Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	138474
Gene name Gene Name - the full gene name approved by the HGNC.	TATA-box binding protein associated factor 1 like
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	TAF1L
Synonyms (NCBI Gene) Gene synonyms aliases	TAF(II)210, TAF2A2
Chromosome Chromosome number	9
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	9p21.1
Summary Summary of gene provided in NCBI Entrez Gene.	This locus is intronless, and apparently arose in the primate lineage from retrotransposition of the transcript from the multi-exon TAF1 locus on the X chromosome. The gene is expressed in male germ cells, and the product has been shown to function interc

Show/Hide all(86)

miRTarBase ID	miRNA	Experiments
MIRT1409274	hsa-miR-1228	CLIP-seq
MIRT1409275	hsa-miR-3135b	CLIP-seq
MIRT1409276	hsa-miR-3652	CLIP-seq
MIRT1409277	hsa-miR-4430	CLIP-seq
MIRT1409278	hsa-miR-4438	CLIP-seq
MIRT1409279	hsa-miR-4450	CLIP-seq
MIRT1409280	hsa-miR-4667-5p	CLIP-seq
MIRT1409281	hsa-miR-4700-5p	CLIP-seq
MIRT1409282	hsa-miR-5095	CLIP-seq
MIRT1409283	hsa-miR-637	CLIP-seq
MIRT1409284	hsa-miR-767-5p	CLIP-seq
MIRT1921390	hsa-miR-1280	CLIP-seq
MIRT1921391	hsa-miR-1302	CLIP-seq
MIRT1921392	hsa-miR-4286	CLIP-seq
MIRT1921393	hsa-miR-4287	CLIP-seq
MIRT1921394	hsa-miR-4298	CLIP-seq
MIRT1921395	hsa-miR-4469	CLIP-seq
MIRT1921396	hsa-miR-4685-3p	CLIP-seq
MIRT2122742	hsa-miR-3680	CLIP-seq
MIRT2122743	hsa-miR-4695-3p	CLIP-seq
MIRT2122744	hsa-miR-4772-3p	CLIP-seq
MIRT2122745	hsa-miR-498	CLIP-seq
MIRT1409275	hsa-miR-3135b	CLIP-seq
MIRT2345113	hsa-miR-3155	CLIP-seq
MIRT2345114	hsa-miR-3155b	CLIP-seq
MIRT1409276	hsa-miR-3652	CLIP-seq
MIRT2122742	hsa-miR-3680	CLIP-seq
MIRT2345115	hsa-miR-4268	CLIP-seq
MIRT1409277	hsa-miR-4430	CLIP-seq
MIRT2345116	hsa-miR-4464	CLIP-seq
MIRT2345117	hsa-miR-4506	CLIP-seq
MIRT2345118	hsa-miR-450b-3p	CLIP-seq
MIRT2345119	hsa-miR-4691-5p	CLIP-seq
MIRT2122743	hsa-miR-4695-3p	CLIP-seq
MIRT2345120	hsa-miR-4713-3p	CLIP-seq
MIRT2345121	hsa-miR-4748	CLIP-seq
MIRT2345122	hsa-miR-4772-5p	CLIP-seq
MIRT2345123	hsa-miR-484	CLIP-seq
MIRT2345124	hsa-miR-638	CLIP-seq
MIRT2345125	hsa-miR-769-3p	CLIP-seq
MIRT1409274	hsa-miR-1228	CLIP-seq
MIRT2461067	hsa-miR-1976	CLIP-seq
MIRT2461068	hsa-miR-3157-5p	CLIP-seq
MIRT2461069	hsa-miR-370	CLIP-seq
MIRT2461070	hsa-miR-3977	CLIP-seq
MIRT2461071	hsa-miR-4279	CLIP-seq
MIRT1409278	hsa-miR-4438	CLIP-seq
MIRT1409279	hsa-miR-4450	CLIP-seq
MIRT2461072	hsa-miR-4532	CLIP-seq
MIRT2461073	hsa-miR-4794	CLIP-seq
MIRT2122745	hsa-miR-498	CLIP-seq
MIRT1409282	hsa-miR-5095	CLIP-seq
MIRT1409284	hsa-miR-767-5p	CLIP-seq
MIRT1409274	hsa-miR-1228	CLIP-seq
MIRT2461067	hsa-miR-1976	CLIP-seq
MIRT2638175	hsa-miR-3149	CLIP-seq
MIRT2461069	hsa-miR-370	CLIP-seq
MIRT2461070	hsa-miR-3977	CLIP-seq
MIRT2638176	hsa-miR-411	CLIP-seq
MIRT2461071	hsa-miR-4279	CLIP-seq
MIRT1409278	hsa-miR-4438	CLIP-seq
MIRT1409279	hsa-miR-4450	CLIP-seq
MIRT2461072	hsa-miR-4532	CLIP-seq
MIRT2638177	hsa-miR-4735-5p	CLIP-seq
MIRT2638178	hsa-miR-4775	CLIP-seq
MIRT2461073	hsa-miR-4794	CLIP-seq
MIRT2122745	hsa-miR-498	CLIP-seq
MIRT1409282	hsa-miR-5095	CLIP-seq
MIRT2638179	hsa-miR-590-3p	CLIP-seq
MIRT1409284	hsa-miR-767-5p	CLIP-seq
MIRT1409274	hsa-miR-1228	CLIP-seq
MIRT2461067	hsa-miR-1976	CLIP-seq
MIRT2638175	hsa-miR-3149	CLIP-seq
MIRT2461069	hsa-miR-370	CLIP-seq
MIRT2461070	hsa-miR-3977	CLIP-seq
MIRT2461071	hsa-miR-4279	CLIP-seq
MIRT1409278	hsa-miR-4438	CLIP-seq
MIRT1409279	hsa-miR-4450	CLIP-seq
MIRT2461072	hsa-miR-4532	CLIP-seq
MIRT2638177	hsa-miR-4735-5p	CLIP-seq
MIRT2638178	hsa-miR-4775	CLIP-seq
MIRT2461073	hsa-miR-4794	CLIP-seq
MIRT2122745	hsa-miR-498	CLIP-seq
MIRT1409282	hsa-miR-5095	CLIP-seq
MIRT2638179	hsa-miR-590-3p	CLIP-seq
MIRT1409284	hsa-miR-767-5p	CLIP-seq

Show/Hide all(19)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003677	Function	DNA binding	IEA
GO:0004402	Function	Histone acetyltransferase activity	ISS	12217962
GO:0004674	Function	Protein serine/threonine kinase activity	ISS	12217962
GO:0005575	Component	Cellular_component	ND
GO:0005654	Component	Nucleoplasm	TAS
GO:0005669	Component	Transcription factor TFIID complex	IBA	21873635
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IDA	12217962
GO:0006366	Process	Transcription by RNA polymerase II	TAS
GO:0006367	Process	Transcription initiation from RNA polymerase II promoter	TAS
GO:0006468	Process	Protein phosphorylation	IEA
GO:0007140	Process	Male meiotic nuclear division	IEP	12217962
GO:0016251	Function	RNA polymerase II general transcription initiation factor activity	IBA	21873635
GO:0016573	Process	Histone acetylation	IEA
GO:0017025	Function	TBP-class protein binding	IBA	21873635
GO:0017025	Function	TBP-class protein binding	IPI	12217962
GO:0045893	Process	Positive regulation of transcription, DNA-templated	IDA	12217962
GO:0051123	Process	RNA polymerase II preinitiation complex assembly	IBA	21873635
GO:0070577	Function	Lysine-acetylated histone binding	IDA	22464331
GO:1901796	Process	Regulation of signal transduction by p53 class mediator	TAS

MIM	HGNC	e!Ensembl
607798	18056	ENSG00000122728

Protein

UniProt ID

Q8IZX4

Protein name

Transcription initiation factor TFIID subunit 1-like (TAF(II)210) (TBP-associated factor 1-like) (TBP-associated factor 210 kDa) (Transcription initiation factor TFIID 210 kDa subunit)

Protein function

May act as a functional substitute for TAF1/TAFII250 during male meiosis, when sex chromosomes are transcriptionally silenced.

PDB

3HMH , 5IGL

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF09247	TBP-binding	22 → 85	TATA box-binding protein binding	Domain
PF12157	DUF3591	584 → 1047	Protein of unknown function (DUF3591)	Family
PF15288	zf-CCHC_6	1280 → 1319	Zinc knuckle	Domain
PF00439	Bromodomain	1408 → 1491	Bromodomain	Domain
PF00439	Bromodomain	1530 → 1614	Bromodomain	Domain

Tissue specificity

TISSUE SPECIFICITY: Testis specific, expressed apparently in germ cells.

Sequence

MRPGCDLLLRAAATVTAAIMSDSDSEEDSSGGGPFTLAGILFGNISGAGQLEGESVLDDE
CKKHLAGLGALGLGSLITELTANEELTGTGGALVNDEGWIRSTEDAVDYSDINEVAEDES
QRHQQTMGSLQPLYHSDYDEDDYDADCEDIDCKLMPPPPPPPGPMKKDKDQDAITCVSES
GEDIILPSIIAPSFLASEKVDFSSYSDSESEMGPQEATQAESEDGKLTLPLAGIMQHDAT
KLLPSVTELFPEFRPGKVLRFLHLFGPGKNVPSVWRSARRKRKKHRELIQEEQIQEVECS
VESEVSQKSLWNYDYAPPPPPEQCLADDEITMMVPVESKFSQSTGDVDKVTDTKPRVAEW
RYGPARLWYDMLGVSEDGSGFDYGFKLRKTQHEPVIKSRMMEEFRKLEESNGTDLLADEN
FLMVTQLHWEDSIIWDGEDIKHKGTKPQGASLAGWLPSIKTRNVMAYNVQQGFAPTLDDD
KPWYSIFPIDNEDLVYGRWEDNIIWDAQAMPRLLEPPVLALDPNDENLILEIPDEKEEAT
SNSPSKESKKESSLKKSRILLGKTGVIREEPQQNMSQPEVKDPWNLSNDEYYFPKQQGLR
GTFGGNIIQHSIPAMELWQPFFPTHMGPIKIRQFHRPPLKKYSFGALSQPGPHSVQPLLK
HIKKKAKMREQERQASGGGELFFMRTPQDLTGKDGDLILAEYSEENGPLMMQVGMATKIK
NYYKRKPGKDPGAPDCKYGETVYCHTSPFLGSLHPGQLLQALENNLFRAPVYLHKMPETD
FLIIRTRQGYYIRELVDIFVVGQQCPLFEVPGPNSRRANMHIRDFLQVFIYRLFWKSKDR
PRRIRMEDIKKAFPSHSESSIRKRLKLCADFKRTGMDSNWWVLKSDFRLPTEEEIRAKVS
PEQCCAYYSMIAAKQRLKDAGYGEKSFFAPEEENEEDFQMKIDDEVHAAPWNTTRAFIAA
MKGKCLLEVTGVADPTGCGEGFSYVKIPNKPTQQKDDKEPQAVKKTVTGTDADLRRLSLK
NAKQLLRKFGVPEEEIKKLSRWEVIDVVRTMSTEQAHSGEGPMSKFARGSRFSVAEHQER
YKEECQRIFDLQNKVLSSTEVLSTDTDSISAEDSDFEEMGKNIENMLQNKKTSSQLSREW
EEQERKELRRMLLVAGSAASGNNHRDDVTASMTSLKSSATGHCLKIYRTFRDEEGKEYVR
CETVRKPAVIDAYVRIRTTKDEKFIQKFALFDEKHREEMRKERRRIQEQLRRLKRNQEKE
KLKGPPEKKPKKMKERPDLKLKCGACGAIGHMRTNKFCPLYYQTNVPPSKPVAMTEEQEE
ELEKTVIHNDNEELIKVEGTKIVFGKQLIENVHEVRRKSLVLKFPKQQLPPKKKRRVGTT
VHCDYLNIPHKSIHRRRTDPMVTLSSILESIINDMRDLPNTHPFHTPVNAKVVKDYYKII
TRPMDLQTLRENVRKCLYPSREEFREHLELIVKNSATYNGPKHSLTQISQSMLDLCDEKL
KEKEDKLARLEKAINPLLDDDDQVAFSFILDNIVTQKMMAVPDSWPFHHPVNKKFVPDYY
KMIVNPVDLETIRKNISKHKYQSRESFLDDVNLILANSVKYNGPESQYTKTAQEIVNICY
QTITEYDEHLTQLEKDICTAKEAALEEAELESLDPMTPGPYTSQPPDMYDTNTSLSTSRD
ASVFQDESNLSVLDISTATPEKQMCQGQGRLGEEDSDVDVEGYDDEEEDGKPKPPAPEGG
DGDLADEEEGTVQQPEASVLYEDLLISEGEDDEEDAGSDEEGDNPFSAIQLSESGSDSDV
GYGGIRPKQPFMLQHASGEHKDGHGK

Sequence length

1826

Interactions

View interactions

	KEGG		Reactome
	Basal transcription factors		RNA Polymerase II Pre-transcription Events Regulation of TP53 Activity through Phosphorylation RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Initiation And Promoter Clearance

Show/Hide Causal Diseases (4)

Disease term	Disease name	dbSNP ID	References
Causal
Glioblastoma	Glioblastoma Multiforme	rs121913500, rs886042842, rs1555138291, rs1558518449, rs1567176006, rs1558650888
Lung carcinoma	Small cell carcinoma of lung	rs1805076, rs121909071, rs121913530, rs112445441, rs121913529, rs121913535, rs121913297, rs121913279, rs104886003, rs397516975, rs11554290, rs121913364, rs121913351, rs121913369, rs121913355 View all (44 more)
Lung adenocarcinoma	Adenocarcinoma of lung (disorder)	rs28934576, rs121913530, rs397516975, rs587776805, rs121913469, rs121913364, rs121913351, rs121913366, rs397516896, rs397516977, rs397516981, rs397517127, rs121913344, rs727504233, rs121913370 View all (5 more)
Prostate cancer	Malignant neoplasm of prostate	rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582	29610475

Show/Hide Text Mining Associations (6)

Disease Name	Relationship Type	References
Associations from Text Mining
Carcinogenesis	Associate	27571988
Colorectal Neoplasms	Associate	27571988
Glioblastoma	Associate	34015961
Microsatellite Instability	Associate	27571988
Neoplasms	Associate	24007313, 27571988
Squamous Cell Carcinoma of Head and Neck	Associate	24007313

TAF1L (TATA-box binding protein associated factor 1 like)