DCAF8L1 (DDB1 and CUL4 associated factor 8 like 1)

Gene

• Entrez ID: 139425
• Gene name: DDB1 and CUL4 associated factor 8 like 1
• Gene symbol: DCAF8L1
• Synonyms (NCBI Gene): WDR42B
• Chromosome: X
• Chromosome location: Xp21.3
• Summary: This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by Gly-His and Trp-Asp (GH-WD), which may facilitate the formation of heterotrimeric or multi-protei

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT925612	hsa-miR-1303	CLIP-seq
MIRT925613	hsa-miR-3156-3p	CLIP-seq
MIRT925614	hsa-miR-4275	CLIP-seq
MIRT925615	hsa-miR-4301	CLIP-seq
MIRT925616	hsa-miR-508-3p	CLIP-seq
MIRT925617	hsa-miR-568	CLIP-seq
MIRT925618	hsa-miR-590-3p	CLIP-seq
MIRT925619	hsa-miR-877	CLIP-seq
MIRT2209693	hsa-miR-1207-5p	CLIP-seq
MIRT2209694	hsa-miR-137	CLIP-seq
MIRT2209695	hsa-miR-25	CLIP-seq
MIRT2209696	hsa-miR-3126-3p	CLIP-seq
MIRT2209697	hsa-miR-32	CLIP-seq
MIRT2209698	hsa-miR-337-3p	CLIP-seq
MIRT2209699	hsa-miR-363	CLIP-seq
MIRT2209700	hsa-miR-367	CLIP-seq
MIRT2209701	hsa-miR-376a	CLIP-seq
MIRT2209702	hsa-miR-376b	CLIP-seq
MIRT2209703	hsa-miR-4279	CLIP-seq
MIRT2209704	hsa-miR-4490	CLIP-seq
MIRT2209705	hsa-miR-4736	CLIP-seq
MIRT2209706	hsa-miR-4763-3p	CLIP-seq
MIRT2209707	hsa-miR-4774-5p	CLIP-seq
MIRT2209708	hsa-miR-891b	CLIP-seq
MIRT2209709	hsa-miR-92a	CLIP-seq
MIRT2209710	hsa-miR-92b	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005737	Component	Cytoplasm	IBA
GO:0080008	Component	Cul4-RING E3 ubiquitin ligase complex	IBA
GO:0080008	Component	Cul4-RING E3 ubiquitin ligase complex	IEA

Other IDs

• MIM: HGNC
• HGNC: N/A
• e!Ensembl: HGNC

Protein

• UniProt ID: A6NGE4
• Protein name: DDB1- and CUL4-associated factor 8-like protein 1 (WD repeat-containing protein 42B)
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00400	WD40	186 → 224	WD domain, G-beta repeat	Repeat
  PF00400	WD40	425 → 466	WD domain, G-beta repeat	Repeat
  PF00400	WD40	470 → 509	WD domain, G-beta repeat	Repeat

• Sequence:

  MSHQEGSTGGLPDLVTESLFSSPEEQSGVAAVTAASSDIEMAATEPSTGDGGDTRDGGFL
  NDASTENQNTDSESSSEDVELESMGEGLFGYPLVGEETEREEEEEEMEEEGEEEEQPRMC
  PRCGGTNHDQCLLDEDQALEEWISSETSALPRSRWQVLTALRQRQLGSSARFVYEACGAR
  TFVQRFRLQYLLGSHAGSVSTIHFNQRGTRLASSGDDLRVIVWDWVRQKPVLNFESGHDI
  NVIQAKFFPNCGDSTLAMCGHDGQVRVAELINASYCENTKRVAKHRGPAHELALEPDSPY
  KFLTSGEDAVVFTIDLRQDRPASKVVVTRENDKKVGLYTISMNPANIYQFAVGGHDQFVR
  IYDQRRIDKKENNGVLKKFTPHHLVYCDFPTNITCVVYSHDGTELLASYNDEDIYLFNSS
  LSDGAQYVKRYKGHRNNDTIKCVNFYGPRSEFVVSGSDCGHVFFWEKSSSQIIQFMEGDR
  GDIVNCLEPHPYLPVLATSGLDQHVRIWTPTAKTATELTGLKDVIKKNKQERDEDNLNYT
  DSFDNRMLRFFVRHLLQRAHQPGWRDHGAEFPDEEELDESSSTSDTSEEEGQDRVQCIPS
  

• Sequence length: 600

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
ERECTILE DYSFUNCTION	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NEUROTIC DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PROSTATE CARCINOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Relationship Type	References	Evidence Score
Breast Neoplasms	Associate	35280675	★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Associate	36714595	★☆☆☆☆ Found in Text Mining only
Hereditary Breast and Ovarian Cancer Syndrome	Associate	35280675	★☆☆☆☆ Found in Text Mining only
Neoplasms	Associate	35280675	★☆☆☆☆ Found in Text Mining only
Obesity	Associate	36714595	★☆☆☆☆ Found in Text Mining only
Overweight	Associate	36714595	★☆☆☆☆ Found in Text Mining only