CRP (C-reactive protein)

Gene
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
1401
Gene name Gene Name - the full gene name approved by the HGNC.
C-reactive protein
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
CRP
Synonyms (NCBI Gene) Gene synonyms aliases
PTX1
Chromosome Chromosome number
1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
1q23.2
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene belongs to the pentraxin family which also includes serum amyloid P component protein and pentraxin 3. Pentraxins are involved in complement activation and amplification via communication with complement initiation pattern
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(27)
miRTarBase ID miRNA Experiments Reference
MIRT732532 hsa-miR-16-5p Microarray 32041109
MIRT732623 hsa-miR-10b-5p qRT-PCR 33787515
MIRT733299 hsa-miR-30a-3p RNA-seq, qRT-PCR 33538126
MIRT733300 hsa-miR-192-3p RNA-seq, qRT-PCR 33538126
MIRT733301 hsa-miR-146a-3p RNA-seq, qRT-PCR 33538126
Transcription factors
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(11)
Transcription factor Regulation Reference
CEBPB Activation 12667216;23361365
FOS Unknown 18292576
HNF1A Unknown 18292576;8703909
NFKB1 Activation 12667216;17704137
NFKB1 Unknown 17513780
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(28)
GO ID Ontology Definition Evidence Reference
GO:0001849 Function Complement component C1q complex binding IBA 21873635
GO:0001849 Function Complement component C1q complex binding IDA 23544079
GO:0005509 Function Calcium ion binding IDA 23544079
GO:0005515 Function Protein binding IPI 17293598, 17339482, 17399790, 17785206, 18786923, 19084272, 19680263, 19850925, 20042240, 21037097, 21930971, 21979047, 25416956, 28533443, 29374201
GO:0005576 Component Extracellular region NAS 14718574
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
123260 2367 ENSG00000132693
Protein
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID P02741
Protein name C-reactive protein [Cleaved into: C-reactive protein(1-205)]
Protein function Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones
PDB 1B09 , 1GNH , 1LJ7 , 3L2Y , 3PVN , 3PVO , 7PK9 , 7PKB , 7PKD , 7PKE , 7PKF , 7PKG , 7PKH , 7TBA , 8WV4 , 8WV5
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00354 Pentaxin 25 → 220 Pentaxin family Domain
Tissue specificity TISSUE SPECIFICITY: Found in plasma.
Sequence
Sequence length 224
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  Reactome
    Classical antibody-mediated complement activation
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Causal Diseases (12)
Causal
Disease term Disease name dbSNP ID References
Coronary artery disease Coronary Artery Disease rs137852988, rs121918313, rs121918529, rs121918531, rs137852340, rs1555800701, rs1215189537 24868163
Diabetes mellitus Diabetes Mellitus, Insulin-Dependent, Diabetes Mellitus, Ketosis-Prone, Diabetes Mellitus, Sudden-Onset rs587776515, rs61730328, rs606231121, rs606231122, rs79020217, rs77625743, rs78378398, rs606231123, rs1362648752, rs104893649, rs80356624, rs80356616, rs80356625, rs80356611, rs104894237
View all (293 more)		 20012460
Hyperparathyroidism Hyperparathyroidism, Secondary rs28942098, rs121434262, rs80356649, rs121434264, rs587776558, rs587776559, rs121909259, rs104893689, rs28936684, rs104893690, rs869320729, rs104893700, rs104893705, rs104893707, rs104893709
View all (14 more)		 21350317
Hypertension Hypertensive disease rs13306026 20667508, 16680063, 19770776, 14620923
Show/Hide Unknown Diseases (8)
Unknown
Disease term Disease name Evidence References Source
Atherosclerosis Atherosclerosis 16931792 ClinVar
Congestive heart failure Congestive heart failure 16360360 ClinVar
Coronary syndrome Acute Coronary Syndrome 15966572, 23305094 ClinVar
Crohn disease Crohn Disease, Regional enteritis 11339241 ClinVar
Show/Hide Text Mining Associations (669)
Associations from Text Mining
Disease Name Relationship Type References
Abdominal Injuries Associate 23505185, 24588117, 35173190, 36533575
Abdominal Pain Associate 30918467
Abnormalities Drug Induced Stimulate 31522452
Acanthosis Nigricans Associate 33057385
Achalasia Addisonianism Alacrimia syndrome Associate 20570470
Achondroplasia and Swiss type agammaglobulinemia Associate 9778529
Acquired Immunodeficiency Syndrome Associate 30845929, 32532356
Acute Aortic Syndrome Associate 30497388
Acute Coronary Syndrome Stimulate 11132167, 22100252
Acute Coronary Syndrome Associate 18957790, 19130414, 23445482, 23950953, 24217304, 24709882