Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
1368
Gene name Gene Name - the full gene name approved by the HGNC.
Carboxypeptidase M
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
CPM
Synonyms (NCBI Gene) Gene synonyms aliases
-
Chromosome Chromosome number
12
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
12q15
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is a membrane-bound arginine/lysine carboxypeptidase. Its expression is associated with monocyte to macrophage differentiation. This encoded protein contains hydrophobic regions at the amino and carboxy termini and has 6 p
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT022624 hsa-miR-124-3p Microarray 18668037
MIRT029472 hsa-miR-26b-5p Microarray 19088304
MIRT708439 hsa-miR-21-3p HITS-CLIP 19536157
MIRT708438 hsa-miR-3591-3p HITS-CLIP 19536157
MIRT708437 hsa-miR-3190-5p HITS-CLIP 19536157
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0004180 Function Carboxypeptidase activity TAS 7797563
GO:0004181 Function Metallocarboxypeptidase activity IBA 21873635
GO:0005576 Component Extracellular region TAS
GO:0005615 Component Extracellular space IBA 21873635
GO:0005886 Component Plasma membrane TAS
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
114860 2311 ENSG00000135678
Protein
UniProt ID P14384
Protein name Carboxypeptidase M (CPM) (EC 3.4.17.12)
Protein function Specifically removes C-terminal basic residues (Arg or Lys) from peptides and proteins. It is believed to play important roles in the control of peptide hormone and growth factor activity at the cell surface, and in the membrane-localized degrad
PDB 1UWY
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00246 Peptidase_M14 28 303 Zinc carboxypeptidase Domain
PF13620 CarboxypepD_reg 314 387 Domain
Sequence
Sequence length 443
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Post-translational modification: synthesis of GPI-anchored proteins
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Unknown
Disease term Disease name Evidence References Source
Endometriosis Endometriosis 20864642 ClinVar
Mental Depression Mental Depression GWAS
Associations from Text Mining
Disease Name Relationship Type References
Carcinoma Renal Cell Associate 23172796
Colorectal Neoplasms Associate 28186967, 40154914
Glioblastoma Associate 26863628
Granuloma Associate 22157720
Liposarcoma Associate 19820690, 29610390
Meningioma Associate 22157720
Neoplasms Associate 23172796, 27255164, 29610390
Plaque Atherosclerotic Associate 22157720
Pneumoconiosis Associate 30674606
Pneumonia Lipid Associate 22157720