Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
143187
Gene name Gene Name - the full gene name approved by the HGNC.
Vesicle transport through interaction with t-SNAREs 1A
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
VTI1A
Synonyms (NCBI Gene) Gene synonyms aliases
MMDS3, MVti1, VTI1RP2, Vti1-rp2
Chromosome Chromosome number
10
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
10q25.2
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is a member of the family of soluble N-ethylmaleimide-sensitive fusion protein-attachment protein receptors (SNAREs) that function in intracellular trafficking. This family member is involved in vesicular transport between
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT042407 hsa-miR-18b-5p CLASH 23622248
MIRT040753 hsa-miR-18a-3p CLASH 23622248
MIRT721733 hsa-miR-141-5p HITS-CLIP 19536157
MIRT721732 hsa-miR-532-5p HITS-CLIP 19536157
MIRT721731 hsa-miR-6793-3p HITS-CLIP 19536157
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000139 Component Golgi membrane IEA
GO:0000139 Component Golgi membrane TAS
GO:0000149 Function SNARE binding IBA
GO:0005484 Function SNAP receptor activity IBA
GO:0005484 Function SNAP receptor activity IDA 15215310
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
614316 17792 ENSG00000151532
Protein
UniProt ID Q96AJ9
Protein name Vesicle transport through interaction with t-SNAREs homolog 1A (Vesicle transport v-SNARE protein Vti1-like 2) (Vti1-rp2)
Protein function V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF05008 V-SNARE 12 90 Vesicle transport v-SNARE protein N-terminus Family
PF12352 V-SNARE_C 123 188 Domain
Sequence
Sequence length 217
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  SNARE interactions in vesicular transport   Intra-Golgi traffic
Retrograde transport at the Trans-Golgi-Network
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Colorectal Cancer Colorectal cancer N/A N/A GWAS
Diabetes Type 2 diabetes N/A N/A GWAS
Heart Failure Heart failure N/A N/A GWAS
Hypertrophic cardiomyopathy Hypertrophic cardiomyopathy N/A N/A GWAS
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Breast Neoplasms Associate 23677579
Carcinoma Non Small Cell Lung Associate 25744365
Colonic Neoplasms Associate 21892161
Colorectal Neoplasms Associate 21892161, 24608966, 26965516, 29975781
Lung Neoplasms Associate 25744365
Stomach Neoplasms Associate 34551773