Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	1434
Gene name Gene Name - the full gene name approved by the HGNC.	Chromosome segregation 1 like
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	CSE1L
Synonyms (NCBI Gene) Gene synonyms aliases	CAS, CSE1, XPO2
Chromosome Chromosome number	20
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	20q13.13
Summary Summary of gene provided in NCBI Entrez Gene.	Proteins that carry a nuclear localization signal (NLS) are transported into the nucleus by the importin-alpha/beta heterodimer. Importin-alpha binds the NLS, while importin-beta mediates translocation through the nuclear pore complex. After translocation

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miRTarBase ID	miRNA	Experiments	Reference
MIRT007252	hsa-miR-137	Luciferase reporter assay, Western blot	23252729
MIRT020837	hsa-miR-155-5p	Proteomics	18668040
MIRT047399	hsa-miR-34a-5p	CLASH	23622248
MIRT044669	hsa-miR-320a	CLASH	23622248
MIRT038321	hsa-miR-130b-5p	CLASH	23622248
MIRT675621	hsa-miR-3529-3p	HITS-CLIP	23824327
MIRT659339	hsa-miR-129-1-3p	HITS-CLIP	23824327
MIRT659338	hsa-miR-129-2-3p	HITS-CLIP	23824327
MIRT675620	hsa-miR-3065-5p	HITS-CLIP	23824327
MIRT659337	hsa-miR-938	HITS-CLIP	23824327
MIRT659341	hsa-miR-3646	HITS-CLIP	23824327
MIRT659340	hsa-miR-1252-3p	HITS-CLIP	23824327
MIRT659339	hsa-miR-129-1-3p	HITS-CLIP	23824327
MIRT659338	hsa-miR-129-2-3p	HITS-CLIP	23824327
MIRT659337	hsa-miR-938	HITS-CLIP	23824327
MIRT626800	hsa-miR-4709-5p	HITS-CLIP	23824327
MIRT626799	hsa-miR-1273g-3p	HITS-CLIP	23824327
MIRT626798	hsa-miR-4793-3p	HITS-CLIP	23824327
MIRT626797	hsa-miR-4252	HITS-CLIP	23824327
MIRT626796	hsa-miR-505-3p	HITS-CLIP	23824327
MIRT626795	hsa-miR-1227-3p	HITS-CLIP	23824327
MIRT626794	hsa-miR-421	HITS-CLIP	23824327
MIRT626793	hsa-miR-6512-3p	HITS-CLIP	23824327
MIRT626792	hsa-miR-6720-5p	HITS-CLIP	23824327
MIRT626791	hsa-miR-7703	HITS-CLIP	23824327
MIRT538365	hsa-miR-548a-5p	PAR-CLIP	21572407
MIRT538364	hsa-miR-548ab	PAR-CLIP	21572407
MIRT538363	hsa-miR-548ad-5p	PAR-CLIP	21572407
MIRT538362	hsa-miR-548ae-5p	PAR-CLIP	21572407
MIRT538361	hsa-miR-548ak	PAR-CLIP	21572407
MIRT538360	hsa-miR-548am-5p	PAR-CLIP	21572407
MIRT538359	hsa-miR-548ap-5p	PAR-CLIP	21572407
MIRT538358	hsa-miR-548aq-5p	PAR-CLIP	21572407
MIRT538357	hsa-miR-548ar-5p	PAR-CLIP	21572407
MIRT538356	hsa-miR-548as-5p	PAR-CLIP	21572407
MIRT538355	hsa-miR-548au-5p	PAR-CLIP	21572407
MIRT538354	hsa-miR-548ay-5p	PAR-CLIP	21572407
MIRT538353	hsa-miR-548b-5p	PAR-CLIP	21572407
MIRT538352	hsa-miR-548bb-5p	PAR-CLIP	21572407
MIRT538351	hsa-miR-548c-5p	PAR-CLIP	21572407
MIRT538350	hsa-miR-548d-5p	PAR-CLIP	21572407
MIRT538349	hsa-miR-548h-5p	PAR-CLIP	21572407
MIRT538347	hsa-miR-548i	PAR-CLIP	21572407
MIRT538348	hsa-miR-548j-5p	PAR-CLIP	21572407
MIRT538346	hsa-miR-548o-5p	PAR-CLIP	21572407
MIRT538345	hsa-miR-548w	PAR-CLIP	21572407
MIRT538344	hsa-miR-548y	PAR-CLIP	21572407
MIRT538343	hsa-miR-559	PAR-CLIP	21572407
MIRT538342	hsa-miR-548av-5p	PAR-CLIP	21572407
MIRT538341	hsa-miR-548k	PAR-CLIP	21572407
MIRT538340	hsa-miR-8054	PAR-CLIP	21572407
MIRT538339	hsa-miR-548l	PAR-CLIP	21572407
MIRT538338	hsa-miR-5692a	PAR-CLIP	21572407
MIRT538337	hsa-miR-142-5p	PAR-CLIP	21572407
MIRT538336	hsa-miR-5590-3p	PAR-CLIP	21572407
MIRT545461	hsa-miR-340-3p	PAR-CLIP	21572407
MIRT545460	hsa-miR-6827-3p	PAR-CLIP	21572407
MIRT545459	hsa-miR-371b-5p	PAR-CLIP	21572407
MIRT545458	hsa-miR-373-5p	PAR-CLIP	21572407
MIRT545457	hsa-miR-616-5p	PAR-CLIP	21572407
MIRT545456	hsa-miR-371a-5p	PAR-CLIP	21572407
MIRT545455	hsa-miR-372-5p	PAR-CLIP	21572407
MIRT545454	hsa-miR-3671	PAR-CLIP	21572407
MIRT538365	hsa-miR-548a-5p	PAR-CLIP	22012620
MIRT538364	hsa-miR-548ab	PAR-CLIP	22012620
MIRT538363	hsa-miR-548ad-5p	PAR-CLIP	22012620
MIRT538362	hsa-miR-548ae-5p	PAR-CLIP	22012620
MIRT538361	hsa-miR-548ak	PAR-CLIP	22012620
MIRT538360	hsa-miR-548am-5p	PAR-CLIP	22012620
MIRT538359	hsa-miR-548ap-5p	PAR-CLIP	22012620
MIRT538358	hsa-miR-548aq-5p	PAR-CLIP	22012620
MIRT538357	hsa-miR-548ar-5p	PAR-CLIP	22012620
MIRT538356	hsa-miR-548as-5p	PAR-CLIP	22012620
MIRT538355	hsa-miR-548au-5p	PAR-CLIP	22012620
MIRT538354	hsa-miR-548ay-5p	PAR-CLIP	22012620
MIRT538353	hsa-miR-548b-5p	PAR-CLIP	22012620
MIRT538352	hsa-miR-548bb-5p	PAR-CLIP	22012620
MIRT538351	hsa-miR-548c-5p	PAR-CLIP	22012620
MIRT538350	hsa-miR-548d-5p	PAR-CLIP	22012620
MIRT538349	hsa-miR-548h-5p	PAR-CLIP	22012620
MIRT538347	hsa-miR-548i	PAR-CLIP	22012620
MIRT538348	hsa-miR-548j-5p	PAR-CLIP	22012620
MIRT538346	hsa-miR-548o-5p	PAR-CLIP	22012620
MIRT538345	hsa-miR-548w	PAR-CLIP	22012620
MIRT538344	hsa-miR-548y	PAR-CLIP	22012620
MIRT538343	hsa-miR-559	PAR-CLIP	22012620
MIRT538342	hsa-miR-548av-5p	PAR-CLIP	22012620
MIRT538341	hsa-miR-548k	PAR-CLIP	22012620
MIRT538340	hsa-miR-8054	PAR-CLIP	22012620
MIRT538339	hsa-miR-548l	PAR-CLIP	22012620
MIRT538338	hsa-miR-5692a	PAR-CLIP	22012620
MIRT538337	hsa-miR-142-5p	PAR-CLIP	22012620
MIRT538336	hsa-miR-5590-3p	PAR-CLIP	22012620
MIRT675620	hsa-miR-3065-5p	HITS-CLIP	27418678
MIRT675620	hsa-miR-3065-5p	HITS-CLIP	27418678
MIRT675621	hsa-miR-3529-3p	HITS-CLIP	27418678
MIRT675621	hsa-miR-3529-3p	HITS-CLIP	27418678
MIRT675621	hsa-miR-3529-3p	HITS-CLIP	27418678
MIRT675621	hsa-miR-3529-3p	HITS-CLIP	23824327
MIRT659339	hsa-miR-129-1-3p	HITS-CLIP	23824327
MIRT659338	hsa-miR-129-2-3p	HITS-CLIP	23824327
MIRT675620	hsa-miR-3065-5p	HITS-CLIP	23824327
MIRT659337	hsa-miR-938	HITS-CLIP	23824327
MIRT659341	hsa-miR-3646	HITS-CLIP	23824327
MIRT659340	hsa-miR-1252-3p	HITS-CLIP	23824327
MIRT659339	hsa-miR-129-1-3p	HITS-CLIP	23824327
MIRT659338	hsa-miR-129-2-3p	HITS-CLIP	23824327
MIRT659337	hsa-miR-938	HITS-CLIP	23824327
MIRT626800	hsa-miR-4709-5p	HITS-CLIP	23824327
MIRT626799	hsa-miR-1273g-3p	HITS-CLIP	23824327
MIRT626798	hsa-miR-4793-3p	HITS-CLIP	23824327
MIRT626797	hsa-miR-4252	HITS-CLIP	23824327
MIRT626796	hsa-miR-505-3p	HITS-CLIP	23824327
MIRT626795	hsa-miR-1227-3p	HITS-CLIP	23824327
MIRT626794	hsa-miR-421	HITS-CLIP	23824327
MIRT626793	hsa-miR-6512-3p	HITS-CLIP	23824327
MIRT626792	hsa-miR-6720-5p	HITS-CLIP	23824327
MIRT626791	hsa-miR-7703	HITS-CLIP	23824327
MIRT538365	hsa-miR-548a-5p	PAR-CLIP	21572407
MIRT538364	hsa-miR-548ab	PAR-CLIP	21572407
MIRT538363	hsa-miR-548ad-5p	PAR-CLIP	21572407
MIRT538362	hsa-miR-548ae-5p	PAR-CLIP	21572407
MIRT538361	hsa-miR-548ak	PAR-CLIP	21572407
MIRT538360	hsa-miR-548am-5p	PAR-CLIP	21572407
MIRT538359	hsa-miR-548ap-5p	PAR-CLIP	21572407
MIRT538358	hsa-miR-548aq-5p	PAR-CLIP	21572407
MIRT538357	hsa-miR-548ar-5p	PAR-CLIP	21572407
MIRT538356	hsa-miR-548as-5p	PAR-CLIP	21572407
MIRT538355	hsa-miR-548au-5p	PAR-CLIP	21572407
MIRT538354	hsa-miR-548ay-5p	PAR-CLIP	21572407
MIRT538353	hsa-miR-548b-5p	PAR-CLIP	21572407
MIRT538352	hsa-miR-548bb-5p	PAR-CLIP	21572407
MIRT538351	hsa-miR-548c-5p	PAR-CLIP	21572407
MIRT538350	hsa-miR-548d-5p	PAR-CLIP	21572407
MIRT538349	hsa-miR-548h-5p	PAR-CLIP	21572407
MIRT538347	hsa-miR-548i	PAR-CLIP	21572407
MIRT538348	hsa-miR-548j-5p	PAR-CLIP	21572407
MIRT538346	hsa-miR-548o-5p	PAR-CLIP	21572407
MIRT538345	hsa-miR-548w	PAR-CLIP	21572407
MIRT538344	hsa-miR-548y	PAR-CLIP	21572407
MIRT538343	hsa-miR-559	PAR-CLIP	21572407
MIRT538342	hsa-miR-548av-5p	PAR-CLIP	21572407
MIRT538341	hsa-miR-548k	PAR-CLIP	21572407
MIRT538340	hsa-miR-8054	PAR-CLIP	21572407
MIRT538339	hsa-miR-548l	PAR-CLIP	21572407
MIRT538338	hsa-miR-5692a	PAR-CLIP	21572407
MIRT538337	hsa-miR-142-5p	PAR-CLIP	21572407
MIRT538336	hsa-miR-5590-3p	PAR-CLIP	21572407
MIRT545461	hsa-miR-340-3p	PAR-CLIP	21572407
MIRT545460	hsa-miR-6827-3p	PAR-CLIP	21572407
MIRT545459	hsa-miR-371b-5p	PAR-CLIP	21572407
MIRT545458	hsa-miR-373-5p	PAR-CLIP	21572407
MIRT545457	hsa-miR-616-5p	PAR-CLIP	21572407
MIRT545456	hsa-miR-371a-5p	PAR-CLIP	21572407
MIRT545455	hsa-miR-372-5p	PAR-CLIP	21572407
MIRT545454	hsa-miR-3671	PAR-CLIP	21572407
MIRT538365	hsa-miR-548a-5p	PAR-CLIP	22012620
MIRT538364	hsa-miR-548ab	PAR-CLIP	22012620
MIRT538363	hsa-miR-548ad-5p	PAR-CLIP	22012620
MIRT538362	hsa-miR-548ae-5p	PAR-CLIP	22012620
MIRT538361	hsa-miR-548ak	PAR-CLIP	22012620
MIRT538360	hsa-miR-548am-5p	PAR-CLIP	22012620
MIRT538359	hsa-miR-548ap-5p	PAR-CLIP	22012620
MIRT538358	hsa-miR-548aq-5p	PAR-CLIP	22012620
MIRT538357	hsa-miR-548ar-5p	PAR-CLIP	22012620
MIRT538356	hsa-miR-548as-5p	PAR-CLIP	22012620
MIRT538355	hsa-miR-548au-5p	PAR-CLIP	22012620
MIRT538354	hsa-miR-548ay-5p	PAR-CLIP	22012620
MIRT538353	hsa-miR-548b-5p	PAR-CLIP	22012620
MIRT538352	hsa-miR-548bb-5p	PAR-CLIP	22012620
MIRT538351	hsa-miR-548c-5p	PAR-CLIP	22012620
MIRT538350	hsa-miR-548d-5p	PAR-CLIP	22012620
MIRT538349	hsa-miR-548h-5p	PAR-CLIP	22012620
MIRT538347	hsa-miR-548i	PAR-CLIP	22012620
MIRT538348	hsa-miR-548j-5p	PAR-CLIP	22012620
MIRT538346	hsa-miR-548o-5p	PAR-CLIP	22012620
MIRT538345	hsa-miR-548w	PAR-CLIP	22012620
MIRT538344	hsa-miR-548y	PAR-CLIP	22012620
MIRT538343	hsa-miR-559	PAR-CLIP	22012620
MIRT538342	hsa-miR-548av-5p	PAR-CLIP	22012620
MIRT538341	hsa-miR-548k	PAR-CLIP	22012620
MIRT538340	hsa-miR-8054	PAR-CLIP	22012620
MIRT538339	hsa-miR-548l	PAR-CLIP	22012620
MIRT538338	hsa-miR-5692a	PAR-CLIP	22012620
MIRT538337	hsa-miR-142-5p	PAR-CLIP	22012620
MIRT538336	hsa-miR-5590-3p	PAR-CLIP	22012620
MIRT911627	hsa-miR-1178	CLIP-seq
MIRT911628	hsa-miR-1537	CLIP-seq
MIRT911629	hsa-miR-1973	CLIP-seq
MIRT911630	hsa-miR-19a	CLIP-seq
MIRT911631	hsa-miR-19b	CLIP-seq
MIRT911632	hsa-miR-203	CLIP-seq
MIRT911633	hsa-miR-340	CLIP-seq
MIRT911634	hsa-miR-3613-3p	CLIP-seq
MIRT911635	hsa-miR-362-5p	CLIP-seq
MIRT911636	hsa-miR-3658	CLIP-seq
MIRT911637	hsa-miR-3685	CLIP-seq
MIRT911638	hsa-miR-384	CLIP-seq
MIRT911639	hsa-miR-3920	CLIP-seq
MIRT911640	hsa-miR-4282	CLIP-seq
MIRT911641	hsa-miR-4422	CLIP-seq
MIRT911642	hsa-miR-4426	CLIP-seq
MIRT911643	hsa-miR-4496	CLIP-seq
MIRT911644	hsa-miR-4504	CLIP-seq
MIRT911645	hsa-miR-4647	CLIP-seq
MIRT911646	hsa-miR-4662b	CLIP-seq
MIRT911647	hsa-miR-4679	CLIP-seq
MIRT911648	hsa-miR-4698	CLIP-seq
MIRT911649	hsa-miR-4735-5p	CLIP-seq
MIRT911650	hsa-miR-4738-3p	CLIP-seq
MIRT911651	hsa-miR-4761-5p	CLIP-seq
MIRT911652	hsa-miR-500b	CLIP-seq
MIRT911653	hsa-miR-501-5p	CLIP-seq
MIRT911654	hsa-miR-539	CLIP-seq
MIRT911655	hsa-miR-574-3p	CLIP-seq
MIRT911656	hsa-miR-628-5p	CLIP-seq
MIRT911657	hsa-miR-629	CLIP-seq
MIRT911658	hsa-miR-889	CLIP-seq
MIRT911627	hsa-miR-1178	CLIP-seq
MIRT1970276	hsa-miR-23a	CLIP-seq
MIRT1970277	hsa-miR-23b	CLIP-seq
MIRT1970278	hsa-miR-23c	CLIP-seq
MIRT1970279	hsa-miR-3129-3p	CLIP-seq
MIRT1970280	hsa-miR-323b-3p	CLIP-seq
MIRT911633	hsa-miR-340	CLIP-seq
MIRT911634	hsa-miR-3613-3p	CLIP-seq
MIRT1970281	hsa-miR-377	CLIP-seq
MIRT911649	hsa-miR-4735-5p	CLIP-seq
MIRT911651	hsa-miR-4761-5p	CLIP-seq
MIRT911627	hsa-miR-1178	CLIP-seq
MIRT2206189	hsa-miR-128	CLIP-seq
MIRT2206190	hsa-miR-1301	CLIP-seq
MIRT2206191	hsa-miR-1323	CLIP-seq
MIRT2206192	hsa-miR-146a	CLIP-seq
MIRT2206193	hsa-miR-146b-5p	CLIP-seq
MIRT911628	hsa-miR-1537	CLIP-seq
MIRT2206194	hsa-miR-155	CLIP-seq
MIRT2206195	hsa-miR-194	CLIP-seq
MIRT911629	hsa-miR-1973	CLIP-seq
MIRT911630	hsa-miR-19a	CLIP-seq
MIRT911631	hsa-miR-19b	CLIP-seq
MIRT1970276	hsa-miR-23a	CLIP-seq
MIRT1970277	hsa-miR-23b	CLIP-seq
MIRT1970278	hsa-miR-23c	CLIP-seq
MIRT2206196	hsa-miR-3121-5p	CLIP-seq
MIRT1970279	hsa-miR-3129-3p	CLIP-seq
MIRT911633	hsa-miR-340	CLIP-seq
MIRT911634	hsa-miR-3613-3p	CLIP-seq
MIRT2206197	hsa-miR-3616-5p	CLIP-seq
MIRT911635	hsa-miR-362-5p	CLIP-seq
MIRT2206198	hsa-miR-3647-5p	CLIP-seq
MIRT911637	hsa-miR-3685	CLIP-seq
MIRT1970281	hsa-miR-377	CLIP-seq
MIRT911638	hsa-miR-384	CLIP-seq
MIRT911640	hsa-miR-4282	CLIP-seq
MIRT911641	hsa-miR-4422	CLIP-seq
MIRT911643	hsa-miR-4496	CLIP-seq
MIRT2206199	hsa-miR-4539	CLIP-seq
MIRT2206200	hsa-miR-4635	CLIP-seq
MIRT2206201	hsa-miR-4660	CLIP-seq
MIRT2206202	hsa-miR-4669	CLIP-seq
MIRT2206203	hsa-miR-4670-3p	CLIP-seq
MIRT911647	hsa-miR-4679	CLIP-seq
MIRT2206204	hsa-miR-4684-3p	CLIP-seq
MIRT911648	hsa-miR-4698	CLIP-seq
MIRT2206205	hsa-miR-4724-5p	CLIP-seq
MIRT911649	hsa-miR-4735-5p	CLIP-seq
MIRT911651	hsa-miR-4761-5p	CLIP-seq
MIRT2206206	hsa-miR-4786-3p	CLIP-seq
MIRT911652	hsa-miR-500b	CLIP-seq
MIRT911653	hsa-miR-501-5p	CLIP-seq
MIRT2206207	hsa-miR-5047	CLIP-seq
MIRT2206208	hsa-miR-518a-5p	CLIP-seq
MIRT2206209	hsa-miR-527	CLIP-seq
MIRT911654	hsa-miR-539	CLIP-seq
MIRT2206210	hsa-miR-548o	CLIP-seq
MIRT2206211	hsa-miR-573	CLIP-seq
MIRT911655	hsa-miR-574-3p	CLIP-seq
MIRT2206212	hsa-miR-802	CLIP-seq
MIRT911658	hsa-miR-889	CLIP-seq
MIRT2206190	hsa-miR-1301	CLIP-seq
MIRT2206194	hsa-miR-155	CLIP-seq
MIRT2206201	hsa-miR-4660	CLIP-seq
MIRT2206207	hsa-miR-5047	CLIP-seq
MIRT2206190	hsa-miR-1301	CLIP-seq
MIRT2206192	hsa-miR-146a	CLIP-seq
MIRT2206193	hsa-miR-146b-5p	CLIP-seq
MIRT2206194	hsa-miR-155	CLIP-seq
MIRT2206196	hsa-miR-3121-5p	CLIP-seq
MIRT911637	hsa-miR-3685	CLIP-seq
MIRT911638	hsa-miR-384	CLIP-seq
MIRT2509432	hsa-miR-4428	CLIP-seq
MIRT911643	hsa-miR-4496	CLIP-seq
MIRT2206201	hsa-miR-4660	CLIP-seq
MIRT911647	hsa-miR-4679	CLIP-seq
MIRT2206207	hsa-miR-5047	CLIP-seq
MIRT2206190	hsa-miR-1301	CLIP-seq
MIRT2206192	hsa-miR-146a	CLIP-seq
MIRT2206193	hsa-miR-146b-5p	CLIP-seq
MIRT2206194	hsa-miR-155	CLIP-seq
MIRT2206196	hsa-miR-3121-5p	CLIP-seq
MIRT911637	hsa-miR-3685	CLIP-seq
MIRT911638	hsa-miR-384	CLIP-seq
MIRT2509432	hsa-miR-4428	CLIP-seq
MIRT911643	hsa-miR-4496	CLIP-seq
MIRT2206201	hsa-miR-4660	CLIP-seq
MIRT911647	hsa-miR-4679	CLIP-seq
MIRT2206207	hsa-miR-5047	CLIP-seq

Show/Hide all(18)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005049	Function	Nuclear export signal receptor activity	IBA
GO:0005049	Function	Nuclear export signal receptor activity	TAS	9323134
GO:0005515	Function	Protein binding	IPI	17719542, 21209336, 30833792
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	TAS	9323134
GO:0005635	Component	Nuclear envelope	IBA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	TAS	9323134
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	IDA
GO:0006606	Process	Protein import into nucleus	IBA
GO:0006611	Process	Protein export from nucleus	IBA
GO:0006886	Process	Intracellular protein transport	IEA
GO:0015031	Process	Protein transport	IEA
GO:0016020	Component	Membrane	HDA	19946888
GO:0031267	Function	Small GTPase binding	IEA
GO:0070062	Component	Extracellular exosome	HDA	19056867, 20458337

MIM	HGNC	e!Ensembl
601342	2431	ENSG00000124207

Protein

UniProt ID

P55060

Protein name

Exportin-2 (Exp2) (Cellular apoptosis susceptibility protein) (Chromosome segregation 1-like protein) (Importin-alpha re-exporter)

Protein function

Export receptor for importin-alpha. Mediates importin-alpha re-export from the nucleus to the cytoplasm after import substrates (cargos) have been released into the nucleoplasm. In the nucleus binds cooperatively to importin-alpha and to the GTP

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF03810	IBN_N	29 → 102	Importin-beta N-terminal domain	Family
PF08506	Cse1	156 → 526	Cse1	Family
PF03378	CAS_CSE1	527 → 962	CAS/CSE protein, C-terminus	Family

Tissue specificity

TISSUE SPECIFICITY: Detected in brain, placenta, ovary, testis and trachea (at protein level) (PubMed:10331944). Widely expressed (PubMed:10331944). Highly expressed in testis and in proliferating cells (PubMed:10331944, PubMed:7479798). {ECO:0000269|PubM

Sequence

MELSDANLQTLTEYLKKTLDPDPAIRRPAEKFLESVEGNQNYPLLLLTLLEKSQDNVIKV
CASVTFKNYIKRNWRIVEDEPNKICEADRVAIKANIVHLMLSSPEQIQKQLSDAISIIGR
EDFPQKWPDLLTEMVNRFQSGDFHVINGVLRTAHSLFKRYRHEFKSNELWTEIKLVLDAF
ALPLTNLFKATIELCSTHANDASALRILFSSLILISKLFYSLNFQDLPEFFEDNMETWMN
NFHTLLTLDNKLLQTDDEEEAGLLELLKSQICDNAALYAQKYDEEFQRYLPRFVTAIWNL
LVTTGQEVKYDLLVSNAIQFLASVCERPHYKNLFEDQNTLTSICEKVIVPNMEFRAADEE
AFEDNSEEYIRRDLEGSDIDTRRRAACDLVRGLCKFFEGPVTGIFSGYVNSMLQEYAKNP
SVNWKHKDAAIYLVTSLASKAQTQKHGITQANELVNLTEFFVNHILPDLKSANVNEFPVL
KADGIKYIMIFRNQVPKEHLLVSIPLLINHLQAESIVVHTYAAHALERLFTMRGPNNATL
FTAAEIAPFVEILLTNLFKALTLPGSSENEYIMKAIMRSFSLLQEAIIPYIPTLITQLTQ
KLLAVSKNPSKPHFNHYMFEAICLSIRITCKANPAAVVNFEEALFLVFTEILQNDVQEFI
PYVFQVMSLLLETHKNDIPSSYMALFPHLLQPVLWERTGNIPALVRLLQAFLERGSNTIA
SAAADKIPGLLGVFQKLIASKANDHQGFYLLNSIIEHMPPESVDQYRKQIFILLFQRLQN
SKTTKFIKSFLVFINLYCIKYGALALQEIFDGIQPKMFGMVLEKIIIPEIQKVSGNVEKK
ICAVGITKLLTECPPMMDTEYTKLWTPLLQSLIGLFELPEDDTIPDEEHFIDIEDTPGYQ
TAFSQLAFAGKKEHDPVGQMVNNPKIHLAQSLHKLSTACPGRVPSMVSTSLNAEALQYLQ
GYLQAASVTLL

Sequence length

971

Interactions

View interactions

	KEGG
	Nucleocytoplasmic transport Salmonella infection

Show/Hide Unknown Diseases (2)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Alzheimer disease	Alzheimer's disease or family history of Alzheimer's disease	N/A	N/A	GWAS
Dyslexia	Dyslexia	N/A	N/A	GWAS

Show/Hide Text Mining Associations (38)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Adenocarcinoma	Associate	27941559
Alzheimer Disease	Stimulate	27521996
Arthritis Rheumatoid	Associate	11181651
Barrett Esophagus	Associate	27941559
Breast Neoplasms	Associate	26668314, 35403306, 8963895
Burkitt Lymphoma	Stimulate	22967991
Carcinogenesis	Associate	11351043, 27521996
Carcinoma Hepatocellular	Associate	31371628, 33602168, 38410971
Carcinoma Non Small Cell Lung	Associate	34299277
Colonic Neoplasms	Associate	18059182
Colorectal Neoplasms	Associate	22711543, 23621178, 27121919, 36319976, 37749132, 8963895
Colorectal Neoplasms	Stimulate	27521996
Drug Related Side Effects and Adverse Reactions	Associate	37759078
Endometriosis	Inhibit	29630856
Glioblastoma	Associate	11351043, 34022224
Hodgkin Disease	Associate	9006318
Infertility Male	Associate	37892144
Leukemia	Associate	8963895
Leukemia Myelogenous Chronic BCR ABL Positive	Stimulate	36652402
Lung Neoplasms	Associate	34022224
Lymphatic Metastasis	Associate	31383592
Lymphoma	Associate	9006318
Lymphoma Large B Cell Diffuse	Associate	22967991
Lymphoma Non Hodgkin	Stimulate	27941559
Lymphoma Non Hodgkin	Associate	9006318
Mouth Neoplasms	Associate	32495878
Neoplasms	Associate	18059182, 18377724, 22653741, 23252729, 26668314, 30485574, 34022224, 35403306, 36652402, 36797043, 37055441, 7479798
Neoplasms	Stimulate	27941559
Osteosarcoma	Associate	28387323
Ovarian Neoplasms	Associate	35013112
Pancreatic Neoplasms	Associate	36332889
Polyposis Syndrome Hereditary Mixed 1	Associate	22711543
Schizophrenia	Associate	32398722
Seminoma	Associate	30485574
Squamous Cell Carcinoma of Head and Neck	Associate	35634436
Triple Negative Breast Neoplasms	Associate	35403306
Urethritis	Associate	22653741
Urinary Bladder Neoplasms	Associate	22653741

CSE1L (chromosome segregation 1 like)