Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	140766
Gene name	ADAM metallopeptidase with thrombospondin type 1 motif 14
Gene symbol	ADAMTS14
Synonyms (NCBI Gene)	-
Chromosome	10
Chromosome location	10q22.1
Summary	This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin

Show/Hide all (95)

miRTarBase ID	miRNA	Experiments	Reference
MIRT496781	hsa-miR-4667-5p	PAR-CLIP	22291592
MIRT496780	hsa-miR-4700-5p	PAR-CLIP	22291592
MIRT496779	hsa-miR-8089	PAR-CLIP	22291592
MIRT496778	hsa-miR-637	PAR-CLIP	22291592
MIRT496777	hsa-miR-7155-5p	PAR-CLIP	22291592
MIRT496776	hsa-miR-3184-5p	PAR-CLIP	22291592
MIRT496775	hsa-miR-423-5p	PAR-CLIP	22291592
MIRT496774	hsa-miR-3926	PAR-CLIP	22291592
MIRT496773	hsa-miR-6731-5p	PAR-CLIP	22291592
MIRT496772	hsa-miR-8085	PAR-CLIP	22291592
MIRT496771	hsa-miR-3175	PAR-CLIP	22291592
MIRT496770	hsa-miR-1343-5p	PAR-CLIP	22291592
MIRT496769	hsa-miR-939-5p	PAR-CLIP	22291592
MIRT496768	hsa-miR-6825-5p	PAR-CLIP	22291592
MIRT496767	hsa-miR-6762-5p	PAR-CLIP	22291592
MIRT496766	hsa-miR-6845-5p	PAR-CLIP	22291592
MIRT496765	hsa-miR-4314	PAR-CLIP	22291592
MIRT496764	hsa-miR-3150a-3p	PAR-CLIP	22291592
MIRT496763	hsa-miR-6763-5p	PAR-CLIP	22291592
MIRT496781	hsa-miR-4667-5p	PAR-CLIP	22291592
MIRT496780	hsa-miR-4700-5p	PAR-CLIP	22291592
MIRT496779	hsa-miR-8089	PAR-CLIP	22291592
MIRT496778	hsa-miR-637	PAR-CLIP	22291592
MIRT496777	hsa-miR-7155-5p	PAR-CLIP	22291592
MIRT496776	hsa-miR-3184-5p	PAR-CLIP	22291592
MIRT496775	hsa-miR-423-5p	PAR-CLIP	22291592
MIRT496774	hsa-miR-3926	PAR-CLIP	22291592
MIRT496773	hsa-miR-6731-5p	PAR-CLIP	22291592
MIRT496772	hsa-miR-8085	PAR-CLIP	22291592
MIRT496771	hsa-miR-3175	PAR-CLIP	22291592
MIRT496770	hsa-miR-1343-5p	PAR-CLIP	22291592
MIRT496769	hsa-miR-939-5p	PAR-CLIP	22291592
MIRT496768	hsa-miR-6825-5p	PAR-CLIP	22291592
MIRT496767	hsa-miR-6762-5p	PAR-CLIP	22291592
MIRT496766	hsa-miR-6845-5p	PAR-CLIP	22291592
MIRT496765	hsa-miR-4314	PAR-CLIP	22291592
MIRT496764	hsa-miR-3150a-3p	PAR-CLIP	22291592
MIRT496763	hsa-miR-6763-5p	PAR-CLIP	22291592
MIRT766370	hsa-let-7a	CLIP-seq
MIRT766371	hsa-let-7b	CLIP-seq
MIRT766372	hsa-let-7c	CLIP-seq
MIRT766373	hsa-let-7d	CLIP-seq
MIRT766374	hsa-let-7e	CLIP-seq
MIRT766375	hsa-let-7f	CLIP-seq
MIRT766376	hsa-let-7g	CLIP-seq
MIRT766377	hsa-let-7i	CLIP-seq
MIRT766378	hsa-miR-202	CLIP-seq
MIRT766379	hsa-miR-2277-3p	CLIP-seq
MIRT766380	hsa-miR-3660	CLIP-seq
MIRT766381	hsa-miR-4458	CLIP-seq
MIRT766382	hsa-miR-4500	CLIP-seq
MIRT766383	hsa-miR-4514	CLIP-seq
MIRT766384	hsa-miR-4526	CLIP-seq
MIRT766385	hsa-miR-4663	CLIP-seq
MIRT766386	hsa-miR-4692	CLIP-seq
MIRT766387	hsa-miR-4732-3p	CLIP-seq
MIRT766388	hsa-miR-486-3p	CLIP-seq
MIRT766389	hsa-miR-628-5p	CLIP-seq
MIRT766390	hsa-miR-940	CLIP-seq
MIRT766391	hsa-miR-98	CLIP-seq
MIRT766392	hsa-miR-218	CLIP-seq
MIRT766393	hsa-miR-3646	CLIP-seq
MIRT766394	hsa-miR-3662	CLIP-seq
MIRT766395	hsa-miR-4327	CLIP-seq
MIRT766396	hsa-miR-636	CLIP-seq
MIRT1925783	hsa-miR-1262	CLIP-seq
MIRT1925784	hsa-miR-3065-3p	CLIP-seq
MIRT1925785	hsa-miR-3120-3p	CLIP-seq
MIRT1925786	hsa-miR-3659	CLIP-seq
MIRT1925787	hsa-miR-4658	CLIP-seq
MIRT1925788	hsa-miR-4701-3p	CLIP-seq
MIRT1925789	hsa-miR-574-5p	CLIP-seq
MIRT1925790	hsa-miR-600	CLIP-seq
MIRT1925791	hsa-miR-938	CLIP-seq
MIRT2167123	hsa-miR-1972	CLIP-seq
MIRT2167124	hsa-miR-29a	CLIP-seq
MIRT2167125	hsa-miR-29b	CLIP-seq
MIRT2167126	hsa-miR-29c	CLIP-seq
MIRT1925784	hsa-miR-3065-3p	CLIP-seq
MIRT2167127	hsa-miR-338-3p	CLIP-seq
MIRT2167128	hsa-miR-4286	CLIP-seq
MIRT2167129	hsa-miR-4530	CLIP-seq
MIRT2167130	hsa-miR-4733-3p	CLIP-seq
MIRT2167131	hsa-miR-508-5p	CLIP-seq
MIRT2167132	hsa-miR-766	CLIP-seq
MIRT2383889	hsa-miR-1289	CLIP-seq
MIRT2383890	hsa-miR-2115	CLIP-seq
MIRT2383891	hsa-miR-3198	CLIP-seq
MIRT2383892	hsa-miR-3607-3p	CLIP-seq
MIRT2383893	hsa-miR-3686	CLIP-seq
MIRT2383894	hsa-miR-4294	CLIP-seq
MIRT2383895	hsa-miR-4309	CLIP-seq
MIRT2383896	hsa-miR-4487	CLIP-seq
MIRT766388	hsa-miR-486-3p	CLIP-seq
MIRT2383897	hsa-miR-516b	CLIP-seq

Show/Hide all (18)

GO ID	Ontology	Definition	Evidence
GO:0004222	Function	Metalloendopeptidase activity	IBA
GO:0004222	Function	Metalloendopeptidase activity	IEA
GO:0004222	Function	Metalloendopeptidase activity	TAS
GO:0005576	Component	Extracellular region	IEA
GO:0005576	Component	Extracellular region	TAS
GO:0006508	Process	Proteolysis	IBA
GO:0006508	Process	Proteolysis	IEA
GO:0008233	Function	Peptidase activity	IEA
GO:0008237	Function	Metallopeptidase activity	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0030198	Process	Extracellular matrix organization	IBA
GO:0030198	Process	Extracellular matrix organization	IEA
GO:0030199	Process	Collagen fibril organization	IEA
GO:0030199	Process	Collagen fibril organization	IEA
GO:0030199	Process	Collagen fibril organization	TAS
GO:0030574	Process	Collagen catabolic process	IEA
GO:0031012	Component	Extracellular matrix	IBA
GO:0046872	Function	Metal ion binding	IEA

MIM	HGNC	e!Ensembl
607506	14899	ENSG00000138316

Q8WXS8

Protein name

A disintegrin and metalloproteinase with thrombospondin motifs 14 (ADAM-TS 14) (ADAM-TS14) (ADAMTS-14) (EC 3.4.24.-)

Protein function

Has aminoprocollagen type I processing activity in the absence of ADAMTS2 (PubMed:11741898). Seems to be synthesized as a latent enzyme that requires activation to display aminoprocollagen peptidase activity (PubMed:11741898). Cleaves lysyl oxid

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01562	Pep_M12B_propep	39 → 207	Reprolysin family propeptide	Family
PF01421	Reprolysin	259 → 460	Reprolysin (M12B) family zinc metalloprotease	Domain
PF17771	ADAM_CR_2	472 → 541	ADAM cysteine-rich domain	Domain
PF00090	TSP_1	556 → 606	Thrombospondin type 1 domain	Domain
PF05986	ADAM_spacer1	714 → 829	ADAM-TS Spacer 1	Family
PF19030	TSP1_ADAMTS	851 → 906		Domain
PF19030	TSP1_ADAMTS	911 → 968		Domain
PF19030	TSP1_ADAMTS	972 → 1021		Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed in retina and at low levels in brain, lung and placenta (PubMed:11779638). High expression in fetal tissues (PubMed:11867212). {ECO:0000269|PubMed:11779638, ECO:0000269|PubMed:11867212}.

Sequence

MAPLRALLSYLLPLHCALCAAAGSRTPELHLSGKLSDYGVTVPCSTDFRGRFLSHVVSGP
AAASAGSMVVDTPPTLPRHSSHLRVARSPLHPGGTLWPGRVGRHSLYFNVTVFGKELHLR
LRPNRRLVVPGSSVEWQEDFRELFRQPLRQECVYTGGVTGMPGAAVAISNCDGLAGLIRT
DSTDFFIEPLERGQQEKEASGRTHVVYRREAVQQEWAEPDGDLHNEAFGLGDLPNLLGLV
GDQLGDTERKRRHAKPGSYSIEVLLVVDDSVVRFHGKEHVQNYVLTLMNIVDEIYHDESL
GVHINIALVRLIMVGYRQSLSLIERGNPSRSLEQVCRWAHSQQRQDPSHAEHHDHVVFLT
RQDFGPSGYAPVTGMCHPLRSCALNHEDGFSSAFVIAHETGHVLGMEHDGQGNGCADETS
LGSVMAPLVQAAFHRFHWSRCSKLELSRYLPSYDCLLDDPFDPAWPQPPELPGINYSMDE
QCRFDFGSGYQTCLAFRTFEPCKQLWCSHPDNPYFCKTKKGPPLDGTECAPGKWCFKGHC
IWKSPEQTYGQDGGWSSWTKFGSCSRSCGGGVRSRSRSCNNPSPAYGGRLCLGPMFEYQV
CNSEECPGTYEDFRAQQCAKRNSYYVHQNAKHSWVPYEPDDDAQKCELICQSADTGDVVF
MNQVVHDGTRCSYRDPYSVCARGECVPVGCDKEVGSMKADDKCGVCGGDNSHCRTVKGTL
GKASKQAGALKLVQIPAGARHIQIEALEKSPHRIVVKNQVTGSFILNPKGKEATSRTFTA
MGLEWEDAVEDAKESLKTSGPLPEAIAILALPPTEGGPRSSLAYKYVIHEDLLPLIGSNN
VLLEEMDTYEWALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPIRRR
CNQHPCSQPVWVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKACAGDRPEAR
RPCLRVPCPAQWRLGAWSQCSATCGEGIQQRQVVCRTNANSLGHCEGDRPDTVQVCSLPA
CGGNHQNSTVRADVWELGTPEGQWVPQSEPLHPINKISSTEPCTGDRSVFCQMEVLDRYC
SIPGYHRLCCVSCIKKASGPNPGPDPGPTSLPPFSTPGSPLPGPQDPADAAEPPGKPTGS
EDHQHGRATQLPGALDTSSPGTQHPFAPETPIPGASWSISPTTPGGLPWGWTQTPTPVPE
DKGQPGEDLRHPGTSLPAASPVT

Sequence length

1223

Interactions

View interactions

	Reactome
			Collagen biosynthesis and modifying enzymes Defective B3GALTL causes Peters-plus syndrome (PpS) O-glycosylation of TSR domain-containing proteins

Show/Hide Unknown Diseases (6)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Acute myeloid leukemia	Uncertain significance	rs143456400	RCV005926936
Clear cell carcinoma of kidney	Uncertain significance	rs143456400	RCV005926937
Fraser syndrome 3	Uncertain significance	rs141442936	RCV001251010
Lung cancer	Likely benign	rs375223153	RCV005930817
Thyroid cancer, nonmedullary, 1	Uncertain significance	rs143456400	RCV005926939
Uterine carcinosarcoma	Uncertain significance	rs143456400	RCV005926938

Show/Hide Text Mining Associations (14)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Arthritis	Associate	27463966
Atherosclerosis	Associate	27463966
Carcinogenesis	Associate	27463966, 28231306
Carcinoma Hepatocellular	Associate	28231306
Colorectal Neoplasms	Associate	25638164
Dupuytren Contracture	Associate	17336841
Fibrosis	Associate	17336841
Gestational Trophoblastic Disease	Associate	24786121
Idiopathic Pulmonary Fibrosis	Associate	36681777
Mouth Neoplasms	Associate	27463966
Neoplasms	Associate	25638164, 27463966, 28231306
Osteoarthritis	Stimulate	14730609
Osteoarthritis	Associate	18790654, 24301791, 30266746
Osteoarthritis Knee	Associate	18790654, 24301791, 30266746

ADAMTS14 (ADAM metallopeptidase with thrombospondin type 1 motif 14)