Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	139324
Gene name	Highly divergent homeobox
Gene symbol	HDX
Synonyms (NCBI Gene)	CXorf43D030011N01Rik
Chromosome	X
Chromosome location	Xq21.1

Show/Hide all (77)

miRTarBase ID	miRNA	Experiments	Reference
MIRT448763	hsa-miR-6888-5p	PAR-CLIP	22100165
MIRT448762	hsa-miR-4635	PAR-CLIP	22100165
MIRT448761	hsa-miR-605-3p	PAR-CLIP	22100165
MIRT448760	hsa-miR-4493	PAR-CLIP	22100165
MIRT448759	hsa-miR-185-5p	PAR-CLIP	22100165
MIRT448758	hsa-miR-4306	PAR-CLIP	22100165
MIRT448757	hsa-miR-4644	PAR-CLIP	22100165
MIRT448756	hsa-miR-6126	PAR-CLIP	22100165
MIRT448754	hsa-miR-6864-5p	PAR-CLIP	22100165
MIRT448755	hsa-miR-652-5p	PAR-CLIP	22100165
MIRT448763	hsa-miR-6888-5p	PAR-CLIP	22100165
MIRT448762	hsa-miR-4635	PAR-CLIP	22100165
MIRT448761	hsa-miR-605-3p	PAR-CLIP	22100165
MIRT448760	hsa-miR-4493	PAR-CLIP	22100165
MIRT448759	hsa-miR-185-5p	PAR-CLIP	22100165
MIRT448758	hsa-miR-4306	PAR-CLIP	22100165
MIRT448757	hsa-miR-4644	PAR-CLIP	22100165
MIRT448756	hsa-miR-6126	PAR-CLIP	22100165
MIRT448754	hsa-miR-6864-5p	PAR-CLIP	22100165
MIRT448755	hsa-miR-652-5p	PAR-CLIP	22100165
MIRT448763	hsa-miR-6888-5p	PAR-CLIP	22100165
MIRT448762	hsa-miR-4635	PAR-CLIP	22100165
MIRT448761	hsa-miR-605-3p	PAR-CLIP	22100165
MIRT448760	hsa-miR-4493	PAR-CLIP	22100165
MIRT448759	hsa-miR-185-5p	PAR-CLIP	22100165
MIRT448758	hsa-miR-4306	PAR-CLIP	22100165
MIRT448757	hsa-miR-4644	PAR-CLIP	22100165
MIRT448756	hsa-miR-6126	PAR-CLIP	22100165
MIRT448754	hsa-miR-6864-5p	PAR-CLIP	22100165
MIRT448755	hsa-miR-652-5p	PAR-CLIP	22100165
MIRT448763	hsa-miR-6888-5p	PAR-CLIP	22100165
MIRT448762	hsa-miR-4635	PAR-CLIP	22100165
MIRT448761	hsa-miR-605-3p	PAR-CLIP	22100165
MIRT448760	hsa-miR-4493	PAR-CLIP	22100165
MIRT448759	hsa-miR-185-5p	PAR-CLIP	22100165
MIRT448758	hsa-miR-4306	PAR-CLIP	22100165
MIRT448757	hsa-miR-4644	PAR-CLIP	22100165
MIRT448756	hsa-miR-6126	PAR-CLIP	22100165
MIRT448754	hsa-miR-6864-5p	PAR-CLIP	22100165
MIRT448755	hsa-miR-652-5p	PAR-CLIP	22100165
MIRT1043023	hsa-miR-3156-5p	CLIP-seq
MIRT1043024	hsa-miR-3647-3p	CLIP-seq
MIRT1043025	hsa-miR-3658	CLIP-seq
MIRT1043026	hsa-miR-4427	CLIP-seq
MIRT1043027	hsa-miR-4668-3p	CLIP-seq
MIRT1043028	hsa-miR-4680-3p	CLIP-seq
MIRT1043029	hsa-miR-548c-3p	CLIP-seq
MIRT1043030	hsa-miR-1255a	CLIP-seq
MIRT1043031	hsa-miR-1255b	CLIP-seq
MIRT1043032	hsa-miR-1299	CLIP-seq
MIRT1043033	hsa-miR-2054	CLIP-seq
MIRT1043034	hsa-miR-25	CLIP-seq
MIRT1043035	hsa-miR-32	CLIP-seq
MIRT1043036	hsa-miR-363	CLIP-seq
MIRT1043037	hsa-miR-367	CLIP-seq
MIRT1043038	hsa-miR-3681	CLIP-seq
MIRT1043039	hsa-miR-3682-3p	CLIP-seq
MIRT1043040	hsa-miR-3691-5p	CLIP-seq
MIRT1043041	hsa-miR-4496	CLIP-seq
MIRT1043042	hsa-miR-4679	CLIP-seq
MIRT1043043	hsa-miR-4782-5p	CLIP-seq
MIRT1043044	hsa-miR-516b	CLIP-seq
MIRT1043045	hsa-miR-548t	CLIP-seq
MIRT1043046	hsa-miR-875-3p	CLIP-seq
MIRT1043047	hsa-miR-92a	CLIP-seq
MIRT1043048	hsa-miR-92b	CLIP-seq
MIRT2009171	hsa-miR-129-5p	CLIP-seq
MIRT2241584	hsa-miR-4659a-3p	CLIP-seq
MIRT2241585	hsa-miR-4659b-3p	CLIP-seq
MIRT2442250	hsa-miR-1305	CLIP-seq
MIRT2442251	hsa-miR-3913-3p	CLIP-seq
MIRT2442252	hsa-miR-3973	CLIP-seq
MIRT2442253	hsa-miR-489	CLIP-seq
MIRT2442254	hsa-miR-520g	CLIP-seq
MIRT2442255	hsa-miR-520h	CLIP-seq
MIRT2442256	hsa-miR-607	CLIP-seq
MIRT2545226	hsa-miR-935	CLIP-seq

Show/Hide all (8)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000785	Component	Chromatin	ISA
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	ISA
GO:0003677	Function	DNA binding	IEA
GO:0005515	Function	Protein binding	IPI	20211142, 32296183
GO:0005634	Component	Nucleus	IEA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA

MIM	HGNC	e!Ensembl
300994	26411	ENSG00000165259

Q7Z353

Protein name

Highly divergent homeobox

PDB

2DA4

Family and domains

Sequence

MNLRSVFTVEQQRILQRYYENGMTNQSKNCFQLILQCAQETKLDFSVVRTWVGNKRRKMS
SKNSESGTATTGTSLSAPDITVRNVVNIARPSSQQSSWTSANNDVIVTGIYSPASSSSRQ
GTNKHTDTQITEAHKIPIQKTATKNDTEFQLHIPVQRQVAHCKNASLLLGEKTIILSRQT
SVLNAGNSVFNHAKKNYGNSSVQASEMTVPQKPSVCHRPCKIEPVGIQRSYKPEHTGPAL
HNLCGQKPTIRDPYCRTQNLEIREVFSLAVSDYPQRILGGNAPQKPSSAEGNCLSIAMET
GDAEDEYAREEELASMRAQIPSYSRFYESGSSLRAENQSTTLPGPGRNMPNSQMVNIRDM
SDNVLYQNRNYHLTPRTSLHTASSTMYSNTNPLRSNFSPHFASSNQLRLSQNQNNYQISG
NLTVPWITGCSRKRALQDRTQFSDRDLATLKKYWDNGMTSLGSVCREKIEAVATELNVDC
EIVRTWIGNRRRKYRLMGIEVPPPRGGPADFSEQPESGSLSALTPGEEAGPEVGEDNDRN
DEVSICLSEGSSQEEPNEVVPNDARAHKEEDHHAVTTDNVKIEIIDDEESDMISNSEVEQ
VNSFLDYKNEEVKFIENELEIQKQKYFKLQTFVRSLILAMKADDKEQQQALLSDLPPELE
EMDFNHASLEPDDTSFSVSSLSEKNVSESL

Sequence length

690

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (3)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
DENTAL CARIES	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
INSOMNIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PREECLAMPSIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

HDX (highly divergent homeobox)