PTPDC1 (protein tyrosine phosphatase domain containing 1)

Gene

• Entrez ID: 138639
• Gene name: Protein tyrosine phosphatase domain containing 1
• Gene symbol: PTPDC1
• Synonyms (NCBI Gene): PTP9Q22
• Chromosome: 9
• Chromosome location: 9q22.32
• Summary: The protein encoded by this gene contains a characteristic motif of protein tyrosine phosphatases (PTPs). PTPs regulate activities of phosphoproteins through dephosphorylation. They are signaling molecules involved in the regulation of a wide variety of b

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT019589	hsa-miR-340-5p	Sequencing	20371350
MIRT031061	hsa-miR-21-5p	Microarray	18591254
MIRT032059	hsa-miR-16-5p	Sequencing	20371350
MIRT325513	hsa-miR-142-5p	HITS-CLIP	23313552
MIRT325534	hsa-miR-5590-3p	HITS-CLIP	23313552
MIRT700540	hsa-miR-4802-5p	HITS-CLIP	23313552
MIRT700539	hsa-miR-6514-5p	HITS-CLIP	23313552
MIRT700538	hsa-miR-1827	HITS-CLIP	23313552
MIRT700537	hsa-miR-504-3p	HITS-CLIP	23313552
MIRT700536	hsa-miR-122-5p	HITS-CLIP	23313552
MIRT700535	hsa-miR-193a-5p	HITS-CLIP	23313552
MIRT019589	hsa-miR-340-5p	HITS-CLIP	23313552
MIRT700534	hsa-miR-6765-5p	HITS-CLIP	23313552
MIRT700533	hsa-miR-1304-5p	HITS-CLIP	23313552
MIRT687161	hsa-miR-5580-3p	HITS-CLIP	23313552
MIRT687160	hsa-miR-3126-3p	HITS-CLIP	23313552
MIRT687159	hsa-miR-1298-3p	HITS-CLIP	23313552
MIRT687158	hsa-miR-4756-3p	HITS-CLIP	23313552
MIRT687157	hsa-miR-4766-5p	HITS-CLIP	23313552
MIRT687156	hsa-miR-378j	HITS-CLIP	23313552
MIRT687155	hsa-miR-6839-5p	HITS-CLIP	23313552
MIRT687154	hsa-miR-130a-5p	HITS-CLIP	23313552
MIRT687153	hsa-miR-23a-3p	HITS-CLIP	23313552
MIRT687152	hsa-miR-23b-3p	HITS-CLIP	23313552
MIRT687151	hsa-miR-23c	HITS-CLIP	23313552
MIRT687150	hsa-miR-4782-5p	HITS-CLIP	23313552
MIRT687149	hsa-miR-5706	HITS-CLIP	23313552
MIRT687148	hsa-miR-6509-5p	HITS-CLIP	23313552
MIRT325520	hsa-miR-373-3p	PAR-CLIP	21572407
MIRT325517	hsa-miR-302c-3p	PAR-CLIP	21572407
MIRT325527	hsa-miR-520b	PAR-CLIP	21572407
MIRT325528	hsa-miR-520c-3p	PAR-CLIP	21572407
MIRT325522	hsa-miR-520e	PAR-CLIP	21572407
MIRT325524	hsa-miR-520a-3p	PAR-CLIP	21572407
MIRT325519	hsa-miR-372-3p	PAR-CLIP	21572407
MIRT325533	hsa-miR-302e	PAR-CLIP	21572407
MIRT325518	hsa-miR-302d-3p	PAR-CLIP	21572407
MIRT325516	hsa-miR-302b-3p	PAR-CLIP	21572407
MIRT325515	hsa-miR-302a-3p	PAR-CLIP	21572407
MIRT325530	hsa-miR-520d-3p	PAR-CLIP	21572407
MIRT325512	hsa-miR-106a-5p	PAR-CLIP	21572407
MIRT325514	hsa-miR-106b-5p	PAR-CLIP	21572407
MIRT325510	hsa-miR-20a-5p	PAR-CLIP	21572407
MIRT325521	hsa-miR-20b-5p	PAR-CLIP	21572407
MIRT325509	hsa-miR-17-5p	PAR-CLIP	21572407
MIRT325529	hsa-miR-519d-3p	PAR-CLIP	21572407
MIRT325525	hsa-miR-526b-3p	PAR-CLIP	21572407
MIRT325511	hsa-miR-93-5p	PAR-CLIP	21572407
MIRT325513	hsa-miR-142-5p	PAR-CLIP	21572407
MIRT325534	hsa-miR-5590-3p	PAR-CLIP	21572407
MIRT325532	hsa-miR-548n	PAR-CLIP	21572407
MIRT555167	hsa-miR-3609	PAR-CLIP	21572407
MIRT555166	hsa-miR-548ah-5p	PAR-CLIP	21572407
MIRT555165	hsa-miR-4796-3p	PAR-CLIP	21572407
MIRT555164	hsa-miR-543	PAR-CLIP	21572407
MIRT555163	hsa-miR-562	PAR-CLIP	21572407
MIRT555162	hsa-miR-181a-5p	PAR-CLIP	21572407
MIRT555161	hsa-miR-181b-5p	PAR-CLIP	21572407
MIRT555160	hsa-miR-181c-5p	PAR-CLIP	21572407
MIRT555159	hsa-miR-181d-5p	PAR-CLIP	21572407
MIRT555158	hsa-miR-4262	PAR-CLIP	21572407
MIRT555157	hsa-miR-4323	PAR-CLIP	21572407
MIRT555156	hsa-miR-3943	PAR-CLIP	21572407
MIRT555155	hsa-miR-6769a-3p	PAR-CLIP	21572407
MIRT555153	hsa-miR-4712-3p	PAR-CLIP	21572407
MIRT555154	hsa-miR-8063	PAR-CLIP	21572407
MIRT555152	hsa-miR-4698	PAR-CLIP	21572407
MIRT555151	hsa-miR-539-5p	PAR-CLIP	21572407
MIRT555150	hsa-miR-4758-3p	PAR-CLIP	21572407
MIRT555149	hsa-miR-31-3p	PAR-CLIP	21572407
MIRT325513	hsa-miR-142-5p	HITS-CLIP	23313552
MIRT325534	hsa-miR-5590-3p	HITS-CLIP	23313552
MIRT700540	hsa-miR-4802-5p	HITS-CLIP	23313552
MIRT700539	hsa-miR-6514-5p	HITS-CLIP	23313552
MIRT700538	hsa-miR-1827	HITS-CLIP	23313552
MIRT700537	hsa-miR-504-3p	HITS-CLIP	23313552
MIRT700536	hsa-miR-122-5p	HITS-CLIP	23313552
MIRT700535	hsa-miR-193a-5p	HITS-CLIP	23313552
MIRT019589	hsa-miR-340-5p	HITS-CLIP	23313552
MIRT700534	hsa-miR-6765-5p	HITS-CLIP	23313552
MIRT700533	hsa-miR-1304-5p	HITS-CLIP	23313552
MIRT687161	hsa-miR-5580-3p	HITS-CLIP	23313552
MIRT687160	hsa-miR-3126-3p	HITS-CLIP	23313552
MIRT687159	hsa-miR-1298-3p	HITS-CLIP	23313552
MIRT687158	hsa-miR-4756-3p	HITS-CLIP	23313552
MIRT687157	hsa-miR-4766-5p	HITS-CLIP	23313552
MIRT687156	hsa-miR-378j	HITS-CLIP	23313552
MIRT687155	hsa-miR-6839-5p	HITS-CLIP	23313552
MIRT687154	hsa-miR-130a-5p	HITS-CLIP	23313552
MIRT687153	hsa-miR-23a-3p	HITS-CLIP	23313552
MIRT687152	hsa-miR-23b-3p	HITS-CLIP	23313552
MIRT687151	hsa-miR-23c	HITS-CLIP	23313552
MIRT687150	hsa-miR-4782-5p	HITS-CLIP	23313552
MIRT687149	hsa-miR-5706	HITS-CLIP	23313552
MIRT687148	hsa-miR-6509-5p	HITS-CLIP	23313552
MIRT325520	hsa-miR-373-3p	PAR-CLIP	21572407
MIRT325517	hsa-miR-302c-3p	PAR-CLIP	21572407
MIRT325527	hsa-miR-520b	PAR-CLIP	21572407
MIRT325528	hsa-miR-520c-3p	PAR-CLIP	21572407
MIRT325522	hsa-miR-520e	PAR-CLIP	21572407
MIRT325524	hsa-miR-520a-3p	PAR-CLIP	21572407
MIRT325519	hsa-miR-372-3p	PAR-CLIP	21572407
MIRT325533	hsa-miR-302e	PAR-CLIP	21572407
MIRT325518	hsa-miR-302d-3p	PAR-CLIP	21572407
MIRT325516	hsa-miR-302b-3p	PAR-CLIP	21572407
MIRT325515	hsa-miR-302a-3p	PAR-CLIP	21572407
MIRT325530	hsa-miR-520d-3p	PAR-CLIP	21572407
MIRT325512	hsa-miR-106a-5p	PAR-CLIP	21572407
MIRT325514	hsa-miR-106b-5p	PAR-CLIP	21572407
MIRT325510	hsa-miR-20a-5p	PAR-CLIP	21572407
MIRT325521	hsa-miR-20b-5p	PAR-CLIP	21572407
MIRT325509	hsa-miR-17-5p	PAR-CLIP	21572407
MIRT325529	hsa-miR-519d-3p	PAR-CLIP	21572407
MIRT325525	hsa-miR-526b-3p	PAR-CLIP	21572407
MIRT325511	hsa-miR-93-5p	PAR-CLIP	21572407
MIRT325513	hsa-miR-142-5p	PAR-CLIP	21572407
MIRT325534	hsa-miR-5590-3p	PAR-CLIP	21572407
MIRT325532	hsa-miR-548n	PAR-CLIP	21572407
MIRT555167	hsa-miR-3609	PAR-CLIP	21572407
MIRT555166	hsa-miR-548ah-5p	PAR-CLIP	21572407
MIRT555165	hsa-miR-4796-3p	PAR-CLIP	21572407
MIRT555164	hsa-miR-543	PAR-CLIP	21572407
MIRT555163	hsa-miR-562	PAR-CLIP	21572407
MIRT555162	hsa-miR-181a-5p	PAR-CLIP	21572407
MIRT555161	hsa-miR-181b-5p	PAR-CLIP	21572407
MIRT555160	hsa-miR-181c-5p	PAR-CLIP	21572407
MIRT555159	hsa-miR-181d-5p	PAR-CLIP	21572407
MIRT555158	hsa-miR-4262	PAR-CLIP	21572407
MIRT555157	hsa-miR-4323	PAR-CLIP	21572407
MIRT555156	hsa-miR-3943	PAR-CLIP	21572407
MIRT555155	hsa-miR-6769a-3p	PAR-CLIP	21572407
MIRT555153	hsa-miR-4712-3p	PAR-CLIP	21572407
MIRT555154	hsa-miR-8063	PAR-CLIP	21572407
MIRT555152	hsa-miR-4698	PAR-CLIP	21572407
MIRT555151	hsa-miR-539-5p	PAR-CLIP	21572407
MIRT555150	hsa-miR-4758-3p	PAR-CLIP	21572407
MIRT555149	hsa-miR-31-3p	PAR-CLIP	21572407
MIRT1274160	hsa-miR-146a	CLIP-seq
MIRT1274161	hsa-miR-146b-5p	CLIP-seq
MIRT1274162	hsa-miR-1976	CLIP-seq
MIRT1274163	hsa-miR-2277-3p	CLIP-seq
MIRT1274164	hsa-miR-23a	CLIP-seq
MIRT1274165	hsa-miR-23b	CLIP-seq
MIRT1274166	hsa-miR-31	CLIP-seq
MIRT1274167	hsa-miR-3128	CLIP-seq
MIRT1274168	hsa-miR-3164	CLIP-seq
MIRT1274169	hsa-miR-3614-5p	CLIP-seq
MIRT1274170	hsa-miR-3671	CLIP-seq
MIRT1274171	hsa-miR-4264	CLIP-seq
MIRT1274172	hsa-miR-4268	CLIP-seq
MIRT1274173	hsa-miR-4289	CLIP-seq
MIRT1274174	hsa-miR-4328	CLIP-seq
MIRT1274175	hsa-miR-4448	CLIP-seq
MIRT1274176	hsa-miR-4704-3p	CLIP-seq
MIRT1274177	hsa-miR-4722-3p	CLIP-seq
MIRT1274178	hsa-miR-4764-3p	CLIP-seq
MIRT1274179	hsa-miR-514	CLIP-seq
MIRT1274180	hsa-miR-514b-3p	CLIP-seq
MIRT1274181	hsa-miR-580	CLIP-seq
MIRT1274182	hsa-miR-589	CLIP-seq
MIRT2306722	hsa-miR-106a	CLIP-seq
MIRT2306723	hsa-miR-106b	CLIP-seq
MIRT2306724	hsa-miR-1227	CLIP-seq
MIRT2306725	hsa-miR-17	CLIP-seq
MIRT2306726	hsa-miR-181a	CLIP-seq
MIRT2306727	hsa-miR-181b	CLIP-seq
MIRT2306728	hsa-miR-181c	CLIP-seq
MIRT2306729	hsa-miR-181d	CLIP-seq
MIRT2306730	hsa-miR-20a	CLIP-seq
MIRT2306731	hsa-miR-20b	CLIP-seq
MIRT2306732	hsa-miR-302a	CLIP-seq
MIRT2306733	hsa-miR-302b	CLIP-seq
MIRT2306734	hsa-miR-302c	CLIP-seq
MIRT2306735	hsa-miR-302d	CLIP-seq
MIRT2306736	hsa-miR-30a	CLIP-seq
MIRT2306737	hsa-miR-30b	CLIP-seq
MIRT2306738	hsa-miR-30c	CLIP-seq
MIRT2306739	hsa-miR-30d	CLIP-seq
MIRT2306740	hsa-miR-30e	CLIP-seq
MIRT2306741	hsa-miR-3591-3p	CLIP-seq
MIRT2306742	hsa-miR-372	CLIP-seq
MIRT2306743	hsa-miR-373	CLIP-seq
MIRT2306744	hsa-miR-4495	CLIP-seq
MIRT2306745	hsa-miR-4659a-5p	CLIP-seq
MIRT2306746	hsa-miR-4659b-5p	CLIP-seq
MIRT2306747	hsa-miR-519d	CLIP-seq
MIRT2306748	hsa-miR-548ah	CLIP-seq
MIRT2306749	hsa-miR-93	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004721	Function	Phosphoprotein phosphatase activity	IEA
GO:0004725	Function	Protein tyrosine phosphatase activity	IBA
GO:0004725	Function	Protein tyrosine phosphatase activity	IEA
GO:0005515	Function	Protein binding	IPI	32296183, 33961781
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IBA
GO:0005829	Component	Cytosol	IDA
GO:0016787	Function	Hydrolase activity	IEA
GO:0030030	Process	Cell projection organization	IEA
GO:0060271	Process	Cilium assembly	IBA
GO:0060271	Process	Cilium assembly	IEA

Other IDs

• MIM: HGNC
• HGNC: N/A
• e!Ensembl: HGNC

Protein

• UniProt ID: A2A3K4
• Protein name: Protein tyrosine phosphatase domain-containing protein 1 (EC 3.1.3.-)
• Protein function: May play roles in cilia formation and/or maintenance.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00782	DSPc	100 → 243	Dual specificity phosphatase, catalytic domain	Domain

• Sequence:

  MAAGVLPQNEQPYSTLVNNSECVANMKGNLERPTPKYTKVGERLRHVIPGHMACSMACGG
  RACKYENPARWSEQEQAIKGVYSSWVTDNILAMARPSSELLEKYHIIDQFLSHGIKTIIN
  LQRPGEHASCGNPLEQESGFTYLPEAFMEAGIYFYNFGWKDYGVASLTTILDMVKVMTFA
  LQEGKVAIHCHAGLGRTGVLIACYLVFATRMTADQAIIFVRAKRPNSIQTRGQLLCVREF
  TQFLTPLRNIFSCCDPKAHAVTLPQYLIRQRHLLHGYEARLLKHVPKIIHLVCKLLLDLA
  ENRPVMMKDVSEGPGLSAEIEKTMSEMVTMQLDKELLRHDSDVSNPPNPTAVAADFDNRG
  MIFSNEQQFDPLWKRRNVECLQPLTHLKRRLSYSDSDLKRAENLLEQGETPQTVPAQILV
  GHKPRQQKLISHCYIPQSPEPDLHKEALVRSTLSFWSQSKFGGLEGLKDNGSPIFHGRII
  PKEAQQSGAFSADVSGSHSPGEPVSPSFANVHKDPNPAHQQVSHCQCKTHGVGSPGSVRQ
  NSRTPRSPLDCGSSPKAQFLVEHETQDSKDLSEAASHSALQSELSAEARRILAAKALANL
  NESVEKEELKRKVEMWQKELNSRDGAWERICGERDPFILCSLMWSWVEQLKEPVITKEDV
  DMLVDRRADAAEALFLLEKGQHQTILCVLHCIVNLQTIPVDVEEAFLAHAIKAFTKVNFD
  SENGPTVYNTLKKIFKHTLEEKRKMTKDGPKPGL

• Sequence length: 754

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
ESOPHAGEAL ADENOCARCINOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GOUT	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
METABOLIC SYNDROME	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations