Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	1409
Gene name Gene Name - the full gene name approved by the HGNC.	Crystallin alpha A
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	CRYAA
Synonyms (NCBI Gene) Gene synonyms aliases	CRYA1, CTRCT9, HSPB4
Chromosome Chromosome number	21
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	21q22.3
Summary Summary of gene provided in NCBI Entrez Gene.	Mammalian lens crystallins are divided into alpha, beta, and gamma families. Alpha crystallins are composed of two gene products: alpha-A and alpha-B, for acidic and basic, respectively. Alpha crystallins can be induced by heat shock and are members of th

Show/Hide all(20)

miRTarBase ID	miRNA	Experiments	Reference
MIRT025225	hsa-miR-34a-5p	Proteomics	21566225
MIRT025225	hsa-miR-34a-5p	Proteomics	21566225
MIRT025225	hsa-miR-34a-5p	Proteomics	21566225
MIRT030179	hsa-miR-26b-5p	Microarray	19088304
MIRT732894	hsa-miR-551b-3p	Western blotting, qRT-PCR	32835529
MIRT911153	hsa-miR-1304	CLIP-seq
MIRT911154	hsa-miR-1915	CLIP-seq
MIRT911155	hsa-miR-214	CLIP-seq
MIRT911156	hsa-miR-219-1-3p	CLIP-seq
MIRT911157	hsa-miR-3197	CLIP-seq
MIRT911158	hsa-miR-3619-5p	CLIP-seq
MIRT911159	hsa-miR-4291	CLIP-seq
MIRT911160	hsa-miR-4755-3p	CLIP-seq
MIRT911161	hsa-miR-566	CLIP-seq
MIRT911162	hsa-miR-761	CLIP-seq
MIRT911163	hsa-miR-922	CLIP-seq
MIRT911164	hsa-miR-939	CLIP-seq
MIRT2206128	hsa-miR-1205	CLIP-seq
MIRT2206129	hsa-miR-1909	CLIP-seq
MIRT911164	hsa-miR-939	CLIP-seq

Show/Hide all(46)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001666	Process	Response to hypoxia	IEA
GO:0002088	Process	Lens development in camera-type eye	IBA
GO:0002088	Process	Lens development in camera-type eye	IEA
GO:0002089	Process	Lens morphogenesis in camera-type eye	IEA
GO:0005198	Function	Structural molecule activity	IDA	16303126
GO:0005198	Function	Structural molecule activity	IEA
GO:0005212	Function	Structural constituent of eye lens	IEA
GO:0005515	Function	Protein binding	IPI	11700327, 12235146, 12601044, 14752512, 19651604, 22085609, 22153508, 23188086, 25416956, 25910212, 29892012, 31515488, 32296183, 32814053, 33961781
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	19464326
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IDA	14752512, 19464326, 19503744, 26004348, 29259299, 30340470
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA
GO:0006915	Process	Apoptotic process	IEA
GO:0007005	Process	Mitochondrion organization	IEA
GO:0007015	Process	Actin filament organization	IEA
GO:0007017	Process	Microtubule-based process	IEA
GO:0007021	Process	Tubulin complex assembly	IEA
GO:0007601	Process	Visual perception	IEA
GO:0007601	Process	Visual perception	IMP	9467006, 14512969
GO:0009408	Process	Response to heat	IBA
GO:0010629	Process	Negative regulation of gene expression	IEA
GO:0030307	Process	Positive regulation of cell growth	IEA
GO:0032387	Process	Negative regulation of intracellular transport	IDA	14752512
GO:0032991	Component	Protein-containing complex	IDA	16303126
GO:0042026	Process	Protein refolding	IBA
GO:0042026	Process	Protein refolding	ISS
GO:0042542	Process	Response to hydrogen peroxide	IEA
GO:0042802	Function	Identical protein binding	IPI	12601044, 16303126, 19651604, 22085609, 25416956, 32296183
GO:0043010	Process	Camera-type eye development	IEA
GO:0043066	Process	Negative regulation of apoptotic process	IBA
GO:0043066	Process	Negative regulation of apoptotic process	IDA	14752512
GO:0043066	Process	Negative regulation of apoptotic process	IEA
GO:0043066	Process	Negative regulation of apoptotic process	IMP	14512969
GO:0046872	Function	Metal ion binding	IEA
GO:0048596	Process	Embryonic camera-type eye morphogenesis	IEA
GO:0050821	Process	Protein stabilization	IMP	12235146
GO:0051082	Function	Unfolded protein binding	IBA
GO:0051082	Function	Unfolded protein binding	IMP	18407550
GO:0051082	Function	Unfolded protein binding	IPI	8943244
GO:0060561	Process	Apoptotic process involved in morphogenesis	IEA
GO:0070141	Process	Response to UV-A	IEA
GO:0070309	Process	Lens fiber cell morphogenesis	IEA

MIM	HGNC	e!Ensembl
123580	2388	ENSG00000160202

	KEGG
	Protein processing in endoplasmic reticulum

Show/Hide Causal Diseases (1)

Disease merge term	Disease name	dbSNP ID	References
Causal Diseases caused by PATHOGENIC or LIKELY PATHOGENIC variants from ClinVar only
Cataract	Cataract 9 multiple types, Developmental cataract	rs397515623, rs397515624, rs397515625, rs397515626, rs74315439, rs864309685, rs74315441, rs121912973, rs398122947	N/A

Show/Hide Unknown Diseases (2)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Microcornea	cataract - microcornea syndrome	N/A	N/A	GenCC
Schizophrenia	Schizophrenia	N/A	N/A	GWAS

Show/Hide Text Mining Associations (19)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
AIDS Related Complex	Associate	28755661
Anterior segment mesenchymal dysgenesis	Associate	32791987
Axial osteomalacia	Associate	21686328
Capsule Opacification	Associate	28640093
Cataract	Associate	16862070, 18587492, 19390652, 20029648, 21686328, 22065922, 23288997, 23441109, 25729975, 26004348, 26867756, 26984531, 28640093, 28839118, 29259299 View all (6 more)
Cataract Age Related Nuclear	Associate	19595763, 26984531, 27507241, 28146420, 28755661, 30286462
Cataract Autosomal Dominant	Associate	29259299
Cataract Autosomal Dominant Nuclear	Associate	19390652, 28146420, 33243271
Cataract microcornea syndrome	Associate	16735993, 21686328, 23441109, 28640093, 32791987
Cataract Nuclear Progressive	Associate	28755661
Corneal Opacity	Associate	28640093
Iris Diseases	Associate	32791987
Left Right Axis Malformations	Associate	28640093
Machado Joseph Disease	Associate	25729975
Microcephaly Retinitis Pigmentosa and Sutural Cataract	Associate	23288997
Microphthalmos	Associate	30340470
Multiple Pterygium Syndrome Autosomal Dominant	Associate	23288997
Myopia	Associate	21686328, 24312600, 32010934
Nystagmus Pathologic	Associate	28640093

CRYAA (crystallin alpha A)