ABRA (actin binding Rho activating protein)

Gene

• Entrez ID: 137735
• Gene name: Actin binding Rho activating protein
• Gene symbol: ABRA
• Synonyms (NCBI Gene): STARS
• Chromosome: 8
• Chromosome location: 8q23.1

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT761055	hsa-miR-1304	CLIP-seq
MIRT761056	hsa-miR-216a	CLIP-seq
MIRT761057	hsa-miR-2964a-3p	CLIP-seq
MIRT761058	hsa-miR-33a	CLIP-seq
MIRT761059	hsa-miR-33b	CLIP-seq
MIRT761060	hsa-miR-342-3p	CLIP-seq
MIRT761061	hsa-miR-3614-5p	CLIP-seq
MIRT761062	hsa-miR-3689a-3p	CLIP-seq
MIRT761063	hsa-miR-3689c	CLIP-seq
MIRT761064	hsa-miR-3929	CLIP-seq
MIRT761065	hsa-miR-4419b	CLIP-seq
MIRT761066	hsa-miR-4478	CLIP-seq
MIRT761067	hsa-miR-4712-5p	CLIP-seq
MIRT761068	hsa-miR-4728-5p	CLIP-seq
MIRT761069	hsa-miR-4797-5p	CLIP-seq
MIRT761070	hsa-miR-485-5p	CLIP-seq
MIRT761071	hsa-miR-579	CLIP-seq
MIRT761072	hsa-miR-770-5p	CLIP-seq
MIRT761073	hsa-miR-890	CLIP-seq
MIRT761061	hsa-miR-3614-5p	CLIP-seq
MIRT1924428	hsa-miR-4795-3p	CLIP-seq
MIRT2165652	hsa-miR-1290	CLIP-seq
MIRT2165653	hsa-miR-200b	CLIP-seq
MIRT2165654	hsa-miR-200c	CLIP-seq
MIRT761061	hsa-miR-3614-5p	CLIP-seq
MIRT761062	hsa-miR-3689a-3p	CLIP-seq
MIRT761063	hsa-miR-3689c	CLIP-seq
MIRT761064	hsa-miR-3929	CLIP-seq
MIRT2165655	hsa-miR-4263	CLIP-seq
MIRT2165656	hsa-miR-429	CLIP-seq
MIRT761065	hsa-miR-4419b	CLIP-seq
MIRT761066	hsa-miR-4478	CLIP-seq
MIRT2165657	hsa-miR-4666-5p	CLIP-seq
MIRT2165658	hsa-miR-4724-5p	CLIP-seq
MIRT761068	hsa-miR-4728-5p	CLIP-seq
MIRT761070	hsa-miR-485-5p	CLIP-seq
MIRT2165659	hsa-miR-543	CLIP-seq
MIRT2165660	hsa-miR-576-5p	CLIP-seq
MIRT761073	hsa-miR-890	CLIP-seq
MIRT761062	hsa-miR-3689a-3p	CLIP-seq
MIRT761063	hsa-miR-3689c	CLIP-seq
MIRT761064	hsa-miR-3929	CLIP-seq
MIRT761065	hsa-miR-4419b	CLIP-seq
MIRT761066	hsa-miR-4478	CLIP-seq
MIRT2165657	hsa-miR-4666-5p	CLIP-seq
MIRT761068	hsa-miR-4728-5p	CLIP-seq
MIRT761070	hsa-miR-485-5p	CLIP-seq
MIRT761073	hsa-miR-890	CLIP-seq
MIRT2442979	hsa-miR-1243	CLIP-seq
MIRT2442980	hsa-miR-1323	CLIP-seq
MIRT2442981	hsa-miR-3120-5p	CLIP-seq
MIRT2442982	hsa-miR-3123	CLIP-seq
MIRT2442983	hsa-miR-3654	CLIP-seq
MIRT2442984	hsa-miR-371-5p	CLIP-seq
MIRT2442985	hsa-miR-371b-5p	CLIP-seq
MIRT2442986	hsa-miR-4261	CLIP-seq
MIRT2442987	hsa-miR-4680-5p	CLIP-seq
MIRT2442988	hsa-miR-548o	CLIP-seq
MIRT2442989	hsa-miR-550b	CLIP-seq
MIRT2442990	hsa-miR-649	CLIP-seq
MIRT2442991	hsa-miR-875-3p	CLIP-seq
MIRT2468181	hsa-miR-1178	CLIP-seq
MIRT2442980	hsa-miR-1323	CLIP-seq
MIRT2468182	hsa-miR-197	CLIP-seq
MIRT2442981	hsa-miR-3120-5p	CLIP-seq
MIRT2442982	hsa-miR-3123	CLIP-seq
MIRT761062	hsa-miR-3689a-3p	CLIP-seq
MIRT761063	hsa-miR-3689c	CLIP-seq
MIRT2442984	hsa-miR-371-5p	CLIP-seq
MIRT2442985	hsa-miR-371b-5p	CLIP-seq
MIRT761064	hsa-miR-3929	CLIP-seq
MIRT761065	hsa-miR-4419b	CLIP-seq
MIRT761066	hsa-miR-4478	CLIP-seq
MIRT761068	hsa-miR-4728-5p	CLIP-seq
MIRT2468183	hsa-miR-4760-3p	CLIP-seq
MIRT2468184	hsa-miR-4762-5p	CLIP-seq
MIRT761070	hsa-miR-485-5p	CLIP-seq
MIRT2442988	hsa-miR-548o	CLIP-seq
MIRT761073	hsa-miR-890	CLIP-seq
MIRT2468181	hsa-miR-1178	CLIP-seq
MIRT2442980	hsa-miR-1323	CLIP-seq
MIRT2468182	hsa-miR-197	CLIP-seq
MIRT2442981	hsa-miR-3120-5p	CLIP-seq
MIRT2442982	hsa-miR-3123	CLIP-seq
MIRT761062	hsa-miR-3689a-3p	CLIP-seq
MIRT761063	hsa-miR-3689c	CLIP-seq
MIRT2442984	hsa-miR-371-5p	CLIP-seq
MIRT2442985	hsa-miR-371b-5p	CLIP-seq
MIRT761064	hsa-miR-3929	CLIP-seq
MIRT761065	hsa-miR-4419b	CLIP-seq
MIRT761066	hsa-miR-4478	CLIP-seq
MIRT761068	hsa-miR-4728-5p	CLIP-seq
MIRT2468183	hsa-miR-4760-3p	CLIP-seq
MIRT2468184	hsa-miR-4762-5p	CLIP-seq
MIRT761070	hsa-miR-485-5p	CLIP-seq
MIRT2442988	hsa-miR-548o	CLIP-seq
MIRT761073	hsa-miR-890	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003779	Function	Actin binding	ISS
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005886	Component	Plasma membrane	IDA
GO:0006606	Process	Protein import into nucleus	IEA
GO:0015629	Component	Actin cytoskeleton	ISS
GO:0030017	Component	Sarcomere	IBA	21873635
GO:0030017	Component	Sarcomere	ISS
GO:0035025	Process	Positive regulation of Rho protein signal transduction	IBA	21873635
GO:0035025	Process	Positive regulation of Rho protein signal transduction	ISS
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IBA	21873635
GO:0051091	Process	Positive regulation of DNA-binding transcription factor activity	IBA	21873635
GO:0051091	Process	Positive regulation of DNA-binding transcription factor activity	ISS

Other IDs

• MIM: 609747
• HGNC: 30655
• e!Ensembl: ENSG00000174429

Protein

• UniProt ID: Q8N0Z2
• Protein name: Actin-binding Rho-activating protein (Striated muscle activator of Rho-dependent signaling) (STARS)
• Protein function: Acts as an activator of serum response factor (SRF)-dependent transcription possibly by inducing nuclear translocation of MKL1 or MKL2 and through a mechanism requiring Rho-actin signaling.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF14705	Costars	305 → 380	Costars	Domain

• Sequence:

  MAPGEKESGEGPAKSALRKIRTATLVISLARGWQQWANENSIRQAQEPTGWLPGGTQDSP
  QAPKPITPPTSHQKAQSAPKSPPRLPEGHGDGQSSEKAPEVSHIKKKEVSKTVVSKTYER
  GGDVSHLSHRYERDAGVLEPGQPENDIDRILHSHGSPTRRRKCANLVSELTKGWRVMEQE
  EPTWRSDSVDTEDSGYGGEAEERPEQDGVQVAVVRIKRPLPSQVNRFTEKLNCKAQQKYS
  PVGNLKGRWQQWADEHIQSQKLNPFSEEFDYELAMSTRLHKGDEGYGRPKEGTKTAERAK
  RAEEHIYREMMDMCFIICTMARHRRDGKIQVTFGDLFDRYVRISDKVVGILMRARKHGLV
  DFEGEMLWQGRDDHVVITLLK

• Sequence length: 381

Associated diseases

Causal
Disease term	Disease name	dbSNP ID	References
Cardiomyopathy	Cardiomyopathy, Dilated, Cardiomyopathy, Familial Idiopathic	rs267607003, rs267607002, rs267607004, rs63750743, rs121908333, rs121908334, rs104894655, rs121434420, rs121434421, rs193922674, rs111517471, rs121908987, rs193922384, rs121909374, rs121909377, rs2856655, rs587776700, rs387906397, rs137854607, rs28935197, rs199473684, rs121964858, rs74315379, rs74315380, rs104894724, rs104894727, rs104894728, rs104894729, rs104894730, rs121917760, rs267607125, rs104894503, rs267607155, rs267607156, rs121918597, rs121918600, rs28933979, rs121918070, rs76992529, rs111033559, rs111033560, rs104894368, rs104894369, rs104894370, rs121913624, rs3218713, rs121913625, rs121913626, rs121913627, rs121913628, rs121913629, rs121913630, rs121913631, rs121913632, rs3218714, rs121913637, rs121913638, rs121913641, rs121913642, rs121913651, rs267606911, rs267606908, rs730880850, rs61046466, rs57520892, rs28933091, rs28933092, rs28933093, rs121913008, rs121913003, rs121912996, rs121912997, rs193922680, rs387906875, rs199474703, rs199476315, rs199476316, rs199476317, rs199476321, rs199476311, rs193922683, rs193922668, rs386134243, rs267607578, rs36211723, rs193922390, rs193922672, rs193922697, rs387907267, rs45546039, rs387907218, rs397515870, rs397515893, rs397515894, rs397515903, rs397515905, rs375882485, rs397515907, rs397515912, rs397515916, rs397515925, rs397515926, rs397515934, rs397515937, rs397515943, rs397515944, rs397515947, rs397515954, rs112738974, rs111729952, rs397515960, rs397515963, rs397515973, rs397515974, rs397515977, rs376395543, rs397515979, rs397515982, rs397515990, rs397515991, rs397515992, rs397516005, rs113358486, rs397516006, rs397516007, rs397516008, rs373746463, rs397516019, rs397516023, rs397516029, rs397516031, rs397516037, rs397516040, rs397516042, rs397516044, rs397516049, rs397516057, rs397516059, rs397516068, rs397516070, rs397516072, rs397516073, rs397516074, rs397516076, rs397516077, rs397516080, rs397516082, rs397516083, rs397516088, rs397516089, rs397516103, rs397516123, rs397516127, rs371898076, rs397516132, rs397516142, rs3218716, rs397516154, rs397516161, rs397516165, rs397516170, rs397516178, rs397516179, rs397516187, rs397516201, rs397516202, rs145213771, rs397516207, rs397516209, rs397516212, rs397516248, rs397516252, rs397516254, rs397516258, rs397516260, rs45516091, rs397516264, rs397516269, rs397516347, rs397516349, rs397516352, rs397516353, rs397516355, rs397516356, rs397516357, rs397516364, rs397516370, rs397516371, rs397516373, rs397516386, rs397516406, rs397516454, rs397516456, rs397516461, rs397516463, rs397516464, rs45525839, rs397516471, rs45578238, rs111377893, rs397516607, rs62636495, rs397516784, rs397516881, rs397516913, rs397516915, rs397516927, rs397516940, rs397516943, rs397516945, rs397516955, rs397516956, rs397516973, rs397516986, rs397516989, rs372827156, rs397516992, rs397516993, rs397516994, rs397516997, rs397517003, rs397517008, rs397517010, rs397517012, rs397517021, rs397517065, rs397517547, rs397517576, rs397517580, rs397517584, rs397517586, rs397517587, rs397517589, rs397517601, rs397517620, rs397517624, rs397517626, rs397517628, rs72646831, rs397517633, rs397517643, rs72646846, rs397517664, rs397517679, rs397517689, rs397517695, rs397517696, rs397517698, rs397517721, rs397517735, rs397517741, rs397517749, rs397517750, rs397517758, rs397517776, rs397517787, rs397517830, rs397517887, rs397517888, rs397517889, rs58013325, rs397517895, rs56984562, rs267607646, rs58917027, rs267607594, rs397517904, rs61195471, rs60682848, rs267607573, rs397517908, rs58978449, rs397517909, rs267607593, rs397517911, rs56816490, rs397517915, rs267607554, rs397514742, rs886041395, rs397515482, rs267607490, rs58999456, rs267607555, rs61672878, rs267607618, rs267607577, rs57730570, rs267607582, rs267607581, rs61444459, rs59270054, rs61661343, rs267607570, rs59026483, rs267607571, rs59332535, rs199473161, rs398123262, rs869320740, rs606231324, rs587782927, rs201754030, rs58389804, rs587782958, rs587782961, rs587782962, rs587782986, rs138049878, rs376897125, rs368765949, rs111569862, rs727504247, rs727503537, rs727504535, rs727504550, rs727504679, rs727503546, rs730880365, rs727504646, rs727505014, rs727505288, rs727503557, rs727503559, rs730880343, rs727503615, rs727504825, rs727503565, rs727504655, rs727505352, rs727504466, rs727504531, rs727503567, rs371678190, rs727503586, rs727505319, rs727503547, rs727505076, rs727505224, rs727503552, rs727504856, rs727504782, rs727504660, rs557312035, rs727505284, rs727504851, rs727504589, rs727504499, rs727504843, rs727504452, rs727503697, rs150974575, rs727504498, rs727503598, rs727503602, rs727503607, rs727504801, rs727504738, rs727505115, rs727505283, rs727505109, rs727504271, rs727504321, rs727504289, rs727503172, rs727503180, rs727503182, rs727504265, rs727504334, rs727503192, rs397515932, rs727504287, rs200411226, rs727503204, rs727504269, rs367947846, rs730880335, rs727502897, rs727503166, rs111683277, rs727503195, rs727503203, rs727503212, rs727503738, rs727504381, rs727504356, rs727503261, rs727504238, rs148808089, rs45544633, rs727503246, rs397516171, rs727503253, rs202141173, rs727504310, rs727503258, rs727503260, rs727504320, rs727504240, rs727503263, rs727503269, rs727503278, rs727504432, rs727504243, rs727504285, rs727503499, rs727503504, rs727504242, rs727504379, rs727504389, rs727504275, rs727504557, rs727502994, rs727504184, rs730880336, rs730880362, rs730880199, rs730880246, rs72648265, rs730880243, rs730880242, rs730880241, rs574660186, rs730880245, rs730880082, rs730880092, rs730880093, rs730880055, rs397515939, rs730881119, rs397516020, rs730880675, rs730880719, rs730880672, rs730880671, rs730880718, rs730880666, rs730880717, rs730880655, rs730880715, rs730880654, rs730880714, rs730880651, rs730880648, rs730880713, rs730880546, rs730880695, rs730880533, rs730880531, rs730880639, rs730880689, rs730880686, rs730880629, rs368121566, rs375607980, rs730880704, rs730880698, rs730880750, rs730880748, rs730880875, rs730880845, rs1565623093, rs786204339, rs786204336, rs786204392, rs786204388, rs786204950, rs786204951, rs794727381, rs760576804, rs112188483, rs794728597, rs794728606, rs794728593, rs59564495, rs190140598, rs794728826, rs794728803, rs794728106, rs149701627, rs1554108152, rs770873593, rs794728124, rs141026028, rs794728094, rs794729098, rs794729116, rs764817683, rs751288871, rs201405287, rs794729137, rs794729133, rs766209297, rs767987619, rs769220833, rs794729120, rs112240298, rs748382770, rs794729365, rs794729301, rs757451467, rs794729359, rs794729354, rs794729353, rs794729285, rs794729284, rs794729338, rs794729332, rs368452607, rs794729278, rs794729325, rs794729324, rs754866489, rs794729265, rs751502842, rs794729320, rs794729380, rs748313513, rs797046064, rs863225113, rs863225106, rs761507504, rs864622224, rs1057515421, rs751039219, rs869025555, rs869025546, rs869025554, rs869025559, rs869025545, rs869025558, rs869025557, rs200797552, rs869025550, rs869025549, rs869025544, rs869025552, rs869025548, rs869025556, rs770029258, rs869025523, rs869025398, rs869025399, rs869025395, rs869025365, rs869025469, rs869025483, rs749838192, rs869312028, rs869312037, rs869312038, rs869312039, rs869312040, rs869312041, rs869312042, rs869312044, rs869312046, rs373040154, rs869312047, rs869312048, rs869312049, rs869312050, rs869312051, rs869312052, rs869312054, rs869312055, rs777602537, rs869312056, rs869312057, rs869312058, rs869312059, rs869312060, rs770038577, rs869312061, rs869312062, rs869312063, rs869312064, rs869312065, rs869312066, rs869312067, rs869312068, rs869312069, rs771562210, rs869312070, rs869312071, rs759231562, rs869312072, rs869312073, rs764243269, rs768345594, rs869312074, rs869312075, rs869312076, rs869312077, rs869312078, rs869312079, rs869312080, rs772121356, rs869312081, rs869312082, rs72648250, rs869312083, rs869312084, rs869312085, rs869312086, rs869312087, rs869312100, rs779129892, rs756367933, rs869312102, rs869312103, rs869312104, rs869312105, rs869312106, rs770767998, rs869312107, rs775186117, rs869312108, rs869312109, rs869312110, rs869312111, rs755261062, rs869312112, rs763824247, rs869312113, rs869312114, rs869312115, rs869312116, rs774604740, rs869312117, rs779996703, rs869312118, rs869312119, rs869312120, rs869312121, rs869312122, rs869312045, rs753948675, rs878854371, rs794728589, rs876657650, rs727503512, rs876658027, rs876657672, rs876657671, rs868494032, rs876657670, rs780512337, rs876657669, rs876657668, rs876657666, rs876657665, rs876657664, rs876657663, rs148894066, rs876657634, rs869248137, rs876657705, rs876657704, rs727503213, rs869025496, rs876657662, rs876657884, rs36211715, rs878855234, rs879255521, rs879255639, rs886038928, rs751746401, rs886039030, rs869038795, rs886039343, rs2069544, rs1114167341, rs1114167340, rs886041322, rs886042331, rs886043718, rs747662439, rs886043924, rs773840992, rs886044536, rs1057517903, rs754354190, rs779650200, rs902082118, rs1057518920, rs1057519457, rs1057523045, rs370072439, rs1064792916, rs1060500495, rs1060500575, rs926741242, rs774763657, rs746877365, rs1060500610, rs1060501484, rs1060501479, rs1064792928, rs1060501443, rs1060499604, rs1064793814, rs1064796347, rs977277400, rs1064793429, rs745811346, rs1064794350, rs1555142963, rs1064793983, rs769665204, rs751261054, rs769139957, rs1131691873, rs1131691655, rs1131691673, rs1464253797, rs1408345511, rs1553603152, rs1554398705, rs1322596650, rs1553539995, rs1553611989, rs749961489, rs1444727212, rs1243301263, rs971618751, rs1553662326, rs1389777522, rs764985774, rs1554108287, rs1554105911, rs1249913357, rs1554108012, rs111806457, rs1402879259, rs748416758, rs794727046, rs1425855043, rs869178171, rs1432810664, rs749465164, rs878898365, rs1419374180, rs770878165, rs1553503113, rs1553691320, rs1553577362, rs1553603456, rs1417036453, rs1553741321, rs1553479603, rs1553607425, rs974671846, rs1420159591, rs745688425, rs1554875409, rs1555144459, rs1555338080, rs1555338574, rs1555148035, rs200889953, rs1401116572, rs1285329277, rs974510652, rs1263987728, rs1555122928, rs992189342, rs1555142971, rs1553261855, rs1553265647, rs1553488049, rs1553644307, rs1553663867, rs1553940122, rs28763965, rs758891557, rs762110595, rs1555436118, rs1555435531, rs565910322, rs376766195, rs1562168768, rs763443331, rs1562169661, rs1370579526, rs1561703922, rs1564773559, rs1559003939, rs1559598775, rs1559415567, rs1559877046, rs776970935, rs553526525, rs1561698362, rs1561694696, rs1561702640, rs730880751, rs1060505018, rs766330686, rs1565631430, rs1565050320, rs876657767, rs1565053085, rs1565053147, rs1557778277, rs1557776329, rs886039136, rs771262904, rs727504314, rs1563000044, rs541612157, rs766265889, rs1558988204, rs1559051231, rs1559262463, rs1559448864, rs1559469421, rs1559556267, rs1559746821, rs1559873786, rs1561323791, rs1561445221, rs1561686893, rs1561698714, rs1561702549, rs1565623439, rs1565623713, rs1565626367, rs1565627110, rs1565627145, rs397515889, rs1565628520, rs774316050, rs1592798444, rs1565590309, rs1566967399, rs1569552936, rs1559712733, rs1561690319, rs1561701721, rs869125101, rs1595843553, rs1576018303, rs746115846, rs777315336, rs1431206462, rs1572358674, rs1477669354, rs1575584918, rs1575614351, rs72648222, rs1575799625, rs1576014673, rs1576147786, rs747469275, rs1581805658, rs1227662860, rs1585169831, rs1592729525, rs762753884, rs1596155145, rs1572358821, rs991187915, rs1575649368, rs1060500562, rs1450218521, rs775256998, rs1572332762, rs1571627006, rs1575253896, rs1575616801, rs1575775337, rs1575948935, rs1574083547, rs1574087037, rs1589632398, rs1585171818, rs1603365762, rs768079285, rs1575663327, rs1575796530, rs1574659116, rs267607001, rs1567093598, rs1572359848, rs1060500505, rs1575512482, rs1575872984, rs1161735211, rs1576141328, rs906494713, rs1576685753, rs1266489077, rs1581813564, rs778808038, rs397516363, rs1596386673, rs1575610911, rs727503266, rs1603377936, rs777702465, rs1708504899, rs2054381012, rs1575285509, rs1695435412, rs1699247877, rs879139686, rs2060187635, rs761380979, rs1464886350, rs1956192035, rs752522753, rs1205836993, rs2095894178	16243910

Unknown
Disease term	Disease name	Evidence	References	Source
Lewy Body Disease	Lewy Body Disease			GWAS
Dental caries	Dental caries			GWAS
Insomnia	Insomnia			GWAS

Associations from Text Mining
Disease Name	Relationship Type	References
Crisponi syndrome	Stimulate	27486743
Muscle Neoplasms	Associate	25531450