Gene Gene information from NCBI Gene database.
Entrez ID 1432
Gene name Mitogen-activated protein kinase 14
Gene symbol MAPK14
Synonyms (NCBI Gene)
CSBPCSBP1CSBP2CSPB1EXIPMxi2PRKM14PRKM15RKSAPK2Ap38p38ALPHA
Chromosome 6
Chromosome location 6p21.31
Summary The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription
miRNA miRNA information provided by mirtarbase database.
712
miRTarBase ID miRNA Experiments Reference
MIRT003986 hsa-miR-199a-3p Western blot 18456660
MIRT002610 hsa-miR-124-3p Microarray 15685193
MIRT002950 hsa-miR-24-3p Luciferase reporter assay 15131085
MIRT006423 hsa-miR-200a-3p Luciferase reporter assayMicroarrayWestern blot 22101765
MIRT006423 hsa-miR-200a-3p Luciferase reporter assayMicroarrayWestern blot 22101765
Transcription factors Transcription factors information provided by TRRUST V2 database.
1
Transcription factor Regulation Reference
MEF2A Activation 18073218
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
132
GO ID Ontology Definition Evidence Reference
GO:0000077 Process DNA damage checkpoint signaling IEA
GO:0000165 Process MAPK cascade IEA
GO:0000165 Process MAPK cascade ISS
GO:0000166 Function Nucleotide binding IEA
GO:0000902 Process Cell morphogenesis IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
600289 6876 ENSG00000112062
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q16539
Protein name Mitogen-activated protein kinase 14 (MAP kinase 14) (MAPK 14) (EC 2.7.11.24) (Cytokine suppressive anti-inflammatory drug-binding protein) (CSAID-binding protein) (CSBP) (MAP kinase MXI2) (MAX-interacting protein 2) (Mitogen-activated protein kinase p38 a
Protein function Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli su
PDB 1A9U , 1BL6 , 1BL7 , 1BMK , 1DI9 , 1IAN , 1KV1 , 1KV2 , 1M7Q , 1OUK , 1OUY , 1OVE , 1OZ1 , 1R39 , 1R3C , 1W7H , 1W82 , 1W83 , 1W84 , 1WBN , 1WBO , 1WBS , 1WBT , 1WBV , 1WBW , 1WFC , 1YQJ , 1ZYJ , 1ZZ2 , 1ZZL , 2BAJ , 2BAK , 2BAL , 2BAQ , 2FSL , 2FSM , 2FSO , 2FST , 2GFS , 2I0H , 2LGC , 2NPQ , 2OKR , 2ONL , 2QD9 , 2RG5 , 2RG6 , 2Y8O , 2YIS , 2YIW , 2YIX
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00069 Pkinase 24 308 Protein kinase domain Domain
Tissue specificity TISSUE SPECIFICITY: Brain, heart, placenta, pancreas and skeletal muscle. Expressed to a lesser extent in lung, liver and kidney.
Sequence
Sequence length 360
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Endocrine resistance
MAPK signaling pathway
Rap1 signaling pathway
FoxO signaling pathway
Sphingolipid signaling pathway
Oocyte meiosis
Efferocytosis
Cellular senescence
Adrenergic signaling in cardiomyocytes
VEGF signaling pathway
Osteoclast differentiation
Signaling pathways regulating pluripotency of stem cells
Platelet activation
Neutrophil extracellular trap formation
Toll-like receptor signaling pathway
NOD-like receptor signaling pathway
RIG-I-like receptor signaling pathway
C-type lectin receptor signaling pathway
IL-17 signaling pathway
Th1 and Th2 cell differentiation
Th17 cell differentiation
T cell receptor signaling pathway
Fc epsilon RI signaling pathway
TNF signaling pathway
Leukocyte transendothelial migration
Thermogenesis
Neurotrophin signaling pathway
Retrograde endocannabinoid signaling
Dopaminergic synapse
Inflammatory mediator regulation of TRP channels
GnRH signaling pathway
Progesterone-mediated oocyte maturation
Prolactin signaling pathway
Relaxin signaling pathway
Non-alcoholic fatty liver disease
AGE-RAGE signaling pathway in diabetic complications
Growth hormone synthesis, secretion and action
Alcoholic liver disease
Amyotrophic lateral sclerosis
Prion disease
Pathways of neurodegeneration - multiple diseases
Epithelial cell signaling in Helicobacter pylori infection
Pathogenic Escherichia coli infection
Shigellosis
Salmonella infection
Pertussis
Yersinia infection
Leishmaniasis
Chagas disease
Toxoplasmosis
Tuberculosis
Hepatitis B
Human cytomegalovirus infection
Kaposi sarcoma-associated herpesvirus infection
Epstein-Barr virus infection
Human immunodeficiency virus 1 infection
Coronavirus disease - COVID-19
Proteoglycans in cancer
Chemical carcinogenesis - reactive oxygen species
PD-L1 expression and PD-1 checkpoint pathway in cancer
Diabetic cardiomyopathy
Lipid and atherosclerosis
Fluid shear stress and atherosclerosis
  NOD1/2 Signaling Pathway
p38MAPK events
ERK/MAPK targets
Oxidative Stress Induced Senescence
DSCAM interactions
ADP signalling through P2Y purinoceptor 1
Platelet sensitization by LDL
VEGFA-VEGFR2 Pathway
activated TAK1 mediates p38 MAPK activation
Activation of the AP-1 family of transcription factors
Myogenesis
RHO GTPases Activate NADPH Oxidases
Neutrophil degranulation
Regulation of TP53 Activity through Phosphorylation
CD163 mediating an anti-inflammatory response