Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	1378
Gene name Gene Name - the full gene name approved by the HGNC.	Complement C3b/C4b receptor 1 (Knops blood group)
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	CR1
Synonyms (NCBI Gene) Gene synonyms aliases	C3BR, C4BR, CD35, KN
Chromosome Chromosome number	1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	1q32.2
Summary Summary of gene provided in NCBI Entrez Gene.	This gene is a member of the receptors of complement activation (RCA) family and is located in the `cluster RCA` region of chromosome 1. The genome is polymorphic at this locus with allele-specific splice variants encoding different isoforms, based on the

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miRTarBase ID	miRNA	Experiments	Reference
MIRT047066	hsa-miR-183-5p	CLASH	23622248
MIRT907825	hsa-miR-10a	CLIP-seq
MIRT907826	hsa-miR-10b	CLIP-seq
MIRT907827	hsa-miR-1207-5p	CLIP-seq
MIRT907828	hsa-miR-1268	CLIP-seq
MIRT907829	hsa-miR-1268b	CLIP-seq
MIRT907830	hsa-miR-1297	CLIP-seq
MIRT907831	hsa-miR-1827	CLIP-seq
MIRT907832	hsa-miR-26a	CLIP-seq
MIRT907833	hsa-miR-26b	CLIP-seq
MIRT907834	hsa-miR-3165	CLIP-seq
MIRT907835	hsa-miR-329	CLIP-seq
MIRT907836	hsa-miR-339-5p	CLIP-seq
MIRT907837	hsa-miR-3613-3p	CLIP-seq
MIRT907838	hsa-miR-362-3p	CLIP-seq
MIRT907839	hsa-miR-3665	CLIP-seq
MIRT907840	hsa-miR-3667-5p	CLIP-seq
MIRT907841	hsa-miR-376a	CLIP-seq
MIRT907842	hsa-miR-376b	CLIP-seq
MIRT907843	hsa-miR-3941	CLIP-seq
MIRT907844	hsa-miR-4421	CLIP-seq
MIRT907845	hsa-miR-4433	CLIP-seq
MIRT907846	hsa-miR-4459	CLIP-seq
MIRT907847	hsa-miR-4465	CLIP-seq
MIRT907848	hsa-miR-451b	CLIP-seq
MIRT907849	hsa-miR-4683	CLIP-seq
MIRT907850	hsa-miR-4684-5p	CLIP-seq
MIRT907851	hsa-miR-4696	CLIP-seq
MIRT907852	hsa-miR-4725-5p	CLIP-seq
MIRT907853	hsa-miR-4736	CLIP-seq
MIRT907854	hsa-miR-4763-3p	CLIP-seq
MIRT907855	hsa-miR-4768-3p	CLIP-seq
MIRT907856	hsa-miR-4793-5p	CLIP-seq
MIRT907857	hsa-miR-4794	CLIP-seq
MIRT907858	hsa-miR-504	CLIP-seq
MIRT907859	hsa-miR-515-5p	CLIP-seq
MIRT907860	hsa-miR-548a-3p	CLIP-seq
MIRT907861	hsa-miR-548a-5p	CLIP-seq
MIRT907862	hsa-miR-548ab	CLIP-seq
MIRT907863	hsa-miR-548ac	CLIP-seq
MIRT907864	hsa-miR-548ae	CLIP-seq
MIRT907865	hsa-miR-548aj	CLIP-seq
MIRT907866	hsa-miR-548ak	CLIP-seq
MIRT907867	hsa-miR-548am	CLIP-seq
MIRT907868	hsa-miR-548b-5p	CLIP-seq
MIRT907869	hsa-miR-548c-3p	CLIP-seq
MIRT907870	hsa-miR-548c-5p	CLIP-seq
MIRT907871	hsa-miR-548d-3p	CLIP-seq
MIRT907872	hsa-miR-548d-5p	CLIP-seq
MIRT907873	hsa-miR-548e	CLIP-seq
MIRT907874	hsa-miR-548f	CLIP-seq
MIRT907875	hsa-miR-548h	CLIP-seq
MIRT907876	hsa-miR-548i	CLIP-seq
MIRT907877	hsa-miR-548j	CLIP-seq
MIRT907878	hsa-miR-548w	CLIP-seq
MIRT907879	hsa-miR-548x	CLIP-seq
MIRT907880	hsa-miR-548y	CLIP-seq
MIRT907881	hsa-miR-548z	CLIP-seq
MIRT907882	hsa-miR-559	CLIP-seq
MIRT907883	hsa-miR-579	CLIP-seq
MIRT907884	hsa-miR-595	CLIP-seq
MIRT907885	hsa-miR-603	CLIP-seq
MIRT907886	hsa-miR-648	CLIP-seq
MIRT907887	hsa-miR-940	CLIP-seq
MIRT907888	hsa-miR-944	CLIP-seq
MIRT907889	hsa-miR-125a-3p	CLIP-seq
MIRT907830	hsa-miR-1297	CLIP-seq
MIRT907831	hsa-miR-1827	CLIP-seq
MIRT907832	hsa-miR-26a	CLIP-seq
MIRT907833	hsa-miR-26b	CLIP-seq
MIRT907890	hsa-miR-297	CLIP-seq
MIRT907891	hsa-miR-3121-5p	CLIP-seq
MIRT907892	hsa-miR-3122	CLIP-seq
MIRT907893	hsa-miR-3147	CLIP-seq
MIRT907834	hsa-miR-3165	CLIP-seq
MIRT907894	hsa-miR-3609	CLIP-seq
MIRT907895	hsa-miR-3664-3p	CLIP-seq
MIRT907839	hsa-miR-3665	CLIP-seq
MIRT907896	hsa-miR-3689a-3p	CLIP-seq
MIRT907897	hsa-miR-3689c	CLIP-seq
MIRT907898	hsa-miR-3913-5p	CLIP-seq
MIRT907899	hsa-miR-3929	CLIP-seq
MIRT907900	hsa-miR-4419b	CLIP-seq
MIRT907901	hsa-miR-4425	CLIP-seq
MIRT907845	hsa-miR-4433	CLIP-seq
MIRT907846	hsa-miR-4459	CLIP-seq
MIRT907847	hsa-miR-4465	CLIP-seq
MIRT907902	hsa-miR-4478	CLIP-seq
MIRT907903	hsa-miR-4490	CLIP-seq
MIRT907904	hsa-miR-4641	CLIP-seq
MIRT907905	hsa-miR-4649-3p	CLIP-seq
MIRT907849	hsa-miR-4683	CLIP-seq
MIRT907906	hsa-miR-4695-5p	CLIP-seq
MIRT907907	hsa-miR-4728-5p	CLIP-seq
MIRT907908	hsa-miR-4733-5p	CLIP-seq
MIRT907853	hsa-miR-4736	CLIP-seq
MIRT907855	hsa-miR-4768-3p	CLIP-seq
MIRT907856	hsa-miR-4793-5p	CLIP-seq
MIRT907857	hsa-miR-4794	CLIP-seq
MIRT907909	hsa-miR-485-5p	CLIP-seq
MIRT907910	hsa-miR-510	CLIP-seq
MIRT907911	hsa-miR-512-5p	CLIP-seq
MIRT907912	hsa-miR-542-3p	CLIP-seq
MIRT907913	hsa-miR-548ah	CLIP-seq
MIRT907914	hsa-miR-548t	CLIP-seq
MIRT907915	hsa-miR-552	CLIP-seq
MIRT907916	hsa-miR-567	CLIP-seq
MIRT907917	hsa-miR-606	CLIP-seq
MIRT907887	hsa-miR-940	CLIP-seq
MIRT907831	hsa-miR-1827	CLIP-seq
MIRT1969113	hsa-miR-2964a-3p	CLIP-seq
MIRT1969114	hsa-miR-300	CLIP-seq
MIRT1969115	hsa-miR-302f	CLIP-seq
MIRT907892	hsa-miR-3122	CLIP-seq
MIRT907896	hsa-miR-3689a-3p	CLIP-seq
MIRT907897	hsa-miR-3689c	CLIP-seq
MIRT1969116	hsa-miR-369-3p	CLIP-seq
MIRT1969117	hsa-miR-374c	CLIP-seq
MIRT1969118	hsa-miR-381	CLIP-seq
MIRT907898	hsa-miR-3913-5p	CLIP-seq
MIRT1969119	hsa-miR-4252	CLIP-seq
MIRT907845	hsa-miR-4433	CLIP-seq
MIRT907846	hsa-miR-4459	CLIP-seq
MIRT1969120	hsa-miR-4720-3p	CLIP-seq
MIRT907907	hsa-miR-4728-5p	CLIP-seq
MIRT907855	hsa-miR-4768-3p	CLIP-seq
MIRT1969121	hsa-miR-4793-3p	CLIP-seq
MIRT1969122	hsa-miR-4804-3p	CLIP-seq
MIRT1969123	hsa-miR-508-5p	CLIP-seq
MIRT1969124	hsa-miR-655	CLIP-seq
MIRT1969125	hsa-miR-661	CLIP-seq
MIRT1969126	hsa-miR-766	CLIP-seq
MIRT907887	hsa-miR-940	CLIP-seq
MIRT907827	hsa-miR-1207-5p	CLIP-seq
MIRT907831	hsa-miR-1827	CLIP-seq
MIRT907892	hsa-miR-3122	CLIP-seq
MIRT907834	hsa-miR-3165	CLIP-seq
MIRT907839	hsa-miR-3665	CLIP-seq
MIRT907896	hsa-miR-3689a-3p	CLIP-seq
MIRT907897	hsa-miR-3689c	CLIP-seq
MIRT907898	hsa-miR-3913-5p	CLIP-seq
MIRT1969119	hsa-miR-4252	CLIP-seq
MIRT2205109	hsa-miR-4422	CLIP-seq
MIRT907845	hsa-miR-4433	CLIP-seq
MIRT907846	hsa-miR-4459	CLIP-seq
MIRT2205110	hsa-miR-4537	CLIP-seq
MIRT907849	hsa-miR-4683	CLIP-seq
MIRT907907	hsa-miR-4728-5p	CLIP-seq
MIRT907853	hsa-miR-4736	CLIP-seq
MIRT907854	hsa-miR-4763-3p	CLIP-seq
MIRT907855	hsa-miR-4768-3p	CLIP-seq
MIRT1969121	hsa-miR-4793-3p	CLIP-seq
MIRT907856	hsa-miR-4793-5p	CLIP-seq
MIRT907857	hsa-miR-4794	CLIP-seq
MIRT1969123	hsa-miR-508-5p	CLIP-seq
MIRT1969126	hsa-miR-766	CLIP-seq
MIRT907887	hsa-miR-940	CLIP-seq
MIRT907828	hsa-miR-1268	CLIP-seq
MIRT907829	hsa-miR-1268b	CLIP-seq
MIRT907831	hsa-miR-1827	CLIP-seq
MIRT2447566	hsa-miR-194	CLIP-seq
MIRT907892	hsa-miR-3122	CLIP-seq
MIRT907834	hsa-miR-3165	CLIP-seq
MIRT907837	hsa-miR-3613-3p	CLIP-seq
MIRT907839	hsa-miR-3665	CLIP-seq
MIRT907840	hsa-miR-3667-5p	CLIP-seq
MIRT907896	hsa-miR-3689a-3p	CLIP-seq
MIRT907897	hsa-miR-3689c	CLIP-seq
MIRT2447567	hsa-miR-371-5p	CLIP-seq
MIRT2447568	hsa-miR-371b-5p	CLIP-seq
MIRT907898	hsa-miR-3913-5p	CLIP-seq
MIRT907848	hsa-miR-451b	CLIP-seq
MIRT907850	hsa-miR-4684-5p	CLIP-seq
MIRT907851	hsa-miR-4696	CLIP-seq
MIRT907852	hsa-miR-4725-5p	CLIP-seq
MIRT907907	hsa-miR-4728-5p	CLIP-seq
MIRT907853	hsa-miR-4736	CLIP-seq
MIRT1969121	hsa-miR-4793-3p	CLIP-seq
MIRT907856	hsa-miR-4793-5p	CLIP-seq
MIRT907857	hsa-miR-4794	CLIP-seq
MIRT907858	hsa-miR-504	CLIP-seq
MIRT1969123	hsa-miR-508-5p	CLIP-seq
MIRT907869	hsa-miR-548c-3p	CLIP-seq
MIRT2447569	hsa-miR-555	CLIP-seq
MIRT1969125	hsa-miR-661	CLIP-seq
MIRT1969126	hsa-miR-766	CLIP-seq
MIRT907887	hsa-miR-940	CLIP-seq
MIRT907825	hsa-miR-10a	CLIP-seq
MIRT907826	hsa-miR-10b	CLIP-seq
MIRT907827	hsa-miR-1207-5p	CLIP-seq
MIRT907828	hsa-miR-1268	CLIP-seq
MIRT907829	hsa-miR-1268b	CLIP-seq
MIRT907831	hsa-miR-1827	CLIP-seq
MIRT2447566	hsa-miR-194	CLIP-seq
MIRT907892	hsa-miR-3122	CLIP-seq
MIRT907834	hsa-miR-3165	CLIP-seq
MIRT907836	hsa-miR-339-5p	CLIP-seq
MIRT907837	hsa-miR-3613-3p	CLIP-seq
MIRT2508452	hsa-miR-361-5p	CLIP-seq
MIRT907839	hsa-miR-3665	CLIP-seq
MIRT907840	hsa-miR-3667-5p	CLIP-seq
MIRT907896	hsa-miR-3689a-3p	CLIP-seq
MIRT907897	hsa-miR-3689c	CLIP-seq
MIRT2447567	hsa-miR-371-5p	CLIP-seq
MIRT2447568	hsa-miR-371b-5p	CLIP-seq
MIRT907898	hsa-miR-3913-5p	CLIP-seq
MIRT907844	hsa-miR-4421	CLIP-seq
MIRT907845	hsa-miR-4433	CLIP-seq
MIRT907846	hsa-miR-4459	CLIP-seq
MIRT907848	hsa-miR-451b	CLIP-seq
MIRT907849	hsa-miR-4683	CLIP-seq
MIRT907850	hsa-miR-4684-5p	CLIP-seq
MIRT907851	hsa-miR-4696	CLIP-seq
MIRT907852	hsa-miR-4725-5p	CLIP-seq
MIRT907907	hsa-miR-4728-5p	CLIP-seq
MIRT907853	hsa-miR-4736	CLIP-seq
MIRT907854	hsa-miR-4763-3p	CLIP-seq
MIRT907855	hsa-miR-4768-3p	CLIP-seq
MIRT1969121	hsa-miR-4793-3p	CLIP-seq
MIRT907856	hsa-miR-4793-5p	CLIP-seq
MIRT907857	hsa-miR-4794	CLIP-seq
MIRT907858	hsa-miR-504	CLIP-seq
MIRT1969123	hsa-miR-508-5p	CLIP-seq
MIRT907859	hsa-miR-515-5p	CLIP-seq
MIRT907869	hsa-miR-548c-3p	CLIP-seq
MIRT2447569	hsa-miR-555	CLIP-seq
MIRT1969125	hsa-miR-661	CLIP-seq
MIRT2508453	hsa-miR-764	CLIP-seq
MIRT1969126	hsa-miR-766	CLIP-seq
MIRT907887	hsa-miR-940	CLIP-seq
MIRT907825	hsa-miR-10a	CLIP-seq
MIRT907826	hsa-miR-10b	CLIP-seq
MIRT907827	hsa-miR-1207-5p	CLIP-seq
MIRT907828	hsa-miR-1268	CLIP-seq
MIRT907829	hsa-miR-1268b	CLIP-seq
MIRT907831	hsa-miR-1827	CLIP-seq
MIRT2447566	hsa-miR-194	CLIP-seq
MIRT907892	hsa-miR-3122	CLIP-seq
MIRT907836	hsa-miR-339-5p	CLIP-seq
MIRT907837	hsa-miR-3613-3p	CLIP-seq
MIRT2508452	hsa-miR-361-5p	CLIP-seq
MIRT907839	hsa-miR-3665	CLIP-seq
MIRT907840	hsa-miR-3667-5p	CLIP-seq
MIRT907896	hsa-miR-3689a-3p	CLIP-seq
MIRT907897	hsa-miR-3689c	CLIP-seq
MIRT2447567	hsa-miR-371-5p	CLIP-seq
MIRT2447568	hsa-miR-371b-5p	CLIP-seq
MIRT907898	hsa-miR-3913-5p	CLIP-seq
MIRT907844	hsa-miR-4421	CLIP-seq
MIRT907848	hsa-miR-451b	CLIP-seq
MIRT907850	hsa-miR-4684-5p	CLIP-seq
MIRT907851	hsa-miR-4696	CLIP-seq
MIRT907852	hsa-miR-4725-5p	CLIP-seq
MIRT907907	hsa-miR-4728-5p	CLIP-seq
MIRT907853	hsa-miR-4736	CLIP-seq
MIRT907854	hsa-miR-4763-3p	CLIP-seq
MIRT1969121	hsa-miR-4793-3p	CLIP-seq
MIRT907856	hsa-miR-4793-5p	CLIP-seq
MIRT907857	hsa-miR-4794	CLIP-seq
MIRT907858	hsa-miR-504	CLIP-seq
MIRT1969123	hsa-miR-508-5p	CLIP-seq
MIRT907869	hsa-miR-548c-3p	CLIP-seq
MIRT2447569	hsa-miR-555	CLIP-seq
MIRT1969125	hsa-miR-661	CLIP-seq
MIRT1969126	hsa-miR-766	CLIP-seq
MIRT907887	hsa-miR-940	CLIP-seq

Transcription factors

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Transcription factor	Regulation	Reference
ETS1	Unknown	10533284

Show/Hide all(49)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001618	Function	Virus receptor activity	IEA
GO:0001848	Function	Complement binding	IEA
GO:0001851	Function	Complement component C3b binding	IDA	2972794
GO:0001855	Function	Complement component C4b binding	IDA	2972794
GO:0001861	Function	Complement component C4b receptor activity	IDA	2972794
GO:0001970	Process	Positive regulation of activation of membrane attack complex	IMP	11981823
GO:0001971	Process	Negative regulation of activation of membrane attack complex	IDA	31862673
GO:0002376	Process	Immune system process	IEA
GO:0002430	Process	Complement receptor mediated signaling pathway	IDA	16360013, 22962438
GO:0002435	Process	Immune complex clearance by erythrocytes	IDA	24022490
GO:0002456	Process	T cell mediated immunity	IBA
GO:0002638	Process	Negative regulation of immunoglobulin production	IDA	22962438
GO:0004875	Function	Complement receptor activity	IEA
GO:0004877	Function	Complement component C3b receptor activity	IDA	2972794
GO:0005515	Function	Protein binding	IPI	18684861, 23460739, 29563915
GO:0005615	Component	Extracellular space	IBA
GO:0005856	Component	Cytoskeleton	IDA	18684861
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	6910481
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0006957	Process	Complement activation, alternative pathway	IEA
GO:0006957	Process	Complement activation, alternative pathway	IMP	11981823
GO:0006958	Process	Complement activation, classical pathway	IEA
GO:0007009	Process	Plasma membrane organization	IDA	24022490
GO:0008284	Process	Positive regulation of cell population proliferation	IDA	25742728
GO:0009986	Component	Cell surface	IDA	2972794, 6978375, 25742728
GO:0016020	Component	Membrane	IEA
GO:0030449	Process	Regulation of complement activation	IEA
GO:0030667	Component	Secretory granule membrane	TAS
GO:0032689	Process	Negative regulation of type II interferon production	IDA	16360013
GO:0032703	Process	Negative regulation of interleukin-2 production	IDA	16360013
GO:0042130	Process	Negative regulation of T cell proliferation	IDA	16360013
GO:0044853	Component	Plasma membrane raft	IDA	24022490
GO:0045087	Process	Innate immune response	IEA
GO:0045591	Process	Positive regulation of regulatory T cell differentiation	IDA	25742728
GO:0045916	Process	Negative regulation of complement activation	IDA	31862673
GO:0045957	Process	Negative regulation of complement activation, alternative pathway	IDA	10531307
GO:0045959	Process	Negative regulation of complement activation, classical pathway	IBA
GO:0045959	Process	Negative regulation of complement activation, classical pathway	IDA	6910481, 10531307
GO:0046718	Process	Symbiont entry into host cell	IEA
GO:0070062	Component	Extracellular exosome	HDA	19056867, 23533145
GO:0101003	Component	Ficolin-1-rich granule membrane	TAS
GO:1900004	Process	Negative regulation of serine-type endopeptidase activity	IDA	6910481
GO:1900005	Process	Positive regulation of serine-type endopeptidase activity	IDA	2972794
GO:1900099	Process	Negative regulation of plasma cell differentiation	IDA	22962438
GO:1903659	Process	Regulation of complement-dependent cytotoxicity	IEA
GO:1903660	Process	Negative regulation of complement-dependent cytotoxicity	IDA	31862673
GO:1904669	Process	ATP export	IDA	24022490

MIM	HGNC	e!Ensembl
120620	2334	ENSG00000203710

Protein

UniProt ID

P17927

Protein name

Complement receptor type 1 (C3b/C4b receptor) (CD antigen CD35)

Protein function

Membrane immune adherence receptor that plays a critical role in the capture and clearance of complement-opsonized pathogens by erythrocytes and monocytes/macrophages (PubMed:2963069). Mediates the binding by these cells of particles and immune

PDB

1GKG , 1GKN , 1PPQ , 2MCY , 2MCZ , 2Q7Z , 5FO9

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00084	Sushi	43 → 99	Sushi repeat (SCR repeat)	Domain
PF00084	Sushi	104 → 161	Sushi repeat (SCR repeat)	Domain
PF00084	Sushi	166 → 232	Sushi repeat (SCR repeat)	Domain
PF00084	Sushi	238 → 293	Sushi repeat (SCR repeat)	Domain
PF00084	Sushi	297 → 353	Sushi repeat (SCR repeat)	Domain
PF00084	Sushi	362 → 416	Sushi repeat (SCR repeat)	Domain
PF00084	Sushi	421 → 487	Sushi repeat (SCR repeat)	Domain
PF00084	Sushi	493 → 549	Sushi repeat (SCR repeat)	Domain
PF00084	Sushi	554 → 611	Sushi repeat (SCR repeat)	Domain
PF00084	Sushi	616 → 682	Sushi repeat (SCR repeat)	Domain
PF00084	Sushi	688 → 743	Sushi repeat (SCR repeat)	Domain
PF00084	Sushi	747 → 803	Sushi repeat (SCR repeat)	Domain
PF00084	Sushi	812 → 866	Sushi repeat (SCR repeat)	Domain
PF00084	Sushi	871 → 937	Sushi repeat (SCR repeat)	Domain
PF00084	Sushi	943 → 999	Sushi repeat (SCR repeat)	Domain
PF00084	Sushi	1004 → 1061	Sushi repeat (SCR repeat)	Domain
PF00084	Sushi	1066 → 1132	Sushi repeat (SCR repeat)	Domain
PF00084	Sushi	1138 → 1193	Sushi repeat (SCR repeat)	Domain
PF00084	Sushi	1197 → 1253	Sushi repeat (SCR repeat)	Domain
PF00084	Sushi	1260 → 1316	Sushi repeat (SCR repeat)	Domain
PF00084	Sushi	1321 → 1387	Sushi repeat (SCR repeat)	Domain
PF00084	Sushi	1396 → 1452	Sushi repeat (SCR repeat)	Domain
PF00084	Sushi	1457 → 1514	Sushi repeat (SCR repeat)	Domain
PF00084	Sushi	1519 → 1585	Sushi repeat (SCR repeat)	Domain
PF00084	Sushi	1591 → 1646	Sushi repeat (SCR repeat)	Domain
PF00084	Sushi	1650 → 1706	Sushi repeat (SCR repeat)	Domain
PF00084	Sushi	1713 → 1769	Sushi repeat (SCR repeat)	Domain
PF00084	Sushi	1774 → 1840	Sushi repeat (SCR repeat)	Domain
PF00084	Sushi	1848 → 1904	Sushi repeat (SCR repeat)	Domain
PF00084	Sushi	1910 → 1965	Sushi repeat (SCR repeat)	Domain

Tissue specificity

TISSUE SPECIFICITY: Present on erythrocytes, a subset of T cells, mature B cells, follicular dendritic cells, monocytes and granulocytes. {ECO:0000269|PubMed:1534036, ECO:0000269|PubMed:25742728, ECO:0000269|PubMed:6233222}.

Sequence

MGASSPRSPEPVGPPAPGLPFCCGGSLLAVVVLLALPVAWGQCNAPEWLPFARPTNLTDE
FEFPIGTYLNYECRPGYSGRPFSIICLKNSVWTGAKDRCRRKSCRNPPDPVNGMVHVIKG
IQFGSQIKYSCTKGYRLIGSSSATCIISGDTVIWDNETPICDRIPCGLPPTITNGDFIST
NRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTP
PNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVCQPP
PDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPTCEVKSCDD
FMGQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCEQIF
CPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVW
SSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRPEYYGRPFSITCLDNL
VWSSPKDVCKRKSCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAECILSGN
AAHWSTKPPICQRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGE
PSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGF
VMKGPRRVKCQALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGY
DLRGAASMRCTPQGDWSPAAPTCEVKSCDDFMGQLLNGRVLFPVNLQLGAKVDFVCDEGF
QLKGSSASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKAVNYTC
DPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNA
SDFPIGTSLKYECRPEYYGRPFSITCLDNLVWSSPKDVCKRKSCKTPPDPVNGMVHVITD
IQVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSTKPPICQRIPCGLPPTIANGDFIST
NRENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTP
PNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVCQPP
PEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAASLHCTPQGDWSPEAPRCAVKSCDD
FLGQLPHGRVLFPLNLQLGAKVSFVCDEGFRLKGSSVSHCVLVGMRSLWNNSVPVCEHIF
CPNPPAILNGRHTGTPSGDIPYGKEISYTCDPHPDRGMTFNLIGESTIRCTSDPHGNGVW
SSPAPRCELSVRAGHCKTPEQFPFASPTIPINDFEFPVGTSLNYECRPGYFGKMFSISCL
ENLVWSSVEDNCRRKSCGPPPEPFNGMVHINTDTQFGSTVNYSCNEGFRLIGSPSTTCLV
SGNNVTWDKKAPICEIISCEPPPTISNGDFYSNNRTSFHNGTVVTYQCHTGPDGEQLFEL
VGERSIYCTSKDDQVGVWSSPPPRCISTNKCTAPEVENAIRVPGNRSFFSLTEIIRFRCQ
PGFVMVGSHTVQCQTNGRWGPKLPHCSRVCQPPPEILHGEHTLSHQDNFSPGQEVFYSCE
PSYDLRGAASLHCTPQGDWSPEAPRCTVKSCDDFLGQLPHGRVLLPLNLQLGAKVSFVCD
EGFRLKGRSASHCVLAGMKALWNSSVPVCEQIFCPNPPAILNGRHTGTPFGDIPYGKEIS
YACDTHPDRGMTFNLIGESSIRCTSDPQGNGVWSSPAPRCELSVPAACPHPPKIQNGHYI
GGHVSLYLPGMTISYICDPGYLLVGKGFIFCTDQGIWSQLDHYCKEVNCSFPLFMNGISK
ELEMKKVYHYGDYVTLKCEDGYTLEGSPWSQCQADDRWDPPLAKCTSRTHDALIVGTLSG
TIFFILLIIFLSWIILKHRKGNNAHENPKEVAIHLHSQGGSSVHPRTLQTNEENSRVLP

Sequence length

2039

Interactions

View interactions

	KEGG		Reactome
	Complement and coagulation cascades Neutrophil extracellular trap formation Hematopoietic cell lineage Legionellosis Leishmaniasis Malaria Tuberculosis		Neutrophil degranulation RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) Regulation of Complement cascade

Show/Hide Unknown Diseases (2)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Alzheimer disease	Alzheimer's disease or family history of Alzheimer's disease	N/A	N/A	GWAS
Dementia	Dementia	N/A	N/A	GWAS

Show/Hide Text Mining Associations (130)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Achondroplasia and Swiss type agammaglobulinemia	Associate	17900300
Acquired Immunodeficiency Syndrome	Inhibit	2944915
Alzheimer Disease	Associate	19734903, 20209083, 20534741, 20554627, 20558387, 20697030, 20739100, 21220176, 21379329, 21391232, 21459483, 21912625, 22015308, 22262751, 22343410 View all (48 more)
Alzheimer Disease	Stimulate	23226438
Alzheimer Disease	Inhibit	29792870
Anemia	Associate	22761633
Anemia	Inhibit	30429373
Anemia Hemolytic	Associate	22405566
Arthritis Rheumatoid	Stimulate	10193433, 1575573
Arthritis Rheumatoid	Inhibit	20850384, 9472668
Arthritis Rheumatoid	Associate	2141558, 2158365, 24433281
Asthma	Stimulate	16600024
Atrial Fibrillation	Associate	32389013
Atypical Hemolytic Uremic Syndrome	Associate	25608561
Autoimmune Diseases	Associate	12519402, 2974768
Bacterial Infections	Associate	27644115
Brain Diseases	Associate	19734903, 23022416
Brain Neoplasms	Associate	26849056
Carcinogenesis	Associate	24621201
Carcinoma Hepatocellular	Associate	17291450
Carcinoma Non Small Cell Lung	Associate	24621201
Carcinoma Renal Cell	Associate	35955933
Cardiovascular Diseases	Associate	25600633, 28033544
Cerebral Amyloid Angiopathy	Associate	22262751, 36181103
Cerebral Hemorrhage	Associate	22262751, 30836997, 36181103
Cholecystitis	Associate	15526369
Cholecystolithiasis	Associate	15526369
Cholelithiasis	Associate	19906204
Cognition Disorders	Associate	21391232, 22343410, 22952074, 29212848
Cognition Disorders	Stimulate	23226438
Cognitive Dysfunction	Associate	22343410
Colonic Neoplasms	Associate	17291450
Colorectal Neoplasms	Associate	17291450
Communication Disorders	Associate	16433910
Coronary Artery Disease	Associate	28033544, 31555286
COVID 19	Associate	34022670
Cystic Fibrosis	Associate	10853863
Dementia	Associate	21297263, 23226438, 24438528, 36191742
Dendritic Cell Sarcoma Follicular	Associate	28145886
Diabetes Mellitus Type 1	Inhibit	1352745
Disease	Associate	24438528
dopamine beta hydroxylase deficiency	Associate	15381816
Down Syndrome	Associate	24438528
Enterocolitis Neutropenic	Associate	1532753
Epileptic Syndromes	Associate	26471127
Fabry Disease	Inhibit	26844958
Frontotemporal Dementia	Associate	32941707
Gallbladder Neoplasms	Associate	15526369, 19906204
Glomerulonephritis	Associate	12519402, 8080606
Glomerulonephritis IGA	Inhibit	20495534
Glomerulonephritis Membranoproliferative	Associate	7743666
Glomerulonephritis Membranous	Inhibit	11135068
Glomerulosclerosis Focal Segmental	Inhibit	11135068
Glucosephosphate Dehydrogenase Deficiency	Associate	26448013
Glycogen Storage Disease Type II	Associate	25214719
Graft vs Host Disease	Associate	20018869
Gray Platelet Syndrome	Associate	28707765
Hemochromatosis	Associate	2899464
Hemoglobinuria Paroxysmal	Associate	2185273, 24038027
HIV Infections	Associate	31772057, 8918576, 9010253
Hypertension	Inhibit	2958187
Immune Complex Diseases	Associate	11495296
Immunologic Deficiency Syndromes	Associate	30333829
Immunologic Deficiency Syndromes	Inhibit	4019777
Infections	Stimulate	20646210
Infections	Associate	23416052, 8461467
Inflammation	Associate	28033544, 30092084
Inflammation	Inhibit	31824479, 36572751
Kidney Diseases	Associate	11135068, 9161700
Leprosy	Associate	15381816, 30092084, 3159807
Leprosy Lepromatous	Associate	3159807
Leprosy Paucibacillary	Associate	30092084
Leprosy Tuberculoid	Associate	3159807
Leukemia Lymphocytic Chronic B Cell	Associate	6949607, 9885225
Leukemia Myeloid	Associate	23416052, 3118989
Leukemia Myeloid Acute	Inhibit	2158365
Leukemia Myeloid Acute	Associate	34619772
Leukemia Promyelocytic Acute	Associate	32847610
Lewy Body Disease	Associate	38527854
Liver Cirrhosis	Associate	12519402
Liver Diseases	Associate	12235086
Liver Neoplasms	Associate	32941707
Lung Neoplasms	Associate	24621201
Lupus Erythematosus Systemic	Associate	10594568, 12519402, 12667215, 1352746, 1531948, 15529364, 22761633, 27981054, 2937582, 2958190, 2974768, 4019777, 6230413, 9161700
Lupus Erythematosus Systemic	Inhibit	1685310, 2955969, 2958187, 3987091, 7621593
Lupus Nephritis	Inhibit	11135068
Lymphatic Diseases	Inhibit	2944915
Lymphoma	Associate	19466261
Lymphoma B Cell Marginal Zone	Associate	19466261
Lymphoma Follicular	Stimulate	12028024
Lymphoma Follicular	Associate	26700650
Lymphoma Large B Cell Diffuse	Stimulate	19466261
Lymphoma Large B Cell Diffuse	Inhibit	2158365
Lymphoma Mantle Cell	Associate	19466261
Lymphoma Non Hodgkin	Associate	2943542
Malaria	Associate	15578041, 16277654, 23614351, 26448013, 26844958, 29690995, 36626386
Malaria Cerebral	Associate	15578041, 36626386
Malaria Falciparum	Associate	20889874
Malaria Vivax	Inhibit	30429373
Mastocytosis Systemic	Associate	12542483, 25171703, 9531582
Melanoma	Associate	9182821
Mouth Diseases	Associate	28707765
Mucocutaneous Lymph Node Syndrome	Associate	34895171
Multiple Myeloma	Associate	12519402
Multiple Sclerosis	Associate	12519402
Myocardial Infarction	Associate	28033544
Myocardial Infarction	Stimulate	32389013
Nasopharyngeal Carcinoma	Associate	23464487
Neoplasms	Associate	17076538, 17291450, 19883432, 32034058
Nephritis	Inhibit	11135068
Nephrosis Lipoid	Associate	11135068
Neurodegenerative Diseases	Associate	25600633
Neuroinflammatory Diseases	Associate	30836997
Parkinson Disease	Associate	21912625, 37108258, 39667505
Pemphigus and fogo selvagem	Associate	31824479
Plaque Amyloid	Associate	19734903, 21391232, 22262751, 22343410, 23022416, 30044434
Pneumonia	Associate	16433910
Pneumonia Bacterial	Associate	16433910
Pneumonia Pneumococcal	Stimulate	16433910
Precursor T Cell Lymphoblastic Leukemia Lymphoma	Associate	18410450
Pulmonary Embolism	Associate	23726092
Retinal Drusen	Associate	25214719
Rheumatoid Vasculitis	Inhibit	2141558
Sarcoidosis	Associate	37298666
Scleroderma Diffuse	Inhibit	39273179
Severe Acute Respiratory Syndrome	Associate	15606620
Small Cell Lung Carcinoma	Inhibit	2158365
Stomach Neoplasms	Associate	32034058
Tuberculosis	Associate	15381817, 33328540, 37298666
Virus Diseases	Associate	16433910

CR1 (complement C3b/C4b receptor 1 (Knops blood group))