DCAF4L2 (DDB1 and CUL4 associated factor 4 like 2)

Gene

• Entrez ID: 138009
• Gene name: DDB1 and CUL4 associated factor 4 like 2
• Gene symbol: DCAF4L2
• Synonyms (NCBI Gene): WDR21C
• Chromosome: 8
• Chromosome location: 8q21.3

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT017989	hsa-miR-335-5p	Microarray	18185580
MIRT569839	hsa-miR-494-3p	PAR-CLIP	20371350
MIRT569839	hsa-miR-494-3p	PAR-CLIP	20371350
MIRT925057	hsa-miR-1233	CLIP-seq
MIRT925058	hsa-miR-1245b-3p	CLIP-seq
MIRT925059	hsa-miR-129-3p	CLIP-seq
MIRT925060	hsa-miR-1297	CLIP-seq
MIRT925061	hsa-miR-1322	CLIP-seq
MIRT925062	hsa-miR-181a	CLIP-seq
MIRT925063	hsa-miR-181b	CLIP-seq
MIRT925064	hsa-miR-181c	CLIP-seq
MIRT925065	hsa-miR-181d	CLIP-seq
MIRT925066	hsa-miR-26a	CLIP-seq
MIRT925067	hsa-miR-26b	CLIP-seq
MIRT925068	hsa-miR-3613-3p	CLIP-seq
MIRT925069	hsa-miR-3614-3p	CLIP-seq
MIRT925070	hsa-miR-3646	CLIP-seq
MIRT925071	hsa-miR-425	CLIP-seq
MIRT925072	hsa-miR-4262	CLIP-seq
MIRT925073	hsa-miR-4465	CLIP-seq
MIRT925074	hsa-miR-4698	CLIP-seq
MIRT925075	hsa-miR-4735-5p	CLIP-seq
MIRT925076	hsa-miR-4780	CLIP-seq
MIRT925077	hsa-miR-494	CLIP-seq
MIRT925078	hsa-miR-548ac	CLIP-seq
MIRT925079	hsa-miR-548ae	CLIP-seq
MIRT925080	hsa-miR-548aj	CLIP-seq
MIRT925081	hsa-miR-548am	CLIP-seq
MIRT925082	hsa-miR-548c-3p	CLIP-seq
MIRT925083	hsa-miR-548d-3p	CLIP-seq
MIRT925084	hsa-miR-548x	CLIP-seq
MIRT925085	hsa-miR-548z	CLIP-seq
MIRT925086	hsa-miR-607	CLIP-seq
MIRT1974023	hsa-miR-331-3p	CLIP-seq
MIRT1974024	hsa-miR-339-5p	CLIP-seq
MIRT925068	hsa-miR-3613-3p	CLIP-seq
MIRT1974025	hsa-miR-3679-3p	CLIP-seq
MIRT1974026	hsa-miR-377	CLIP-seq
MIRT2209607	hsa-miR-129-5p	CLIP-seq
MIRT2209608	hsa-miR-1910	CLIP-seq
MIRT2209609	hsa-miR-455-3p	CLIP-seq
MIRT2209610	hsa-miR-4776-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0080008	Component	Cul4-RING E3 ubiquitin ligase complex	IBA

Other IDs

• MIM: 620421
• HGNC: 26657
• e!Ensembl: ENSG00000176566

Protein

• UniProt ID: Q8NA75
• Protein name: DDB1- and CUL4-associated factor 4-like protein 2 (WD repeat-containing protein 21C)
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00400	WD40	262 → 298	WD domain, G-beta repeat	Repeat

• Sequence:

  MESKRPRLLEEADKQKKTVRVGLNAPSMLRKNQLGFLRFANYCRIARELRVSCMQRKKVQ
  IHSWDPSSLASDRFNRILANTNTDQLFTVNQVEAGGSKYGIITMRGLTTPELRVYPHKTL
  YVPNRKVNSMCWASLNHLDSHLLLCFVGLADTPSCAVLLPASLFIGSFPGMRRPGMLCSF
  QIPDAWSCAWSLSIHAYHSFSTGLSQQVLLTNVVTGHQQSFGTSSDVLAQQFAIMTPLLF
  NGCRSGEIFGIDLRCGNQGSGWKAICLSHDSAVTSLQILQDGQFLVSSDMTGTIKLWDLR
  ATKCVTQYEGHVNNSAYLPVHVNEEEGVVAAVGQDCYTRIWSLRHGHLLTTIPSPYPASE
  NDIPSVAFSSRLGGFRGAPGLLMAVREDLYCFSYG

• Sequence length: 395

Associated diseases

Unknown
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
DCAF4L2-related disorder	Likely benign; Benign; Uncertain significance	rs537310751, rs113061626, rs149030322, rs146716352, rs142584363, rs141776325, rs146197461, rs141645313, rs866117569, rs773515750, rs376969727, rs149891752	RCV003929181 RCV003909225 RCV003907161 RCV003919656 RCV003904249 RCV003951982 RCV003919457 RCV003931734 RCV003931383 RCV003934360 RCV003947068 RCV003924287

Associations from Text Mining
Disease Name	Relationship Type	References
Carcinoma Hepatocellular	Associate	32685988
Cleft Lip	Associate	35191549
Cleft Palate	Associate	23512105, 35191549
Fatty Liver Alcoholic	Associate	32685988
Neoplasms	Associate	32685988
Orofacial Cleft 1	Associate	35191549
Otofaciocervical Syndrome	Associate	35191549
Virus Diseases	Associate	32685988