Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	1400
Gene name	Collapsin response mediator protein 1
Gene symbol	CRMP1
Synonyms (NCBI Gene)	CRMP-1DPYSL1DRP-1DRP1ULIP-3
Chromosome	4
Chromosome location	4p16.2
Summary	This gene encodes a member of a family of cytosolic phosphoproteins expressed exclusively in the nervous system. The encoded protein is thought to be a part of the semaphorin signal transduction pathway implicated in semaphorin-induced growth cone collaps

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Show/Hide all (170)

miRTarBase ID	miRNA	Experiments	Reference
MIRT569829	hsa-miR-4781-5p	PAR-CLIP	20371350
MIRT569828	hsa-miR-151a-5p	PAR-CLIP	20371350
MIRT569827	hsa-miR-151b	PAR-CLIP	20371350
MIRT569826	hsa-miR-3150b-3p	PAR-CLIP	20371350
MIRT569825	hsa-miR-4784	PAR-CLIP	20371350
MIRT569824	hsa-miR-4434	PAR-CLIP	20371350
MIRT569823	hsa-miR-4516	PAR-CLIP	20371350
MIRT569822	hsa-miR-5703	PAR-CLIP	20371350
MIRT569821	hsa-miR-765	PAR-CLIP	20371350
MIRT569819	hsa-miR-7106-5p	PAR-CLIP	20371350
MIRT569820	hsa-miR-6825-5p	PAR-CLIP	20371350
MIRT569818	hsa-miR-4723-5p	PAR-CLIP	20371350
MIRT569817	hsa-miR-5698	PAR-CLIP	20371350
MIRT569816	hsa-miR-6870-5p	PAR-CLIP	20371350
MIRT569815	hsa-miR-7111-5p	PAR-CLIP	20371350
MIRT569814	hsa-miR-7109-5p	PAR-CLIP	20371350
MIRT569829	hsa-miR-4781-5p	PAR-CLIP	20371350
MIRT569828	hsa-miR-151a-5p	PAR-CLIP	20371350
MIRT569827	hsa-miR-151b	PAR-CLIP	20371350
MIRT569826	hsa-miR-3150b-3p	PAR-CLIP	20371350
MIRT569825	hsa-miR-4784	PAR-CLIP	20371350
MIRT569824	hsa-miR-4434	PAR-CLIP	20371350
MIRT569823	hsa-miR-4516	PAR-CLIP	20371350
MIRT569822	hsa-miR-5703	PAR-CLIP	20371350
MIRT569821	hsa-miR-765	PAR-CLIP	20371350
MIRT569819	hsa-miR-7106-5p	PAR-CLIP	20371350
MIRT569820	hsa-miR-6825-5p	PAR-CLIP	20371350
MIRT569818	hsa-miR-4723-5p	PAR-CLIP	20371350
MIRT569817	hsa-miR-5698	PAR-CLIP	20371350
MIRT569816	hsa-miR-6870-5p	PAR-CLIP	20371350
MIRT569815	hsa-miR-7111-5p	PAR-CLIP	20371350
MIRT569814	hsa-miR-7109-5p	PAR-CLIP	20371350
MIRT910372	hsa-miR-1208	CLIP-seq
MIRT910373	hsa-miR-1265	CLIP-seq
MIRT910374	hsa-miR-141	CLIP-seq
MIRT910375	hsa-miR-1909	CLIP-seq
MIRT910376	hsa-miR-1972	CLIP-seq
MIRT910377	hsa-miR-200a	CLIP-seq
MIRT910378	hsa-miR-30a	CLIP-seq
MIRT910379	hsa-miR-30b	CLIP-seq
MIRT910380	hsa-miR-30c	CLIP-seq
MIRT910381	hsa-miR-30d	CLIP-seq
MIRT910382	hsa-miR-30e	CLIP-seq
MIRT910383	hsa-miR-3190	CLIP-seq
MIRT910384	hsa-miR-3202	CLIP-seq
MIRT910385	hsa-miR-3660	CLIP-seq
MIRT910386	hsa-miR-412	CLIP-seq
MIRT910387	hsa-miR-4256	CLIP-seq
MIRT910388	hsa-miR-4420	CLIP-seq
MIRT910389	hsa-miR-4475	CLIP-seq
MIRT910390	hsa-miR-4491	CLIP-seq
MIRT910391	hsa-miR-4526	CLIP-seq
MIRT910392	hsa-miR-4533	CLIP-seq
MIRT910393	hsa-miR-4650-5p	CLIP-seq
MIRT910394	hsa-miR-4657	CLIP-seq
MIRT910395	hsa-miR-4688	CLIP-seq
MIRT910396	hsa-miR-4717-5p	CLIP-seq
MIRT910397	hsa-miR-4762-3p	CLIP-seq
MIRT910398	hsa-miR-4764-5p	CLIP-seq
MIRT910399	hsa-miR-4795-5p	CLIP-seq
MIRT910400	hsa-miR-486-3p	CLIP-seq
MIRT910401	hsa-miR-510	CLIP-seq
MIRT910402	hsa-miR-642b	CLIP-seq
MIRT1969889	hsa-miR-4318	CLIP-seq
MIRT910385	hsa-miR-3660	CLIP-seq
MIRT910386	hsa-miR-412	CLIP-seq
MIRT910391	hsa-miR-4526	CLIP-seq
MIRT910373	hsa-miR-1265	CLIP-seq
MIRT2447658	hsa-miR-130a	CLIP-seq
MIRT2447659	hsa-miR-130b	CLIP-seq
MIRT2447660	hsa-miR-139-5p	CLIP-seq
MIRT2447661	hsa-miR-153	CLIP-seq
MIRT910375	hsa-miR-1909	CLIP-seq
MIRT910376	hsa-miR-1972	CLIP-seq
MIRT2447662	hsa-miR-19a	CLIP-seq
MIRT2447663	hsa-miR-19b	CLIP-seq
MIRT2447664	hsa-miR-2276	CLIP-seq
MIRT2447665	hsa-miR-301a	CLIP-seq
MIRT2447666	hsa-miR-301b	CLIP-seq
MIRT2447667	hsa-miR-3126-5p	CLIP-seq
MIRT2447668	hsa-miR-331-3p	CLIP-seq
MIRT2447669	hsa-miR-3605-5p	CLIP-seq
MIRT2447670	hsa-miR-3666	CLIP-seq
MIRT2447671	hsa-miR-3943	CLIP-seq
MIRT2447672	hsa-miR-4257	CLIP-seq
MIRT2447673	hsa-miR-4295	CLIP-seq
MIRT2447674	hsa-miR-448	CLIP-seq
MIRT910390	hsa-miR-4491	CLIP-seq
MIRT2447675	hsa-miR-454	CLIP-seq
MIRT910393	hsa-miR-4650-5p	CLIP-seq
MIRT910394	hsa-miR-4657	CLIP-seq
MIRT2447676	hsa-miR-4671-3p	CLIP-seq
MIRT910395	hsa-miR-4688	CLIP-seq
MIRT2447677	hsa-miR-4690-3p	CLIP-seq
MIRT2447678	hsa-miR-4708-3p	CLIP-seq
MIRT2447679	hsa-miR-4711-5p	CLIP-seq
MIRT2447680	hsa-miR-4714-3p	CLIP-seq
MIRT910396	hsa-miR-4717-5p	CLIP-seq
MIRT2447681	hsa-miR-4722-3p	CLIP-seq
MIRT910398	hsa-miR-4764-5p	CLIP-seq
MIRT2447682	hsa-miR-4769-3p	CLIP-seq
MIRT2447683	hsa-miR-4772-3p	CLIP-seq
MIRT2447684	hsa-miR-4773	CLIP-seq
MIRT910400	hsa-miR-486-3p	CLIP-seq
MIRT2447685	hsa-miR-499a-5p	CLIP-seq
MIRT910401	hsa-miR-510	CLIP-seq
MIRT910402	hsa-miR-642b	CLIP-seq
MIRT2447686	hsa-miR-802	CLIP-seq
MIRT2447687	hsa-miR-942	CLIP-seq
MIRT2447667	hsa-miR-3126-5p	CLIP-seq
MIRT2447672	hsa-miR-4257	CLIP-seq
MIRT910373	hsa-miR-1265	CLIP-seq
MIRT2447658	hsa-miR-130a	CLIP-seq
MIRT2447659	hsa-miR-130b	CLIP-seq
MIRT2447664	hsa-miR-2276	CLIP-seq
MIRT2447665	hsa-miR-301a	CLIP-seq
MIRT2447666	hsa-miR-301b	CLIP-seq
MIRT2447668	hsa-miR-331-3p	CLIP-seq
MIRT2509137	hsa-miR-342-3p	CLIP-seq
MIRT2447669	hsa-miR-3605-5p	CLIP-seq
MIRT2447670	hsa-miR-3666	CLIP-seq
MIRT2447673	hsa-miR-4295	CLIP-seq
MIRT910390	hsa-miR-4491	CLIP-seq
MIRT2447675	hsa-miR-454	CLIP-seq
MIRT910394	hsa-miR-4657	CLIP-seq
MIRT2447676	hsa-miR-4671-3p	CLIP-seq
MIRT2509138	hsa-miR-4695-3p	CLIP-seq
MIRT2447678	hsa-miR-4708-3p	CLIP-seq
MIRT2447680	hsa-miR-4714-3p	CLIP-seq
MIRT2447681	hsa-miR-4722-3p	CLIP-seq
MIRT910398	hsa-miR-4764-5p	CLIP-seq
MIRT2447682	hsa-miR-4769-3p	CLIP-seq
MIRT2447683	hsa-miR-4772-3p	CLIP-seq
MIRT2509139	hsa-miR-513a-5p	CLIP-seq
MIRT2509140	hsa-miR-552	CLIP-seq
MIRT910402	hsa-miR-642b	CLIP-seq
MIRT2447687	hsa-miR-942	CLIP-seq
MIRT910373	hsa-miR-1265	CLIP-seq
MIRT2447658	hsa-miR-130a	CLIP-seq
MIRT2447659	hsa-miR-130b	CLIP-seq
MIRT910375	hsa-miR-1909	CLIP-seq
MIRT910376	hsa-miR-1972	CLIP-seq
MIRT2447664	hsa-miR-2276	CLIP-seq
MIRT2447665	hsa-miR-301a	CLIP-seq
MIRT2447666	hsa-miR-301b	CLIP-seq
MIRT2447667	hsa-miR-3126-5p	CLIP-seq
MIRT2447668	hsa-miR-331-3p	CLIP-seq
MIRT2447669	hsa-miR-3605-5p	CLIP-seq
MIRT2447670	hsa-miR-3666	CLIP-seq
MIRT2447671	hsa-miR-3943	CLIP-seq
MIRT2447672	hsa-miR-4257	CLIP-seq
MIRT2447673	hsa-miR-4295	CLIP-seq
MIRT910390	hsa-miR-4491	CLIP-seq
MIRT2447675	hsa-miR-454	CLIP-seq
MIRT910393	hsa-miR-4650-5p	CLIP-seq
MIRT910394	hsa-miR-4657	CLIP-seq
MIRT2447676	hsa-miR-4671-3p	CLIP-seq
MIRT910395	hsa-miR-4688	CLIP-seq
MIRT2447677	hsa-miR-4690-3p	CLIP-seq
MIRT2447678	hsa-miR-4708-3p	CLIP-seq
MIRT2447680	hsa-miR-4714-3p	CLIP-seq
MIRT910396	hsa-miR-4717-5p	CLIP-seq
MIRT2447681	hsa-miR-4722-3p	CLIP-seq
MIRT910398	hsa-miR-4764-5p	CLIP-seq
MIRT2447682	hsa-miR-4769-3p	CLIP-seq
MIRT2447683	hsa-miR-4772-3p	CLIP-seq
MIRT910400	hsa-miR-486-3p	CLIP-seq
MIRT910401	hsa-miR-510	CLIP-seq
MIRT910402	hsa-miR-642b	CLIP-seq
MIRT2447687	hsa-miR-942	CLIP-seq

Show/Hide all (3)

Transcription factor	Regulation	Reference
CEBPA	Unknown	18524846
NFKB1	Unknown	18782567
SP1	Unknown	18524846

Show/Hide all (31)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004157	Function	Dihydropyrimidinase activity	IBA
GO:0005515	Function	Protein binding	IPI	15383276, 16169070, 21900206, 24722188, 25416956, 32296183, 32814053
GO:0005737	Component	Cytoplasm	IEA
GO:0005813	Component	Centrosome	IDA
GO:0005813	Component	Centrosome	IEA
GO:0005819	Component	Spindle	IEA
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0005856	Component	Cytoskeleton	IEA
GO:0006139	Process	Nucleobase-containing compound metabolic process	TAS	8973361
GO:0006208	Process	Pyrimidine nucleobase catabolic process	IBA
GO:0007399	Process	Nervous system development	TAS	8973361
GO:0010977	Process	Negative regulation of neuron projection development	IGI	25358863
GO:0015629	Component	Actin cytoskeleton	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0016810	Function	Hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	IEA
GO:0016812	Function	Hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides	IBA
GO:0030425	Component	Dendrite	IEA
GO:0030426	Component	Growth cone	IEA
GO:0030496	Component	Midbody	IDA	19799413
GO:0031005	Function	Filamin binding	IPI	25358863
GO:0042802	Function	Identical protein binding	IPI	24722188, 25416956
GO:0042995	Component	Cell projection	IEA
GO:0043025	Component	Neuronal cell body	IEA
GO:0043204	Component	Perikaryon	IEA
GO:0051219	Function	Phosphoprotein binding	IEA
GO:0071526	Process	Semaphorin-plexin signaling pathway	IEA
GO:0098793	Component	Presynapse	IEA
GO:0098794	Component	Postsynapse	IEA
GO:0150052	Process	Regulation of postsynapse assembly	IEA

MIM	HGNC	e!Ensembl
602462	2365	ENSG00000072832

Q14194

Protein name

Dihydropyrimidinase-related protein 1 (DRP-1) (Collapsin response mediator protein 1) (CRMP-1) (Inactive dihydropyrimidinase) (Unc-33-like phosphoprotein 3) (ULIP-3)

Protein function

Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton (PubMed:25358863). Plays a role in axon guidance (PubMed:25358863). During the axon guidance process, acts downstream of SEMA3A to promote FLNA dissocia

PDB

4B3Z

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01979	Amidohydro_1	64 → 453	Amidohydrolase family	Domain

Tissue specificity

TISSUE SPECIFICITY: Brain.

Sequence

MSYQGKKSIPHITSDRLLIKGGRIINDDQSLYADVYLEDGLIKQIGENLIVPGGVKTIEA
NGRMVIPGGIDVNTYLQKPSQGMTAADDFFQGTRAALVGGTTMIIDHVVPEPGSSLLTSF
EKWHEAADTKSCCDYSLHVDITSWYDGVREELEVLVQDKGVNSFQVYMAYKDVYQMSDSQ
LYEAFTFLKGLGAVILVHAENGDLIAQEQKRILEMGITGPEGHALSRPEELEAEAVFRAI
TIAGRINCPVYITKVMSKSAADIIALARKKGPLVFGEPIAASLGTDGTHYWSKNWAKAAA
FVTSPPLSPDPTTPDYLTSLLACGDLQVTGSGHCPYSTAQKAVGKDNFTLIPEGVNGIEE
RMTVVWDKAVATGKMDENQFVAVTSTNAAKIFNLYPRKGRIAVGSDADVVIWDPDKLKTI
TAKSHKSAVEYNIFEGMECHGSPLVVISQGKIVFEDGNINVNKGMGRFIPRKAFPEHLYQ
RVKIRNKVFGLQGVSRGMYDGPVYEVPATPKYATPAPSAKSSPSKHQPPPIRNLHQSNFS
LSGAQIDDNNPRRTGHRIVAPPGGRSNITSLG

Sequence length

572

Interactions

View interactions

	Reactome
			CRMPs in Sema3A signaling

Show/Hide Unknown Diseases (5)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Clear cell carcinoma of kidney	Benign	rs61034456	RCV005913502
EBV-positive nodal T- and NK-cell lymphoma	Likely benign	rs2474171074	RCV004560208
Malignant tumor of esophagus	Benign	rs61034456	RCV005913501
Ovarian serous cystadenocarcinoma	Benign	rs61034456	RCV005913503
Uterine corpus endometrial carcinoma	Benign	rs61034456	RCV005913504

Show/Hide Text Mining Associations (16)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Bipolar Disorder	Associate	29666369
Breast Neoplasms	Associate	36454866
Cancer Pain	Associate	27456940
Carcinoma Non Small Cell Lung	Inhibit	24011394
Glioblastoma	Associate	28498803
Malformations of Cortical Development	Stimulate	28222113
Medulloblastoma	Associate	26009886
Mental Disorders	Associate	37508512
Mood Disorders	Associate	29666369
Neoplasm Metastasis	Inhibit	24011394
Neuroblastoma	Associate	18980998
Optic Nerve Injuries	Associate	37059258
Osteoglophonic dwarfism	Associate	38287382
Pulmonary Disease Chronic Obstructive	Associate	38110986
Schizophrenia	Associate	25333879
Tomaculous neuropathy	Associate	37508512

CRMP1 (collapsin response mediator protein 1)