Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
1398
Gene name Gene Name - the full gene name approved by the HGNC.
CRK proto-oncogene, adaptor protein
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
CRK
Synonyms (NCBI Gene) Gene synonyms aliases
CRKII, p38
Chromosome Chromosome number
17
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
17p13.3
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytop
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT002993 hsa-miR-126-3p Luciferase reporter assay 18602365
MIRT002993 hsa-miR-126-3p Luciferase reporter assay, Western blot 18602365
MIRT002993 hsa-miR-126-3p qRT-PCR 18602365
MIRT002993 hsa-miR-126-3p Review 19935707
MIRT002993 hsa-miR-126-3p Luciferase reporter assay 18602365
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000186 Process Activation of MAPKK activity TAS
GO:0001764 Process Neuron migration IEA
GO:0001784 Function Phosphotyrosine residue binding IPI 20624904
GO:0001878 Process Response to yeast IEA
GO:0005159 Function Insulin-like growth factor receptor binding IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
164762 2362 ENSG00000167193
Protein
UniProt ID P46108
Protein name Adapter molecule crk (Proto-oncogene c-Crk) (p38)
Protein function Involved in cell branching and adhesion mediated by BCAR1-CRK-RAPGEF1 signaling and activation of RAP1. ; [Isoform Crk-II]: Regulates cell adhesion, spreading and migration (PubMed:31311869). Mediates atta
PDB 1JU5 , 2DVJ , 2EYV , 2EYW , 2EYX , 2EYY , 2EYZ , 2MS4 , 5UL6 , 6ATV
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00017 SH2 13 104 SH2 domain Domain
PF00018 SH3_1 138 184 SH3 domain Domain
PF07653 SH3_2 239 294 Variant SH3 domain Domain
Sequence
Sequence length 304
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  MAPK signaling pathway
ErbB signaling pathway
Rap1 signaling pathway
Chemokine signaling pathway
Efferocytosis
Focal adhesion
Fc gamma R-mediated phagocytosis
Neurotrophin signaling pathway
Regulation of actin cytoskeleton
Insulin signaling pathway
Growth hormone synthesis, secretion and action
Bacterial invasion of epithelial cells
Shigellosis
Yersinia infection
Human cytomegalovirus infection
Human immunodeficiency virus 1 infection
Pathways in cancer
MicroRNAs in cancer
Renal cell carcinoma
Chronic myeloid leukemia
  ARMS-mediated activation
Downstream signal transduction
Regulation of actin dynamics for phagocytic cup formation
p130Cas linkage to MAPK signaling for integrins
VEGFA-VEGFR2 Pathway
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
MET activates RAP1 and RAC1
MET receptor recycling
Regulation of signaling by CBL
FCGR3A-mediated phagocytosis
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Unknown
Disease term Disease name Evidence References Source
Atrial Fibrillation Atrial Fibrillation GWAS
Hypertension Hypertension GWAS
Crohn Disease Crohn Disease GWAS
Alzheimer disease Alzheimer disease GWAS
Associations from Text Mining
Disease Name Relationship Type References
Adenoma Islet Cell Associate 22274926
Arthritis Rheumatoid Associate 29973208
Astrocytoma Stimulate 24252689
Autism Spectrum Disorder Associate 23813913
Autistic Disorder Associate 23035971
Brachydactyly type A3 Associate 39513527
Breast Neoplasms Associate 12006644, 15831672
Cafe au Lait Spots Associate 39513527
Calcinosis Cutis Associate 23345605
Carcinogenesis Associate 22383989