Gene Gene information from NCBI Gene database.
Entrez ID 1382
Gene name Cellular retinoic acid binding protein 2
Gene symbol CRABP2
Synonyms (NCBI Gene)
CRABP-IIRBP6
Chromosome 1
Chromosome location 1q23.1
Summary This gene encodes a member of the retinoic acid (RA, a form of vitamin A) binding protein family and lipocalin/cytosolic fatty-acid binding protein family. The protein is a cytosol-to-nuclear shuttling protein, which facilitates RA binding to its cognate
miRNA miRNA information provided by mirtarbase database.
256
miRTarBase ID miRNA Experiments Reference
MIRT019800 hsa-miR-375 Microarray 20215506
MIRT907929 hsa-miR-1262 CLIP-seq
MIRT907930 hsa-miR-1285 CLIP-seq
MIRT907931 hsa-miR-1288 CLIP-seq
MIRT907932 hsa-miR-1301 CLIP-seq
Transcription factors Transcription factors information provided by TRRUST V2 database.
2
Transcription factor Regulation Reference
TFAP2A Activation 17187826
TFAP2C Activation 17187826
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
28
GO ID Ontology Definition Evidence Reference
GO:0001972 Function Retinoic acid binding IBA
GO:0001972 Function Retinoic acid binding IEA
GO:0005501 Function Retinoid binding TAS 1334086
GO:0005504 Function Fatty acid binding IBA
GO:0005515 Function Protein binding IPI 25416956, 25910212, 32296183
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
180231 2339 ENSG00000143320
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P29373
Protein name Cellular retinoic acid-binding protein 2 (Cellular retinoic acid-binding protein II) (CRABP-II)
Protein function Transports retinoic acid to the nucleus. Regulates the access of retinoic acid to the nuclear retinoic acid receptors.
PDB 1BLR , 1BM5 , 1CBQ , 1CBS , 1XCA , 2CBS , 2FR3 , 2FRS , 2FS6 , 2FS7 , 2G78 , 2G79 , 2G7B , 3CBS , 3CR6 , 3CWK , 3D95 , 3D96 , 3D97 , 3F8A , 3F9D , 3FA6 , 3FA7 , 3FA8 , 3FA9 , 3FEK , 3FEL , 3FEN , 3FEP , 3I17 , 4I9R , 4I9S , 4M6S , 4M7M , 4QGV , 4QGW , 4QGX , 4YBP , 4YBU , 4YCE , 4YCH , 4YDA , 4YDB , 4YFP , 4YFQ , 4YFR , 4YGG , 4YGH , 4YGZ , 4YH0 , 4YKM
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00061 Lipocalin 5 138 Lipocalin / cytosolic fatty-acid binding protein family Domain
Sequence
Sequence length 138
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Signaling by Retinoic Acid
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
10
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
AORTIC DISEASE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Cervical cancer Likely benign ClinVar
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Lung cancer Likely benign ClinVar
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Malignant tumor of esophagus Likely benign ClinVar
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References Evidence Score
Adenocarcinoma Associate 37004157
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma in Situ Associate 37004157
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma of Lung Associate 35966249, 37004157
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma of Lung Stimulate 37016102
★☆☆☆☆
Found in Text Mining only
Arthritis Rheumatoid Associate 29880835, 37597518
★☆☆☆☆
Found in Text Mining only
Autoimmune Diseases Associate 37597518
★☆☆☆☆
Found in Text Mining only
Breast Neoplasms Associate 26142905, 29731607, 37715025
★☆☆☆☆
Found in Text Mining only
Carcinogenesis Associate 24709110
★☆☆☆☆
Found in Text Mining only
Carcinoma Non Small Cell Lung Stimulate 25034531, 29930489
★☆☆☆☆
Found in Text Mining only
Carcinoma Non Small Cell Lung Associate 34932899
★☆☆☆☆
Found in Text Mining only