Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
1432
Gene name Gene Name - the full gene name approved by the HGNC.
Mitogen-activated protein kinase 14
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
MAPK14
Synonyms (NCBI Gene) Gene synonyms aliases
CSBP, CSBP1, CSBP2, CSPB1, EXIP, Mxi2, PRKM14, PRKM15, RK, SAPK2A, p38, p38ALPHA
Chromosome Chromosome number
6
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
6p21.31
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT003986 hsa-miR-199a-3p Western blot 18456660
MIRT002610 hsa-miR-124-3p Microarray 15685193
MIRT002950 hsa-miR-24-3p Luciferase reporter assay 15131085
MIRT006423 hsa-miR-200a-3p Luciferase reporter assay, Microarray, Western blot 22101765
MIRT006423 hsa-miR-200a-3p Luciferase reporter assay, Microarray, Western blot 22101765
Transcription factors
Transcription factor Regulation Reference
MEF2A Activation 18073218
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000077 Process DNA damage checkpoint IEA
GO:0000187 Process Activation of MAPK activity TAS
GO:0000902 Process Cell morphogenesis IEA
GO:0000922 Component Spindle pole IEA
GO:0001502 Process Cartilage condensation IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
600289 6876 ENSG00000112062
Protein
UniProt ID Q16539
Protein name Mitogen-activated protein kinase 14 (MAP kinase 14) (MAPK 14) (EC 2.7.11.24) (Cytokine suppressive anti-inflammatory drug-binding protein) (CSAID-binding protein) (CSBP) (MAP kinase MXI2) (MAX-interacting protein 2) (Mitogen-activated protein kinase p38 a
Protein function Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli su
PDB 1A9U , 1BL6 , 1BL7 , 1BMK , 1DI9 , 1IAN , 1KV1 , 1KV2 , 1M7Q , 1OUK , 1OUY , 1OVE , 1OZ1 , 1R39 , 1R3C , 1W7H , 1W82 , 1W83 , 1W84 , 1WBN , 1WBO , 1WBS , 1WBT , 1WBV , 1WBW , 1WFC , 1YQJ , 1ZYJ , 1ZZ2 , 1ZZL , 2BAJ , 2BAK , 2BAL , 2BAQ , 2FSL , 2FSM , 2FSO , 2FST , 2GFS , 2I0H , 2LGC , 2NPQ , 2OKR , 2ONL , 2QD9 , 2RG5 , 2RG6 , 2Y8O , 2YIS , 2YIW , 2YIX
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00069 Pkinase 24 308 Protein kinase domain Domain
Tissue specificity TISSUE SPECIFICITY: Brain, heart, placenta, pancreas and skeletal muscle. Expressed to a lesser extent in lung, liver and kidney.
Sequence
Sequence length 360
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Endocrine resistance
MAPK signaling pathway
Rap1 signaling pathway
FoxO signaling pathway
Sphingolipid signaling pathway
Oocyte meiosis
Efferocytosis
Cellular senescence
Adrenergic signaling in cardiomyocytes
VEGF signaling pathway
Osteoclast differentiation
Signaling pathways regulating pluripotency of stem cells
Platelet activation
Neutrophil extracellular trap formation
Toll-like receptor signaling pathway
NOD-like receptor signaling pathway
RIG-I-like receptor signaling pathway
C-type lectin receptor signaling pathway
IL-17 signaling pathway
Th1 and Th2 cell differentiation
Th17 cell differentiation
T cell receptor signaling pathway
Fc epsilon RI signaling pathway
TNF signaling pathway
Leukocyte transendothelial migration
Thermogenesis
Neurotrophin signaling pathway
Retrograde endocannabinoid signaling
Dopaminergic synapse
Inflammatory mediator regulation of TRP channels
GnRH signaling pathway
Progesterone-mediated oocyte maturation
Prolactin signaling pathway
Relaxin signaling pathway
Non-alcoholic fatty liver disease
AGE-RAGE signaling pathway in diabetic complications
Growth hormone synthesis, secretion and action
Alcoholic liver disease
Amyotrophic lateral sclerosis
Prion disease
Pathways of neurodegeneration - multiple diseases
Epithelial cell signaling in Helicobacter pylori infection
Pathogenic Escherichia coli infection
Shigellosis
Salmonella infection
Pertussis
Yersinia infection
Leishmaniasis
Chagas disease
Toxoplasmosis
Tuberculosis
Hepatitis B
Human cytomegalovirus infection
Kaposi sarcoma-associated herpesvirus infection
Epstein-Barr virus infection
Human immunodeficiency virus 1 infection
Coronavirus disease - COVID-19
Proteoglycans in cancer
Chemical carcinogenesis - reactive oxygen species
PD-L1 expression and PD-1 checkpoint pathway in cancer
Diabetic cardiomyopathy
Lipid and atherosclerosis
Fluid shear stress and atherosclerosis
  NOD1/2 Signaling Pathway
p38MAPK events
ERK/MAPK targets
Oxidative Stress Induced Senescence
DSCAM interactions
ADP signalling through P2Y purinoceptor 1
Platelet sensitization by LDL
VEGFA-VEGFR2 Pathway
activated TAK1 mediates p38 MAPK activation
Activation of the AP-1 family of transcription factors
Myogenesis
RHO GTPases Activate NADPH Oxidases
Neutrophil degranulation
Regulation of TP53 Activity through Phosphorylation
CD163 mediating an anti-inflammatory response
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Cardiomyopathy Cardiomyopathies, Primary, Cardiomyopathies rs267607003, rs267607002, rs267607004, rs63750743, rs121908333, rs121908334, rs104894655, rs121434420, rs121434421, rs193922674, rs111517471, rs121908987, rs193922384, rs121909374, rs121909377
View all (900 more)
10620750
Cholestasis Cholestasis, Extrahepatic, Cholestasis rs121909103, rs751511532, rs376368459, rs762702807, rs1578490102, rs1578499691, rs1578504946, rs1317656688, rs199791850, rs1452792080, rs1578491039 30026087, 20626112
Diabetes mellitus Diabetes Mellitus, Insulin-Dependent, Diabetes Mellitus, Non-Insulin-Dependent rs587776515, rs61730328, rs606231121, rs606231122, rs79020217, rs77625743, rs78378398, rs606231123, rs1362648752, rs104893649, rs80356624, rs80356616, rs80356625, rs80356611, rs104894237
View all (293 more)
28672053
Gastric cancer Gastric Adenocarcinoma rs137854571, rs63751108, rs34612342, rs121908383, rs121909144, rs121909775, rs121909219, rs121909223, rs63750871, rs80359530, rs121964873, rs121913530, rs606231203, rs121918505, rs587776802
View all (244 more)
Unknown
Disease term Disease name Evidence References Source
Rheumatoid arthritis Rheumatoid arthritis GWAS
Associations from Text Mining
Disease Name Relationship Type References
Acute Coronary Syndrome Associate 25164947
Acute Lung Injury Associate 33949285
Acute On Chronic Liver Failure Associate 26391982
Adenocarcinoma Associate 22375031, 26559273, 27540973
Adenocarcinoma Stimulate 27775076
Adenocarcinoma of Lung Associate 24317180, 25434989, 26661061, 33361736
Adenoma Oxyphilic Associate 33960011
Adenomatous Polyposis Coli Associate 12865273
Adjustment Disorders Associate 15830375
Adrenoleukodystrophy Stimulate 37974207