Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	139716
Gene name Gene Name - the full gene name approved by the HGNC.	GRB2 associated binding protein 3
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	GAB3
Synonyms (NCBI Gene) Gene synonyms aliases	-
Chromosome Chromosome number	X
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	Xq28
Summary Summary of gene provided in NCBI Entrez Gene.	This gene is a member of the GRB2-associated binding protein gene family. These proteins are scaffolding/docking proteins that are involved in several growth factor and cytokine signaling pathways, and they contain a pleckstrin homology domain, and bind S

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miRTarBase ID	miRNA	Experiments	Reference
MIRT018672	hsa-miR-335-5p	Microarray	18185580
MIRT022935	hsa-miR-124-3p	Microarray	18668037
MIRT1009315	hsa-miR-1260	CLIP-seq
MIRT1009316	hsa-miR-1260b	CLIP-seq
MIRT1009317	hsa-miR-1286	CLIP-seq
MIRT1009318	hsa-miR-188-3p	CLIP-seq
MIRT1009319	hsa-miR-216a	CLIP-seq
MIRT1009320	hsa-miR-302f	CLIP-seq
MIRT1009321	hsa-miR-3156-3p	CLIP-seq
MIRT1009322	hsa-miR-362-5p	CLIP-seq
MIRT1009323	hsa-miR-3934	CLIP-seq
MIRT1009324	hsa-miR-4264	CLIP-seq
MIRT1009325	hsa-miR-4704-3p	CLIP-seq
MIRT1009326	hsa-miR-4720-3p	CLIP-seq
MIRT1009327	hsa-miR-4722-5p	CLIP-seq
MIRT1009328	hsa-miR-4797-3p	CLIP-seq
MIRT1009329	hsa-miR-4804-3p	CLIP-seq
MIRT1009330	hsa-miR-500b	CLIP-seq
MIRT1009331	hsa-miR-501-5p	CLIP-seq
MIRT1009332	hsa-miR-515-5p	CLIP-seq
MIRT1009333	hsa-miR-1184	CLIP-seq
MIRT1009334	hsa-miR-1205	CLIP-seq
MIRT1009335	hsa-miR-1273g	CLIP-seq
MIRT1009336	hsa-miR-155	CLIP-seq
MIRT1009337	hsa-miR-2113	CLIP-seq
MIRT1009338	hsa-miR-3117-5p	CLIP-seq
MIRT1009339	hsa-miR-3158-5p	CLIP-seq
MIRT1009340	hsa-miR-346	CLIP-seq
MIRT1009341	hsa-miR-365	CLIP-seq
MIRT1009342	hsa-miR-3650	CLIP-seq
MIRT1009343	hsa-miR-3665	CLIP-seq
MIRT1009323	hsa-miR-3934	CLIP-seq
MIRT1009344	hsa-miR-4288	CLIP-seq
MIRT1009345	hsa-miR-4299	CLIP-seq
MIRT1009346	hsa-miR-4432	CLIP-seq
MIRT1009347	hsa-miR-4456	CLIP-seq
MIRT1009348	hsa-miR-4477a	CLIP-seq
MIRT1009349	hsa-miR-4711-3p	CLIP-seq
MIRT1009350	hsa-miR-499-5p	CLIP-seq
MIRT1009351	hsa-miR-514	CLIP-seq
MIRT1009352	hsa-miR-514b-3p	CLIP-seq
MIRT1009353	hsa-miR-526b	CLIP-seq
MIRT1009354	hsa-miR-548q	CLIP-seq
MIRT1009355	hsa-miR-592	CLIP-seq
MIRT1009356	hsa-miR-599	CLIP-seq
MIRT1009357	hsa-miR-632	CLIP-seq
MIRT1009358	hsa-miR-657	CLIP-seq
MIRT1999083	hsa-miR-3180-5p	CLIP-seq
MIRT1999084	hsa-miR-3607-3p	CLIP-seq
MIRT1009342	hsa-miR-3650	CLIP-seq
MIRT1999085	hsa-miR-4267	CLIP-seq
MIRT1009345	hsa-miR-4299	CLIP-seq
MIRT1009347	hsa-miR-4456	CLIP-seq
MIRT1999086	hsa-miR-548aa	CLIP-seq
MIRT1009354	hsa-miR-548q	CLIP-seq
MIRT2232754	hsa-miR-1226	CLIP-seq
MIRT2232755	hsa-miR-1236	CLIP-seq
MIRT1009335	hsa-miR-1273g	CLIP-seq
MIRT2232756	hsa-miR-132	CLIP-seq
MIRT2232757	hsa-miR-212	CLIP-seq
MIRT1009338	hsa-miR-3117-5p	CLIP-seq
MIRT1009342	hsa-miR-3650	CLIP-seq
MIRT2232758	hsa-miR-377	CLIP-seq
MIRT2232759	hsa-miR-421	CLIP-seq
MIRT1009345	hsa-miR-4299	CLIP-seq
MIRT1009347	hsa-miR-4456	CLIP-seq
MIRT2232760	hsa-miR-4642	CLIP-seq
MIRT2232761	hsa-miR-4709-5p	CLIP-seq
MIRT1009351	hsa-miR-514	CLIP-seq
MIRT1009352	hsa-miR-514b-3p	CLIP-seq
MIRT1009353	hsa-miR-526b	CLIP-seq
MIRT1999086	hsa-miR-548aa	CLIP-seq
MIRT1009354	hsa-miR-548q	CLIP-seq
MIRT2437343	hsa-miR-1179	CLIP-seq
MIRT2437343	hsa-miR-1179	CLIP-seq
MIRT2449984	hsa-miR-22	CLIP-seq
MIRT1009326	hsa-miR-4720-3p	CLIP-seq
MIRT2449985	hsa-miR-4794	CLIP-seq
MIRT1009329	hsa-miR-4804-3p	CLIP-seq
MIRT2449986	hsa-miR-548v	CLIP-seq
MIRT2449987	hsa-miR-552	CLIP-seq
MIRT2449984	hsa-miR-22	CLIP-seq
MIRT1009326	hsa-miR-4720-3p	CLIP-seq
MIRT2449985	hsa-miR-4794	CLIP-seq
MIRT1009329	hsa-miR-4804-3p	CLIP-seq
MIRT2449986	hsa-miR-548v	CLIP-seq
MIRT2449987	hsa-miR-552	CLIP-seq
MIRT2536246	hsa-miR-1298	CLIP-seq
MIRT2536247	hsa-miR-147	CLIP-seq
MIRT2536248	hsa-miR-149	CLIP-seq
MIRT2536249	hsa-miR-193a-5p	CLIP-seq
MIRT2536250	hsa-miR-1976	CLIP-seq
MIRT2536251	hsa-miR-205	CLIP-seq
MIRT2536252	hsa-miR-2110	CLIP-seq
MIRT2536253	hsa-miR-224	CLIP-seq
MIRT2536254	hsa-miR-2467-3p	CLIP-seq
MIRT2536255	hsa-miR-3064-5p	CLIP-seq
MIRT2536256	hsa-miR-3151	CLIP-seq
MIRT2536257	hsa-miR-3155	CLIP-seq
MIRT2536258	hsa-miR-3155b	CLIP-seq
MIRT2536259	hsa-miR-3185	CLIP-seq
MIRT1999084	hsa-miR-3607-3p	CLIP-seq
MIRT2536260	hsa-miR-3672	CLIP-seq
MIRT2536261	hsa-miR-3678-3p	CLIP-seq
MIRT2536262	hsa-miR-3690	CLIP-seq
MIRT2536263	hsa-miR-3714	CLIP-seq
MIRT2536264	hsa-miR-3911	CLIP-seq
MIRT2536265	hsa-miR-4254	CLIP-seq
MIRT2536266	hsa-miR-4268	CLIP-seq
MIRT2536267	hsa-miR-4271	CLIP-seq
MIRT2536268	hsa-miR-4283	CLIP-seq
MIRT2536269	hsa-miR-4314	CLIP-seq
MIRT2536270	hsa-miR-4438	CLIP-seq
MIRT2536271	hsa-miR-4447	CLIP-seq
MIRT2536272	hsa-miR-4472	CLIP-seq
MIRT2536273	hsa-miR-4487	CLIP-seq
MIRT2536274	hsa-miR-4489	CLIP-seq
MIRT2536275	hsa-miR-450b-5p	CLIP-seq
MIRT2536276	hsa-miR-4660	CLIP-seq
MIRT2536277	hsa-miR-4687-3p	CLIP-seq
MIRT2536278	hsa-miR-4717-3p	CLIP-seq
MIRT2536279	hsa-miR-4725-3p	CLIP-seq
MIRT2449985	hsa-miR-4794	CLIP-seq
MIRT2536280	hsa-miR-484	CLIP-seq
MIRT2536281	hsa-miR-491-5p	CLIP-seq
MIRT2536282	hsa-miR-492	CLIP-seq
MIRT2536283	hsa-miR-513a-5p	CLIP-seq
MIRT2536284	hsa-miR-644	CLIP-seq
MIRT2536285	hsa-miR-711	CLIP-seq
MIRT2536286	hsa-miR-760	CLIP-seq
MIRT2536246	hsa-miR-1298	CLIP-seq
MIRT2681278	hsa-miR-1343	CLIP-seq
MIRT2536249	hsa-miR-193a-5p	CLIP-seq
MIRT2536250	hsa-miR-1976	CLIP-seq
MIRT2536251	hsa-miR-205	CLIP-seq
MIRT2681279	hsa-miR-3074-5p	CLIP-seq
MIRT2681280	hsa-miR-3179	CLIP-seq
MIRT2681281	hsa-miR-3202	CLIP-seq
MIRT1999084	hsa-miR-3607-3p	CLIP-seq
MIRT2536262	hsa-miR-3690	CLIP-seq
MIRT2681282	hsa-miR-376a	CLIP-seq
MIRT2681283	hsa-miR-376b	CLIP-seq
MIRT2681284	hsa-miR-3936	CLIP-seq
MIRT2536265	hsa-miR-4254	CLIP-seq
MIRT2536269	hsa-miR-4314	CLIP-seq
MIRT2681285	hsa-miR-4464	CLIP-seq
MIRT2681286	hsa-miR-4476	CLIP-seq
MIRT2681287	hsa-miR-4748	CLIP-seq
MIRT2681288	hsa-miR-4760-3p	CLIP-seq
MIRT2536282	hsa-miR-492	CLIP-seq
MIRT2536285	hsa-miR-711	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0030225	Process	Macrophage differentiation	IEA

MIM	HGNC	e!Ensembl
300482	17515	ENSG00000160219

Protein

UniProt ID

Q8WWW8

Protein name

GRB2-associated-binding protein 3 (GRB2-associated binder 3) (Growth factor receptor bound protein 2-associated protein 3)

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00169	PH	6 → 117	PH domain	Domain

Sequence

MSAGDAVCTGWLVKSPPERKLQRYAWRKRWFVLRRGRMSGNPDVLEYYRNKHSSKPIRVI
DLSECAVWKHVGPSFVRKEFQNNFVFIVKTTSRTFYLVAKTEQEMQVWVHSISQVCNLGH
LEDGADSMESLSYTPSSLQPSSASSLLTAHAASSSLPRDDPNTNAVATEETRSESELLFL
PDYLVLSNCETGRLHHTSLPTRCDSWSNSDRSLEQASFDDVFVDCLQPLPSSHLVHPSCH
GSGAQEVPSSRPQAALIWSREINGPPRDHLSSSPLLESSLSSTIQVDKNQGSLPCGAKEL
DIMSNTPPPRPPKPSHLSERRQEEWSTHSGSKKPECTLVPRRISLSGLDNMRTWKADVEG
QSLRHRDKRLSLNLPCRFSPMYPTASASIEDSYVPMSPQAGASGLGPHCSPDDYIPMNSG
SISSPLPELPANLEPPPVNRDLKPQRKSRPPPLDLRNLSIIREHASLTRTRTVPCSRTSF
LSPERNGINSARFFANPVSREDEESYIEMEEHRTASSLSSGALTWTKKFSLDYLALDFNS
ASPAPMQQKLLLSEEQRVDYVQVDEQKTQALQSTKQEWTDERQSKV

Sequence length

586

Interactions

View interactions

Show/Hide Causal Diseases (1)

Disease term	Disease name	dbSNP ID	References
Causal
Diabetes mellitus	Diabetes Mellitus, Insulin-Dependent	rs587776515, rs61730328, rs606231121, rs606231122, rs79020217, rs77625743, rs78378398, rs606231123, rs1362648752, rs104893649, rs80356624, rs80356616, rs80356625, rs80356611, rs104894237 View all (293 more)	19430480

Show/Hide Text Mining Associations (3)

Disease Name	Relationship Type	References
Associations from Text Mining
Essential Hypertension	Associate	40140746
Myopathies Structural Congenital	Associate	36275756
Urinary Bladder Neoplasms	Associate	36275756

GAB3 (GRB2 associated binding protein 3)