Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	1400
Gene name Gene Name - the full gene name approved by the HGNC.	Collapsin response mediator protein 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	CRMP1
Synonyms (NCBI Gene) Gene synonyms aliases	CRMP-1, DPYSL1, DRP-1, DRP1, ULIP-3
Chromosome Chromosome number	4
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	4p16.2
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a member of a family of cytosolic phosphoproteins expressed exclusively in the nervous system. The encoded protein is thought to be a part of the semaphorin signal transduction pathway implicated in semaphorin-induced growth cone collaps

Show/Hide all(170)

miRTarBase ID	miRNA	Experiments	Reference
MIRT569829	hsa-miR-4781-5p	PAR-CLIP	20371350
MIRT569828	hsa-miR-151a-5p	PAR-CLIP	20371350
MIRT569827	hsa-miR-151b	PAR-CLIP	20371350
MIRT569826	hsa-miR-3150b-3p	PAR-CLIP	20371350
MIRT569825	hsa-miR-4784	PAR-CLIP	20371350
MIRT569824	hsa-miR-4434	PAR-CLIP	20371350
MIRT569823	hsa-miR-4516	PAR-CLIP	20371350
MIRT569822	hsa-miR-5703	PAR-CLIP	20371350
MIRT569821	hsa-miR-765	PAR-CLIP	20371350
MIRT569819	hsa-miR-7106-5p	PAR-CLIP	20371350
MIRT569820	hsa-miR-6825-5p	PAR-CLIP	20371350
MIRT569818	hsa-miR-4723-5p	PAR-CLIP	20371350
MIRT569817	hsa-miR-5698	PAR-CLIP	20371350
MIRT569816	hsa-miR-6870-5p	PAR-CLIP	20371350
MIRT569815	hsa-miR-7111-5p	PAR-CLIP	20371350
MIRT569814	hsa-miR-7109-5p	PAR-CLIP	20371350
MIRT569829	hsa-miR-4781-5p	PAR-CLIP	20371350
MIRT569828	hsa-miR-151a-5p	PAR-CLIP	20371350
MIRT569827	hsa-miR-151b	PAR-CLIP	20371350
MIRT569826	hsa-miR-3150b-3p	PAR-CLIP	20371350
MIRT569825	hsa-miR-4784	PAR-CLIP	20371350
MIRT569824	hsa-miR-4434	PAR-CLIP	20371350
MIRT569823	hsa-miR-4516	PAR-CLIP	20371350
MIRT569822	hsa-miR-5703	PAR-CLIP	20371350
MIRT569821	hsa-miR-765	PAR-CLIP	20371350
MIRT569819	hsa-miR-7106-5p	PAR-CLIP	20371350
MIRT569820	hsa-miR-6825-5p	PAR-CLIP	20371350
MIRT569818	hsa-miR-4723-5p	PAR-CLIP	20371350
MIRT569817	hsa-miR-5698	PAR-CLIP	20371350
MIRT569816	hsa-miR-6870-5p	PAR-CLIP	20371350
MIRT569815	hsa-miR-7111-5p	PAR-CLIP	20371350
MIRT569814	hsa-miR-7109-5p	PAR-CLIP	20371350
MIRT910372	hsa-miR-1208	CLIP-seq
MIRT910373	hsa-miR-1265	CLIP-seq
MIRT910374	hsa-miR-141	CLIP-seq
MIRT910375	hsa-miR-1909	CLIP-seq
MIRT910376	hsa-miR-1972	CLIP-seq
MIRT910377	hsa-miR-200a	CLIP-seq
MIRT910378	hsa-miR-30a	CLIP-seq
MIRT910379	hsa-miR-30b	CLIP-seq
MIRT910380	hsa-miR-30c	CLIP-seq
MIRT910381	hsa-miR-30d	CLIP-seq
MIRT910382	hsa-miR-30e	CLIP-seq
MIRT910383	hsa-miR-3190	CLIP-seq
MIRT910384	hsa-miR-3202	CLIP-seq
MIRT910385	hsa-miR-3660	CLIP-seq
MIRT910386	hsa-miR-412	CLIP-seq
MIRT910387	hsa-miR-4256	CLIP-seq
MIRT910388	hsa-miR-4420	CLIP-seq
MIRT910389	hsa-miR-4475	CLIP-seq
MIRT910390	hsa-miR-4491	CLIP-seq
MIRT910391	hsa-miR-4526	CLIP-seq
MIRT910392	hsa-miR-4533	CLIP-seq
MIRT910393	hsa-miR-4650-5p	CLIP-seq
MIRT910394	hsa-miR-4657	CLIP-seq
MIRT910395	hsa-miR-4688	CLIP-seq
MIRT910396	hsa-miR-4717-5p	CLIP-seq
MIRT910397	hsa-miR-4762-3p	CLIP-seq
MIRT910398	hsa-miR-4764-5p	CLIP-seq
MIRT910399	hsa-miR-4795-5p	CLIP-seq
MIRT910400	hsa-miR-486-3p	CLIP-seq
MIRT910401	hsa-miR-510	CLIP-seq
MIRT910402	hsa-miR-642b	CLIP-seq
MIRT1969889	hsa-miR-4318	CLIP-seq
MIRT910385	hsa-miR-3660	CLIP-seq
MIRT910386	hsa-miR-412	CLIP-seq
MIRT910391	hsa-miR-4526	CLIP-seq
MIRT910373	hsa-miR-1265	CLIP-seq
MIRT2447658	hsa-miR-130a	CLIP-seq
MIRT2447659	hsa-miR-130b	CLIP-seq
MIRT2447660	hsa-miR-139-5p	CLIP-seq
MIRT2447661	hsa-miR-153	CLIP-seq
MIRT910375	hsa-miR-1909	CLIP-seq
MIRT910376	hsa-miR-1972	CLIP-seq
MIRT2447662	hsa-miR-19a	CLIP-seq
MIRT2447663	hsa-miR-19b	CLIP-seq
MIRT2447664	hsa-miR-2276	CLIP-seq
MIRT2447665	hsa-miR-301a	CLIP-seq
MIRT2447666	hsa-miR-301b	CLIP-seq
MIRT2447667	hsa-miR-3126-5p	CLIP-seq
MIRT2447668	hsa-miR-331-3p	CLIP-seq
MIRT2447669	hsa-miR-3605-5p	CLIP-seq
MIRT2447670	hsa-miR-3666	CLIP-seq
MIRT2447671	hsa-miR-3943	CLIP-seq
MIRT2447672	hsa-miR-4257	CLIP-seq
MIRT2447673	hsa-miR-4295	CLIP-seq
MIRT2447674	hsa-miR-448	CLIP-seq
MIRT910390	hsa-miR-4491	CLIP-seq
MIRT2447675	hsa-miR-454	CLIP-seq
MIRT910393	hsa-miR-4650-5p	CLIP-seq
MIRT910394	hsa-miR-4657	CLIP-seq
MIRT2447676	hsa-miR-4671-3p	CLIP-seq
MIRT910395	hsa-miR-4688	CLIP-seq
MIRT2447677	hsa-miR-4690-3p	CLIP-seq
MIRT2447678	hsa-miR-4708-3p	CLIP-seq
MIRT2447679	hsa-miR-4711-5p	CLIP-seq
MIRT2447680	hsa-miR-4714-3p	CLIP-seq
MIRT910396	hsa-miR-4717-5p	CLIP-seq
MIRT2447681	hsa-miR-4722-3p	CLIP-seq
MIRT910398	hsa-miR-4764-5p	CLIP-seq
MIRT2447682	hsa-miR-4769-3p	CLIP-seq
MIRT2447683	hsa-miR-4772-3p	CLIP-seq
MIRT2447684	hsa-miR-4773	CLIP-seq
MIRT910400	hsa-miR-486-3p	CLIP-seq
MIRT2447685	hsa-miR-499a-5p	CLIP-seq
MIRT910401	hsa-miR-510	CLIP-seq
MIRT910402	hsa-miR-642b	CLIP-seq
MIRT2447686	hsa-miR-802	CLIP-seq
MIRT2447687	hsa-miR-942	CLIP-seq
MIRT2447667	hsa-miR-3126-5p	CLIP-seq
MIRT2447672	hsa-miR-4257	CLIP-seq
MIRT910373	hsa-miR-1265	CLIP-seq
MIRT2447658	hsa-miR-130a	CLIP-seq
MIRT2447659	hsa-miR-130b	CLIP-seq
MIRT2447664	hsa-miR-2276	CLIP-seq
MIRT2447665	hsa-miR-301a	CLIP-seq
MIRT2447666	hsa-miR-301b	CLIP-seq
MIRT2447668	hsa-miR-331-3p	CLIP-seq
MIRT2509137	hsa-miR-342-3p	CLIP-seq
MIRT2447669	hsa-miR-3605-5p	CLIP-seq
MIRT2447670	hsa-miR-3666	CLIP-seq
MIRT2447673	hsa-miR-4295	CLIP-seq
MIRT910390	hsa-miR-4491	CLIP-seq
MIRT2447675	hsa-miR-454	CLIP-seq
MIRT910394	hsa-miR-4657	CLIP-seq
MIRT2447676	hsa-miR-4671-3p	CLIP-seq
MIRT2509138	hsa-miR-4695-3p	CLIP-seq
MIRT2447678	hsa-miR-4708-3p	CLIP-seq
MIRT2447680	hsa-miR-4714-3p	CLIP-seq
MIRT2447681	hsa-miR-4722-3p	CLIP-seq
MIRT910398	hsa-miR-4764-5p	CLIP-seq
MIRT2447682	hsa-miR-4769-3p	CLIP-seq
MIRT2447683	hsa-miR-4772-3p	CLIP-seq
MIRT2509139	hsa-miR-513a-5p	CLIP-seq
MIRT2509140	hsa-miR-552	CLIP-seq
MIRT910402	hsa-miR-642b	CLIP-seq
MIRT2447687	hsa-miR-942	CLIP-seq
MIRT910373	hsa-miR-1265	CLIP-seq
MIRT2447658	hsa-miR-130a	CLIP-seq
MIRT2447659	hsa-miR-130b	CLIP-seq
MIRT910375	hsa-miR-1909	CLIP-seq
MIRT910376	hsa-miR-1972	CLIP-seq
MIRT2447664	hsa-miR-2276	CLIP-seq
MIRT2447665	hsa-miR-301a	CLIP-seq
MIRT2447666	hsa-miR-301b	CLIP-seq
MIRT2447667	hsa-miR-3126-5p	CLIP-seq
MIRT2447668	hsa-miR-331-3p	CLIP-seq
MIRT2447669	hsa-miR-3605-5p	CLIP-seq
MIRT2447670	hsa-miR-3666	CLIP-seq
MIRT2447671	hsa-miR-3943	CLIP-seq
MIRT2447672	hsa-miR-4257	CLIP-seq
MIRT2447673	hsa-miR-4295	CLIP-seq
MIRT910390	hsa-miR-4491	CLIP-seq
MIRT2447675	hsa-miR-454	CLIP-seq
MIRT910393	hsa-miR-4650-5p	CLIP-seq
MIRT910394	hsa-miR-4657	CLIP-seq
MIRT2447676	hsa-miR-4671-3p	CLIP-seq
MIRT910395	hsa-miR-4688	CLIP-seq
MIRT2447677	hsa-miR-4690-3p	CLIP-seq
MIRT2447678	hsa-miR-4708-3p	CLIP-seq
MIRT2447680	hsa-miR-4714-3p	CLIP-seq
MIRT910396	hsa-miR-4717-5p	CLIP-seq
MIRT2447681	hsa-miR-4722-3p	CLIP-seq
MIRT910398	hsa-miR-4764-5p	CLIP-seq
MIRT2447682	hsa-miR-4769-3p	CLIP-seq
MIRT2447683	hsa-miR-4772-3p	CLIP-seq
MIRT910400	hsa-miR-486-3p	CLIP-seq
MIRT910401	hsa-miR-510	CLIP-seq
MIRT910402	hsa-miR-642b	CLIP-seq
MIRT2447687	hsa-miR-942	CLIP-seq

Transcription factors

Show/Hide all(3)

Transcription factor	Regulation	Reference
CEBPA	Unknown	18524846
NFKB1	Unknown	18782567
SP1	Unknown	18524846

Show/Hide all(31)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004157	Function	Dihydropyrimidinase activity	IBA
GO:0005515	Function	Protein binding	IPI	15383276, 16169070, 21900206, 24722188, 25416956, 32296183, 32814053
GO:0005737	Component	Cytoplasm	IEA
GO:0005813	Component	Centrosome	IDA
GO:0005813	Component	Centrosome	IEA
GO:0005819	Component	Spindle	IEA
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0005856	Component	Cytoskeleton	IEA
GO:0006139	Process	Nucleobase-containing compound metabolic process	TAS	8973361
GO:0006208	Process	Pyrimidine nucleobase catabolic process	IBA
GO:0007399	Process	Nervous system development	TAS	8973361
GO:0010977	Process	Negative regulation of neuron projection development	IGI	25358863
GO:0015629	Component	Actin cytoskeleton	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0016810	Function	Hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	IEA
GO:0016812	Function	Hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides	IBA
GO:0030425	Component	Dendrite	IEA
GO:0030426	Component	Growth cone	IEA
GO:0030496	Component	Midbody	IDA	19799413
GO:0031005	Function	Filamin binding	IPI	25358863
GO:0042802	Function	Identical protein binding	IPI	24722188, 25416956
GO:0042995	Component	Cell projection	IEA
GO:0043025	Component	Neuronal cell body	IEA
GO:0043204	Component	Perikaryon	IEA
GO:0051219	Function	Phosphoprotein binding	IEA
GO:0071526	Process	Semaphorin-plexin signaling pathway	IEA
GO:0098793	Component	Presynapse	IEA
GO:0098794	Component	Postsynapse	IEA
GO:0150052	Process	Regulation of postsynapse assembly	IEA

MIM	HGNC	e!Ensembl
602462	2365	ENSG00000072832

Protein

UniProt ID

Q14194

Protein name

Dihydropyrimidinase-related protein 1 (DRP-1) (Collapsin response mediator protein 1) (CRMP-1) (Inactive dihydropyrimidinase) (Unc-33-like phosphoprotein 3) (ULIP-3)

Protein function

Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton (PubMed:25358863). Plays a role in axon guidance (PubMed:25358863). During the axon guidance process, acts downstream of SEMA3A to promote FLNA dissocia

PDB

4B3Z

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01979	Amidohydro_1	64 → 453	Amidohydrolase family	Domain

Tissue specificity

TISSUE SPECIFICITY: Brain.

Sequence

MSYQGKKSIPHITSDRLLIKGGRIINDDQSLYADVYLEDGLIKQIGENLIVPGGVKTIEA
NGRMVIPGGIDVNTYLQKPSQGMTAADDFFQGTRAALVGGTTMIIDHVVPEPGSSLLTSF
EKWHEAADTKSCCDYSLHVDITSWYDGVREELEVLVQDKGVNSFQVYMAYKDVYQMSDSQ
LYEAFTFLKGLGAVILVHAENGDLIAQEQKRILEMGITGPEGHALSRPEELEAEAVFRAI
TIAGRINCPVYITKVMSKSAADIIALARKKGPLVFGEPIAASLGTDGTHYWSKNWAKAAA
FVTSPPLSPDPTTPDYLTSLLACGDLQVTGSGHCPYSTAQKAVGKDNFTLIPEGVNGIEE
RMTVVWDKAVATGKMDENQFVAVTSTNAAKIFNLYPRKGRIAVGSDADVVIWDPDKLKTI
TAKSHKSAVEYNIFEGMECHGSPLVVISQGKIVFEDGNINVNKGMGRFIPRKAFPEHLYQ
RVKIRNKVFGLQGVSRGMYDGPVYEVPATPKYATPAPSAKSSPSKHQPPPIRNLHQSNFS
LSGAQIDDNNPRRTGHRIVAPPGGRSNITSLG

Sequence length

572

Interactions

View interactions

	Reactome
			CRMPs in Sema3A signaling

CRMP1 (collapsin response mediator protein 1)