Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
143098
Gene name Gene Name - the full gene name approved by the HGNC.
MAGUK p55 scaffold protein 7
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
MPP7
Synonyms (NCBI Gene) Gene synonyms aliases
-
Chromosome Chromosome number
10
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
10p12.1
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is a member of the p55 Stardust family of membrane-associated guanylate kinase (MAGUK) proteins, which function in the establishment of epithelial cell polarity. This family member forms a complex with the polarity protein
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT028259 hsa-miR-32-5p Sequencing 20371350
MIRT1156495 hsa-miR-10a CLIP-seq
MIRT1156496 hsa-miR-10b CLIP-seq
MIRT1156497 hsa-miR-1179 CLIP-seq
MIRT1156498 hsa-miR-122 CLIP-seq
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 17237226, 24366813, 28514442, 32296183, 33961781
GO:0005654 Component Nucleoplasm IDA
GO:0005737 Component Cytoplasm IEA
GO:0005886 Component Plasma membrane IBA
GO:0005886 Component Plasma membrane IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
610973 26542 ENSG00000150054
Protein
UniProt ID Q5T2T1
Protein name MAGUK p55 subfamily member 7
Protein function Acts as an important adapter that promotes epithelial cell polarity and tight junction formation via its interaction with DLG1. Involved in the assembly of protein complexes at sites of cell-cell contact.
PDB 3LRA , 3O46
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF02828 L27 15 67 L27 domain Domain
PF02828 L27 73 124 L27 domain Domain
PF00595 PDZ 139 217 PDZ domain Domain
PF00018 SH3_1 234 290 SH3 domain Domain
PF00625 Guanylate_kin 367 562 Guanylate kinase Domain
Sequence
Sequence length 576
Interactions View interactions
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Dementia Dementia N/A N/A GWAS
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Breast Neoplasms Associate 37194388
Carcinoma Pancreatic Ductal Associate 30765601
Carcinoma Renal Cell Associate 31746384
Neoplasms Cystic Mucinous and Serous Associate 38016970
Pancreatic Neoplasms Associate 30765601