NANP (N-acetylneuraminic acid phosphatase)

Gene

• Entrez ID: 140838
• Gene name: N-acetylneuraminic acid phosphatase
• Gene symbol: NANP
• Synonyms (NCBI Gene): C20orf147, HDHD4, dJ694B14.3
• Chromosome: 20
• Chromosome location: 20p11.21

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT440154	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT440154	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT1173414	hsa-miR-1225-5p	CLIP-seq
MIRT1173415	hsa-miR-124	CLIP-seq
MIRT1173416	hsa-miR-128	CLIP-seq
MIRT1173417	hsa-miR-1283	CLIP-seq
MIRT1173418	hsa-miR-1285	CLIP-seq
MIRT1173419	hsa-miR-132	CLIP-seq
MIRT1173420	hsa-miR-181a	CLIP-seq
MIRT1173421	hsa-miR-181b	CLIP-seq
MIRT1173422	hsa-miR-181c	CLIP-seq
MIRT1173423	hsa-miR-181d	CLIP-seq
MIRT1173424	hsa-miR-186	CLIP-seq
MIRT1173425	hsa-miR-1914	CLIP-seq
MIRT1173426	hsa-miR-19a	CLIP-seq
MIRT1173427	hsa-miR-19b	CLIP-seq
MIRT1173428	hsa-miR-212	CLIP-seq
MIRT1173429	hsa-miR-217	CLIP-seq
MIRT1173430	hsa-miR-24	CLIP-seq
MIRT1173431	hsa-miR-299-5p	CLIP-seq
MIRT1173432	hsa-miR-29a	CLIP-seq
MIRT1173433	hsa-miR-29b	CLIP-seq
MIRT1173434	hsa-miR-29c	CLIP-seq
MIRT1173435	hsa-miR-3115	CLIP-seq
MIRT1173436	hsa-miR-3121-3p	CLIP-seq
MIRT1173437	hsa-miR-3133	CLIP-seq
MIRT1173438	hsa-miR-3140-5p	CLIP-seq
MIRT1173439	hsa-miR-3143	CLIP-seq
MIRT1173440	hsa-miR-3184	CLIP-seq
MIRT1173441	hsa-miR-3187-5p	CLIP-seq
MIRT1173442	hsa-miR-3202	CLIP-seq
MIRT1173443	hsa-miR-323b-5p	CLIP-seq
MIRT1173444	hsa-miR-3663-3p	CLIP-seq
MIRT1173445	hsa-miR-3714	CLIP-seq
MIRT1173446	hsa-miR-3910	CLIP-seq
MIRT1173447	hsa-miR-3927	CLIP-seq
MIRT1173448	hsa-miR-3935	CLIP-seq
MIRT1173449	hsa-miR-3942-3p	CLIP-seq
MIRT1173450	hsa-miR-3974	CLIP-seq
MIRT1173451	hsa-miR-410	CLIP-seq
MIRT1173452	hsa-miR-423-5p	CLIP-seq
MIRT1173453	hsa-miR-4262	CLIP-seq
MIRT1173454	hsa-miR-4269	CLIP-seq
MIRT1173455	hsa-miR-4284	CLIP-seq
MIRT1173456	hsa-miR-4307	CLIP-seq
MIRT1173457	hsa-miR-4418	CLIP-seq
MIRT1173458	hsa-miR-4427	CLIP-seq
MIRT1173459	hsa-miR-4436b-5p	CLIP-seq
MIRT1173460	hsa-miR-4452	CLIP-seq
MIRT1173461	hsa-miR-4470	CLIP-seq
MIRT1173462	hsa-miR-4476	CLIP-seq
MIRT1173463	hsa-miR-4477b	CLIP-seq
MIRT1173464	hsa-miR-4517	CLIP-seq
MIRT1173465	hsa-miR-4521	CLIP-seq
MIRT1173466	hsa-miR-4640-5p	CLIP-seq
MIRT1173467	hsa-miR-4645-5p	CLIP-seq
MIRT1173468	hsa-miR-4648	CLIP-seq
MIRT1173469	hsa-miR-4654	CLIP-seq
MIRT1173470	hsa-miR-4668-3p	CLIP-seq
MIRT1173471	hsa-miR-4673	CLIP-seq
MIRT1173472	hsa-miR-4680-3p	CLIP-seq
MIRT1173473	hsa-miR-4694-3p	CLIP-seq
MIRT1173474	hsa-miR-4698	CLIP-seq
MIRT1173475	hsa-miR-4726-5p	CLIP-seq
MIRT1173476	hsa-miR-4738-3p	CLIP-seq
MIRT1173477	hsa-miR-4744	CLIP-seq
MIRT1173478	hsa-miR-4755-3p	CLIP-seq
MIRT1173479	hsa-miR-4760-3p	CLIP-seq
MIRT1173480	hsa-miR-4761-5p	CLIP-seq
MIRT1173481	hsa-miR-4769-5p	CLIP-seq
MIRT1173482	hsa-miR-4775	CLIP-seq
MIRT1173483	hsa-miR-4786-5p	CLIP-seq
MIRT1173484	hsa-miR-4793-5p	CLIP-seq
MIRT1173485	hsa-miR-4794	CLIP-seq
MIRT1173486	hsa-miR-485-3p	CLIP-seq
MIRT1173487	hsa-miR-506	CLIP-seq
MIRT1173488	hsa-miR-509-3-5p	CLIP-seq
MIRT1173489	hsa-miR-509-5p	CLIP-seq
MIRT1173490	hsa-miR-510	CLIP-seq
MIRT1173491	hsa-miR-512-5p	CLIP-seq
MIRT1173492	hsa-miR-543	CLIP-seq
MIRT1173493	hsa-miR-545	CLIP-seq
MIRT1173494	hsa-miR-548ae	CLIP-seq
MIRT1173495	hsa-miR-548aj	CLIP-seq
MIRT1173496	hsa-miR-548am	CLIP-seq
MIRT1173497	hsa-miR-548x	CLIP-seq
MIRT1173498	hsa-miR-577	CLIP-seq
MIRT1173499	hsa-miR-584	CLIP-seq
MIRT1173500	hsa-miR-590-3p	CLIP-seq
MIRT1173501	hsa-miR-605	CLIP-seq
MIRT1173502	hsa-miR-612	CLIP-seq
MIRT1173503	hsa-miR-618	CLIP-seq
MIRT1173504	hsa-miR-654-3p	CLIP-seq
MIRT1173505	hsa-miR-661	CLIP-seq
MIRT1173506	hsa-miR-7	CLIP-seq
MIRT1173507	hsa-miR-767-5p	CLIP-seq
MIRT1173508	hsa-miR-892b	CLIP-seq
MIRT2050265	hsa-miR-1258	CLIP-seq
MIRT2050266	hsa-miR-1263	CLIP-seq
MIRT1173416	hsa-miR-128	CLIP-seq
MIRT1173417	hsa-miR-1283	CLIP-seq
MIRT1173430	hsa-miR-24	CLIP-seq
MIRT2050267	hsa-miR-3117-3p	CLIP-seq
MIRT2050268	hsa-miR-3169	CLIP-seq
MIRT2050269	hsa-miR-3607-3p	CLIP-seq
MIRT2050270	hsa-miR-3614-5p	CLIP-seq
MIRT2050271	hsa-miR-3686	CLIP-seq
MIRT2050272	hsa-miR-3689a-3p	CLIP-seq
MIRT2050273	hsa-miR-3689c	CLIP-seq
MIRT2050274	hsa-miR-4266	CLIP-seq
MIRT1173455	hsa-miR-4284	CLIP-seq
MIRT2050275	hsa-miR-4486	CLIP-seq
MIRT2050276	hsa-miR-4728-5p	CLIP-seq
MIRT2050277	hsa-miR-4756-3p	CLIP-seq
MIRT2050278	hsa-miR-4759	CLIP-seq
MIRT2050279	hsa-miR-4761-3p	CLIP-seq
MIRT2050280	hsa-miR-4779	CLIP-seq
MIRT2050281	hsa-miR-548g	CLIP-seq
MIRT2050282	hsa-miR-651	CLIP-seq
MIRT2050283	hsa-miR-9	CLIP-seq
MIRT2279191	hsa-miR-1208	CLIP-seq
MIRT2050266	hsa-miR-1263	CLIP-seq
MIRT1173417	hsa-miR-1283	CLIP-seq
MIRT1173424	hsa-miR-186	CLIP-seq
MIRT1173437	hsa-miR-3133	CLIP-seq
MIRT1173438	hsa-miR-3140-5p	CLIP-seq
MIRT1173439	hsa-miR-3143	CLIP-seq
MIRT2279192	hsa-miR-3189-3p	CLIP-seq
MIRT2279193	hsa-miR-329	CLIP-seq
MIRT2050270	hsa-miR-3614-5p	CLIP-seq
MIRT2279194	hsa-miR-362-3p	CLIP-seq
MIRT2050272	hsa-miR-3689a-3p	CLIP-seq
MIRT2050273	hsa-miR-3689c	CLIP-seq
MIRT1173447	hsa-miR-3927	CLIP-seq
MIRT2279195	hsa-miR-3929	CLIP-seq
MIRT1173448	hsa-miR-3935	CLIP-seq
MIRT1173450	hsa-miR-3974	CLIP-seq
MIRT1173455	hsa-miR-4284	CLIP-seq
MIRT2279196	hsa-miR-4419b	CLIP-seq
MIRT2279197	hsa-miR-4422	CLIP-seq
MIRT2279198	hsa-miR-4424	CLIP-seq
MIRT2279199	hsa-miR-4433	CLIP-seq
MIRT1173459	hsa-miR-4436b-5p	CLIP-seq
MIRT2279200	hsa-miR-4464	CLIP-seq
MIRT2279201	hsa-miR-4478	CLIP-seq
MIRT1173468	hsa-miR-4648	CLIP-seq
MIRT1173469	hsa-miR-4654	CLIP-seq
MIRT1173472	hsa-miR-4680-3p	CLIP-seq
MIRT2279202	hsa-miR-4716-5p	CLIP-seq
MIRT2279203	hsa-miR-4717-3p	CLIP-seq
MIRT2050276	hsa-miR-4728-5p	CLIP-seq
MIRT1173477	hsa-miR-4744	CLIP-seq
MIRT2279204	hsa-miR-4748	CLIP-seq
MIRT1173480	hsa-miR-4761-5p	CLIP-seq
MIRT1173481	hsa-miR-4769-5p	CLIP-seq
MIRT2279205	hsa-miR-485-5p	CLIP-seq
MIRT1173492	hsa-miR-543	CLIP-seq
MIRT1173498	hsa-miR-577	CLIP-seq
MIRT2279206	hsa-miR-659	CLIP-seq
MIRT2050283	hsa-miR-9	CLIP-seq
MIRT1173417	hsa-miR-1283	CLIP-seq
MIRT2454840	hsa-miR-3675-3p	CLIP-seq
MIRT1173470	hsa-miR-4668-3p	CLIP-seq
MIRT2454841	hsa-miR-4684-5p	CLIP-seq
MIRT1173501	hsa-miR-605	CLIP-seq
MIRT2577322	hsa-miR-103a	CLIP-seq
MIRT2577323	hsa-miR-107	CLIP-seq
MIRT2577324	hsa-miR-1184	CLIP-seq
MIRT2279191	hsa-miR-1208	CLIP-seq
MIRT2577325	hsa-miR-1251	CLIP-seq
MIRT2050266	hsa-miR-1263	CLIP-seq
MIRT1173417	hsa-miR-1283	CLIP-seq
MIRT1173418	hsa-miR-1285	CLIP-seq
MIRT2577326	hsa-miR-134	CLIP-seq
MIRT1173425	hsa-miR-1914	CLIP-seq
MIRT2577327	hsa-miR-296-3p	CLIP-seq
MIRT2577328	hsa-miR-3117-5p	CLIP-seq
MIRT2577329	hsa-miR-3118	CLIP-seq
MIRT1173436	hsa-miR-3121-3p	CLIP-seq
MIRT1173438	hsa-miR-3140-5p	CLIP-seq
MIRT2577330	hsa-miR-3164	CLIP-seq
MIRT2577331	hsa-miR-3187-3p	CLIP-seq
MIRT1173441	hsa-miR-3187-5p	CLIP-seq
MIRT1173443	hsa-miR-323b-5p	CLIP-seq
MIRT2577332	hsa-miR-3607-5p	CLIP-seq
MIRT2577333	hsa-miR-3613-3p	CLIP-seq
MIRT2577334	hsa-miR-361-5p	CLIP-seq
MIRT2577335	hsa-miR-3661	CLIP-seq
MIRT2454840	hsa-miR-3675-3p	CLIP-seq
MIRT2577336	hsa-miR-3682-5p	CLIP-seq
MIRT2577337	hsa-miR-378g	CLIP-seq
MIRT1173449	hsa-miR-3942-3p	CLIP-seq
MIRT2577338	hsa-miR-3942-5p	CLIP-seq
MIRT2577339	hsa-miR-3943	CLIP-seq
MIRT2577340	hsa-miR-4286	CLIP-seq
MIRT2577341	hsa-miR-4312	CLIP-seq
MIRT2577342	hsa-miR-4313	CLIP-seq
MIRT2577343	hsa-miR-4314	CLIP-seq
MIRT2577344	hsa-miR-4420	CLIP-seq
MIRT2279198	hsa-miR-4424	CLIP-seq
MIRT2577345	hsa-miR-4425	CLIP-seq
MIRT1173458	hsa-miR-4427	CLIP-seq
MIRT2279199	hsa-miR-4433	CLIP-seq
MIRT2577346	hsa-miR-4435	CLIP-seq
MIRT1173460	hsa-miR-4452	CLIP-seq
MIRT2577347	hsa-miR-4469	CLIP-seq
MIRT2050275	hsa-miR-4486	CLIP-seq
MIRT2577348	hsa-miR-4501	CLIP-seq
MIRT2577349	hsa-miR-4639-3p	CLIP-seq
MIRT1173468	hsa-miR-4648	CLIP-seq
MIRT1173469	hsa-miR-4654	CLIP-seq
MIRT1173470	hsa-miR-4668-3p	CLIP-seq
MIRT1173472	hsa-miR-4680-3p	CLIP-seq
MIRT2454841	hsa-miR-4684-5p	CLIP-seq
MIRT2577350	hsa-miR-4691-5p	CLIP-seq
MIRT1173474	hsa-miR-4698	CLIP-seq
MIRT2577351	hsa-miR-4700-3p	CLIP-seq
MIRT2577352	hsa-miR-4701-5p	CLIP-seq
MIRT2577353	hsa-miR-4703-5p	CLIP-seq
MIRT2577354	hsa-miR-4719	CLIP-seq
MIRT2577355	hsa-miR-4727-5p	CLIP-seq
MIRT1173476	hsa-miR-4738-3p	CLIP-seq
MIRT2577356	hsa-miR-4747-5p	CLIP-seq
MIRT1173479	hsa-miR-4760-3p	CLIP-seq
MIRT2577357	hsa-miR-4765	CLIP-seq
MIRT2577358	hsa-miR-4769-3p	CLIP-seq
MIRT1173481	hsa-miR-4769-5p	CLIP-seq
MIRT1173482	hsa-miR-4775	CLIP-seq
MIRT1173484	hsa-miR-4793-5p	CLIP-seq
MIRT2577359	hsa-miR-495	CLIP-seq
MIRT2577360	hsa-miR-513a-3p	CLIP-seq
MIRT2577361	hsa-miR-513b	CLIP-seq
MIRT2577362	hsa-miR-548p	CLIP-seq
MIRT2577363	hsa-miR-548s	CLIP-seq
MIRT2577364	hsa-miR-588	CLIP-seq
MIRT1173500	hsa-miR-590-3p	CLIP-seq
MIRT1173501	hsa-miR-605	CLIP-seq
MIRT1173502	hsa-miR-612	CLIP-seq
MIRT2577365	hsa-miR-631	CLIP-seq
MIRT1173506	hsa-miR-7	CLIP-seq
MIRT2577366	hsa-miR-892a	CLIP-seq
MIRT2050283	hsa-miR-9	CLIP-seq
MIRT2577322	hsa-miR-103a	CLIP-seq
MIRT2577323	hsa-miR-107	CLIP-seq
MIRT2577324	hsa-miR-1184	CLIP-seq
MIRT2279191	hsa-miR-1208	CLIP-seq
MIRT2577325	hsa-miR-1251	CLIP-seq
MIRT1173417	hsa-miR-1283	CLIP-seq
MIRT1173418	hsa-miR-1285	CLIP-seq
MIRT2577326	hsa-miR-134	CLIP-seq
MIRT1173425	hsa-miR-1914	CLIP-seq
MIRT2577327	hsa-miR-296-3p	CLIP-seq
MIRT2577328	hsa-miR-3117-5p	CLIP-seq
MIRT2577329	hsa-miR-3118	CLIP-seq
MIRT1173438	hsa-miR-3140-5p	CLIP-seq
MIRT2577330	hsa-miR-3164	CLIP-seq
MIRT1173441	hsa-miR-3187-5p	CLIP-seq
MIRT1173443	hsa-miR-323b-5p	CLIP-seq
MIRT2577332	hsa-miR-3607-5p	CLIP-seq
MIRT2577334	hsa-miR-361-5p	CLIP-seq
MIRT2577335	hsa-miR-3661	CLIP-seq
MIRT2454840	hsa-miR-3675-3p	CLIP-seq
MIRT2577336	hsa-miR-3682-5p	CLIP-seq
MIRT2577337	hsa-miR-378g	CLIP-seq
MIRT1173449	hsa-miR-3942-3p	CLIP-seq
MIRT2577338	hsa-miR-3942-5p	CLIP-seq
MIRT2577339	hsa-miR-3943	CLIP-seq
MIRT2577341	hsa-miR-4312	CLIP-seq
MIRT2577342	hsa-miR-4313	CLIP-seq
MIRT2577343	hsa-miR-4314	CLIP-seq
MIRT2577344	hsa-miR-4420	CLIP-seq
MIRT2279198	hsa-miR-4424	CLIP-seq
MIRT2577345	hsa-miR-4425	CLIP-seq
MIRT1173458	hsa-miR-4427	CLIP-seq
MIRT1173460	hsa-miR-4452	CLIP-seq
MIRT1173461	hsa-miR-4470	CLIP-seq
MIRT2050275	hsa-miR-4486	CLIP-seq
MIRT2577348	hsa-miR-4501	CLIP-seq
MIRT1173468	hsa-miR-4648	CLIP-seq
MIRT1173469	hsa-miR-4654	CLIP-seq
MIRT1173470	hsa-miR-4668-3p	CLIP-seq
MIRT1173472	hsa-miR-4680-3p	CLIP-seq
MIRT2454841	hsa-miR-4684-5p	CLIP-seq
MIRT2577350	hsa-miR-4691-5p	CLIP-seq
MIRT2577353	hsa-miR-4703-5p	CLIP-seq
MIRT2577354	hsa-miR-4719	CLIP-seq
MIRT2577355	hsa-miR-4727-5p	CLIP-seq
MIRT1173476	hsa-miR-4738-3p	CLIP-seq
MIRT2577356	hsa-miR-4747-5p	CLIP-seq
MIRT1173479	hsa-miR-4760-3p	CLIP-seq
MIRT2577358	hsa-miR-4769-3p	CLIP-seq
MIRT1173481	hsa-miR-4769-5p	CLIP-seq
MIRT1173482	hsa-miR-4775	CLIP-seq
MIRT1173483	hsa-miR-4786-5p	CLIP-seq
MIRT1173484	hsa-miR-4793-5p	CLIP-seq
MIRT2577360	hsa-miR-513a-3p	CLIP-seq
MIRT2577361	hsa-miR-513b	CLIP-seq
MIRT2577362	hsa-miR-548p	CLIP-seq
MIRT1173500	hsa-miR-590-3p	CLIP-seq
MIRT1173501	hsa-miR-605	CLIP-seq
MIRT1173502	hsa-miR-612	CLIP-seq
MIRT2577365	hsa-miR-631	CLIP-seq
MIRT1173505	hsa-miR-661	CLIP-seq
MIRT1173506	hsa-miR-7	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005829	Component	Cytosol	TAS
GO:0006045	Process	N-acetylglucosamine biosynthetic process	IEA
GO:0006054	Process	N-acetylneuraminate metabolic process	IEA
GO:0006055	Process	CMP-N-acetylneuraminate biosynthetic process	IEA
GO:0006055	Process	CMP-N-acetylneuraminate biosynthetic process	IMP	31121216
GO:0016787	Function	Hydrolase activity	IEA
GO:0046380	Process	N-acetylneuraminate biosynthetic process	IBA
GO:0046380	Process	N-acetylneuraminate biosynthetic process	IDA	16237198
GO:0050124	Function	N-acylneuraminate-9-phosphatase activity	IBA
GO:0050124	Function	N-acylneuraminate-9-phosphatase activity	IDA	16237198, 23747226
GO:0050124	Function	N-acylneuraminate-9-phosphatase activity	IEA
GO:0070085	Process	Glycosylation	IMP	31121216
GO:1901137	Process	Carbohydrate derivative biosynthetic process	IEA

Other IDs

• MIM: 610763
• HGNC: 16140
• e!Ensembl: ENSG00000170191

Protein

• UniProt ID: Q8TBE9
• Protein name: N-acylneuraminate-9-phosphatase (EC 3.1.3.29) (Haloacid dehalogenase-like hydrolase domain-containing protein 4) (HDHD4) (N-acetylneuraminate-9-phosphate phosphatase) (Neu5Ac-9-Pase)
• Protein function: Catalyzes the dephosphorylation of N-acylneuraminate 9-phosphate (Neu5Ac-9-P) to N-acetylneuraminic acid (Neu5Ac or sialic acid) (PubMed:14235556, PubMed:16237198, PubMed:23747226). Can also use N-glycoloylneuraminate 9-phosphate as substrate (P
• PDB: 2W4M, 4KNV, 4KNW
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF13419	HAD_2	9 → 208	Haloacid dehalogenase-like hydrolase	Family

• Sequence:

  MGLSRVRAVFFDLDNTLIDTAGASRRGMLEVIKLLQSKYHYKEEAEIICDKVQVKLSKEC
  FHPYNTCITDLRTSHWEEAIQETKGGAANRKLAEECYFLWKSTRLQHMTLAEDVKAMLTE
  LRKEVRLLLLTNGDRQTQREKIEACACQSYFDAVVVGGEQREEKPAPSIFYYCCNLLGVQ
  PGDCVMVGDTLETDIQGGLNAGLKATVWINKNGIVPLKSSPVPHYMVSSVLELPALLQSI
  DCKVSMST

• Sequence length: 248

Pathways

KEGG:

Biosynthesis of various nucleotide sugars
Metabolic pathways
Biosynthesis of nucleotide sugars

Reactome:

Sialic acid metabolism