Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	140733
Gene name	Mono-ADP ribosylhydrolase 2
Gene symbol	MACROD2
Synonyms (NCBI Gene)	C20orf133C2orf133
Chromosome	20
Chromosome location	20p12.1
Summary	The protein encoded by this gene is a deacetylase involved in removing ADP-ribose from mono-ADP-ribosylated proteins. The encoded protein has been shown to translocate from the nucleus to the cytoplasm upon DNA damage. [provided by RefSeq, May 2017]

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Show/Hide all (109)

miRTarBase ID	miRNA	Experiments	Reference
MIRT712425	hsa-miR-504-5p	HITS-CLIP	19536157
MIRT712424	hsa-miR-4292	HITS-CLIP	19536157
MIRT712423	hsa-miR-6791-5p	HITS-CLIP	19536157
MIRT712422	hsa-miR-6852-5p	HITS-CLIP	19536157
MIRT712421	hsa-miR-4725-5p	HITS-CLIP	19536157
MIRT712420	hsa-miR-4252	HITS-CLIP	19536157
MIRT712419	hsa-miR-486-3p	HITS-CLIP	19536157
MIRT712418	hsa-miR-7973	HITS-CLIP	19536157
MIRT712417	hsa-miR-6808-3p	HITS-CLIP	19536157
MIRT712425	hsa-miR-504-5p	HITS-CLIP	19536157
MIRT712424	hsa-miR-4292	HITS-CLIP	19536157
MIRT712423	hsa-miR-6791-5p	HITS-CLIP	19536157
MIRT712422	hsa-miR-6852-5p	HITS-CLIP	19536157
MIRT712421	hsa-miR-4725-5p	HITS-CLIP	19536157
MIRT712420	hsa-miR-4252	HITS-CLIP	19536157
MIRT712419	hsa-miR-486-3p	HITS-CLIP	19536157
MIRT712418	hsa-miR-7973	HITS-CLIP	19536157
MIRT712417	hsa-miR-6808-3p	HITS-CLIP	19536157
MIRT667494	hsa-miR-153-5p	HITS-CLIP	23824327
MIRT667493	hsa-miR-6841-3p	HITS-CLIP	23824327
MIRT667492	hsa-miR-1915-5p	HITS-CLIP	23824327
MIRT667491	hsa-miR-4786-3p	HITS-CLIP	23824327
MIRT667490	hsa-miR-502-5p	HITS-CLIP	23824327
MIRT641748	hsa-miR-618	HITS-CLIP	23824327
MIRT641747	hsa-miR-1470	HITS-CLIP	23824327
MIRT641746	hsa-miR-4667-3p	HITS-CLIP	23824327
MIRT641745	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT641744	hsa-miR-486-5p	HITS-CLIP	23824327
MIRT641743	hsa-miR-4469	HITS-CLIP	23824327
MIRT641742	hsa-miR-670-3p	HITS-CLIP	23824327
MIRT641741	hsa-miR-1238-3p	HITS-CLIP	23824327
MIRT712425	hsa-miR-504-5p	HITS-CLIP	19536157
MIRT712424	hsa-miR-4292	HITS-CLIP	19536157
MIRT712423	hsa-miR-6791-5p	HITS-CLIP	19536157
MIRT712422	hsa-miR-6852-5p	HITS-CLIP	19536157
MIRT712421	hsa-miR-4725-5p	HITS-CLIP	19536157
MIRT712420	hsa-miR-4252	HITS-CLIP	19536157
MIRT712419	hsa-miR-486-3p	HITS-CLIP	19536157
MIRT712418	hsa-miR-7973	HITS-CLIP	19536157
MIRT712417	hsa-miR-6808-3p	HITS-CLIP	19536157
MIRT712425	hsa-miR-504-5p	HITS-CLIP	19536157
MIRT712424	hsa-miR-4292	HITS-CLIP	19536157
MIRT712423	hsa-miR-6791-5p	HITS-CLIP	19536157
MIRT712422	hsa-miR-6852-5p	HITS-CLIP	19536157
MIRT712421	hsa-miR-4725-5p	HITS-CLIP	19536157
MIRT712420	hsa-miR-4252	HITS-CLIP	19536157
MIRT712419	hsa-miR-486-3p	HITS-CLIP	19536157
MIRT712418	hsa-miR-7973	HITS-CLIP	19536157
MIRT712417	hsa-miR-6808-3p	HITS-CLIP	19536157
MIRT667494	hsa-miR-153-5p	HITS-CLIP	23824327
MIRT667493	hsa-miR-6841-3p	HITS-CLIP	23824327
MIRT667492	hsa-miR-1915-5p	HITS-CLIP	23824327
MIRT667491	hsa-miR-4786-3p	HITS-CLIP	23824327
MIRT667490	hsa-miR-502-5p	HITS-CLIP	23824327
MIRT641748	hsa-miR-618	HITS-CLIP	23824327
MIRT641747	hsa-miR-1470	HITS-CLIP	23824327
MIRT641746	hsa-miR-4667-3p	HITS-CLIP	23824327
MIRT641745	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT641744	hsa-miR-486-5p	HITS-CLIP	23824327
MIRT641743	hsa-miR-4469	HITS-CLIP	23824327
MIRT641742	hsa-miR-670-3p	HITS-CLIP	23824327
MIRT641741	hsa-miR-1238-3p	HITS-CLIP	23824327
MIRT1125019	hsa-miR-1324	CLIP-seq
MIRT1125020	hsa-miR-3166	CLIP-seq
MIRT1125021	hsa-miR-3614-5p	CLIP-seq
MIRT1125022	hsa-miR-4662a-5p	CLIP-seq
MIRT1125023	hsa-miR-890	CLIP-seq
MIRT1125024	hsa-miR-3121-5p	CLIP-seq
MIRT1125025	hsa-miR-3127-3p	CLIP-seq
MIRT1125026	hsa-miR-3145-3p	CLIP-seq
MIRT1125021	hsa-miR-3614-5p	CLIP-seq
MIRT1125027	hsa-miR-3667-3p	CLIP-seq
MIRT1125028	hsa-miR-4433	CLIP-seq
MIRT1125029	hsa-miR-4459	CLIP-seq
MIRT1125022	hsa-miR-4662a-5p	CLIP-seq
MIRT1125030	hsa-miR-4691-5p	CLIP-seq
MIRT1125031	hsa-miR-4699-5p	CLIP-seq
MIRT1125032	hsa-miR-4753-3p	CLIP-seq
MIRT1125033	hsa-miR-4768-3p	CLIP-seq
MIRT1125034	hsa-miR-7	CLIP-seq
MIRT1125023	hsa-miR-890	CLIP-seq
MIRT1551013	hsa-miR-378g	CLIP-seq
MIRT1551014	hsa-miR-4437	CLIP-seq
MIRT1551015	hsa-miR-4674	CLIP-seq
MIRT1551016	hsa-miR-4731-5p	CLIP-seq
MIRT2035276	hsa-miR-136	CLIP-seq
MIRT2035277	hsa-miR-1972	CLIP-seq
MIRT2035278	hsa-miR-203	CLIP-seq
MIRT2035279	hsa-miR-2277-3p	CLIP-seq
MIRT1125024	hsa-miR-3121-5p	CLIP-seq
MIRT1125025	hsa-miR-3127-3p	CLIP-seq
MIRT2035280	hsa-miR-3607-5p	CLIP-seq
MIRT2035281	hsa-miR-3611	CLIP-seq
MIRT1125027	hsa-miR-3667-3p	CLIP-seq
MIRT2035282	hsa-miR-3668	CLIP-seq
MIRT2035283	hsa-miR-4310	CLIP-seq
MIRT2035284	hsa-miR-4474-5p	CLIP-seq
MIRT1125030	hsa-miR-4691-5p	CLIP-seq
MIRT2035285	hsa-miR-4716-5p	CLIP-seq
MIRT2035286	hsa-miR-4738-3p	CLIP-seq
MIRT2035287	hsa-miR-4749-3p	CLIP-seq
MIRT2035288	hsa-miR-501-5p	CLIP-seq
MIRT2035289	hsa-miR-542-3p	CLIP-seq
MIRT2035290	hsa-miR-548g	CLIP-seq
MIRT2035277	hsa-miR-1972	CLIP-seq
MIRT2035279	hsa-miR-2277-3p	CLIP-seq
MIRT2035283	hsa-miR-4310	CLIP-seq
MIRT2265789	hsa-miR-4642	CLIP-seq
MIRT2035289	hsa-miR-542-3p	CLIP-seq

Show/Hide all (24)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005634	Component	Nucleus	IDA	23474712
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IBA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005730	Component	Nucleolus	IDA
GO:0006974	Process	DNA damage response	IBA
GO:0006974	Process	DNA damage response	IEA
GO:0006974	Process	DNA damage response	IMP	23474712
GO:0007420	Process	Brain development	IEA
GO:0009617	Process	Response to bacterium	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0016798	Function	Hydrolase activity, acting on glycosyl bonds	IDA	23474712
GO:0019213	Function	Deacetylase activity	IDA	21257746
GO:0019213	Function	Deacetylase activity	IEA
GO:0042278	Process	Purine nucleoside metabolic process	IBA
GO:0042278	Process	Purine nucleoside metabolic process	IDA	21257746
GO:0042278	Process	Purine nucleoside metabolic process	IEA
GO:0051725	Process	Protein de-ADP-ribosylation	IDA	23474712
GO:0061463	Function	O-acetyl-ADP-ribose deacetylase activity	IEA
GO:0140291	Process	Peptidyl-glutamate ADP-deribosylation	IDA	23474714
GO:0140291	Process	Peptidyl-glutamate ADP-deribosylation	IEA
GO:0140293	Function	ADP-ribosylglutamate hydrolase activity	IBA
GO:0140293	Function	ADP-ribosylglutamate hydrolase activity	IDA	23474714
GO:0140293	Function	ADP-ribosylglutamate hydrolase activity	IEA

MIM	HGNC	e!Ensembl
611567	16126	ENSG00000172264

A1Z1Q3

Protein name

ADP-ribose glycohydrolase MACROD2 (MACRO domain-containing protein 2) (O-acetyl-ADP-ribose deacetylase MACROD2) (EC 3.5.1.-) ([Protein ADP-ribosylaspartate] hydrolase MACROD2) (EC 3.2.2.-) ([Protein ADP-ribosylglutamate] hydrolase MACROD2) (EC 3.2.2.-)

Protein function

Removes ADP-ribose from aspartate and glutamate residues in proteins bearing a single ADP-ribose moiety (PubMed:23474712, PubMed:23474714). Inactive towards proteins bearing poly-ADP-ribose (PubMed:23474712, PubMed:23474714). Deacetylates O-acet

PDB

4IQY , 6Y4Y , 6Y4Z , 6Y73

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01661	Macro	88 → 201	Macro domain	Domain

Sequence

MYPSNKKKKVWREEKERLLKMTLEERRKEYLRDYIPLNSILSWKEEMKGKGQNDEENTQE
TSQVKKSLTEKVSLYRGDITLLEVDAIVNAANASLLGGGGVDGCIHRAAGPCLLAECRNL
NGCDTGHAKITCGYDLPAKYVIHTVGPIARGHINGSHKEDLANCYKSSLKLVKENNIRSV
AFPCISTGIYGFPNEPAAVIALNTIKEWLAKNHHEVDRIIFCVFLEVDFKIYKKKMNEFF
SVDDNNEEEEDVEMKEDSDENGPEEKQSVEEMEEQSQDADGVNTVTVPGPASEEAVEDCK
DEDFAKDENITKGGEVTDHSVRDQDHPDGQENDSTKNEIKIETESQSSYMETEELSSNQE
DAVIVEQPEVIPLTEDQEEKEGEKAPGEDTPRMPGKSEGSSDLENTPGPDAGAQDEAKEQ
RNGTK

Sequence length

425

Interactions

View interactions

Show/Hide Unknown Diseases (8)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Adrenocortical carcinoma, hereditary	Benign	rs80044408	RCV005938600
Cervical cancer	Benign	rs80044408	RCV005938601
Colon adenocarcinoma	Benign	rs80044408	RCV005938598
MACROD2-related disorder	Benign; Likely benign	rs80044408, rs200598669, rs2990505, rs201701473, rs150617904, rs763857357, rs139092334, rs2076945732, rs41275442, rs114484322	RCV003919585 RCV003919755 RCV003974637 RCV003911811 RCV003974028 RCV003911386 RCV003951964 RCV003931807 RCV003979266 RCV003960687
Malignant lymphoma, large B-cell, diffuse	Benign	rs80044408	RCV005938602
Nonpapillary renal cell carcinoma	Benign	rs80044408	RCV005938599
Thymoma	Benign	rs80044408	RCV005938603
Uterine corpus endometrial carcinoma	Benign	rs80044408	RCV005938604

Show/Hide Text Mining Associations (27)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Adenocarcinoma	Associate	20651033
Alzheimer Disease	Associate	36553611
Asthma	Associate	31379025
Atherosclerosis	Associate	24954375
Autism Spectrum Disorder	Associate	20663923, 32081867, 34069769
Autistic Disorder	Associate	20663923, 23471985, 23575222, 24204716, 25360606, 25975968, 36150388
Breast Neoplasms	Associate	25422431, 35485697
Carcinoma	Associate	31467233
Cerebral Infarction	Associate	24954375
Colorectal Neoplasms	Associate	26375816, 39332629
Esophageal Squamous Cell Carcinoma	Associate	26857264
Graves Ophthalmopathy	Associate	27304844
Heart Defects Congenital	Associate	33463545
Heart Diseases	Associate	33463545
Heart Failure	Associate	34572079
Hypertension	Associate	21626137
Infarction	Associate	24954375
Lung Neoplasms	Associate	35138370
Lymphatic Metastasis	Stimulate	20331625
Neoplasms	Associate	25422431, 26857264
Neurobehavioral Manifestations	Associate	31004082
Neuroblastoma	Associate	32427867
Obesity	Associate	33624934
Primary Myelofibrosis	Associate	23733509
Squamous Cell Carcinoma of Head and Neck	Associate	35398964
Stomach Neoplasms	Associate	20331625, 26857264
Uterine Cervical Neoplasms	Associate	33191407

MACROD2 (mono-ADP ribosylhydrolase 2)