MYO3B (myosin IIIB)

Gene

• Entrez ID: 140469
• Gene name: Myosin IIIB
• Gene symbol: MYO3B
• Synonyms (NCBI Gene): -
• Chromosome: 2
• Chromosome location: 2q31.1
• Summary: This gene encodes one of the class III myosins. Myosins are ATPases, activated by actin, that move along actin filaments in the cell. This class of myosins are characterized by an amino-terminal kinase domain and shown to be present in photoreceptors. Alt

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT017678	hsa-miR-335-5p	Microarray	18185580
MIRT023748	hsa-miR-1-3p	Proteomics;Microarray	18668037
MIRT1169573	hsa-miR-1200	CLIP-seq
MIRT1169574	hsa-miR-1207-3p	CLIP-seq
MIRT1169575	hsa-miR-1275	CLIP-seq
MIRT1169576	hsa-miR-1539	CLIP-seq
MIRT1169577	hsa-miR-197	CLIP-seq
MIRT1169578	hsa-miR-1976	CLIP-seq
MIRT1169579	hsa-miR-3119	CLIP-seq
MIRT1169580	hsa-miR-3121-5p	CLIP-seq
MIRT1169581	hsa-miR-3155	CLIP-seq
MIRT1169582	hsa-miR-3155b	CLIP-seq
MIRT1169583	hsa-miR-3163	CLIP-seq
MIRT1169584	hsa-miR-3193	CLIP-seq
MIRT1169585	hsa-miR-326	CLIP-seq
MIRT1169586	hsa-miR-330-5p	CLIP-seq
MIRT1169587	hsa-miR-345	CLIP-seq
MIRT1169588	hsa-miR-3663-5p	CLIP-seq
MIRT1169589	hsa-miR-3689d	CLIP-seq
MIRT1169590	hsa-miR-411	CLIP-seq
MIRT1169591	hsa-miR-4282	CLIP-seq
MIRT1169592	hsa-miR-4324	CLIP-seq
MIRT1169593	hsa-miR-433	CLIP-seq
MIRT1169594	hsa-miR-4454	CLIP-seq
MIRT1169595	hsa-miR-4522	CLIP-seq
MIRT1169596	hsa-miR-4525	CLIP-seq
MIRT1169597	hsa-miR-4665-5p	CLIP-seq
MIRT1169598	hsa-miR-4667-5p	CLIP-seq
MIRT1169599	hsa-miR-4686	CLIP-seq
MIRT1169600	hsa-miR-4700-5p	CLIP-seq
MIRT1169601	hsa-miR-4716-5p	CLIP-seq
MIRT1169602	hsa-miR-4723-5p	CLIP-seq
MIRT1169603	hsa-miR-4732-3p	CLIP-seq
MIRT1169604	hsa-miR-4765	CLIP-seq
MIRT1169605	hsa-miR-4772-3p	CLIP-seq
MIRT1169606	hsa-miR-4781-3p	CLIP-seq
MIRT1169607	hsa-miR-483-5p	CLIP-seq
MIRT1169608	hsa-miR-484	CLIP-seq
MIRT1169609	hsa-miR-5096	CLIP-seq
MIRT1169610	hsa-miR-544	CLIP-seq
MIRT1169611	hsa-miR-544b	CLIP-seq
MIRT1169612	hsa-miR-578	CLIP-seq
MIRT1169613	hsa-miR-617	CLIP-seq
MIRT1169614	hsa-miR-625	CLIP-seq
MIRT1169615	hsa-miR-637	CLIP-seq
MIRT1169616	hsa-miR-941	CLIP-seq
MIRT1169617	hsa-miR-1297	CLIP-seq
MIRT1169618	hsa-miR-2115	CLIP-seq
MIRT1169619	hsa-miR-26a	CLIP-seq
MIRT1169620	hsa-miR-26b	CLIP-seq
MIRT1169580	hsa-miR-3121-5p	CLIP-seq
MIRT1169621	hsa-miR-3977	CLIP-seq
MIRT1169622	hsa-miR-4465	CLIP-seq
MIRT1169623	hsa-miR-4532	CLIP-seq
MIRT1169624	hsa-miR-516a-3p	CLIP-seq
MIRT2048871	hsa-miR-122	CLIP-seq
MIRT2048872	hsa-miR-146b-3p	CLIP-seq
MIRT2048873	hsa-miR-3135b	CLIP-seq
MIRT2048874	hsa-miR-3173-5p	CLIP-seq
MIRT2048875	hsa-miR-339-5p	CLIP-seq
MIRT2048876	hsa-miR-3652	CLIP-seq
MIRT2048877	hsa-miR-4430	CLIP-seq
MIRT2048878	hsa-miR-4466	CLIP-seq
MIRT2048879	hsa-miR-675	CLIP-seq
MIRT2048880	hsa-miR-874	CLIP-seq
MIRT2277766	hsa-miR-142-5p	CLIP-seq
MIRT2277767	hsa-miR-150	CLIP-seq
MIRT2277768	hsa-miR-340	CLIP-seq
MIRT2277769	hsa-miR-3613-3p	CLIP-seq
MIRT2277770	hsa-miR-371b-5p	CLIP-seq
MIRT2277771	hsa-miR-3907	CLIP-seq
MIRT2277772	hsa-miR-410	CLIP-seq
MIRT2277773	hsa-miR-4438	CLIP-seq
MIRT2277774	hsa-miR-4757-5p	CLIP-seq
MIRT2277775	hsa-miR-5095	CLIP-seq
MIRT2277776	hsa-miR-548a-5p	CLIP-seq
MIRT2277777	hsa-miR-548ab	CLIP-seq
MIRT2277778	hsa-miR-548ak	CLIP-seq
MIRT2277779	hsa-miR-548b-5p	CLIP-seq
MIRT2277780	hsa-miR-548c-5p	CLIP-seq
MIRT2277781	hsa-miR-548d-5p	CLIP-seq
MIRT2277782	hsa-miR-548h	CLIP-seq
MIRT2277783	hsa-miR-548i	CLIP-seq
MIRT2277784	hsa-miR-548j	CLIP-seq
MIRT2277785	hsa-miR-548k	CLIP-seq
MIRT2277786	hsa-miR-548l	CLIP-seq
MIRT2277787	hsa-miR-548w	CLIP-seq
MIRT2277788	hsa-miR-548y	CLIP-seq
MIRT2277789	hsa-miR-559	CLIP-seq
MIRT2277790	hsa-miR-561	CLIP-seq
MIRT2048871	hsa-miR-122	CLIP-seq
MIRT2048872	hsa-miR-146b-3p	CLIP-seq
MIRT2048873	hsa-miR-3135b	CLIP-seq
MIRT2454717	hsa-miR-3157-3p	CLIP-seq
MIRT2048874	hsa-miR-3173-5p	CLIP-seq
MIRT2048875	hsa-miR-339-5p	CLIP-seq
MIRT2048876	hsa-miR-3652	CLIP-seq
MIRT2454718	hsa-miR-431	CLIP-seq
MIRT2048877	hsa-miR-4430	CLIP-seq
MIRT2454719	hsa-miR-4797-5p	CLIP-seq
MIRT2048880	hsa-miR-874	CLIP-seq
MIRT2454720	hsa-miR-924	CLIP-seq
MIRT2576474	hsa-miR-378g	CLIP-seq
MIRT2576475	hsa-miR-4731-5p	CLIP-seq
MIRT2576476	hsa-miR-501-3p	CLIP-seq
MIRT2576477	hsa-miR-502-3p	CLIP-seq
MIRT2277775	hsa-miR-5095	CLIP-seq
MIRT2576478	hsa-miR-552	CLIP-seq
MIRT2576479	hsa-miR-767-5p	CLIP-seq
MIRT2048871	hsa-miR-122	CLIP-seq
MIRT2048872	hsa-miR-146b-3p	CLIP-seq
MIRT2048873	hsa-miR-3135b	CLIP-seq
MIRT2454717	hsa-miR-3157-3p	CLIP-seq
MIRT2048874	hsa-miR-3173-5p	CLIP-seq
MIRT2048875	hsa-miR-339-5p	CLIP-seq
MIRT2048876	hsa-miR-3652	CLIP-seq
MIRT2454718	hsa-miR-431	CLIP-seq
MIRT2048877	hsa-miR-4430	CLIP-seq
MIRT2576475	hsa-miR-4731-5p	CLIP-seq
MIRT2454719	hsa-miR-4797-5p	CLIP-seq
MIRT2576476	hsa-miR-501-3p	CLIP-seq
MIRT2576477	hsa-miR-502-3p	CLIP-seq
MIRT2277775	hsa-miR-5095	CLIP-seq
MIRT2576478	hsa-miR-552	CLIP-seq
MIRT2576479	hsa-miR-767-5p	CLIP-seq
MIRT2048880	hsa-miR-874	CLIP-seq
MIRT2454720	hsa-miR-924	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000146	Function	Microfilament motor activity	IBA
GO:0000146	Function	Microfilament motor activity	IEA
GO:0000166	Function	Nucleotide binding	IEA
GO:0001917	Component	Photoreceptor inner segment	IBA
GO:0003774	Function	Cytoskeletal motor activity	IEA
GO:0003779	Function	Actin binding	IEA
GO:0004672	Function	Protein kinase activity	IEA
GO:0004674	Function	Protein serine/threonine kinase activity	IBA
GO:0004674	Function	Protein serine/threonine kinase activity	IEA
GO:0005515	Function	Protein binding	IPI	22939624, 32707033
GO:0005524	Function	ATP binding	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005856	Component	Cytoskeleton	IEA
GO:0007601	Process	Visual perception	IEA
GO:0007605	Process	Sensory perception of sound	IBA
GO:0007605	Process	Sensory perception of sound	IEA
GO:0007605	Process	Sensory perception of sound	ISS
GO:0016301	Function	Kinase activity	IEA
GO:0016459	Component	Myosin complex	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0030832	Process	Regulation of actin filament length	IBA
GO:0032420	Component	Stereocilium	IEA
GO:0032426	Component	Stereocilium tip	IBA
GO:0032426	Component	Stereocilium tip	ISS
GO:0032433	Component	Filopodium tip	IBA
GO:0032433	Component	Filopodium tip	IEA
GO:0042995	Component	Cell projection	IEA
GO:0043226	Component	Organelle	IEA
GO:0051491	Process	Positive regulation of filopodium assembly	IBA
GO:0090103	Process	Cochlea morphogenesis	ISS
GO:0106310	Function	Protein serine kinase activity	IEA

Other IDs

• MIM: 610040
• HGNC: 15576
• e!Ensembl: ENSG00000071909

Protein

• UniProt ID: Q8WXR4
• Protein name: Myosin-IIIb (EC 2.7.11.1)
• Protein function: Probable actin-based motor with a protein kinase activity. Required for normal cochlear hair bundle development and hearing. Plays an important role in the early steps of cochlear hair bundle morphogenesis. Influences the number and lengths of s
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00069	Pkinase	27 → 293	Protein kinase domain	Domain
  PF00063	Myosin_head	345 → 1046	Myosin head (motor domain)	Domain
  PF00612	IQ	1088 → 1108	IQ calmodulin-binding motif	Motif

• Tissue specificity: TISSUE SPECIFICITY: Expressed in retina, kidney and testis.
• Sequence:

  MKHLYGLFHYNPMMLGLESLPDPTDTWEIIETIGKGTYGKVYKVTNKRDGSLAAVKILDP
  VSDMDEEIEAEYNILQFLPNHPNVVKFYGMFYKADHCVGGQLWLVLELCNGGSVTELVKG
  LLRCGQRLDEAMISYILYGALLGLQHLHNNRIIHRDVKGNNILLTTEGGVKLVDFGVSAQ
  LTSTRLRRNTSVGTPFWMAPEVIACEQQYDSSYDARCDVWSLGITAIELGDGDPPLFDMH
  PVKTLFKIPRNPPPTLLHPEKWCEEFNHFISQCLIKDFERRPSVTHLLDHPFIKGVHGKV
  LFLQKQLAKVLQDQKHQNPVAKTRHERMHTRRPYHVEDAEKYCLEDDLVNLEVLDEDTII
  HQLQKRYADLLIYTYVGDILIALNPFQNLSIYSPQFSRLYHGVKRASNPPHIFASADAAY
  QCMVTLSKDQCIVISGESGSGKTESAHLIVQHLTFLGKANNQTLREKILQVNSLVEAFGN
  SCTAINDNSSRFGKYLEMMFTPTGVVMGARISEYLLEKSRVIKQAAREKNFHIFYYIYAG
  LHHQKKLSDFRLPEEKPPRYIADETGRVMHDITSKESYRRQFEAIQHCFRIIGFTDKEVH
  SVYRILAGILNIGNIEFAAISSQHQTDKSEVPNAEALQNAASVLCISPEELQEALTSHCV
  VTRGETIIRANTVDRAADVRDAMSKALYGRLFSWIVNRINTLLQPDENICSAGGGMNVGI
  LDIFGFENFQRNSFEQLCINIANEQIQYYFNQHVFALEQMEYQNEGIDAVPVEYEDNRPL
  LDMFLQKPLGLLALLDEESRFPQATDQTLVDKFEDNLRCKYFWRPKGVELCFGIQHYAGK
  VLYDASGVLEKNRDTLPADVVVVLRTSENKLLQQLFSIPLTKTGNLAQTRARITVASSSL
  PPHFSAGKAKVDTLEVIRHPEETTNMKRQTVASYFRYSLMDLLSKMVVGQPHFVRCIKPN
  DDREALQFSRERVLAQLRSTGILETVSIRRQGYSHRILFEEFVKRYYYLAFTAHQTPLAS
  KESCVAILEKSRLDHWVLGKTKVFLKYYHVEQLNLLLREVIGRVVVLQAYTKGWLGARRY
  KRVREKREKGAIAIQSAWRGYDARRKFKKISNRRNESAAHNQAGDTSNQSSGPHSPVAAG
  TRGSAEVQDCSEPGDHKVLRGSVHRRSHSQAESNNGRTQTSSNSPAVTEKNGHSQAQSSP
  KGCDIFAGHANKHSVSGTDLLSSRICHPAPDQQGLSLWGAPQKPGSENGLAQKHRTPRRR
  CQQPKMLSSPEDTMYYNQLNGTLEYQGSKRKPRKLGQIKVLDGEDEYYKSLSPVDCIPEE
  NNSAHPSFFSSSSKGDSFAQH

• Sequence length: 1341

Pathways

KEGG:

Motor proteins