Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
1394
Gene name Gene Name - the full gene name approved by the HGNC.
Corticotropin releasing hormone receptor 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
CRHR1
Synonyms (NCBI Gene) Gene synonyms aliases
CRF-R, CRF-R-1, CRF-R1, CRF1, CRFR-1, CRFR1, CRH-R-1, CRH-R1, CRHR, CRHR1L
Chromosome Chromosome number
17
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
17q21.31
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a G-protein coupled receptor that binds neuropeptides of the corticotropin releasing hormone family that are major regulators of the hypothalamic-pituitary-adrenal pathway. The encoded protein is essential for the activation of signal tr
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT909538 hsa-miR-1202 CLIP-seq
MIRT909539 hsa-miR-1275 CLIP-seq
MIRT909540 hsa-miR-1343 CLIP-seq
MIRT909541 hsa-miR-148a CLIP-seq
MIRT909542 hsa-miR-148b CLIP-seq
Transcription factors
Transcription factor Regulation Reference
NFKB1 Activation 20233629
RELA Activation 20233629
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 18801728, 26352593, 30126976
GO:0005768 Component Endosome IEA
GO:0005886 Component Plasma membrane IBA 21873635
GO:0005886 Component Plasma membrane TAS
GO:0005887 Component Integral component of plasma membrane TAS 10598591
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
122561 2357 ENSG00000120088
Protein
UniProt ID P34998
Protein name Corticotropin-releasing factor receptor 1 (CRF-R-1) (CRF-R1) (CRFR-1) (Corticotropin-releasing hormone receptor 1) (CRH-R-1) (CRH-R1)
Protein function G-protein coupled receptor for CRH (corticotropin-releasing factor) and UCN (urocortin). Has high affinity for CRH and UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins)
PDB 2L27 , 3EHS , 3EHT , 3EHU , 4K5Y , 4Z9G , 6P9X , 6PB0 , 8GTG , 8GTI , 8GTM
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF02793 HRM 41 105 Hormone receptor domain Family
PF00002 7tm_2 168 388 7 transmembrane receptor (Secretin family) Family
Tissue specificity TISSUE SPECIFICITY: Predominantly expressed in the cerebellum, pituitary, cerebral cortex and olfactory lobe. {ECO:0000269|PubMed:8243652}.
Sequence
Sequence length 444
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  cAMP signaling pathway
Neuroactive ligand-receptor interaction
Hormone signaling
Long-term depression
Cushing syndrome
  Class B/2 (Secretin family receptors)
G alpha (s) signalling events
ADORA2B mediated anti-inflammatory cytokines production
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Breast cancer Malignant neoplasm of breast rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158
View all (309 more)
29915430
Breast carcinoma Breast Carcinoma rs80359671, rs11540652, rs28934575, rs28897672, rs137886232, rs193922376, rs80357783, rs80359306, rs80359405, rs80359507, rs80359598, rs80358429, rs397507683, rs397515636, rs80359451
View all (71 more)
29915430
Dermatitis Contact Dermatitis rs61816761, rs150597413, rs138726443, rs201356558, rs149484917, rs372754256, rs747301529, rs567795279, rs745915174 12631246
Marfan syndrome Mammary Carcinoma, Human rs137854456, rs137854457, rs267606796, rs137854458, rs137854459, rs137854460, rs137854470, rs137854471, rs267606797, rs137854461, rs137854462, rs137854463, rs869025419, rs137854464, rs137854465
View all (942 more)
29915430
Unknown
Disease term Disease name Evidence References Source
Mental depression Mental Depression, Depressive disorder, Unipolar Depression, Major Depressive Disorder 24931706, 25422957, 24933348, 24867333, 25422958, 23962971, 23157339, 22249355, 22467522, 23529111 ClinVar
Neuroticism Neuroticism GWAS
Corticobasal Degeneration Corticobasal Degeneration GWAS
Schizophrenia Schizophrenia GWAS
Associations from Text Mining
Disease Name Relationship Type References
Abdominal Injuries Associate 27497153
Abuse dwarfism syndrome Associate 18250257
Alcoholism Associate 20374216
Alzheimer Disease Associate 37354922
Anxiety Associate 18801728, 23274505, 26643280, 26923505, 31908177
Anxiety Disorders Associate 19596121, 25059547, 26923505
Arthritis Psoriatic Associate 22089831
Asthma Associate 18622266, 19409562
Autism Spectrum Disorder Associate 37907504
Axial osteomalacia Associate 34602499