Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	140739
Gene name Gene Name - the full gene name approved by the HGNC.	Ubiquitin conjugating enzyme E2 F (putative)
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	UBE2F
Synonyms (NCBI Gene) Gene synonyms aliases	NCE2
Chromosome Chromosome number	2
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	2q37.3

Show/Hide all(265)

miRTarBase ID	miRNA	Experiments	Reference
MIRT004083	hsa-miR-335-5p	Luciferase reporter assay	18185580
MIRT006660	hsa-miR-129-5p	Luciferase reporter assay	19887623
MIRT006661	hsa-miR-129-2-3p	Luciferase reporter assay	19887623
MIRT040036	hsa-miR-615-3p	CLASH	23622248
MIRT633889	hsa-miR-3922-5p	HITS-CLIP	23313552
MIRT633888	hsa-miR-383-3p	HITS-CLIP	23313552
MIRT633887	hsa-miR-5187-5p	HITS-CLIP	23313552
MIRT633886	hsa-miR-7977	HITS-CLIP	23313552
MIRT633885	hsa-miR-450b-3p	HITS-CLIP	23313552
MIRT633884	hsa-miR-769-3p	HITS-CLIP	23313552
MIRT633883	hsa-miR-6728-5p	HITS-CLIP	23313552
MIRT633882	hsa-miR-5089-5p	HITS-CLIP	23313552
MIRT633881	hsa-miR-450a-1-3p	HITS-CLIP	23313552
MIRT633880	hsa-miR-3122	HITS-CLIP	23313552
MIRT633879	hsa-miR-3913-5p	HITS-CLIP	23313552
MIRT633878	hsa-miR-887-5p	HITS-CLIP	23313552
MIRT633877	hsa-miR-6513-5p	HITS-CLIP	23313552
MIRT633889	hsa-miR-3922-5p	HITS-CLIP	23824327
MIRT633888	hsa-miR-383-3p	HITS-CLIP	23824327
MIRT633887	hsa-miR-5187-5p	HITS-CLIP	23824327
MIRT633886	hsa-miR-7977	HITS-CLIP	23824327
MIRT633885	hsa-miR-450b-3p	HITS-CLIP	23824327
MIRT633884	hsa-miR-769-3p	HITS-CLIP	23824327
MIRT633883	hsa-miR-6728-5p	HITS-CLIP	23824327
MIRT633882	hsa-miR-5089-5p	HITS-CLIP	23824327
MIRT633881	hsa-miR-450a-1-3p	HITS-CLIP	23824327
MIRT633880	hsa-miR-3122	HITS-CLIP	23824327
MIRT633879	hsa-miR-3913-5p	HITS-CLIP	23824327
MIRT633878	hsa-miR-887-5p	HITS-CLIP	23824327
MIRT633877	hsa-miR-6513-5p	HITS-CLIP	23824327
MIRT464803	hsa-miR-320e	PAR-CLIP	23592263
MIRT464801	hsa-miR-4459	PAR-CLIP	23592263
MIRT464802	hsa-miR-665	PAR-CLIP	23592263
MIRT464800	hsa-miR-6840-3p	PAR-CLIP	23592263
MIRT464799	hsa-miR-1225-3p	PAR-CLIP	23592263
MIRT464798	hsa-miR-1233-3p	PAR-CLIP	23592263
MIRT464797	hsa-miR-6134	PAR-CLIP	23592263
MIRT464796	hsa-miR-3689d	PAR-CLIP	23592263
MIRT464794	hsa-miR-6851-5p	PAR-CLIP	23592263
MIRT464795	hsa-miR-876-3p	PAR-CLIP	23592263
MIRT464793	hsa-miR-656-5p	PAR-CLIP	23592263
MIRT464792	hsa-miR-1273g-5p	PAR-CLIP	23592263
MIRT464791	hsa-miR-455-3p	PAR-CLIP	23592263
MIRT464790	hsa-miR-6516-5p	PAR-CLIP	23592263
MIRT633889	hsa-miR-3922-5p	HITS-CLIP	23313552
MIRT633888	hsa-miR-383-3p	HITS-CLIP	23313552
MIRT633887	hsa-miR-5187-5p	HITS-CLIP	23313552
MIRT633886	hsa-miR-7977	HITS-CLIP	23313552
MIRT633885	hsa-miR-450b-3p	HITS-CLIP	23313552
MIRT633884	hsa-miR-769-3p	HITS-CLIP	23313552
MIRT633883	hsa-miR-6728-5p	HITS-CLIP	23313552
MIRT633882	hsa-miR-5089-5p	HITS-CLIP	23313552
MIRT633881	hsa-miR-450a-1-3p	HITS-CLIP	23313552
MIRT633880	hsa-miR-3122	HITS-CLIP	23313552
MIRT633879	hsa-miR-3913-5p	HITS-CLIP	23313552
MIRT633878	hsa-miR-887-5p	HITS-CLIP	23313552
MIRT633877	hsa-miR-6513-5p	HITS-CLIP	23313552
MIRT633889	hsa-miR-3922-5p	HITS-CLIP	23824327
MIRT633888	hsa-miR-383-3p	HITS-CLIP	23824327
MIRT633887	hsa-miR-5187-5p	HITS-CLIP	23824327
MIRT633886	hsa-miR-7977	HITS-CLIP	23824327
MIRT633885	hsa-miR-450b-3p	HITS-CLIP	23824327
MIRT633884	hsa-miR-769-3p	HITS-CLIP	23824327
MIRT633883	hsa-miR-6728-5p	HITS-CLIP	23824327
MIRT633882	hsa-miR-5089-5p	HITS-CLIP	23824327
MIRT633881	hsa-miR-450a-1-3p	HITS-CLIP	23824327
MIRT633880	hsa-miR-3122	HITS-CLIP	23824327
MIRT633879	hsa-miR-3913-5p	HITS-CLIP	23824327
MIRT633878	hsa-miR-887-5p	HITS-CLIP	23824327
MIRT633877	hsa-miR-6513-5p	HITS-CLIP	23824327
MIRT464803	hsa-miR-320e	PAR-CLIP	23592263
MIRT464801	hsa-miR-4459	PAR-CLIP	23592263
MIRT464802	hsa-miR-665	PAR-CLIP	23592263
MIRT464800	hsa-miR-6840-3p	PAR-CLIP	23592263
MIRT464799	hsa-miR-1225-3p	PAR-CLIP	23592263
MIRT464798	hsa-miR-1233-3p	PAR-CLIP	23592263
MIRT464797	hsa-miR-6134	PAR-CLIP	23592263
MIRT464796	hsa-miR-3689d	PAR-CLIP	23592263
MIRT464794	hsa-miR-6851-5p	PAR-CLIP	23592263
MIRT464795	hsa-miR-876-3p	PAR-CLIP	23592263
MIRT464793	hsa-miR-656-5p	PAR-CLIP	23592263
MIRT464792	hsa-miR-1273g-5p	PAR-CLIP	23592263
MIRT464791	hsa-miR-455-3p	PAR-CLIP	23592263
MIRT464790	hsa-miR-6516-5p	PAR-CLIP	23592263
MIRT1467463	hsa-miR-101	CLIP-seq
MIRT1467464	hsa-miR-1224-5p	CLIP-seq
MIRT1467465	hsa-miR-128	CLIP-seq
MIRT1467466	hsa-miR-1284	CLIP-seq
MIRT1467467	hsa-miR-144	CLIP-seq
MIRT1467468	hsa-miR-197	CLIP-seq
MIRT1467469	hsa-miR-27a	CLIP-seq
MIRT1467470	hsa-miR-27b	CLIP-seq
MIRT1467471	hsa-miR-324-5p	CLIP-seq
MIRT1467472	hsa-miR-3613-3p	CLIP-seq
MIRT1467473	hsa-miR-3646	CLIP-seq
MIRT1467474	hsa-miR-3653	CLIP-seq
MIRT1467475	hsa-miR-3658	CLIP-seq
MIRT1467476	hsa-miR-3674	CLIP-seq
MIRT1467477	hsa-miR-4489	CLIP-seq
MIRT1467478	hsa-miR-450b-5p	CLIP-seq
MIRT1467479	hsa-miR-4705	CLIP-seq
MIRT1467480	hsa-miR-4717-3p	CLIP-seq
MIRT1467481	hsa-miR-4724-5p	CLIP-seq
MIRT1467482	hsa-miR-4751	CLIP-seq
MIRT1467483	hsa-miR-4781-5p	CLIP-seq
MIRT1467484	hsa-miR-495	CLIP-seq
MIRT1467485	hsa-miR-507	CLIP-seq
MIRT1467486	hsa-miR-5096	CLIP-seq
MIRT1467487	hsa-miR-557	CLIP-seq
MIRT1467488	hsa-miR-580	CLIP-seq
MIRT2140480	hsa-miR-1184	CLIP-seq
MIRT2140481	hsa-miR-1205	CLIP-seq
MIRT2140482	hsa-miR-1236	CLIP-seq
MIRT2140483	hsa-miR-1238	CLIP-seq
MIRT2140484	hsa-miR-3119	CLIP-seq
MIRT2140485	hsa-miR-3127-5p	CLIP-seq
MIRT2140486	hsa-miR-3152-5p	CLIP-seq
MIRT2140487	hsa-miR-3158-3p	CLIP-seq
MIRT2140488	hsa-miR-3158-5p	CLIP-seq
MIRT2140489	hsa-miR-3183	CLIP-seq
MIRT2140490	hsa-miR-3918	CLIP-seq
MIRT2140491	hsa-miR-4723-3p	CLIP-seq
MIRT2140492	hsa-miR-490-3p	CLIP-seq
MIRT2140493	hsa-miR-649	CLIP-seq
MIRT2140494	hsa-miR-656	CLIP-seq
MIRT1467463	hsa-miR-101	CLIP-seq
MIRT2361239	hsa-miR-1267	CLIP-seq
MIRT1467466	hsa-miR-1284	CLIP-seq
MIRT2361240	hsa-miR-1324	CLIP-seq
MIRT2361241	hsa-miR-137	CLIP-seq
MIRT1467467	hsa-miR-144	CLIP-seq
MIRT2361242	hsa-miR-298	CLIP-seq
MIRT2361243	hsa-miR-30a	CLIP-seq
MIRT2361244	hsa-miR-30b	CLIP-seq
MIRT2361245	hsa-miR-30c	CLIP-seq
MIRT2361246	hsa-miR-30d	CLIP-seq
MIRT2361247	hsa-miR-30e	CLIP-seq
MIRT2140485	hsa-miR-3127-5p	CLIP-seq
MIRT2361248	hsa-miR-3166	CLIP-seq
MIRT2361249	hsa-miR-3169	CLIP-seq
MIRT1467472	hsa-miR-3613-3p	CLIP-seq
MIRT2361250	hsa-miR-3913-3p	CLIP-seq
MIRT2140490	hsa-miR-3918	CLIP-seq
MIRT2361251	hsa-miR-3944-5p	CLIP-seq
MIRT2361252	hsa-miR-4264	CLIP-seq
MIRT2361253	hsa-miR-4276	CLIP-seq
MIRT2361254	hsa-miR-4420	CLIP-seq
MIRT2361255	hsa-miR-4515	CLIP-seq
MIRT2361256	hsa-miR-4685-5p	CLIP-seq
MIRT2361257	hsa-miR-4700-3p	CLIP-seq
MIRT1467479	hsa-miR-4705	CLIP-seq
MIRT1467480	hsa-miR-4717-3p	CLIP-seq
MIRT2361258	hsa-miR-4797-3p	CLIP-seq
MIRT2361259	hsa-miR-486-3p	CLIP-seq
MIRT2361260	hsa-miR-489	CLIP-seq
MIRT2361261	hsa-miR-513a-5p	CLIP-seq
MIRT2361262	hsa-miR-548a-5p	CLIP-seq
MIRT2361263	hsa-miR-548aa	CLIP-seq
MIRT2361264	hsa-miR-548ab	CLIP-seq
MIRT2361265	hsa-miR-548ag	CLIP-seq
MIRT2361266	hsa-miR-548ai	CLIP-seq
MIRT2361267	hsa-miR-548ak	CLIP-seq
MIRT2361268	hsa-miR-548b-5p	CLIP-seq
MIRT2361269	hsa-miR-548c-5p	CLIP-seq
MIRT2361270	hsa-miR-548d-5p	CLIP-seq
MIRT2361271	hsa-miR-548h	CLIP-seq
MIRT2361272	hsa-miR-548i	CLIP-seq
MIRT2361273	hsa-miR-548j	CLIP-seq
MIRT2361274	hsa-miR-548n	CLIP-seq
MIRT2361275	hsa-miR-548w	CLIP-seq
MIRT2361276	hsa-miR-548y	CLIP-seq
MIRT2361277	hsa-miR-559	CLIP-seq
MIRT2655072	hsa-miR-1207-5p	CLIP-seq
MIRT1467464	hsa-miR-1224-5p	CLIP-seq
MIRT1467465	hsa-miR-128	CLIP-seq
MIRT1467466	hsa-miR-1284	CLIP-seq
MIRT2655073	hsa-miR-1303	CLIP-seq
MIRT2655074	hsa-miR-194	CLIP-seq
MIRT2655075	hsa-miR-2682	CLIP-seq
MIRT1467469	hsa-miR-27a	CLIP-seq
MIRT1467470	hsa-miR-27b	CLIP-seq
MIRT2655076	hsa-miR-2861	CLIP-seq
MIRT2361242	hsa-miR-298	CLIP-seq
MIRT2655077	hsa-miR-3153	CLIP-seq
MIRT2655078	hsa-miR-3176	CLIP-seq
MIRT2655079	hsa-miR-3188	CLIP-seq
MIRT2655080	hsa-miR-3192	CLIP-seq
MIRT1467471	hsa-miR-324-5p	CLIP-seq
MIRT1467474	hsa-miR-3653	CLIP-seq
MIRT1467475	hsa-miR-3658	CLIP-seq
MIRT1467476	hsa-miR-3674	CLIP-seq
MIRT2655081	hsa-miR-3689a-3p	CLIP-seq
MIRT2655082	hsa-miR-3689c	CLIP-seq
MIRT2140490	hsa-miR-3918	CLIP-seq
MIRT2655083	hsa-miR-3922-3p	CLIP-seq
MIRT2361251	hsa-miR-3944-5p	CLIP-seq
MIRT2655084	hsa-miR-4314	CLIP-seq
MIRT2655085	hsa-miR-4419a	CLIP-seq
MIRT1467477	hsa-miR-4489	CLIP-seq
MIRT2655086	hsa-miR-449c	CLIP-seq
MIRT1467478	hsa-miR-450b-5p	CLIP-seq
MIRT2655087	hsa-miR-4510	CLIP-seq
MIRT2655088	hsa-miR-4522	CLIP-seq
MIRT2655089	hsa-miR-4646-5p	CLIP-seq
MIRT2655090	hsa-miR-4668-5p	CLIP-seq
MIRT1467479	hsa-miR-4705	CLIP-seq
MIRT1467481	hsa-miR-4724-5p	CLIP-seq
MIRT2655091	hsa-miR-4728-5p	CLIP-seq
MIRT1467482	hsa-miR-4751	CLIP-seq
MIRT2655092	hsa-miR-4757-5p	CLIP-seq
MIRT2655093	hsa-miR-4763-3p	CLIP-seq
MIRT1467483	hsa-miR-4781-5p	CLIP-seq
MIRT1467485	hsa-miR-507	CLIP-seq
MIRT2655094	hsa-miR-513b	CLIP-seq
MIRT2655095	hsa-miR-543	CLIP-seq
MIRT2361263	hsa-miR-548aa	CLIP-seq
MIRT2655096	hsa-miR-548g	CLIP-seq
MIRT1467487	hsa-miR-557	CLIP-seq
MIRT2655097	hsa-miR-586	CLIP-seq
MIRT2655098	hsa-miR-645	CLIP-seq
MIRT2655099	hsa-miR-940	CLIP-seq
MIRT2655072	hsa-miR-1207-5p	CLIP-seq
MIRT1467464	hsa-miR-1224-5p	CLIP-seq
MIRT1467465	hsa-miR-128	CLIP-seq
MIRT2655073	hsa-miR-1303	CLIP-seq
MIRT2655074	hsa-miR-194	CLIP-seq
MIRT2655075	hsa-miR-2682	CLIP-seq
MIRT1467469	hsa-miR-27a	CLIP-seq
MIRT1467470	hsa-miR-27b	CLIP-seq
MIRT2655076	hsa-miR-2861	CLIP-seq
MIRT2361242	hsa-miR-298	CLIP-seq
MIRT2655077	hsa-miR-3153	CLIP-seq
MIRT2655078	hsa-miR-3176	CLIP-seq
MIRT2655079	hsa-miR-3188	CLIP-seq
MIRT2655080	hsa-miR-3192	CLIP-seq
MIRT1467471	hsa-miR-324-5p	CLIP-seq
MIRT2655081	hsa-miR-3689a-3p	CLIP-seq
MIRT2655082	hsa-miR-3689c	CLIP-seq
MIRT2140490	hsa-miR-3918	CLIP-seq
MIRT2655083	hsa-miR-3922-3p	CLIP-seq
MIRT2361251	hsa-miR-3944-5p	CLIP-seq
MIRT2655084	hsa-miR-4314	CLIP-seq
MIRT2655085	hsa-miR-4419a	CLIP-seq
MIRT1467477	hsa-miR-4489	CLIP-seq
MIRT2655086	hsa-miR-449c	CLIP-seq
MIRT1467478	hsa-miR-450b-5p	CLIP-seq
MIRT2655087	hsa-miR-4510	CLIP-seq
MIRT2655088	hsa-miR-4522	CLIP-seq
MIRT2655089	hsa-miR-4646-5p	CLIP-seq
MIRT2655090	hsa-miR-4668-5p	CLIP-seq
MIRT1467479	hsa-miR-4705	CLIP-seq
MIRT1467481	hsa-miR-4724-5p	CLIP-seq
MIRT2655091	hsa-miR-4728-5p	CLIP-seq
MIRT1467482	hsa-miR-4751	CLIP-seq
MIRT2655092	hsa-miR-4757-5p	CLIP-seq
MIRT2655093	hsa-miR-4763-3p	CLIP-seq
MIRT1467485	hsa-miR-507	CLIP-seq
MIRT2655094	hsa-miR-513b	CLIP-seq
MIRT2655095	hsa-miR-543	CLIP-seq
MIRT2361263	hsa-miR-548aa	CLIP-seq
MIRT2655096	hsa-miR-548g	CLIP-seq
MIRT1467487	hsa-miR-557	CLIP-seq
MIRT2655097	hsa-miR-586	CLIP-seq
MIRT2655098	hsa-miR-645	CLIP-seq
MIRT2655099	hsa-miR-940	CLIP-seq

Show/Hide all(19)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0005515	Function	Protein binding	IPI	19250909, 23201271, 32296183, 32814053
GO:0005524	Function	ATP binding	IEA
GO:0005634	Component	Nucleus	IBA
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	TAS
GO:0016740	Function	Transferase activity	IEA
GO:0019788	Function	NEDD8 transferase activity	IBA
GO:0019788	Function	NEDD8 transferase activity	IEA
GO:0019788	Function	NEDD8 transferase activity	TAS
GO:0043161	Process	Proteasome-mediated ubiquitin-dependent protein catabolic process	IDA	22190037, 31253590
GO:0043687	Process	Post-translational protein modification	TAS
GO:0045087	Process	Innate immune response	IDA	22915799
GO:0045116	Process	Protein neddylation	IBA
GO:0045116	Process	Protein neddylation	IDA	19250909, 23300442
GO:0045116	Process	Protein neddylation	IEA
GO:0051607	Process	Defense response to virus	IDA	22915799
GO:0061654	Function	NEDD8 conjugating enzyme activity	IDA	19250909, 23300442
GO:0061663	Function	NEDD8 ligase activity	IEA

MIM	HGNC	e!Ensembl
617700	12480	ENSG00000184182

Protein

UniProt ID

Q969M7

Protein name

NEDD8-conjugating enzyme UBE2F (EC 2.3.2.34) (NEDD8 carrier protein UBE2F) (NEDD8 protein ligase UBE2F) (NEDD8-conjugating enzyme 2) (RING-type E3 NEDD8 transferase UBE2F) (Ubiquitin-conjugating enzyme E2 F)

Protein function

Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins (PubMed:19250909, PubMed:23201271). Together with the E3 ubiquitin ligase RNF7/RBX2, specifically neddylates cullin-5

PDB

2EDI , 3FN1 , 4GBA

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00179	UQ_con	36 → 180	Ubiquitin-conjugating enzyme	Domain

Tissue specificity

TISSUE SPECIFICITY: Widely expressed (at protein level). {ECO:0000269|PubMed:19250909}.

Sequence

MLTLASKLKRDDGLKGSRTAATASDSTRRVSVRDKLLVKEVAELEANLPCTCKVHFPDPN
KLHCFQLTVTPDEGYYQGGKFQFETEVPDAYNMVPPKVKCLTKIWHPNITETGEICLSLL
REHSIDGTGWAPTRTLKDVVWGLNSLFTDLLNFDDPLNIEAAEHHLRDKEDFRNKVDDYI
KRYAR

Sequence length

185

Interactions

View interactions

	KEGG		Reactome
	Ubiquitin mediated proteolysis		Neddylation Antigen processing: Ubiquitination & Proteasome degradation

Show/Hide Unknown Diseases (2)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Ovarian cancer	Epithelial ovarian cancer	N/A	N/A	GWAS
Psoriasis	Psoriasis	N/A	N/A	GWAS

Show/Hide Text Mining Associations (6)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Colorectal Neoplasms	Associate	33712558
Drug Related Side Effects and Adverse Reactions	Associate	30545630
Endometrial Neoplasms	Associate	34082605
Lung Neoplasms	Associate	36253371
Neoplasms	Associate	36253371
Sarcoma	Associate	36232302

UBE2F (ubiquitin conjugating enzyme E2 F (putative))