UBE2F (ubiquitin conjugating enzyme E2 F (putative))

Gene

• Entrez ID: 140739
• Gene name: Ubiquitin conjugating enzyme E2 F (putative)
• Gene symbol: UBE2F
• Synonyms (NCBI Gene): NCE2
• Chromosome: 2
• Chromosome location: 2q37.3

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT004083	hsa-miR-335-5p	Luciferase reporter assay	18185580
MIRT006660	hsa-miR-129-5p	Luciferase reporter assay	19887623
MIRT006661	hsa-miR-129-2-3p	Luciferase reporter assay	19887623
MIRT040036	hsa-miR-615-3p	CLASH	23622248
MIRT633889	hsa-miR-3922-5p	HITS-CLIP	23313552
MIRT633888	hsa-miR-383-3p	HITS-CLIP	23313552
MIRT633887	hsa-miR-5187-5p	HITS-CLIP	23313552
MIRT633886	hsa-miR-7977	HITS-CLIP	23313552
MIRT633885	hsa-miR-450b-3p	HITS-CLIP	23313552
MIRT633884	hsa-miR-769-3p	HITS-CLIP	23313552
MIRT633883	hsa-miR-6728-5p	HITS-CLIP	23313552
MIRT633882	hsa-miR-5089-5p	HITS-CLIP	23313552
MIRT633881	hsa-miR-450a-1-3p	HITS-CLIP	23313552
MIRT633880	hsa-miR-3122	HITS-CLIP	23313552
MIRT633879	hsa-miR-3913-5p	HITS-CLIP	23313552
MIRT633878	hsa-miR-887-5p	HITS-CLIP	23313552
MIRT633877	hsa-miR-6513-5p	HITS-CLIP	23313552
MIRT633889	hsa-miR-3922-5p	HITS-CLIP	23824327
MIRT633888	hsa-miR-383-3p	HITS-CLIP	23824327
MIRT633887	hsa-miR-5187-5p	HITS-CLIP	23824327
MIRT633886	hsa-miR-7977	HITS-CLIP	23824327
MIRT633885	hsa-miR-450b-3p	HITS-CLIP	23824327
MIRT633884	hsa-miR-769-3p	HITS-CLIP	23824327
MIRT633883	hsa-miR-6728-5p	HITS-CLIP	23824327
MIRT633882	hsa-miR-5089-5p	HITS-CLIP	23824327
MIRT633881	hsa-miR-450a-1-3p	HITS-CLIP	23824327
MIRT633880	hsa-miR-3122	HITS-CLIP	23824327
MIRT633879	hsa-miR-3913-5p	HITS-CLIP	23824327
MIRT633878	hsa-miR-887-5p	HITS-CLIP	23824327
MIRT633877	hsa-miR-6513-5p	HITS-CLIP	23824327
MIRT464803	hsa-miR-320e	PAR-CLIP	23592263
MIRT464801	hsa-miR-4459	PAR-CLIP	23592263
MIRT464802	hsa-miR-665	PAR-CLIP	23592263
MIRT464800	hsa-miR-6840-3p	PAR-CLIP	23592263
MIRT464799	hsa-miR-1225-3p	PAR-CLIP	23592263
MIRT464798	hsa-miR-1233-3p	PAR-CLIP	23592263
MIRT464797	hsa-miR-6134	PAR-CLIP	23592263
MIRT464796	hsa-miR-3689d	PAR-CLIP	23592263
MIRT464794	hsa-miR-6851-5p	PAR-CLIP	23592263
MIRT464795	hsa-miR-876-3p	PAR-CLIP	23592263
MIRT464793	hsa-miR-656-5p	PAR-CLIP	23592263
MIRT464792	hsa-miR-1273g-5p	PAR-CLIP	23592263
MIRT464791	hsa-miR-455-3p	PAR-CLIP	23592263
MIRT464790	hsa-miR-6516-5p	PAR-CLIP	23592263
MIRT633889	hsa-miR-3922-5p	HITS-CLIP	23313552
MIRT633888	hsa-miR-383-3p	HITS-CLIP	23313552
MIRT633887	hsa-miR-5187-5p	HITS-CLIP	23313552
MIRT633886	hsa-miR-7977	HITS-CLIP	23313552
MIRT633885	hsa-miR-450b-3p	HITS-CLIP	23313552
MIRT633884	hsa-miR-769-3p	HITS-CLIP	23313552
MIRT633883	hsa-miR-6728-5p	HITS-CLIP	23313552
MIRT633882	hsa-miR-5089-5p	HITS-CLIP	23313552
MIRT633881	hsa-miR-450a-1-3p	HITS-CLIP	23313552
MIRT633880	hsa-miR-3122	HITS-CLIP	23313552
MIRT633879	hsa-miR-3913-5p	HITS-CLIP	23313552
MIRT633878	hsa-miR-887-5p	HITS-CLIP	23313552
MIRT633877	hsa-miR-6513-5p	HITS-CLIP	23313552
MIRT633889	hsa-miR-3922-5p	HITS-CLIP	23824327
MIRT633888	hsa-miR-383-3p	HITS-CLIP	23824327
MIRT633887	hsa-miR-5187-5p	HITS-CLIP	23824327
MIRT633886	hsa-miR-7977	HITS-CLIP	23824327
MIRT633885	hsa-miR-450b-3p	HITS-CLIP	23824327
MIRT633884	hsa-miR-769-3p	HITS-CLIP	23824327
MIRT633883	hsa-miR-6728-5p	HITS-CLIP	23824327
MIRT633882	hsa-miR-5089-5p	HITS-CLIP	23824327
MIRT633881	hsa-miR-450a-1-3p	HITS-CLIP	23824327
MIRT633880	hsa-miR-3122	HITS-CLIP	23824327
MIRT633879	hsa-miR-3913-5p	HITS-CLIP	23824327
MIRT633878	hsa-miR-887-5p	HITS-CLIP	23824327
MIRT633877	hsa-miR-6513-5p	HITS-CLIP	23824327
MIRT464803	hsa-miR-320e	PAR-CLIP	23592263
MIRT464801	hsa-miR-4459	PAR-CLIP	23592263
MIRT464802	hsa-miR-665	PAR-CLIP	23592263
MIRT464800	hsa-miR-6840-3p	PAR-CLIP	23592263
MIRT464799	hsa-miR-1225-3p	PAR-CLIP	23592263
MIRT464798	hsa-miR-1233-3p	PAR-CLIP	23592263
MIRT464797	hsa-miR-6134	PAR-CLIP	23592263
MIRT464796	hsa-miR-3689d	PAR-CLIP	23592263
MIRT464794	hsa-miR-6851-5p	PAR-CLIP	23592263
MIRT464795	hsa-miR-876-3p	PAR-CLIP	23592263
MIRT464793	hsa-miR-656-5p	PAR-CLIP	23592263
MIRT464792	hsa-miR-1273g-5p	PAR-CLIP	23592263
MIRT464791	hsa-miR-455-3p	PAR-CLIP	23592263
MIRT464790	hsa-miR-6516-5p	PAR-CLIP	23592263
MIRT1467463	hsa-miR-101	CLIP-seq
MIRT1467464	hsa-miR-1224-5p	CLIP-seq
MIRT1467465	hsa-miR-128	CLIP-seq
MIRT1467466	hsa-miR-1284	CLIP-seq
MIRT1467467	hsa-miR-144	CLIP-seq
MIRT1467468	hsa-miR-197	CLIP-seq
MIRT1467469	hsa-miR-27a	CLIP-seq
MIRT1467470	hsa-miR-27b	CLIP-seq
MIRT1467471	hsa-miR-324-5p	CLIP-seq
MIRT1467472	hsa-miR-3613-3p	CLIP-seq
MIRT1467473	hsa-miR-3646	CLIP-seq
MIRT1467474	hsa-miR-3653	CLIP-seq
MIRT1467475	hsa-miR-3658	CLIP-seq
MIRT1467476	hsa-miR-3674	CLIP-seq
MIRT1467477	hsa-miR-4489	CLIP-seq
MIRT1467478	hsa-miR-450b-5p	CLIP-seq
MIRT1467479	hsa-miR-4705	CLIP-seq
MIRT1467480	hsa-miR-4717-3p	CLIP-seq
MIRT1467481	hsa-miR-4724-5p	CLIP-seq
MIRT1467482	hsa-miR-4751	CLIP-seq
MIRT1467483	hsa-miR-4781-5p	CLIP-seq
MIRT1467484	hsa-miR-495	CLIP-seq
MIRT1467485	hsa-miR-507	CLIP-seq
MIRT1467486	hsa-miR-5096	CLIP-seq
MIRT1467487	hsa-miR-557	CLIP-seq
MIRT1467488	hsa-miR-580	CLIP-seq
MIRT2140480	hsa-miR-1184	CLIP-seq
MIRT2140481	hsa-miR-1205	CLIP-seq
MIRT2140482	hsa-miR-1236	CLIP-seq
MIRT2140483	hsa-miR-1238	CLIP-seq
MIRT2140484	hsa-miR-3119	CLIP-seq
MIRT2140485	hsa-miR-3127-5p	CLIP-seq
MIRT2140486	hsa-miR-3152-5p	CLIP-seq
MIRT2140487	hsa-miR-3158-3p	CLIP-seq
MIRT2140488	hsa-miR-3158-5p	CLIP-seq
MIRT2140489	hsa-miR-3183	CLIP-seq
MIRT2140490	hsa-miR-3918	CLIP-seq
MIRT2140491	hsa-miR-4723-3p	CLIP-seq
MIRT2140492	hsa-miR-490-3p	CLIP-seq
MIRT2140493	hsa-miR-649	CLIP-seq
MIRT2140494	hsa-miR-656	CLIP-seq
MIRT1467463	hsa-miR-101	CLIP-seq
MIRT2361239	hsa-miR-1267	CLIP-seq
MIRT1467466	hsa-miR-1284	CLIP-seq
MIRT2361240	hsa-miR-1324	CLIP-seq
MIRT2361241	hsa-miR-137	CLIP-seq
MIRT1467467	hsa-miR-144	CLIP-seq
MIRT2361242	hsa-miR-298	CLIP-seq
MIRT2361243	hsa-miR-30a	CLIP-seq
MIRT2361244	hsa-miR-30b	CLIP-seq
MIRT2361245	hsa-miR-30c	CLIP-seq
MIRT2361246	hsa-miR-30d	CLIP-seq
MIRT2361247	hsa-miR-30e	CLIP-seq
MIRT2140485	hsa-miR-3127-5p	CLIP-seq
MIRT2361248	hsa-miR-3166	CLIP-seq
MIRT2361249	hsa-miR-3169	CLIP-seq
MIRT1467472	hsa-miR-3613-3p	CLIP-seq
MIRT2361250	hsa-miR-3913-3p	CLIP-seq
MIRT2140490	hsa-miR-3918	CLIP-seq
MIRT2361251	hsa-miR-3944-5p	CLIP-seq
MIRT2361252	hsa-miR-4264	CLIP-seq
MIRT2361253	hsa-miR-4276	CLIP-seq
MIRT2361254	hsa-miR-4420	CLIP-seq
MIRT2361255	hsa-miR-4515	CLIP-seq
MIRT2361256	hsa-miR-4685-5p	CLIP-seq
MIRT2361257	hsa-miR-4700-3p	CLIP-seq
MIRT1467479	hsa-miR-4705	CLIP-seq
MIRT1467480	hsa-miR-4717-3p	CLIP-seq
MIRT2361258	hsa-miR-4797-3p	CLIP-seq
MIRT2361259	hsa-miR-486-3p	CLIP-seq
MIRT2361260	hsa-miR-489	CLIP-seq
MIRT2361261	hsa-miR-513a-5p	CLIP-seq
MIRT2361262	hsa-miR-548a-5p	CLIP-seq
MIRT2361263	hsa-miR-548aa	CLIP-seq
MIRT2361264	hsa-miR-548ab	CLIP-seq
MIRT2361265	hsa-miR-548ag	CLIP-seq
MIRT2361266	hsa-miR-548ai	CLIP-seq
MIRT2361267	hsa-miR-548ak	CLIP-seq
MIRT2361268	hsa-miR-548b-5p	CLIP-seq
MIRT2361269	hsa-miR-548c-5p	CLIP-seq
MIRT2361270	hsa-miR-548d-5p	CLIP-seq
MIRT2361271	hsa-miR-548h	CLIP-seq
MIRT2361272	hsa-miR-548i	CLIP-seq
MIRT2361273	hsa-miR-548j	CLIP-seq
MIRT2361274	hsa-miR-548n	CLIP-seq
MIRT2361275	hsa-miR-548w	CLIP-seq
MIRT2361276	hsa-miR-548y	CLIP-seq
MIRT2361277	hsa-miR-559	CLIP-seq
MIRT2655072	hsa-miR-1207-5p	CLIP-seq
MIRT1467464	hsa-miR-1224-5p	CLIP-seq
MIRT1467465	hsa-miR-128	CLIP-seq
MIRT1467466	hsa-miR-1284	CLIP-seq
MIRT2655073	hsa-miR-1303	CLIP-seq
MIRT2655074	hsa-miR-194	CLIP-seq
MIRT2655075	hsa-miR-2682	CLIP-seq
MIRT1467469	hsa-miR-27a	CLIP-seq
MIRT1467470	hsa-miR-27b	CLIP-seq
MIRT2655076	hsa-miR-2861	CLIP-seq
MIRT2361242	hsa-miR-298	CLIP-seq
MIRT2655077	hsa-miR-3153	CLIP-seq
MIRT2655078	hsa-miR-3176	CLIP-seq
MIRT2655079	hsa-miR-3188	CLIP-seq
MIRT2655080	hsa-miR-3192	CLIP-seq
MIRT1467471	hsa-miR-324-5p	CLIP-seq
MIRT1467474	hsa-miR-3653	CLIP-seq
MIRT1467475	hsa-miR-3658	CLIP-seq
MIRT1467476	hsa-miR-3674	CLIP-seq
MIRT2655081	hsa-miR-3689a-3p	CLIP-seq
MIRT2655082	hsa-miR-3689c	CLIP-seq
MIRT2140490	hsa-miR-3918	CLIP-seq
MIRT2655083	hsa-miR-3922-3p	CLIP-seq
MIRT2361251	hsa-miR-3944-5p	CLIP-seq
MIRT2655084	hsa-miR-4314	CLIP-seq
MIRT2655085	hsa-miR-4419a	CLIP-seq
MIRT1467477	hsa-miR-4489	CLIP-seq
MIRT2655086	hsa-miR-449c	CLIP-seq
MIRT1467478	hsa-miR-450b-5p	CLIP-seq
MIRT2655087	hsa-miR-4510	CLIP-seq
MIRT2655088	hsa-miR-4522	CLIP-seq
MIRT2655089	hsa-miR-4646-5p	CLIP-seq
MIRT2655090	hsa-miR-4668-5p	CLIP-seq
MIRT1467479	hsa-miR-4705	CLIP-seq
MIRT1467481	hsa-miR-4724-5p	CLIP-seq
MIRT2655091	hsa-miR-4728-5p	CLIP-seq
MIRT1467482	hsa-miR-4751	CLIP-seq
MIRT2655092	hsa-miR-4757-5p	CLIP-seq
MIRT2655093	hsa-miR-4763-3p	CLIP-seq
MIRT1467483	hsa-miR-4781-5p	CLIP-seq
MIRT1467485	hsa-miR-507	CLIP-seq
MIRT2655094	hsa-miR-513b	CLIP-seq
MIRT2655095	hsa-miR-543	CLIP-seq
MIRT2361263	hsa-miR-548aa	CLIP-seq
MIRT2655096	hsa-miR-548g	CLIP-seq
MIRT1467487	hsa-miR-557	CLIP-seq
MIRT2655097	hsa-miR-586	CLIP-seq
MIRT2655098	hsa-miR-645	CLIP-seq
MIRT2655099	hsa-miR-940	CLIP-seq
MIRT2655072	hsa-miR-1207-5p	CLIP-seq
MIRT1467464	hsa-miR-1224-5p	CLIP-seq
MIRT1467465	hsa-miR-128	CLIP-seq
MIRT2655073	hsa-miR-1303	CLIP-seq
MIRT2655074	hsa-miR-194	CLIP-seq
MIRT2655075	hsa-miR-2682	CLIP-seq
MIRT1467469	hsa-miR-27a	CLIP-seq
MIRT1467470	hsa-miR-27b	CLIP-seq
MIRT2655076	hsa-miR-2861	CLIP-seq
MIRT2361242	hsa-miR-298	CLIP-seq
MIRT2655077	hsa-miR-3153	CLIP-seq
MIRT2655078	hsa-miR-3176	CLIP-seq
MIRT2655079	hsa-miR-3188	CLIP-seq
MIRT2655080	hsa-miR-3192	CLIP-seq
MIRT1467471	hsa-miR-324-5p	CLIP-seq
MIRT2655081	hsa-miR-3689a-3p	CLIP-seq
MIRT2655082	hsa-miR-3689c	CLIP-seq
MIRT2140490	hsa-miR-3918	CLIP-seq
MIRT2655083	hsa-miR-3922-3p	CLIP-seq
MIRT2361251	hsa-miR-3944-5p	CLIP-seq
MIRT2655084	hsa-miR-4314	CLIP-seq
MIRT2655085	hsa-miR-4419a	CLIP-seq
MIRT1467477	hsa-miR-4489	CLIP-seq
MIRT2655086	hsa-miR-449c	CLIP-seq
MIRT1467478	hsa-miR-450b-5p	CLIP-seq
MIRT2655087	hsa-miR-4510	CLIP-seq
MIRT2655088	hsa-miR-4522	CLIP-seq
MIRT2655089	hsa-miR-4646-5p	CLIP-seq
MIRT2655090	hsa-miR-4668-5p	CLIP-seq
MIRT1467479	hsa-miR-4705	CLIP-seq
MIRT1467481	hsa-miR-4724-5p	CLIP-seq
MIRT2655091	hsa-miR-4728-5p	CLIP-seq
MIRT1467482	hsa-miR-4751	CLIP-seq
MIRT2655092	hsa-miR-4757-5p	CLIP-seq
MIRT2655093	hsa-miR-4763-3p	CLIP-seq
MIRT1467485	hsa-miR-507	CLIP-seq
MIRT2655094	hsa-miR-513b	CLIP-seq
MIRT2655095	hsa-miR-543	CLIP-seq
MIRT2361263	hsa-miR-548aa	CLIP-seq
MIRT2655096	hsa-miR-548g	CLIP-seq
MIRT1467487	hsa-miR-557	CLIP-seq
MIRT2655097	hsa-miR-586	CLIP-seq
MIRT2655098	hsa-miR-645	CLIP-seq
MIRT2655099	hsa-miR-940	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0005515	Function	Protein binding	IPI	19250909, 23201271, 32296183, 32814053
GO:0005524	Function	ATP binding	IEA
GO:0005634	Component	Nucleus	IBA
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	TAS
GO:0016740	Function	Transferase activity	IEA
GO:0019788	Function	NEDD8 transferase activity	IBA
GO:0019788	Function	NEDD8 transferase activity	IEA
GO:0019788	Function	NEDD8 transferase activity	TAS
GO:0043161	Process	Proteasome-mediated ubiquitin-dependent protein catabolic process	IDA	22190037, 31253590
GO:0043687	Process	Post-translational protein modification	TAS
GO:0045087	Process	Innate immune response	IDA	22915799
GO:0045116	Process	Protein neddylation	IBA
GO:0045116	Process	Protein neddylation	IDA	19250909, 23300442
GO:0045116	Process	Protein neddylation	IEA
GO:0051607	Process	Defense response to virus	IDA	22915799
GO:0061654	Function	NEDD8 conjugating enzyme activity	IDA	19250909, 23300442
GO:0061663	Function	NEDD8 ligase activity	IEA

Other IDs

• MIM: 617700
• HGNC: 12480
• e!Ensembl: ENSG00000184182

Protein

• UniProt ID: Q969M7
• Protein name: NEDD8-conjugating enzyme UBE2F (EC 2.3.2.34) (NEDD8 carrier protein UBE2F) (NEDD8 protein ligase UBE2F) (NEDD8-conjugating enzyme 2) (RING-type E3 NEDD8 transferase UBE2F) (Ubiquitin-conjugating enzyme E2 F)
• Protein function: Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins (PubMed:19250909, PubMed:23201271). Together with the E3 ubiquitin ligase RNF7/RBX2, specifically neddylates cullin-5
• PDB: 2EDI, 3FN1, 4GBA
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00179	UQ_con	36 → 180	Ubiquitin-conjugating enzyme	Domain

• Tissue specificity: TISSUE SPECIFICITY: Widely expressed (at protein level). {ECO:0000269|PubMed:19250909}.
• Sequence:

  MLTLASKLKRDDGLKGSRTAATASDSTRRVSVRDKLLVKEVAELEANLPCTCKVHFPDPN
  KLHCFQLTVTPDEGYYQGGKFQFETEVPDAYNMVPPKVKCLTKIWHPNITETGEICLSLL
  REHSIDGTGWAPTRTLKDVVWGLNSLFTDLLNFDDPLNIEAAEHHLRDKEDFRNKVDDYI
  KRYAR

• Sequence length: 185

Pathways

KEGG:

Ubiquitin mediated proteolysis

Reactome:

Neddylation
Antigen processing: Ubiquitination & Proteasome degradation