ABRA (actin binding Rho activating protein)

Gene

• Entrez ID: 137735
• Gene name: Actin binding Rho activating protein
• Gene symbol: ABRA
• Synonyms (NCBI Gene): STARS
• Chromosome: 8
• Chromosome location: 8q23.1

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT761055	hsa-miR-1304	CLIP-seq
MIRT761056	hsa-miR-216a	CLIP-seq
MIRT761057	hsa-miR-2964a-3p	CLIP-seq
MIRT761058	hsa-miR-33a	CLIP-seq
MIRT761059	hsa-miR-33b	CLIP-seq
MIRT761060	hsa-miR-342-3p	CLIP-seq
MIRT761061	hsa-miR-3614-5p	CLIP-seq
MIRT761062	hsa-miR-3689a-3p	CLIP-seq
MIRT761063	hsa-miR-3689c	CLIP-seq
MIRT761064	hsa-miR-3929	CLIP-seq
MIRT761065	hsa-miR-4419b	CLIP-seq
MIRT761066	hsa-miR-4478	CLIP-seq
MIRT761067	hsa-miR-4712-5p	CLIP-seq
MIRT761068	hsa-miR-4728-5p	CLIP-seq
MIRT761069	hsa-miR-4797-5p	CLIP-seq
MIRT761070	hsa-miR-485-5p	CLIP-seq
MIRT761071	hsa-miR-579	CLIP-seq
MIRT761072	hsa-miR-770-5p	CLIP-seq
MIRT761073	hsa-miR-890	CLIP-seq
MIRT761061	hsa-miR-3614-5p	CLIP-seq
MIRT1924428	hsa-miR-4795-3p	CLIP-seq
MIRT2165652	hsa-miR-1290	CLIP-seq
MIRT2165653	hsa-miR-200b	CLIP-seq
MIRT2165654	hsa-miR-200c	CLIP-seq
MIRT761061	hsa-miR-3614-5p	CLIP-seq
MIRT761062	hsa-miR-3689a-3p	CLIP-seq
MIRT761063	hsa-miR-3689c	CLIP-seq
MIRT761064	hsa-miR-3929	CLIP-seq
MIRT2165655	hsa-miR-4263	CLIP-seq
MIRT2165656	hsa-miR-429	CLIP-seq
MIRT761065	hsa-miR-4419b	CLIP-seq
MIRT761066	hsa-miR-4478	CLIP-seq
MIRT2165657	hsa-miR-4666-5p	CLIP-seq
MIRT2165658	hsa-miR-4724-5p	CLIP-seq
MIRT761068	hsa-miR-4728-5p	CLIP-seq
MIRT761070	hsa-miR-485-5p	CLIP-seq
MIRT2165659	hsa-miR-543	CLIP-seq
MIRT2165660	hsa-miR-576-5p	CLIP-seq
MIRT761073	hsa-miR-890	CLIP-seq
MIRT761062	hsa-miR-3689a-3p	CLIP-seq
MIRT761063	hsa-miR-3689c	CLIP-seq
MIRT761064	hsa-miR-3929	CLIP-seq
MIRT761065	hsa-miR-4419b	CLIP-seq
MIRT761066	hsa-miR-4478	CLIP-seq
MIRT2165657	hsa-miR-4666-5p	CLIP-seq
MIRT761068	hsa-miR-4728-5p	CLIP-seq
MIRT761070	hsa-miR-485-5p	CLIP-seq
MIRT761073	hsa-miR-890	CLIP-seq
MIRT2442979	hsa-miR-1243	CLIP-seq
MIRT2442980	hsa-miR-1323	CLIP-seq
MIRT2442981	hsa-miR-3120-5p	CLIP-seq
MIRT2442982	hsa-miR-3123	CLIP-seq
MIRT2442983	hsa-miR-3654	CLIP-seq
MIRT2442984	hsa-miR-371-5p	CLIP-seq
MIRT2442985	hsa-miR-371b-5p	CLIP-seq
MIRT2442986	hsa-miR-4261	CLIP-seq
MIRT2442987	hsa-miR-4680-5p	CLIP-seq
MIRT2442988	hsa-miR-548o	CLIP-seq
MIRT2442989	hsa-miR-550b	CLIP-seq
MIRT2442990	hsa-miR-649	CLIP-seq
MIRT2442991	hsa-miR-875-3p	CLIP-seq
MIRT2468181	hsa-miR-1178	CLIP-seq
MIRT2442980	hsa-miR-1323	CLIP-seq
MIRT2468182	hsa-miR-197	CLIP-seq
MIRT2442981	hsa-miR-3120-5p	CLIP-seq
MIRT2442982	hsa-miR-3123	CLIP-seq
MIRT761062	hsa-miR-3689a-3p	CLIP-seq
MIRT761063	hsa-miR-3689c	CLIP-seq
MIRT2442984	hsa-miR-371-5p	CLIP-seq
MIRT2442985	hsa-miR-371b-5p	CLIP-seq
MIRT761064	hsa-miR-3929	CLIP-seq
MIRT761065	hsa-miR-4419b	CLIP-seq
MIRT761066	hsa-miR-4478	CLIP-seq
MIRT761068	hsa-miR-4728-5p	CLIP-seq
MIRT2468183	hsa-miR-4760-3p	CLIP-seq
MIRT2468184	hsa-miR-4762-5p	CLIP-seq
MIRT761070	hsa-miR-485-5p	CLIP-seq
MIRT2442988	hsa-miR-548o	CLIP-seq
MIRT761073	hsa-miR-890	CLIP-seq
MIRT2468181	hsa-miR-1178	CLIP-seq
MIRT2442980	hsa-miR-1323	CLIP-seq
MIRT2468182	hsa-miR-197	CLIP-seq
MIRT2442981	hsa-miR-3120-5p	CLIP-seq
MIRT2442982	hsa-miR-3123	CLIP-seq
MIRT761062	hsa-miR-3689a-3p	CLIP-seq
MIRT761063	hsa-miR-3689c	CLIP-seq
MIRT2442984	hsa-miR-371-5p	CLIP-seq
MIRT2442985	hsa-miR-371b-5p	CLIP-seq
MIRT761064	hsa-miR-3929	CLIP-seq
MIRT761065	hsa-miR-4419b	CLIP-seq
MIRT761066	hsa-miR-4478	CLIP-seq
MIRT761068	hsa-miR-4728-5p	CLIP-seq
MIRT2468183	hsa-miR-4760-3p	CLIP-seq
MIRT2468184	hsa-miR-4762-5p	CLIP-seq
MIRT761070	hsa-miR-485-5p	CLIP-seq
MIRT2442988	hsa-miR-548o	CLIP-seq
MIRT761073	hsa-miR-890	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003779	Function	Actin binding	IEA
GO:0003779	Function	Actin binding	ISS
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005737	Component	Cytoplasm	IEA
GO:0005856	Component	Cytoskeleton	IEA
GO:0005886	Component	Plasma membrane	IDA
GO:0006366	Process	Transcription by RNA polymerase II	IEA
GO:0006606	Process	Protein import into nucleus	IEA
GO:0015031	Process	Protein transport	IEA
GO:0015629	Component	Actin cytoskeleton	IEA
GO:0015629	Component	Actin cytoskeleton	ISS
GO:0030016	Component	Myofibril	IEA
GO:0030017	Component	Sarcomere	IBA
GO:0030017	Component	Sarcomere	IEA
GO:0030017	Component	Sarcomere	ISS
GO:0030036	Process	Actin cytoskeleton organization	IEA
GO:0030036	Process	Actin cytoskeleton organization	ISS
GO:0035025	Process	Positive regulation of Rho protein signal transduction	IBA
GO:0035025	Process	Positive regulation of Rho protein signal transduction	IEA
GO:0035025	Process	Positive regulation of Rho protein signal transduction	ISS
GO:0045893	Process	Positive regulation of DNA-templated transcription	IEA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IBA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IEA

Other IDs

• MIM: 609747
• HGNC: 30655
• e!Ensembl: ENSG00000174429

Protein

• UniProt ID: Q8N0Z2
• Protein name: Actin-binding Rho-activating protein (Striated muscle activator of Rho-dependent signaling) (STARS)
• Protein function: Acts as an activator of serum response factor (SRF)-dependent transcription possibly by inducing nuclear translocation of MKL1 or MKL2 and through a mechanism requiring Rho-actin signaling.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF14705	Costars	305 → 380	Costars	Domain

• Sequence:

  MAPGEKESGEGPAKSALRKIRTATLVISLARGWQQWANENSIRQAQEPTGWLPGGTQDSP
  QAPKPITPPTSHQKAQSAPKSPPRLPEGHGDGQSSEKAPEVSHIKKKEVSKTVVSKTYER
  GGDVSHLSHRYERDAGVLEPGQPENDIDRILHSHGSPTRRRKCANLVSELTKGWRVMEQE
  EPTWRSDSVDTEDSGYGGEAEERPEQDGVQVAVVRIKRPLPSQVNRFTEKLNCKAQQKYS
  PVGNLKGRWQQWADEHIQSQKLNPFSEEFDYELAMSTRLHKGDEGYGRPKEGTKTAERAK
  RAEEHIYREMMDMCFIICTMARHRRDGKIQVTFGDLFDRYVRISDKVVGILMRARKHGLV
  DFEGEMLWQGRDDHVVITLLK

• Sequence length: 381