GAB3 (GRB2 associated binding protein 3)

Gene

• Entrez ID: 139716
• Gene name: GRB2 associated binding protein 3
• Gene symbol: GAB3
• Synonyms (NCBI Gene): -
• Chromosome: X
• Chromosome location: Xq28
• Summary: This gene is a member of the GRB2-associated binding protein gene family. These proteins are scaffolding/docking proteins that are involved in several growth factor and cytokine signaling pathways, and they contain a pleckstrin homology domain, and bind S

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT018672	hsa-miR-335-5p	Microarray	18185580
MIRT022935	hsa-miR-124-3p	Microarray	18668037
MIRT1009315	hsa-miR-1260	CLIP-seq
MIRT1009316	hsa-miR-1260b	CLIP-seq
MIRT1009317	hsa-miR-1286	CLIP-seq
MIRT1009318	hsa-miR-188-3p	CLIP-seq
MIRT1009319	hsa-miR-216a	CLIP-seq
MIRT1009320	hsa-miR-302f	CLIP-seq
MIRT1009321	hsa-miR-3156-3p	CLIP-seq
MIRT1009322	hsa-miR-362-5p	CLIP-seq
MIRT1009323	hsa-miR-3934	CLIP-seq
MIRT1009324	hsa-miR-4264	CLIP-seq
MIRT1009325	hsa-miR-4704-3p	CLIP-seq
MIRT1009326	hsa-miR-4720-3p	CLIP-seq
MIRT1009327	hsa-miR-4722-5p	CLIP-seq
MIRT1009328	hsa-miR-4797-3p	CLIP-seq
MIRT1009329	hsa-miR-4804-3p	CLIP-seq
MIRT1009330	hsa-miR-500b	CLIP-seq
MIRT1009331	hsa-miR-501-5p	CLIP-seq
MIRT1009332	hsa-miR-515-5p	CLIP-seq
MIRT1009333	hsa-miR-1184	CLIP-seq
MIRT1009334	hsa-miR-1205	CLIP-seq
MIRT1009335	hsa-miR-1273g	CLIP-seq
MIRT1009336	hsa-miR-155	CLIP-seq
MIRT1009337	hsa-miR-2113	CLIP-seq
MIRT1009338	hsa-miR-3117-5p	CLIP-seq
MIRT1009339	hsa-miR-3158-5p	CLIP-seq
MIRT1009340	hsa-miR-346	CLIP-seq
MIRT1009341	hsa-miR-365	CLIP-seq
MIRT1009342	hsa-miR-3650	CLIP-seq
MIRT1009343	hsa-miR-3665	CLIP-seq
MIRT1009323	hsa-miR-3934	CLIP-seq
MIRT1009344	hsa-miR-4288	CLIP-seq
MIRT1009345	hsa-miR-4299	CLIP-seq
MIRT1009346	hsa-miR-4432	CLIP-seq
MIRT1009347	hsa-miR-4456	CLIP-seq
MIRT1009348	hsa-miR-4477a	CLIP-seq
MIRT1009349	hsa-miR-4711-3p	CLIP-seq
MIRT1009350	hsa-miR-499-5p	CLIP-seq
MIRT1009351	hsa-miR-514	CLIP-seq
MIRT1009352	hsa-miR-514b-3p	CLIP-seq
MIRT1009353	hsa-miR-526b	CLIP-seq
MIRT1009354	hsa-miR-548q	CLIP-seq
MIRT1009355	hsa-miR-592	CLIP-seq
MIRT1009356	hsa-miR-599	CLIP-seq
MIRT1009357	hsa-miR-632	CLIP-seq
MIRT1009358	hsa-miR-657	CLIP-seq
MIRT1999083	hsa-miR-3180-5p	CLIP-seq
MIRT1999084	hsa-miR-3607-3p	CLIP-seq
MIRT1009342	hsa-miR-3650	CLIP-seq
MIRT1999085	hsa-miR-4267	CLIP-seq
MIRT1009345	hsa-miR-4299	CLIP-seq
MIRT1009347	hsa-miR-4456	CLIP-seq
MIRT1999086	hsa-miR-548aa	CLIP-seq
MIRT1009354	hsa-miR-548q	CLIP-seq
MIRT2232754	hsa-miR-1226	CLIP-seq
MIRT2232755	hsa-miR-1236	CLIP-seq
MIRT1009335	hsa-miR-1273g	CLIP-seq
MIRT2232756	hsa-miR-132	CLIP-seq
MIRT2232757	hsa-miR-212	CLIP-seq
MIRT1009338	hsa-miR-3117-5p	CLIP-seq
MIRT1009342	hsa-miR-3650	CLIP-seq
MIRT2232758	hsa-miR-377	CLIP-seq
MIRT2232759	hsa-miR-421	CLIP-seq
MIRT1009345	hsa-miR-4299	CLIP-seq
MIRT1009347	hsa-miR-4456	CLIP-seq
MIRT2232760	hsa-miR-4642	CLIP-seq
MIRT2232761	hsa-miR-4709-5p	CLIP-seq
MIRT1009351	hsa-miR-514	CLIP-seq
MIRT1009352	hsa-miR-514b-3p	CLIP-seq
MIRT1009353	hsa-miR-526b	CLIP-seq
MIRT1999086	hsa-miR-548aa	CLIP-seq
MIRT1009354	hsa-miR-548q	CLIP-seq
MIRT2437343	hsa-miR-1179	CLIP-seq
MIRT2437343	hsa-miR-1179	CLIP-seq
MIRT2449984	hsa-miR-22	CLIP-seq
MIRT1009326	hsa-miR-4720-3p	CLIP-seq
MIRT2449985	hsa-miR-4794	CLIP-seq
MIRT1009329	hsa-miR-4804-3p	CLIP-seq
MIRT2449986	hsa-miR-548v	CLIP-seq
MIRT2449987	hsa-miR-552	CLIP-seq
MIRT2449984	hsa-miR-22	CLIP-seq
MIRT1009326	hsa-miR-4720-3p	CLIP-seq
MIRT2449985	hsa-miR-4794	CLIP-seq
MIRT1009329	hsa-miR-4804-3p	CLIP-seq
MIRT2449986	hsa-miR-548v	CLIP-seq
MIRT2449987	hsa-miR-552	CLIP-seq
MIRT2536246	hsa-miR-1298	CLIP-seq
MIRT2536247	hsa-miR-147	CLIP-seq
MIRT2536248	hsa-miR-149	CLIP-seq
MIRT2536249	hsa-miR-193a-5p	CLIP-seq
MIRT2536250	hsa-miR-1976	CLIP-seq
MIRT2536251	hsa-miR-205	CLIP-seq
MIRT2536252	hsa-miR-2110	CLIP-seq
MIRT2536253	hsa-miR-224	CLIP-seq
MIRT2536254	hsa-miR-2467-3p	CLIP-seq
MIRT2536255	hsa-miR-3064-5p	CLIP-seq
MIRT2536256	hsa-miR-3151	CLIP-seq
MIRT2536257	hsa-miR-3155	CLIP-seq
MIRT2536258	hsa-miR-3155b	CLIP-seq
MIRT2536259	hsa-miR-3185	CLIP-seq
MIRT1999084	hsa-miR-3607-3p	CLIP-seq
MIRT2536260	hsa-miR-3672	CLIP-seq
MIRT2536261	hsa-miR-3678-3p	CLIP-seq
MIRT2536262	hsa-miR-3690	CLIP-seq
MIRT2536263	hsa-miR-3714	CLIP-seq
MIRT2536264	hsa-miR-3911	CLIP-seq
MIRT2536265	hsa-miR-4254	CLIP-seq
MIRT2536266	hsa-miR-4268	CLIP-seq
MIRT2536267	hsa-miR-4271	CLIP-seq
MIRT2536268	hsa-miR-4283	CLIP-seq
MIRT2536269	hsa-miR-4314	CLIP-seq
MIRT2536270	hsa-miR-4438	CLIP-seq
MIRT2536271	hsa-miR-4447	CLIP-seq
MIRT2536272	hsa-miR-4472	CLIP-seq
MIRT2536273	hsa-miR-4487	CLIP-seq
MIRT2536274	hsa-miR-4489	CLIP-seq
MIRT2536275	hsa-miR-450b-5p	CLIP-seq
MIRT2536276	hsa-miR-4660	CLIP-seq
MIRT2536277	hsa-miR-4687-3p	CLIP-seq
MIRT2536278	hsa-miR-4717-3p	CLIP-seq
MIRT2536279	hsa-miR-4725-3p	CLIP-seq
MIRT2449985	hsa-miR-4794	CLIP-seq
MIRT2536280	hsa-miR-484	CLIP-seq
MIRT2536281	hsa-miR-491-5p	CLIP-seq
MIRT2536282	hsa-miR-492	CLIP-seq
MIRT2536283	hsa-miR-513a-5p	CLIP-seq
MIRT2536284	hsa-miR-644	CLIP-seq
MIRT2536285	hsa-miR-711	CLIP-seq
MIRT2536286	hsa-miR-760	CLIP-seq
MIRT2536246	hsa-miR-1298	CLIP-seq
MIRT2681278	hsa-miR-1343	CLIP-seq
MIRT2536249	hsa-miR-193a-5p	CLIP-seq
MIRT2536250	hsa-miR-1976	CLIP-seq
MIRT2536251	hsa-miR-205	CLIP-seq
MIRT2681279	hsa-miR-3074-5p	CLIP-seq
MIRT2681280	hsa-miR-3179	CLIP-seq
MIRT2681281	hsa-miR-3202	CLIP-seq
MIRT1999084	hsa-miR-3607-3p	CLIP-seq
MIRT2536262	hsa-miR-3690	CLIP-seq
MIRT2681282	hsa-miR-376a	CLIP-seq
MIRT2681283	hsa-miR-376b	CLIP-seq
MIRT2681284	hsa-miR-3936	CLIP-seq
MIRT2536265	hsa-miR-4254	CLIP-seq
MIRT2536269	hsa-miR-4314	CLIP-seq
MIRT2681285	hsa-miR-4464	CLIP-seq
MIRT2681286	hsa-miR-4476	CLIP-seq
MIRT2681287	hsa-miR-4748	CLIP-seq
MIRT2681288	hsa-miR-4760-3p	CLIP-seq
MIRT2536282	hsa-miR-492	CLIP-seq
MIRT2536285	hsa-miR-711	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005737	Component	Cytoplasm	IBA
GO:0007165	Process	Signal transduction	IBA
GO:0030225	Process	Macrophage differentiation	IEA
GO:0035591	Function	Signaling adaptor activity	IBA

Other IDs

• MIM: 300482
• HGNC: 17515
• e!Ensembl: ENSG00000160219

Protein

• UniProt ID: Q8WWW8
• Protein name: GRB2-associated-binding protein 3 (GRB2-associated binder 3) (Growth factor receptor bound protein 2-associated protein 3)
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00169	PH	6 → 117	PH domain	Domain

• Sequence:

  MSAGDAVCTGWLVKSPPERKLQRYAWRKRWFVLRRGRMSGNPDVLEYYRNKHSSKPIRVI
  DLSECAVWKHVGPSFVRKEFQNNFVFIVKTTSRTFYLVAKTEQEMQVWVHSISQVCNLGH
  LEDGADSMESLSYTPSSLQPSSASSLLTAHAASSSLPRDDPNTNAVATEETRSESELLFL
  PDYLVLSNCETGRLHHTSLPTRCDSWSNSDRSLEQASFDDVFVDCLQPLPSSHLVHPSCH
  GSGAQEVPSSRPQAALIWSREINGPPRDHLSSSPLLESSLSSTIQVDKNQGSLPCGAKEL
  DIMSNTPPPRPPKPSHLSERRQEEWSTHSGSKKPECTLVPRRISLSGLDNMRTWKADVEG
  QSLRHRDKRLSLNLPCRFSPMYPTASASIEDSYVPMSPQAGASGLGPHCSPDDYIPMNSG
  SISSPLPELPANLEPPPVNRDLKPQRKSRPPPLDLRNLSIIREHASLTRTRTVPCSRTSF
  LSPERNGINSARFFANPVSREDEESYIEMEEHRTASSLSSGALTWTKKFSLDYLALDFNS
  ASPAPMQQKLLLSEEQRVDYVQVDEQKTQALQSTKQEWTDERQSKV

• Sequence length: 586