Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	140738
Gene name Gene Name - the full gene name approved by the HGNC.	Transmembrane protein 37
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	TMEM37
Synonyms (NCBI Gene) Gene synonyms aliases	PR, PR1
Chromosome Chromosome number	2
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	2q14.2

Show/Hide all(82)

miRTarBase ID	miRNA	Experiments	Reference
MIRT459460	hsa-miR-552-3p	PAR-CLIP	23592263
MIRT459459	hsa-miR-4272	PAR-CLIP	23592263
MIRT459458	hsa-miR-4709-5p	PAR-CLIP	23592263
MIRT459457	hsa-miR-125a-3p	PAR-CLIP	23592263
MIRT459456	hsa-miR-3126-5p	PAR-CLIP	23592263
MIRT459454	hsa-miR-6875-5p	PAR-CLIP	23592263
MIRT459455	hsa-miR-4419a	PAR-CLIP	23592263
MIRT459453	hsa-miR-4510	PAR-CLIP	23592263
MIRT459452	hsa-miR-6127	PAR-CLIP	23592263
MIRT459451	hsa-miR-6129	PAR-CLIP	23592263
MIRT459450	hsa-miR-6130	PAR-CLIP	23592263
MIRT459449	hsa-miR-6133	PAR-CLIP	23592263
MIRT459447	hsa-miR-5702	PAR-CLIP	23592263
MIRT459448	hsa-miR-4533	PAR-CLIP	23592263
MIRT459446	hsa-miR-4747-5p	PAR-CLIP	23592263
MIRT459445	hsa-miR-5196-5p	PAR-CLIP	23592263
MIRT459444	hsa-miR-6716-5p	PAR-CLIP	23592263
MIRT459443	hsa-miR-4697-3p	PAR-CLIP	23592263
MIRT459442	hsa-miR-7159-5p	PAR-CLIP	23592263
MIRT459441	hsa-miR-505-3p	PAR-CLIP	23592263
MIRT459440	hsa-miR-421	PAR-CLIP	23592263
MIRT459439	hsa-miR-6834-5p	PAR-CLIP	23592263
MIRT459460	hsa-miR-552-3p	PAR-CLIP	23592263
MIRT459459	hsa-miR-4272	PAR-CLIP	23592263
MIRT459458	hsa-miR-4709-5p	PAR-CLIP	23592263
MIRT459457	hsa-miR-125a-3p	PAR-CLIP	23592263
MIRT459456	hsa-miR-3126-5p	PAR-CLIP	23592263
MIRT459454	hsa-miR-6875-5p	PAR-CLIP	23592263
MIRT459455	hsa-miR-4419a	PAR-CLIP	23592263
MIRT459453	hsa-miR-4510	PAR-CLIP	23592263
MIRT459452	hsa-miR-6127	PAR-CLIP	23592263
MIRT459451	hsa-miR-6129	PAR-CLIP	23592263
MIRT459450	hsa-miR-6130	PAR-CLIP	23592263
MIRT459449	hsa-miR-6133	PAR-CLIP	23592263
MIRT459447	hsa-miR-5702	PAR-CLIP	23592263
MIRT459448	hsa-miR-4533	PAR-CLIP	23592263
MIRT459446	hsa-miR-4747-5p	PAR-CLIP	23592263
MIRT459445	hsa-miR-5196-5p	PAR-CLIP	23592263
MIRT459444	hsa-miR-6716-5p	PAR-CLIP	23592263
MIRT459443	hsa-miR-4697-3p	PAR-CLIP	23592263
MIRT459442	hsa-miR-7159-5p	PAR-CLIP	23592263
MIRT459441	hsa-miR-505-3p	PAR-CLIP	23592263
MIRT459440	hsa-miR-421	PAR-CLIP	23592263
MIRT459439	hsa-miR-6834-5p	PAR-CLIP	23592263
MIRT1436871	hsa-miR-1909	CLIP-seq
MIRT1436872	hsa-miR-320a	CLIP-seq
MIRT1436873	hsa-miR-320b	CLIP-seq
MIRT1436874	hsa-miR-320c	CLIP-seq
MIRT1436875	hsa-miR-320d	CLIP-seq
MIRT1436876	hsa-miR-3622b-5p	CLIP-seq
MIRT1436877	hsa-miR-3944-5p	CLIP-seq
MIRT1436878	hsa-miR-4303	CLIP-seq
MIRT1436879	hsa-miR-4318	CLIP-seq
MIRT1436880	hsa-miR-4429	CLIP-seq
MIRT1436881	hsa-miR-4642	CLIP-seq
MIRT1436882	hsa-miR-4649-3p	CLIP-seq
MIRT1436883	hsa-miR-4693-5p	CLIP-seq
MIRT1436884	hsa-miR-4761-3p	CLIP-seq
MIRT1436885	hsa-miR-4786-3p	CLIP-seq
MIRT1436886	hsa-miR-892a	CLIP-seq
MIRT2130940	hsa-miR-2053	CLIP-seq
MIRT2130941	hsa-miR-2115	CLIP-seq
MIRT2130942	hsa-miR-218	CLIP-seq
MIRT2130943	hsa-miR-2355-5p	CLIP-seq
MIRT2130944	hsa-miR-2392	CLIP-seq
MIRT2130945	hsa-miR-324-5p	CLIP-seq
MIRT2130946	hsa-miR-338-3p	CLIP-seq
MIRT2130947	hsa-miR-3647-3p	CLIP-seq
MIRT2130948	hsa-miR-3688-3p	CLIP-seq
MIRT2130949	hsa-miR-4455	CLIP-seq
MIRT2130950	hsa-miR-4694-5p	CLIP-seq
MIRT2130951	hsa-miR-516a-3p	CLIP-seq
MIRT2130952	hsa-miR-569	CLIP-seq
MIRT2130953	hsa-miR-609	CLIP-seq
MIRT2130954	hsa-miR-636	CLIP-seq
MIRT2130944	hsa-miR-2392	CLIP-seq
MIRT2352196	hsa-miR-31	CLIP-seq
MIRT2352197	hsa-miR-3128	CLIP-seq
MIRT2130948	hsa-miR-3688-3p	CLIP-seq
MIRT2352198	hsa-miR-4643	CLIP-seq
MIRT2352199	hsa-miR-4719	CLIP-seq
MIRT2352200	hsa-miR-642b	CLIP-seq

Show/Hide all(8)

GO ID	Ontology	Definition	Evidence
GO:0005244	Function	Voltage-gated monoatomic ion channel activity	IEA
GO:0005262	Function	Calcium channel activity	IEA
GO:0006811	Process	Monoatomic ion transport	IEA
GO:0006816	Process	Calcium ion transport	IEA
GO:0016020	Component	Membrane	IEA
GO:0034220	Process	Monoatomic ion transmembrane transport	IEA
GO:0034702	Component	Monoatomic ion channel complex	IEA
GO:0070588	Process	Calcium ion transmembrane transport	IEA

MIM	HGNC	e!Ensembl
618831	18216	ENSG00000171227

Protein

UniProt ID

Q8WXS4

Protein name

Voltage-dependent calcium channel gamma-like subunit (Neuronal voltage-gated calcium channel gamma-like subunit) (Transmembrane protein 37)

Protein function

Thought to stabilize the calcium channel in an inactivated (closed) state. Modulates calcium current when coexpressed with CACNA1G (By similarity).

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF15108	TMEM37	7 → 187	Voltage-dependent calcium channel gamma-like subunit protein family	Family

Sequence

MTAVGVQAQRPLGQRQPRRSFFESFIRTLIITCVALAVVLSSVSICDGHWLLAEDRLFGL
WHFCTTTNQTICFRDLGQAHVPGLAVGMGLVRSVGALAVVAAIFGLEFLMVSQLCEDKHS
QCKWVMGSILLLVSFVLSSGGLLGFVILLRNQVTLIGFTLMFWCEFTASFLLFLNAISGL
HINSITHPWE

Sequence length

190

Interactions

View interactions

Show/Hide Unknown Diseases (1)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Dementia	Dementia	N/A	N/A	GWAS

Show/Hide Text Mining Associations (15)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Adenocarcinoma	Associate	8421689
Breast Neoplasms	Associate	23105141, 28468826
Diabetes Mellitus Type 2	Associate	29185012, 32705173
Graft vs Host Disease	Stimulate	12829610
Graves Ophthalmopathy	Associate	37900130
Hematologic Neoplasms	Associate	28468826
Leukemia	Associate	17412886, 22495388, 9326217
Leukemia Myelogenous Chronic BCR ABL Positive	Associate	12393722, 12829610, 17412886, 9326217
Leukemia Myeloid	Associate	23105141
Leukemia Myeloid Chronic Phase	Associate	18548092
Lung Neoplasms	Associate	28254787
Melanoma	Associate	23105141
Metabolic Syndrome	Associate	22480845
Neoplasms	Associate	23105141, 28254787, 28468826
Pancreatic Neoplasms	Associate	30880498

TMEM37 (transmembrane protein 37)