-511-3p	PAR-CLIP	20371350
MIRT571232	hsa-miR-1252-5p	PAR-CLIP	20371350
MIRT571231	hsa-miR-4795-5p	PAR-CLIP	20371350
MIRT571230	hsa-miR-1253	PAR-CLIP	20371350
MIRT571229	hsa-miR-6770-5p	PAR-CLIP	20371350
MIRT571228	hsa-miR-3171	PAR-CLIP	20371350
MIRT571227	hsa-miR-567	PAR-CLIP	20371350
MIRT571225	hsa-miR-4711-3p	PAR-CLIP	20371350
MIRT571226	hsa-miR-3616-5p	PAR-CLIP	20371350
MIRT571224	hsa-miR-573	PAR-CLIP	20371350
MIRT571223	hsa-miR-297	PAR-CLIP	20371350
MIRT571234	hsa-miR-651-3p	PAR-CLIP	20371350
MIRT571233	hsa-miR-511-3p	PAR-CLIP	20371350
MIRT571232	hsa-miR-1252-5p	PAR-CLIP	20371350
MIRT571231	hsa-miR-4795-5p	PAR-CLIP	20371350
MIRT571230	hsa-miR-1253	PAR-CLIP	20371350
MIRT571229	hsa-miR-6770-5p	PAR-CLIP	20371350
MIRT571228	hsa-miR-3171	PAR-CLIP	20371350
MIRT571227	hsa-miR-567	PAR-CLIP	20371350
MIRT571225	hsa-miR-4711-3p	PAR-CLIP	20371350
MIRT571226	hsa-miR-3616-5p	PAR-CLIP	20371350
MIRT571224	hsa-miR-573	PAR-CLIP	20371350
MIRT571223	hsa-miR-297	PAR-CLIP	20371350
MIRT450067	hsa-miR-100-3p	PAR-CLIP	22100165
MIRT450065	hsa-miR-3919	PAR-CLIP	22100165
MIRT450066	hsa-miR-4756-3p	PAR-CLIP	22100165
MIRT450064	hsa-miR-3928-5p	PAR-CLIP	22100165
MIRT450063	hsa-miR-6806-3p	PAR-CLIP	22100165
MIRT450062	hsa-miR-127-5p	PAR-CLIP	22100165
MIRT571234	hsa-miR-651-3p	PAR-CLIP	20371350
MIRT571233	hsa-miR-511-3p	PAR-CLIP	20371350
MIRT571232	hsa-miR-1252-5p	PAR-CLIP	20371350
MIRT571231	hsa-miR-4795-5p	PAR-CLIP	20371350
MIRT571230	hsa-miR-1253	PAR-CLIP	20371350
MIRT571229	hsa-miR-6770-5p	PAR-CLIP	20371350
MIRT571228	hsa-miR-3171	PAR-CLIP	20371350
MIRT571227	hsa-miR-567	PAR-CLIP	20371350
MIRT571225	hsa-miR-4711-3p	PAR-CLIP	20371350
MIRT571226	hsa-miR-3616-5p	PAR-CLIP	20371350
MIRT571224	hsa-miR-573	PAR-CLIP	20371350
MIRT571223	hsa-miR-297	PAR-CLIP	20371350
MIRT571234	hsa-miR-651-3p	PAR-CLIP	20371350
MIRT571233	hsa-miR-511-3p	PAR-CLIP	20371350
MIRT571232	hsa-miR-1252-5p	PAR-CLIP	20371350
MIRT571231	hsa-miR-4795-5p	PAR-CLIP	20371350
MIRT571230	hsa-miR-1253	PAR-CLIP	20371350
MIRT571229	hsa-miR-6770-5p	PAR-CLIP	20371350
MIRT571228	hsa-miR-3171	PAR-CLIP	20371350
MIRT571227	hsa-miR-567	PAR-CLIP	20371350
MIRT571225	hsa-miR-4711-3p	PAR-CLIP	20371350
MIRT571226	hsa-miR-3616-5p	PAR-CLIP	20371350
MIRT571224	hsa-miR-573	PAR-CLIP	20371350
MIRT571223	hsa-miR-297	PAR-CLIP	20371350
MIRT450067	hsa-miR-100-3p	PAR-CLIP	22100165
MIRT450065	hsa-miR-3919	PAR-CLIP	22100165
MIRT450066	hsa-miR-4756-3p	PAR-CLIP	22100165
MIRT450064	hsa-miR-3928-5p	PAR-CLIP	22100165
MIRT450063	hsa-miR-6806-3p	PAR-CLIP	22100165
MIRT450062	hsa-miR-127-5p	PAR-CLIP	22100165
MIRT1407780	hsa-miR-1229	CLIP-seq
MIRT1407781	hsa-miR-1257	CLIP-seq
MIRT1407782	hsa-miR-136	CLIP-seq
MIRT1407783	hsa-miR-141	CLIP-seq
MIRT1407784	hsa-miR-196a	CLIP-seq
MIRT1407785	hsa-miR-196b	CLIP-seq
MIRT1407786	hsa-miR-200a	CLIP-seq
MIRT1407787	hsa-miR-2052	CLIP-seq
MIRT1407788	hsa-miR-219-2-3p	CLIP-seq
MIRT1407789	hsa-miR-2964a-3p	CLIP-seq
MIRT1407790	hsa-miR-3117-5p	CLIP-seq
MIRT1407791	hsa-miR-324-5p	CLIP-seq
MIRT1407792	hsa-miR-3607-5p	CLIP-seq
MIRT1407793	hsa-miR-3622b-5p	CLIP-seq
MIRT1407794	hsa-miR-380	CLIP-seq
MIRT1407795	hsa-miR-3977	CLIP-seq
MIRT1407796	hsa-miR-425	CLIP-seq
MIRT1407797	hsa-miR-4642	CLIP-seq
MIRT1407798	hsa-miR-4676-5p	CLIP-seq
MIRT1407799	hsa-miR-4695-3p	CLIP-seq
MIRT1407800	hsa-miR-4712-3p	CLIP-seq
MIRT1407801	hsa-miR-4774-5p	CLIP-seq
MIRT1407802	hsa-miR-4799-5p	CLIP-seq
MIRT1407803	hsa-miR-548m	CLIP-seq
MIRT1407804	hsa-miR-575	CLIP-seq
MIRT1407805	hsa-miR-659	CLIP-seq
MIRT1554386	hsa-miR-676	CLIP-seq
MIRT2122248	hsa-miR-1972	CLIP-seq
MIRT2122249	hsa-miR-2467-3p	CLIP-seq
MIRT2122250	hsa-miR-3619-3p	CLIP-seq
MIRT2122251	hsa-miR-4468	CLIP-seq
MIRT2122252	hsa-miR-4650-5p	CLIP-seq
MIRT2122253	hsa-miR-4782-5p	CLIP-seq
MIRT2637896	hsa-miR-1252	CLIP-seq
MIRT2637897	hsa-miR-3647-5p	CLIP-seq
MIRT2637898	hsa-miR-4496	CLIP-seq
MIRT2637896	hsa-miR-1252	CLIP-seq
MIRT2637897	hsa-miR-3647-5p	CLIP-seq
MIRT2637898	hsa-miR-4496	CLIP-seq

Show/Hide all (27)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000149	Function	SNARE binding	IBA
GO:0000149	Function	SNARE binding	IEA
GO:0001786	Function	Phosphatidylserine binding	IEA
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005544	Function	Calcium-dependent phospholipid binding	IBA
GO:0005546	Function	Phosphatidylinositol-4,5-bisphosphate binding	IEA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	TAS
GO:0007268	Process	Chemical synaptic transmission	IBA
GO:0016020	Component	Membrane	IEA
GO:0016192	Process	Vesicle-mediated transport	IBA
GO:0017158	Process	Regulation of calcium ion-dependent exocytosis	IBA
GO:0017158	Process	Regulation of calcium ion-dependent exocytosis	IEA
GO:0030669	Component	Clathrin-coated endocytic vesicle membrane	TAS
GO:0030672	Component	Synaptic vesicle membrane	IEA
GO:0030672	Component	Synaptic vesicle membrane	IEA
GO:0031045	Component	Dense core granule	IBA
GO:0031045	Component	Dense core granule	IEA
GO:0031340	Process	Positive regulation of vesicle fusion	IBA
GO:0031410	Component	Cytoplasmic vesicle	IEA
GO:0042802	Function	Identical protein binding	IEA
GO:0045202	Component	Synapse	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0061891	Function	Calcium ion sensor activity	IBA
GO:0070382	Component	Exocytic vesicle	IBA
GO:0098686	Component	Hippocampal mossy fiber to CA3 synapse	IEA
GO:0099502	Process	Calcium-dependent activation of synaptic vesicle fusion	IEA

MIM	HGNC	e!Ensembl
613528	19265	ENSG00000170743

Q86SS6

Protein name

Synaptotagmin-9 (Synaptotagmin IX) (SytIX)

Protein function

May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00168	C2	235 → 333	C2 domain	Domain
PF00168	C2	367 → 476	C2 domain	Domain

Sequence

MPGARDALCHQALQLLAELCARGALEHDSCQDFIYHLRDRARPRLRDPDISVSLLTLVVT
ACGLALFGVSLFVSWKLCWVPWRERGLPSGSKDNNQEPLNYMDTETNEQENSEDFLDPPT
PCPDSSMKISHTSPDIPLSTQTGIQENCAHGVRVQRQVTEPTSSARHNSIRRQLNLSNPD
FNIQQLQKQEQLTGIGRIKPELYKQRSLDNDDGRRSNSKACGKLNFILKYDCDLEQLIVK
IHKAVNLPAKDFSGTSDPYVKIYLLPDRKTKHQTKVHRKTLNPVFDEVFLFPVPYNDLEA
RKLHFSVYDFDRFSRHDLIGQVVVDHFLDLADFPRECILWKDIEYVTNDNVDLGELMFSL
CYLPTAGRLTITIIKARNLKAMDITGASDPYVKVSLMCDGRRLKKRKTSTKRNTLNPVYN
EAIVFDVPPENIDQIHLSIAVMDYDRVGHNEIIGVCQVGNEAERLGRDHWSEMLSYPRKP
IAHWHSLVEKR

Sequence length

491

Interactions

View interactions

	Reactome
			Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (5)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ASTHMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BREAST CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CHAGAS CARDIOMYOPATHY	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COLORECTAL CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LUNG CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (4)

Disease Name	Relationship Type	References	Evidence Score
Associations from Text MiningDisease associations identified through Pubtator
Cockayne Syndrome	Associate	26972010	★★★★★ ★☆☆☆☆ Found in Text Mining only
Heart Septal Defects	Associate	28834160	★★★★★ ★☆☆☆☆ Found in Text Mining only
Pancreatic Neoplasms	Associate	23334854	★★★★★ ★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Associate	34229539	★★★★★ ★☆☆☆☆ Found in Text Mining only

SYT9 (synaptotagmin 9)