PNCK (pregnancy up-regulated nonubiquitous CaM kinase)

Gene

• Entrez ID: 139728
• Gene name: Pregnancy up-regulated nonubiquitous CaM kinase
• Gene symbol: PNCK
• Synonyms (NCBI Gene): BSTK3, CaMK1b
• Chromosome: X
• Chromosome location: Xq28
• Summary: PNCK is a member of the calcium/calmodulin-dependent protein kinase family of protein serine/threonine kinases (see CAMK1; MIM 604998) (Gardner et al., 2000 [PubMed 10673339]).[supplied by OMIM, Mar 2008]

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1244696	hsa-miR-1915	CLIP-seq
MIRT1244697	hsa-miR-2467-3p	CLIP-seq
MIRT1244698	hsa-miR-3194-5p	CLIP-seq
MIRT1244699	hsa-miR-338-3p	CLIP-seq
MIRT1244700	hsa-miR-4323	CLIP-seq
MIRT1244701	hsa-miR-4530	CLIP-seq
MIRT1244702	hsa-miR-4716-3p	CLIP-seq
MIRT1244703	hsa-miR-922	CLIP-seq
MIRT1244704	hsa-miR-1286	CLIP-seq
MIRT1244705	hsa-miR-425	CLIP-seq
MIRT1244706	hsa-miR-4493	CLIP-seq
MIRT1244707	hsa-miR-4731-3p	CLIP-seq
MIRT1244708	hsa-miR-4753-5p	CLIP-seq
MIRT1244709	hsa-miR-4801	CLIP-seq
MIRT1244710	hsa-miR-591	CLIP-seq
MIRT1244711	hsa-miR-642b	CLIP-seq
MIRT2392738	hsa-miR-125a-5p	CLIP-seq
MIRT2392739	hsa-miR-125b	CLIP-seq
MIRT1244704	hsa-miR-1286	CLIP-seq
MIRT2392740	hsa-miR-1973	CLIP-seq
MIRT2392741	hsa-miR-4319	CLIP-seq
MIRT2392742	hsa-miR-4649-3p	CLIP-seq
MIRT2392743	hsa-miR-4722-5p	CLIP-seq
MIRT2392744	hsa-miR-544b	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004683	Function	Calmodulin-dependent protein kinase activity	IBA	21873635
GO:0005516	Function	Calmodulin binding	IBA	21873635
GO:0005524	Function	ATP binding	IEA
GO:0005622	Component	Intracellular anatomical structure	IBA	21873635
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0018105	Process	Peptidyl-serine phosphorylation	IBA	21873635

Other IDs

• MIM: 300680
• HGNC: 13415
• e!Ensembl: ENSG00000130822

Protein

• UniProt ID: Q6P2M8
• Protein name: Calcium/calmodulin-dependent protein kinase type 1B (EC 2.7.11.17) (CaM kinase I beta) (CaM kinase IB) (CaM-KI beta) (CaMKI-beta) (Pregnancy up-regulated non-ubiquitously-expressed CaM kinase)
• Protein function: Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade. In vitro phosphorylates CREB1 and SYN1/synapsin I. Phosphorylates and activates CAMK1 (By similarity).
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00069	Pkinase	15 → 270	Protein kinase domain	Domain

• Sequence:

  MLLLKKHTEDISSVYEIRERLGSGAFSEVVLAQERGSAHLVALKCIPKKALRGKEALVEN
  EIAVLRRISHPNIVALEDVHESPSHLYLAMELVTGGELFDRIMERGSYTEKDASHLVGQV
  LGAVSYLHSLGIVHRDLKPENLLYATPFEDSKIMVSDFGLSKIQAGNMLGTACGTPGYVA
  PELLEQKPYGKAVDVWALGVISYILLCGYPPFYDESDPELFSQILRASYEFDSPFWDDIS
  ESAKDFIRHLLERDPQKRFTCQQALRHLWISGDTAFDRDILGSVSEQIRKNFARTHWKRA
  FNATSFLRHIRKLGQIPEGEGASEQGMARHSHSGLRAGQPPKW

• Sequence length: 343

Associated diseases

Unknown
Disease term	Disease name	Evidence	References	Source
Creatine deficiency	Creatine deficiency, X-linked			ClinVar

Associations from Text Mining
Disease Name	Relationship Type	References
Breast Neoplasms	Associate	18562482, 24552815, 33099476
Carcinogenesis	Associate	33099476
Carcinoma Hepatocellular	Associate	33099476, 35865652
Carcinoma Renal Cell	Associate	21253009, 23634203
Carcinoma Renal Cell	Stimulate	33099476
Chromosomal Instability	Associate	31515286
Chromosome Disorders	Associate	31515286
Hypertension	Associate	37451613
Mosaic variegated aneuploidy syndrome	Associate	31515286
Neoplasm Metastasis	Stimulate	33099476
Neoplasms	Stimulate	33099476