UNC5D (unc-5 netrin receptor D)

Gene

• Entrez ID: 137970
• Gene name: Unc-5 netrin receptor D
• Gene symbol: UNC5D
• Synonyms (NCBI Gene): PRO34692, Unc5h4
• Chromosome: 8
• Chromosome location: 8p12

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT022228	hsa-miR-124-3p	Microarray	18668037
MIRT651857	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT651856	hsa-miR-4328	HITS-CLIP	23824327
MIRT651855	hsa-miR-145-5p	HITS-CLIP	23824327
MIRT651854	hsa-miR-5195-3p	HITS-CLIP	23824327
MIRT651853	hsa-miR-548aw	HITS-CLIP	23824327
MIRT651852	hsa-miR-518a-5p	HITS-CLIP	23824327
MIRT651851	hsa-miR-527	HITS-CLIP	23824327
MIRT651850	hsa-miR-450b-5p	HITS-CLIP	23824327
MIRT651849	hsa-miR-507	HITS-CLIP	23824327
MIRT651848	hsa-miR-557	HITS-CLIP	23824327
MIRT651847	hsa-miR-3680-3p	HITS-CLIP	23824327
MIRT651857	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT651856	hsa-miR-4328	HITS-CLIP	23824327
MIRT651855	hsa-miR-145-5p	HITS-CLIP	23824327
MIRT651854	hsa-miR-5195-3p	HITS-CLIP	23824327
MIRT651853	hsa-miR-548aw	HITS-CLIP	23824327
MIRT651852	hsa-miR-518a-5p	HITS-CLIP	23824327
MIRT651851	hsa-miR-527	HITS-CLIP	23824327
MIRT651850	hsa-miR-450b-5p	HITS-CLIP	23824327
MIRT651849	hsa-miR-507	HITS-CLIP	23824327
MIRT651848	hsa-miR-557	HITS-CLIP	23824327
MIRT651847	hsa-miR-3680-3p	HITS-CLIP	23824327
MIRT1475579	hsa-miR-1200	CLIP-seq
MIRT1475580	hsa-miR-1266	CLIP-seq
MIRT1475581	hsa-miR-1322	CLIP-seq
MIRT1475582	hsa-miR-182	CLIP-seq
MIRT1475583	hsa-miR-3140-5p	CLIP-seq
MIRT1475584	hsa-miR-3148	CLIP-seq
MIRT1475585	hsa-miR-3154	CLIP-seq
MIRT1475586	hsa-miR-3163	CLIP-seq
MIRT1475587	hsa-miR-325	CLIP-seq
MIRT1475588	hsa-miR-365	CLIP-seq
MIRT1475589	hsa-miR-3660	CLIP-seq
MIRT1475590	hsa-miR-3664-3p	CLIP-seq
MIRT1475591	hsa-miR-374a	CLIP-seq
MIRT1475592	hsa-miR-374b	CLIP-seq
MIRT1475593	hsa-miR-3913-3p	CLIP-seq
MIRT1475594	hsa-miR-3921	CLIP-seq
MIRT1475595	hsa-miR-3942-3p	CLIP-seq
MIRT1475596	hsa-miR-421	CLIP-seq
MIRT1475597	hsa-miR-4276	CLIP-seq
MIRT1475598	hsa-miR-4282	CLIP-seq
MIRT1475599	hsa-miR-4470	CLIP-seq
MIRT1475600	hsa-miR-4493	CLIP-seq
MIRT1475601	hsa-miR-4518	CLIP-seq
MIRT1475602	hsa-miR-4526	CLIP-seq
MIRT1475603	hsa-miR-4641	CLIP-seq
MIRT1475604	hsa-miR-4653-5p	CLIP-seq
MIRT1475605	hsa-miR-4659a-3p	CLIP-seq
MIRT1475606	hsa-miR-4659b-3p	CLIP-seq
MIRT1475607	hsa-miR-4695-3p	CLIP-seq
MIRT1475608	hsa-miR-4709-5p	CLIP-seq
MIRT1475609	hsa-miR-4714-5p	CLIP-seq
MIRT1475610	hsa-miR-4797-5p	CLIP-seq
MIRT1475611	hsa-miR-489	CLIP-seq
MIRT1475612	hsa-miR-499-3p	CLIP-seq
MIRT1475613	hsa-miR-499a-3p	CLIP-seq
MIRT1475614	hsa-miR-516a-3p	CLIP-seq
MIRT1475615	hsa-miR-548a-5p	CLIP-seq
MIRT1475616	hsa-miR-548ab	CLIP-seq
MIRT1475617	hsa-miR-548ak	CLIP-seq
MIRT1475618	hsa-miR-548b-5p	CLIP-seq
MIRT1475619	hsa-miR-548c-5p	CLIP-seq
MIRT1475620	hsa-miR-548d-5p	CLIP-seq
MIRT1475621	hsa-miR-548h	CLIP-seq
MIRT1475622	hsa-miR-548i	CLIP-seq
MIRT1475623	hsa-miR-548j	CLIP-seq
MIRT1475624	hsa-miR-548n	CLIP-seq
MIRT1475625	hsa-miR-548w	CLIP-seq
MIRT1475626	hsa-miR-548y	CLIP-seq
MIRT1475627	hsa-miR-559	CLIP-seq
MIRT1475628	hsa-miR-628-3p	CLIP-seq
MIRT1475629	hsa-miR-769-5p	CLIP-seq
MIRT1475630	hsa-miR-873	CLIP-seq
MIRT1555343	hsa-miR-3124-3p	CLIP-seq
MIRT1555344	hsa-miR-4422	CLIP-seq
MIRT1555345	hsa-miR-4757-5p	CLIP-seq
MIRT1475579	hsa-miR-1200	CLIP-seq
MIRT2143339	hsa-miR-1252	CLIP-seq
MIRT1475581	hsa-miR-1322	CLIP-seq
MIRT2143340	hsa-miR-3074-5p	CLIP-seq
MIRT2143341	hsa-miR-330-3p	CLIP-seq
MIRT2143342	hsa-miR-3646	CLIP-seq
MIRT2143343	hsa-miR-3929	CLIP-seq
MIRT2143344	hsa-miR-4325	CLIP-seq
MIRT2143345	hsa-miR-4419b	CLIP-seq
MIRT1555344	hsa-miR-4422	CLIP-seq
MIRT2143346	hsa-miR-4438	CLIP-seq
MIRT2143347	hsa-miR-4478	CLIP-seq
MIRT2143348	hsa-miR-4490	CLIP-seq
MIRT2143349	hsa-miR-4666-5p	CLIP-seq
MIRT2143350	hsa-miR-4793-3p	CLIP-seq
MIRT2143351	hsa-miR-548p	CLIP-seq
MIRT2143352	hsa-miR-548u	CLIP-seq
MIRT2143353	hsa-miR-607	CLIP-seq
MIRT2363591	hsa-miR-1290	CLIP-seq
MIRT2363592	hsa-miR-3127-5p	CLIP-seq
MIRT2143341	hsa-miR-330-3p	CLIP-seq
MIRT2363593	hsa-miR-3616-5p	CLIP-seq
MIRT2363594	hsa-miR-3647-5p	CLIP-seq
MIRT2363595	hsa-miR-3655	CLIP-seq
MIRT2363596	hsa-miR-3940-5p	CLIP-seq
MIRT2363597	hsa-miR-4270	CLIP-seq
MIRT2143344	hsa-miR-4325	CLIP-seq
MIRT1555344	hsa-miR-4422	CLIP-seq
MIRT2363598	hsa-miR-4436a	CLIP-seq
MIRT2363599	hsa-miR-4441	CLIP-seq
MIRT2363600	hsa-miR-4474-5p	CLIP-seq
MIRT2363601	hsa-miR-4506	CLIP-seq
MIRT2363602	hsa-miR-4507	CLIP-seq
MIRT1475610	hsa-miR-4797-5p	CLIP-seq
MIRT2363603	hsa-miR-485-3p	CLIP-seq
MIRT2363604	hsa-miR-513a-5p	CLIP-seq
MIRT2363605	hsa-miR-573	CLIP-seq
MIRT2143353	hsa-miR-607	CLIP-seq
MIRT2363606	hsa-miR-653	CLIP-seq
MIRT2143341	hsa-miR-330-3p	CLIP-seq
MIRT2143344	hsa-miR-4325	CLIP-seq
MIRT1555344	hsa-miR-4422	CLIP-seq
MIRT2143353	hsa-miR-607	CLIP-seq
MIRT1475588	hsa-miR-365	CLIP-seq
MIRT2462933	hsa-miR-4290	CLIP-seq
MIRT2462934	hsa-miR-4667-3p	CLIP-seq
MIRT2462935	hsa-miR-4799-5p	CLIP-seq
MIRT1475588	hsa-miR-365	CLIP-seq
MIRT2462933	hsa-miR-4290	CLIP-seq
MIRT2462934	hsa-miR-4667-3p	CLIP-seq
MIRT2462935	hsa-miR-4799-5p	CLIP-seq
MIRT1475588	hsa-miR-365	CLIP-seq
MIRT2462933	hsa-miR-4290	CLIP-seq
MIRT2462934	hsa-miR-4667-3p	CLIP-seq
MIRT2462935	hsa-miR-4799-5p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005042	Function	Netrin receptor activity	IBA
GO:0005042	Function	Netrin receptor activity	IEA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0006915	Process	Apoptotic process	IEA
GO:0007165	Process	Signal transduction	IEA
GO:0007411	Process	Axon guidance	IBA
GO:0007411	Process	Axon guidance	IEA
GO:0009986	Component	Cell surface	IEA
GO:0016020	Component	Membrane	IEA
GO:0021859	Process	Pyramidal neuron differentiation	IEA
GO:0038007	Process	Netrin-activated signaling pathway	IEA
GO:0098742	Process	Cell-cell adhesion via plasma-membrane adhesion molecules	IDA	26235030
GO:2001222	Process	Regulation of neuron migration	IEA

Other IDs

• MIM: 616466
• HGNC: 18634
• e!Ensembl: ENSG00000156687

Protein

• UniProt ID: Q6UXZ4
• Protein name: Netrin receptor UNC5D (Protein unc-5 homolog 4) (Protein unc-5 homolog D)
• Protein function: Receptor for the netrin NTN4 that promotes neuronal cell survival (By similarity). Plays a role in cell-cell adhesion and cell guidance. Receptor for netrin involved in cell migration. Plays a role in axon guidance by mediating axon repulsion of
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF07679	I-set	159 → 249	Immunoglobulin I-set domain	Domain
  PF00090	TSP_1	256 → 306	Thrombospondin type 1 domain	Domain
  PF00090	TSP_1	312 → 359	Thrombospondin type 1 domain	Domain
  PF00791	ZU5	543 → 639	ZU5 domain	Family
  PF17217	UPA	687 → 826	UPA domain	Domain
  PF00531	Death	858 → 936	Death domain	Domain

• Sequence:

  MGRAAATAGGGGGARRWLPWLGLCFWAAGTAAARGTDNGEALPESIPSAPGTLPHFIEEP
  DDAYIIKSNPIALRCKARPAMQIFFKCNGEWVHQNEHVSEETLDESSGLKVREVFINVTR
  QQVEDFHGPEDYWCQCVAWSHLGTSKSRKASVRIAYLRKNFEQDPQGREVPIEGMIVLHC
  RPPEGVPAAEVEWLKNEEPIDSEQDENIDTRADHNLIIRQARLSDSGNYTCMAANIVAKR
  RSLSATVVVYVNGGWSSWTEWSACNVRCGRGWQKRSRTCTNPAPLNGGAFCEGMSVQKIT
  CTSLCPVDGSWEVWSEWSVCSPECEHLRIRECTAPPPRNGGKFCEGLSQESENCTDGLCI
  LDKKPLHEIKPQSIENASDIALYSGLGAAVVAVAVLVIGVTLYRRSQSDYGVDVIDSSAL
  TGGFQTFNFKTVRQGNSLLLNSAMQPDLTVSRTYSGPICLQDPLDKELMTESSLFNPLSD
  IKVKVQSSFMVSLGVSERAEYHGKNHSRTFPHGNNHSFSTMHPRNKMPYIQNLSSLPTRT
  ELRTTGVFGHLGGRLVMPNTGVSLLIPHGAIPEENSWEIYMSINQGEPSLQSDGSEVLLS
  PEVTCGPPDMIVTTPFALTIPHCADVSSEHWNIHLKKRTQQGKWEEVMSVEDESTSCYCL
  LDPFACHVLLDSFGTYALTGEPITDCAVKQLKVAVFGCMSCNSLDYNLRVYCVDNTPCAF
  QEVVSDERHQGGQLLEEPKLLHFKGNTFSLQISVLDIPPFLWRIKPFTACQEVPFSRVWC
  SNRQPLHCAFSLERYTPTTTQLSCKICIRQLKGHEQILQVQTSILESERETITFFAQEDS
  TFPAQTGPKAFKIPYSIRQRICATFDTPNAKGKDWQMLAQKNSINRNLSYFATQSSPSAV
  ILNLWEARHQHDGDLDSLACALEEIGRTHTKLSNISESQLDEADFNYSRQNGL

• Sequence length: 953

Pathways

KEGG:

Axon guidance