Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways
Entrez ID	1366
Gene name	Claudin 7
Gene symbol	CLDN7
Synonyms (NCBI Gene)	CEPTRL2CLDN-7CPETRL2Hs.84359claudin-1
Chromosome	17
Chromosome location	17p13.1
Summary	This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellula

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miRTarBase ID	miRNA	Experiments	Reference
MIRT017878	hsa-miR-335-5p	Microarray	18185580
MIRT042085	hsa-miR-484	CLASH	23622248
MIRT736372	hsa-miR-1193	Luciferase reporter assayWestern blottingqRT-PCR	32547067
MIRT895523	hsa-miR-1183	CLIP-seq
MIRT895524	hsa-miR-1289	CLIP-seq
MIRT895525	hsa-miR-223	CLIP-seq
MIRT895526	hsa-miR-3198	CLIP-seq
MIRT895527	hsa-miR-323b-3p	CLIP-seq
MIRT895528	hsa-miR-342-5p	CLIP-seq
MIRT895529	hsa-miR-3545-3p	CLIP-seq
MIRT895530	hsa-miR-4255	CLIP-seq
MIRT895531	hsa-miR-4294	CLIP-seq
MIRT895532	hsa-miR-4309	CLIP-seq
MIRT895533	hsa-miR-4539	CLIP-seq
MIRT895534	hsa-miR-4639-5p	CLIP-seq
MIRT895535	hsa-miR-4651	CLIP-seq
MIRT895536	hsa-miR-4664-5p	CLIP-seq
MIRT895537	hsa-miR-4693-5p	CLIP-seq
MIRT895538	hsa-miR-4697-3p	CLIP-seq
MIRT895539	hsa-miR-556-3p	CLIP-seq
MIRT895540	hsa-miR-595	CLIP-seq
MIRT895541	hsa-miR-608	CLIP-seq
MIRT895523	hsa-miR-1183	CLIP-seq
MIRT895542	hsa-miR-1224-3p	CLIP-seq
MIRT895543	hsa-miR-1260	CLIP-seq
MIRT895544	hsa-miR-1260b	CLIP-seq
MIRT895545	hsa-miR-1280	CLIP-seq
MIRT895546	hsa-miR-150	CLIP-seq
MIRT895547	hsa-miR-2115	CLIP-seq
MIRT895548	hsa-miR-3148	CLIP-seq
MIRT895527	hsa-miR-323b-3p	CLIP-seq
MIRT895549	hsa-miR-3620	CLIP-seq
MIRT895550	hsa-miR-4269	CLIP-seq
MIRT895551	hsa-miR-4287	CLIP-seq
MIRT895552	hsa-miR-4305	CLIP-seq
MIRT895553	hsa-miR-4323	CLIP-seq
MIRT895554	hsa-miR-4469	CLIP-seq
MIRT895555	hsa-miR-4514	CLIP-seq
MIRT895556	hsa-miR-4639-3p	CLIP-seq
MIRT895557	hsa-miR-4668-5p	CLIP-seq
MIRT895558	hsa-miR-4685-3p	CLIP-seq
MIRT895559	hsa-miR-4690-3p	CLIP-seq
MIRT895560	hsa-miR-4692	CLIP-seq
MIRT895537	hsa-miR-4693-5p	CLIP-seq
MIRT895561	hsa-miR-4713-5p	CLIP-seq
MIRT895562	hsa-miR-4742-5p	CLIP-seq
MIRT895563	hsa-miR-516a-3p	CLIP-seq
MIRT895564	hsa-miR-532-3p	CLIP-seq
MIRT895565	hsa-miR-593	CLIP-seq
MIRT895566	hsa-miR-596	CLIP-seq
MIRT895567	hsa-miR-642a	CLIP-seq
MIRT895547	hsa-miR-2115	CLIP-seq
MIRT895548	hsa-miR-3148	CLIP-seq
MIRT1965518	hsa-miR-3179	CLIP-seq
MIRT895527	hsa-miR-323b-3p	CLIP-seq
MIRT895557	hsa-miR-4668-5p	CLIP-seq
MIRT895563	hsa-miR-516a-3p	CLIP-seq
MIRT895539	hsa-miR-556-3p	CLIP-seq
MIRT895566	hsa-miR-596	CLIP-seq
MIRT895535	hsa-miR-4651	CLIP-seq
MIRT895541	hsa-miR-608	CLIP-seq
MIRT895524	hsa-miR-1289	CLIP-seq
MIRT895526	hsa-miR-3198	CLIP-seq
MIRT895528	hsa-miR-342-5p	CLIP-seq
MIRT895530	hsa-miR-4255	CLIP-seq
MIRT895531	hsa-miR-4294	CLIP-seq
MIRT895532	hsa-miR-4309	CLIP-seq
MIRT895534	hsa-miR-4639-5p	CLIP-seq
MIRT895535	hsa-miR-4651	CLIP-seq
MIRT895536	hsa-miR-4664-5p	CLIP-seq
MIRT895538	hsa-miR-4697-3p	CLIP-seq
MIRT895540	hsa-miR-595	CLIP-seq
MIRT895541	hsa-miR-608	CLIP-seq

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Transcription factor	Regulation	Reference
CTBP1	Repression	19277896
ELF3	Unknown	17060315
HDAC1	Activation	19277896
RUNX3	Activation	19706291

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GO ID	Ontology	Definition	Evidence	Reference
GO:0005198	Function	Structural molecule activity	IEA
GO:0005515	Function	Protein binding	IPI	16054130, 25416956, 32296183
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	12673207, 20375010
GO:0005886	Component	Plasma membrane	IEA
GO:0005923	Component	Bicellular tight junction	IBA
GO:0005923	Component	Bicellular tight junction	IEA
GO:0005923	Component	Bicellular tight junction	ISS
GO:0007155	Process	Cell adhesion	IBA
GO:0016020	Component	Membrane	IEA
GO:0016323	Component	Basolateral plasma membrane	IEA
GO:0016327	Component	Apicolateral plasma membrane	IEA
GO:0016328	Component	Lateral plasma membrane	IEA
GO:0016338	Process	Calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules	ISS
GO:0042802	Function	Identical protein binding	ISS
GO:0070161	Component	Anchoring junction	IEA
GO:0070830	Process	Bicellular tight junction assembly	IBA

MIM	HGNC	e!Ensembl
609131	2049	ENSG00000181885

O95471

Protein name

Claudin-7 (CLDN-7)

Protein function

Plays a major role in tight junction-specific obliteration of the intercellular space.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00822	PMP22_Claudin	4 → 182	PMP-22/EMP/MP20/Claudin family	Family

Tissue specificity

TISSUE SPECIFICITY: Expressed in kidney, lung and prostate. Isoform 1 seems to be predominant, except in some normal prostate samples, where isoform 2 is the major form. Down-regulated in breast cancers, including ductal carcinoma in situ (DCIS), lobular

Sequence

MANSGLQLLGFSMALLGWVGLVACTAIPQWQMSSYAGDNIITAQAMYKGLWMDCVTQSTG
MMSCKMYDSVLALSAALQATRALMVVSLVLGFLAMFVATMGMKCTRCGGDDKVKKARIAM
GGGIIFIVAGLAALVACSWYGHQIVTDFYNPLIPTNIKYEFGPAIFIGWAGSALVILGGA
LLSCSCPGNESKAGYRVPRSYPKSNSSKEYV

Sequence length

211

Interactions

View interactions

	KEGG
	Virion - Hepatitis viruses Cell adhesion molecules Tight junction Leukocyte transendothelial migration Pathogenic Escherichia coli infection Hepatitis C

CLDN7 (claudin 7)