CPN1 (carboxypeptidase N subunit 1)

Gene
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
1369
Gene name Gene Name - the full gene name approved by the HGNC.
Carboxypeptidase N subunit 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
CPN1
Synonyms (NCBI Gene) Gene synonyms aliases
CPN, SCPN
Chromosome Chromosome number
10
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
10q24.2
Summary Summary of gene provided in NCBI Entrez Gene.
Carboxypeptidase N is a plasma metallo-protease that cleaves basic amino acids from the C terminal of peptides and proteins. The enzyme is important in the regulation of peptides like kinins and anaphylatoxins, and has also been known as kininase-1 and an
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(3)
miRTarBase ID miRNA Experiments Reference
MIRT2508143 hsa-miR-2278 CLIP-seq
MIRT2508144 hsa-miR-4722-5p CLIP-seq
MIRT2508145 hsa-miR-4762-3p CLIP-seq
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(10)
GO ID Ontology Definition Evidence Reference
GO:0004181 Function Metallocarboxypeptidase activity IBA 21873635
GO:0005515 Function Protein binding IPI 32814053
GO:0005576 Component Extracellular region TAS
GO:0005615 Component Extracellular space IBA 21873635
GO:0006518 Process Peptide metabolic process IBA 21873635
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
603103 2312 ENSG00000120054
Protein
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID P15169
Protein name Carboxypeptidase N catalytic chain (CPN) (EC 3.4.17.3) (Anaphylatoxin inactivator) (Arginine carboxypeptidase) (Carboxypeptidase N polypeptide 1) (Carboxypeptidase N small subunit) (Kininase-1) (Lysine carboxypeptidase) (Plasma carboxypeptidase B) (Serum
Protein function Protects the body from potent vasoactive and inflammatory peptides containing C-terminal Arg or Lys (such as kinins or anaphylatoxins) which are released into the circulation.
PDB 2NSM
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00246 Peptidase_M14 31 → 330 Zinc carboxypeptidase Domain
PF13620 CarboxypepD_reg 341 → 416 Domain
Tissue specificity TISSUE SPECIFICITY: Synthesized in the liver and secreted in plasma.
Sequence
Sequence length 458
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
  Reactome
    Regulation of Complement cascade
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Unknown Diseases (2)
Unknown
Disease term Disease name Evidence References Source
Dermatomyositis Dermatomyositis GWAS
Diabetes Diabetes GWAS
Show/Hide Text Mining Associations (4)
Associations from Text Mining
Disease Name Relationship Type References
Acute Aortic Syndrome Associate 32256857
Breast Neoplasms Associate 25803781, 27058005
COVID 19 Associate 35458690
Weight Loss Associate 27897403