CR1L (complement C3b/C4b receptor 1 like)

Gene

• Entrez ID: 1379
• Gene name: Complement C3b/C4b receptor 1 like
• Gene symbol: CR1L
• Synonyms (NCBI Gene): -
• Chromosome: 1
• Chromosome location: 1q32.2

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002456	Process	T cell mediated immunity	IBA
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005576	Component	Extracellular region	IEA
GO:0005615	Component	Extracellular space	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005886	Component	Plasma membrane	IBA
GO:0016020	Component	Membrane	IEA
GO:0030449	Process	Regulation of complement activation	IDA	25284781
GO:0030449	Process	Regulation of complement activation	IEA
GO:0043235	Component	Receptor complex	IDA	23382219
GO:0045959	Process	Negative regulation of complement activation, classical pathway	IBA
GO:1903659	Process	Regulation of complement-dependent cytotoxicity	IDA	25284781
GO:1903659	Process	Regulation of complement-dependent cytotoxicity	IEA

Other IDs

• MIM: 605886
• HGNC: 2335
• e!Ensembl: ENSG00000197721

Protein

• UniProt ID: Q2VPA4
• Protein name: Complement component receptor 1-like protein (Complement C4b-binding protein CR-1-like protein)
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00084	Sushi	35 → 91	Sushi repeat (SCR repeat)	Domain
  PF00084	Sushi	96 → 153	Sushi repeat (SCR repeat)	Domain
  PF00084	Sushi	158 → 224	Sushi repeat (SCR repeat)	Domain
  PF00084	Sushi	230 → 285	Sushi repeat (SCR repeat)	Domain
  PF00084	Sushi	289 → 345	Sushi repeat (SCR repeat)	Domain
  PF00084	Sushi	351 → 408	Sushi repeat (SCR repeat)	Domain
  PF00084	Sushi	413 → 470	Sushi repeat (SCR repeat)	Domain
  PF00084	Sushi	475 → 541	Sushi repeat (SCR repeat)	Domain

• Tissue specificity: TISSUE SPECIFICITY: Expressed in fetal liver and to a lesser extent in fetal spleen and thymus. Expression appears to be limited to hematopoietic and fetal lymphoid tissue. {ECO:0000269|PubMed:14687939}.
• Sequence:

  MAPPVRLERPFPSRRFPGLLLAALVLLLSSFSDQCNVPEWLPFARPTNLTDDFEFPIGTY
  LNYECRPGYSGRPFSIICLKNSVWTSAKDKCKRKSCRNPPDPVNGMAHVIKDIQFRSQIK
  YSCPKGYRLIGSSSATCIISGNTVIWDNKTPVCDRIICGLPPTIANGDFTSISREYFHYG
  SVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVGIWSGPAPQCIIPNKCTPPNVENGIL
  VSDNRSLFSLNEVVEFRCQPGFGMKGPSHVKCQALNKWEPELPSCSRVCQPPPDVLHAER
  TQRDKDNFSPGQEVFYSCEPGYDLRGSTYLHCTPQGDWSPAAPRCEVKSCDDFLGQLPNG
  HVLFPLNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCERKSCETPPVPV
  NGMVHVITDIHVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSMKPPICQQIFCPNPPA
  ILNGRHTGTPLGDIPYGKEVSYTCDPHPDRGMTFNLIGESTIRRTSEPHGNGVWSSPAPR
  CELPVGAGSHDALIVGKFYEVFAEEFCHL

• Sequence length: 569

Pathways

KEGG:

Complement and coagulation cascades
Neutrophil extracellular trap formation
Hematopoietic cell lineage
Legionellosis
Leishmaniasis
Malaria
Tuberculosis