CRP (C-reactive protein)

Gene Gene information from NCBI Gene database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID 1401
Gene name C-reactive protein
Gene symbol CRP
Synonyms (NCBI Gene)
PTX1
Chromosome 1
Chromosome location 1q23.2
Summary The protein encoded by this gene belongs to the pentraxin family which also includes serum amyloid P component protein and pentraxin 3. Pentraxins are involved in complement activation and amplification via communication with complement initiation pattern
miRNA miRNA information provided by mirtarbase database.
27
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
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miRTarBase ID miRNA Experiments Reference
MIRT732532 hsa-miR-16-5p Microarray 32041109
MIRT732623 hsa-miR-10b-5p qRT-PCR 33787515
MIRT733299 hsa-miR-30a-3p RNA-seqqRT-PCR 33538126
MIRT733300 hsa-miR-192-3p RNA-seqqRT-PCR 33538126
MIRT733301 hsa-miR-146a-3p RNA-seqqRT-PCR 33538126
Transcription factors Transcription factors information provided by TRRUST V2 database.
11
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
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Transcription factor Regulation Reference
CEBPB Activation 12667216;23361365
FOS Unknown 18292576
HNF1A Unknown 18292576;8703909
NFKB1 Activation 12667216;17704137
NFKB1 Unknown 17513780
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
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Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
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GO ID Ontology Definition Evidence Reference
GO:0001849 Function Complement component C1q complex binding IBA
GO:0001849 Function Complement component C1q complex binding IDA 23544079
GO:0001849 Function Complement component C1q complex binding IEA
GO:0005509 Function Calcium ion binding IDA 23544079
GO:0005515 Function Protein binding IPI 17244159, 17293598, 17339482, 17399790, 17785206, 18786923, 19084272, 19680263, 19850925, 20042240, 21037097, 21930971, 25416956, 26922829, 26984957, 28533443, 29374201
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
123260 2367 ENSG00000132693
Protein Protein information from UniProt database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P02741
Protein name C-reactive protein [Cleaved into: C-reactive protein(1-205)]
Protein function Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones
PDB 1B09 , 1GNH , 1LJ7 , 3L2Y , 3PVN , 3PVO , 7PK9 , 7PKB , 7PKD , 7PKE , 7PKF , 7PKG , 7PKH , 7TBA , 8WV4 , 8WV5
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00354 Pentaxin 25 → 220 Pentaxin family Domain
Tissue specificity TISSUE SPECIFICITY: Found in plasma.
Sequence
Sequence length 224
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  Reactome
    Classical antibody-mediated complement activation
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
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Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Unknown Diseases (2)
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
CRP-related disorder Uncertain significance rs77832441, rs2525660438, rs1660738597 RCV003918877
RCV003982728
RCV003933910
Inflammation Uncertain significance rs1205 RCV002259422
Show/Hide Text Mining Associations (669)
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Abdominal Injuries Associate 23505185, 24588117, 35173190, 36533575
Abdominal Pain Associate 30918467
Abnormalities Drug Induced Stimulate 31522452
Acanthosis Nigricans Associate 33057385
Achalasia Addisonianism Alacrimia syndrome Associate 20570470
Achondroplasia and Swiss type agammaglobulinemia Associate 9778529
Acquired Immunodeficiency Syndrome Associate 30845929, 32532356
Acute Aortic Syndrome Associate 30497388
Acute Coronary Syndrome Stimulate 11132167, 22100252
Acute Coronary Syndrome Associate 18957790, 19130414, 23445482, 23950953, 24217304, 24709882