Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	1364
Gene name Gene Name - the full gene name approved by the HGNC.	Claudin 4
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	CLDN4
Synonyms (NCBI Gene) Gene synonyms aliases	CPE-R, CPER, CPETR, CPETR1, WBSCR8, hCPE-R
Chromosome Chromosome number	7
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	7q11.23
Summary Summary of gene provided in NCBI Entrez Gene.	The protein encoded by this intronless gene belongs to the claudin family. Claudins are integral membrane proteins that are components of the epithelial cell tight junctions, which regulate movement of solutes and ions through the paracellular space. This

Show/Hide all(275)

miRTarBase ID	miRNA	Experiments	Reference
MIRT017395	hsa-miR-335-5p	Microarray	18185580
MIRT051675	hsa-let-7e-5p	CLASH	23622248
MIRT895415	hsa-miR-124	CLIP-seq
MIRT895416	hsa-miR-1252	CLIP-seq
MIRT895417	hsa-miR-1254	CLIP-seq
MIRT895418	hsa-miR-127-5p	CLIP-seq
MIRT895419	hsa-miR-1291	CLIP-seq
MIRT895420	hsa-miR-1910	CLIP-seq
MIRT895421	hsa-miR-1914	CLIP-seq
MIRT895422	hsa-miR-1915	CLIP-seq
MIRT895423	hsa-miR-2116	CLIP-seq
MIRT895424	hsa-miR-298	CLIP-seq
MIRT895425	hsa-miR-3074-5p	CLIP-seq
MIRT895426	hsa-miR-3116	CLIP-seq
MIRT895427	hsa-miR-3150b-3p	CLIP-seq
MIRT895428	hsa-miR-3155	CLIP-seq
MIRT895429	hsa-miR-3155b	CLIP-seq
MIRT895430	hsa-miR-3179	CLIP-seq
MIRT895431	hsa-miR-3189-3p	CLIP-seq
MIRT895432	hsa-miR-3202	CLIP-seq
MIRT895433	hsa-miR-3591-5p	CLIP-seq
MIRT895434	hsa-miR-3664-5p	CLIP-seq
MIRT895435	hsa-miR-3667-3p	CLIP-seq
MIRT895436	hsa-miR-3674	CLIP-seq
MIRT895437	hsa-miR-3689a-5p	CLIP-seq
MIRT895438	hsa-miR-3689b	CLIP-seq
MIRT895439	hsa-miR-3689e	CLIP-seq
MIRT895440	hsa-miR-3689f	CLIP-seq
MIRT895441	hsa-miR-382	CLIP-seq
MIRT895442	hsa-miR-3922-5p	CLIP-seq
MIRT895443	hsa-miR-3925-3p	CLIP-seq
MIRT895444	hsa-miR-3928	CLIP-seq
MIRT895445	hsa-miR-4257	CLIP-seq
MIRT895446	hsa-miR-4264	CLIP-seq
MIRT895447	hsa-miR-4292	CLIP-seq
MIRT895448	hsa-miR-4297	CLIP-seq
MIRT895449	hsa-miR-4435	CLIP-seq
MIRT895450	hsa-miR-4459	CLIP-seq
MIRT895451	hsa-miR-4493	CLIP-seq
MIRT895452	hsa-miR-4522	CLIP-seq
MIRT895453	hsa-miR-4530	CLIP-seq
MIRT895454	hsa-miR-4533	CLIP-seq
MIRT895455	hsa-miR-455-3p	CLIP-seq
MIRT895456	hsa-miR-4640-5p	CLIP-seq
MIRT895457	hsa-miR-4677-5p	CLIP-seq
MIRT895458	hsa-miR-4685-5p	CLIP-seq
MIRT895459	hsa-miR-4688	CLIP-seq
MIRT895460	hsa-miR-4690-5p	CLIP-seq
MIRT895461	hsa-miR-4695-5p	CLIP-seq
MIRT895462	hsa-miR-4708-3p	CLIP-seq
MIRT895463	hsa-miR-4708-5p	CLIP-seq
MIRT895464	hsa-miR-4715-3p	CLIP-seq
MIRT895465	hsa-miR-4722-3p	CLIP-seq
MIRT895466	hsa-miR-4722-5p	CLIP-seq
MIRT895467	hsa-miR-4726-3p	CLIP-seq
MIRT895468	hsa-miR-4726-5p	CLIP-seq
MIRT895469	hsa-miR-4729	CLIP-seq
MIRT895470	hsa-miR-4733-5p	CLIP-seq
MIRT895471	hsa-miR-4747-5p	CLIP-seq
MIRT895472	hsa-miR-4778-3p	CLIP-seq
MIRT895473	hsa-miR-4779	CLIP-seq
MIRT895474	hsa-miR-4784	CLIP-seq
MIRT895475	hsa-miR-4786-3p	CLIP-seq
MIRT895476	hsa-miR-4792	CLIP-seq
MIRT895477	hsa-miR-484	CLIP-seq
MIRT895478	hsa-miR-486-3p	CLIP-seq
MIRT895479	hsa-miR-506	CLIP-seq
MIRT895480	hsa-miR-520a-5p	CLIP-seq
MIRT895481	hsa-miR-520d-5p	CLIP-seq
MIRT895482	hsa-miR-524-5p	CLIP-seq
MIRT895483	hsa-miR-525-5p	CLIP-seq
MIRT895484	hsa-miR-582-5p	CLIP-seq
MIRT895485	hsa-miR-617	CLIP-seq
MIRT895486	hsa-miR-621	CLIP-seq
MIRT895487	hsa-miR-622	CLIP-seq
MIRT895488	hsa-miR-661	CLIP-seq
MIRT895489	hsa-miR-766	CLIP-seq
MIRT895490	hsa-miR-922	CLIP-seq
MIRT895491	hsa-miR-941	CLIP-seq
MIRT1965495	hsa-miR-10a	CLIP-seq
MIRT1965496	hsa-miR-10b	CLIP-seq
MIRT895415	hsa-miR-124	CLIP-seq
MIRT895416	hsa-miR-1252	CLIP-seq
MIRT895417	hsa-miR-1254	CLIP-seq
MIRT1965497	hsa-miR-1285	CLIP-seq
MIRT895419	hsa-miR-1291	CLIP-seq
MIRT1965498	hsa-miR-1343	CLIP-seq
MIRT895420	hsa-miR-1910	CLIP-seq
MIRT895421	hsa-miR-1914	CLIP-seq
MIRT1965499	hsa-miR-2277-5p	CLIP-seq
MIRT895424	hsa-miR-298	CLIP-seq
MIRT895425	hsa-miR-3074-5p	CLIP-seq
MIRT895426	hsa-miR-3116	CLIP-seq
MIRT1965500	hsa-miR-3148	CLIP-seq
MIRT895427	hsa-miR-3150b-3p	CLIP-seq
MIRT1965501	hsa-miR-3176	CLIP-seq
MIRT1965502	hsa-miR-3178	CLIP-seq
MIRT895430	hsa-miR-3179	CLIP-seq
MIRT1965503	hsa-miR-3183	CLIP-seq
MIRT1965504	hsa-miR-3191	CLIP-seq
MIRT895432	hsa-miR-3202	CLIP-seq
MIRT1965505	hsa-miR-326	CLIP-seq
MIRT1965506	hsa-miR-330-5p	CLIP-seq
MIRT1965507	hsa-miR-339-5p	CLIP-seq
MIRT1965508	hsa-miR-3620	CLIP-seq
MIRT895435	hsa-miR-3667-3p	CLIP-seq
MIRT895436	hsa-miR-3674	CLIP-seq
MIRT895437	hsa-miR-3689a-5p	CLIP-seq
MIRT895438	hsa-miR-3689b	CLIP-seq
MIRT895439	hsa-miR-3689e	CLIP-seq
MIRT895440	hsa-miR-3689f	CLIP-seq
MIRT1965509	hsa-miR-3922-3p	CLIP-seq
MIRT895442	hsa-miR-3922-5p	CLIP-seq
MIRT895443	hsa-miR-3925-3p	CLIP-seq
MIRT895444	hsa-miR-3928	CLIP-seq
MIRT895445	hsa-miR-4257	CLIP-seq
MIRT895446	hsa-miR-4264	CLIP-seq
MIRT1965510	hsa-miR-4267	CLIP-seq
MIRT1965511	hsa-miR-4286	CLIP-seq
MIRT895447	hsa-miR-4292	CLIP-seq
MIRT895448	hsa-miR-4297	CLIP-seq
MIRT895449	hsa-miR-4435	CLIP-seq
MIRT1965512	hsa-miR-4486	CLIP-seq
MIRT895451	hsa-miR-4493	CLIP-seq
MIRT895453	hsa-miR-4530	CLIP-seq
MIRT895454	hsa-miR-4533	CLIP-seq
MIRT1965513	hsa-miR-4537	CLIP-seq
MIRT895455	hsa-miR-455-3p	CLIP-seq
MIRT895458	hsa-miR-4685-5p	CLIP-seq
MIRT895459	hsa-miR-4688	CLIP-seq
MIRT895462	hsa-miR-4708-3p	CLIP-seq
MIRT895463	hsa-miR-4708-5p	CLIP-seq
MIRT895465	hsa-miR-4722-3p	CLIP-seq
MIRT1965514	hsa-miR-4723-3p	CLIP-seq
MIRT895469	hsa-miR-4729	CLIP-seq
MIRT895470	hsa-miR-4733-5p	CLIP-seq
MIRT1965515	hsa-miR-4736	CLIP-seq
MIRT895472	hsa-miR-4778-3p	CLIP-seq
MIRT895474	hsa-miR-4784	CLIP-seq
MIRT895475	hsa-miR-4786-3p	CLIP-seq
MIRT895476	hsa-miR-4792	CLIP-seq
MIRT895478	hsa-miR-486-3p	CLIP-seq
MIRT895479	hsa-miR-506	CLIP-seq
MIRT895481	hsa-miR-520d-5p	CLIP-seq
MIRT1965516	hsa-miR-522	CLIP-seq
MIRT895482	hsa-miR-524-5p	CLIP-seq
MIRT895484	hsa-miR-582-5p	CLIP-seq
MIRT895487	hsa-miR-622	CLIP-seq
MIRT895488	hsa-miR-661	CLIP-seq
MIRT1965517	hsa-miR-668	CLIP-seq
MIRT895489	hsa-miR-766	CLIP-seq
MIRT895490	hsa-miR-922	CLIP-seq
MIRT895491	hsa-miR-941	CLIP-seq
MIRT1965495	hsa-miR-10a	CLIP-seq
MIRT1965496	hsa-miR-10b	CLIP-seq
MIRT2201449	hsa-miR-1207-5p	CLIP-seq
MIRT895415	hsa-miR-124	CLIP-seq
MIRT2201450	hsa-miR-1247	CLIP-seq
MIRT895418	hsa-miR-127-5p	CLIP-seq
MIRT1965497	hsa-miR-1285	CLIP-seq
MIRT2201451	hsa-miR-1293	CLIP-seq
MIRT1965498	hsa-miR-1343	CLIP-seq
MIRT2201452	hsa-miR-1470	CLIP-seq
MIRT2201453	hsa-miR-1539	CLIP-seq
MIRT895420	hsa-miR-1910	CLIP-seq
MIRT2201454	hsa-miR-1913	CLIP-seq
MIRT895422	hsa-miR-1915	CLIP-seq
MIRT895423	hsa-miR-2116	CLIP-seq
MIRT1965499	hsa-miR-2277-5p	CLIP-seq
MIRT2201455	hsa-miR-2355-5p	CLIP-seq
MIRT895424	hsa-miR-298	CLIP-seq
MIRT2201456	hsa-miR-3065-3p	CLIP-seq
MIRT2201457	hsa-miR-3130-3p	CLIP-seq
MIRT895427	hsa-miR-3150b-3p	CLIP-seq
MIRT895428	hsa-miR-3155	CLIP-seq
MIRT895429	hsa-miR-3155b	CLIP-seq
MIRT1965501	hsa-miR-3176	CLIP-seq
MIRT1965502	hsa-miR-3178	CLIP-seq
MIRT1965503	hsa-miR-3183	CLIP-seq
MIRT895431	hsa-miR-3189-3p	CLIP-seq
MIRT2201458	hsa-miR-324-3p	CLIP-seq
MIRT1965505	hsa-miR-326	CLIP-seq
MIRT1965506	hsa-miR-330-5p	CLIP-seq
MIRT1965507	hsa-miR-339-5p	CLIP-seq
MIRT895433	hsa-miR-3591-5p	CLIP-seq
MIRT2201459	hsa-miR-361-3p	CLIP-seq
MIRT1965508	hsa-miR-3620	CLIP-seq
MIRT895434	hsa-miR-3664-5p	CLIP-seq
MIRT2201460	hsa-miR-3665	CLIP-seq
MIRT2201461	hsa-miR-3670	CLIP-seq
MIRT895437	hsa-miR-3689a-5p	CLIP-seq
MIRT895438	hsa-miR-3689b	CLIP-seq
MIRT895439	hsa-miR-3689e	CLIP-seq
MIRT895440	hsa-miR-3689f	CLIP-seq
MIRT895441	hsa-miR-382	CLIP-seq
MIRT2201462	hsa-miR-3918	CLIP-seq
MIRT1965509	hsa-miR-3922-3p	CLIP-seq
MIRT895442	hsa-miR-3922-5p	CLIP-seq
MIRT895444	hsa-miR-3928	CLIP-seq
MIRT895445	hsa-miR-4257	CLIP-seq
MIRT895446	hsa-miR-4264	CLIP-seq
MIRT1965510	hsa-miR-4267	CLIP-seq
MIRT1965511	hsa-miR-4286	CLIP-seq
MIRT2201463	hsa-miR-4290	CLIP-seq
MIRT895447	hsa-miR-4292	CLIP-seq
MIRT2201464	hsa-miR-4313	CLIP-seq
MIRT2201465	hsa-miR-4325	CLIP-seq
MIRT895449	hsa-miR-4435	CLIP-seq
MIRT895450	hsa-miR-4459	CLIP-seq
MIRT2201466	hsa-miR-4483	CLIP-seq
MIRT1965512	hsa-miR-4486	CLIP-seq
MIRT895451	hsa-miR-4493	CLIP-seq
MIRT895452	hsa-miR-4522	CLIP-seq
MIRT895453	hsa-miR-4530	CLIP-seq
MIRT895455	hsa-miR-455-3p	CLIP-seq
MIRT2201467	hsa-miR-4645-5p	CLIP-seq
MIRT2201468	hsa-miR-4663	CLIP-seq
MIRT2201469	hsa-miR-4667-3p	CLIP-seq
MIRT2201470	hsa-miR-4673	CLIP-seq
MIRT2201471	hsa-miR-4676-5p	CLIP-seq
MIRT895457	hsa-miR-4677-5p	CLIP-seq
MIRT895458	hsa-miR-4685-5p	CLIP-seq
MIRT895460	hsa-miR-4690-5p	CLIP-seq
MIRT895461	hsa-miR-4695-5p	CLIP-seq
MIRT895462	hsa-miR-4708-3p	CLIP-seq
MIRT895463	hsa-miR-4708-5p	CLIP-seq
MIRT895464	hsa-miR-4715-3p	CLIP-seq
MIRT895465	hsa-miR-4722-3p	CLIP-seq
MIRT895466	hsa-miR-4722-5p	CLIP-seq
MIRT1965514	hsa-miR-4723-3p	CLIP-seq
MIRT895467	hsa-miR-4726-3p	CLIP-seq
MIRT895469	hsa-miR-4729	CLIP-seq
MIRT895470	hsa-miR-4733-5p	CLIP-seq
MIRT1965515	hsa-miR-4736	CLIP-seq
MIRT895471	hsa-miR-4747-5p	CLIP-seq
MIRT2201472	hsa-miR-4749-3p	CLIP-seq
MIRT2201473	hsa-miR-4763-3p	CLIP-seq
MIRT895473	hsa-miR-4779	CLIP-seq
MIRT895474	hsa-miR-4784	CLIP-seq
MIRT895475	hsa-miR-4786-3p	CLIP-seq
MIRT895476	hsa-miR-4792	CLIP-seq
MIRT2201474	hsa-miR-4793-3p	CLIP-seq
MIRT895477	hsa-miR-484	CLIP-seq
MIRT895479	hsa-miR-506	CLIP-seq
MIRT895480	hsa-miR-520a-5p	CLIP-seq
MIRT895483	hsa-miR-525-5p	CLIP-seq
MIRT2201475	hsa-miR-541	CLIP-seq
MIRT2201476	hsa-miR-548ac	CLIP-seq
MIRT2201477	hsa-miR-548d-3p	CLIP-seq
MIRT2201478	hsa-miR-548z	CLIP-seq
MIRT2201479	hsa-miR-575	CLIP-seq
MIRT2201480	hsa-miR-593	CLIP-seq
MIRT2201481	hsa-miR-596	CLIP-seq
MIRT2201482	hsa-miR-615-5p	CLIP-seq
MIRT895485	hsa-miR-617	CLIP-seq
MIRT895486	hsa-miR-621	CLIP-seq
MIRT895487	hsa-miR-622	CLIP-seq
MIRT2201483	hsa-miR-654-5p	CLIP-seq
MIRT1965517	hsa-miR-668	CLIP-seq
MIRT895490	hsa-miR-922	CLIP-seq
MIRT2201484	hsa-miR-940	CLIP-seq
MIRT895491	hsa-miR-941	CLIP-seq
MIRT2201453	hsa-miR-1539	CLIP-seq
MIRT895420	hsa-miR-1910	CLIP-seq
MIRT895423	hsa-miR-2116	CLIP-seq
MIRT895434	hsa-miR-3664-5p	CLIP-seq
MIRT2201461	hsa-miR-3670	CLIP-seq
MIRT895444	hsa-miR-3928	CLIP-seq
MIRT895446	hsa-miR-4264	CLIP-seq
MIRT895452	hsa-miR-4522	CLIP-seq
MIRT895455	hsa-miR-455-3p	CLIP-seq
MIRT2201468	hsa-miR-4663	CLIP-seq
MIRT895457	hsa-miR-4677-5p	CLIP-seq
MIRT895458	hsa-miR-4685-5p	CLIP-seq
MIRT895486	hsa-miR-621	CLIP-seq

Show/Hide all(31)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004888	Function	Transmembrane signaling receptor activity	TAS	9334247
GO:0005198	Function	Structural molecule activity	IEA
GO:0005254	Function	Chloride channel activity	ISS
GO:0005515	Function	Protein binding	IPI	27647526, 32296183
GO:0005886	Component	Plasma membrane	IBA	21873635
GO:0005886	Component	Plasma membrane	IDA	20375010
GO:0005887	Component	Integral component of plasma membrane	IMP	23407391
GO:0005911	Component	Cell-cell junction	IDA	18774778
GO:0005923	Component	Bicellular tight junction	IBA	21873635
GO:0005923	Component	Bicellular tight junction	IDA	23407391
GO:0005923	Component	Bicellular tight junction	ISS
GO:0007155	Process	Cell adhesion	IBA	21873635
GO:0007565	Process	Female pregnancy	IEA
GO:0007623	Process	Circadian rhythm	IEA
GO:0009925	Component	Basal plasma membrane	IEA
GO:0016324	Component	Apical plasma membrane	IEA
GO:0016327	Component	Apicolateral plasma membrane	IEA
GO:0016328	Component	Lateral plasma membrane	IEA
GO:0016338	Process	Calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules	ISS
GO:0022604	Process	Regulation of cell morphogenesis	IMP	16103090
GO:0030335	Process	Positive regulation of cell migration	IMP	16103090
GO:0032570	Process	Response to progesterone	IEA
GO:0034707	Component	Chloride channel complex	IEA
GO:0042802	Function	Identical protein binding	ISS
GO:0061436	Process	Establishment of skin barrier	IMP	23407391
GO:0070160	Component	Tight junction	IDA	30734065
GO:0070293	Process	Renal absorption	ISS
GO:0070830	Process	Bicellular tight junction assembly	IBA	21873635
GO:0090303	Process	Positive regulation of wound healing	IMP	16103090
GO:1902476	Process	Chloride transmembrane transport	IEA
GO:1905050	Process	Positive regulation of metallopeptidase activity	IMP	16103090

MIM	HGNC	e!Ensembl
602909	2046	ENSG00000189143

Protein

UniProt ID

O14493

Protein name

Claudin-4 (Clostridium perfringens enterotoxin receptor) (CPE-R) (CPE-receptor) (Williams-Beuren syndrome chromosomal region 8 protein)

Protein function

Can associate with other claudins to regulate tight junction structural and functional strand dynamics (PubMed:35773259, PubMed:36008380). May coassemble with CLDN8 into tight junction strands containing anion-selective channels that convey para

PDB

5B2G , 7KP4 , 7TDM , 7TDN , 8U4V , 8U5B , 9CMH , 9CMI

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00822	PMP22_Claudin	4 → 181	PMP-22/EMP/MP20/Claudin family	Family

Sequence

MASMGLQVMGIALAVLGWLAVMLCCALPMWRVTAFIGSNIVTSQTIWEGLWMNCVVQSTG
QMQCKVYDSLLALPQDLQAARALVIISIIVAALGVLLSVVGGKCTNCLEDESAKAKTMIV
AGVVFLLAGLMVIVPVSWTAHNIIQDFYNPLVASGQKREMGASLYVGWAASGLLLLGGGL
LCCNCPPRTDKPYSAKYSAARSAAASNYV

Sequence length

209

Interactions

View interactions

	KEGG
	Virion - Hepatitis viruses Cell adhesion molecules Tight junction Leukocyte transendothelial migration Pathogenic Escherichia coli infection Hepatitis C

Show/Hide Causal Diseases (3)

Disease term	Disease name	dbSNP ID	References
Causal
Breast cancer	Malignant neoplasm of breast	rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158 View all (309 more)	19142967
Breast carcinoma	Breast Carcinoma	rs80359671, rs11540652, rs28934575, rs28897672, rs137886232, rs193922376, rs80357783, rs80359306, rs80359405, rs80359507, rs80359598, rs80358429, rs397507683, rs397515636, rs80359451 View all (71 more)	19142967
Marfan syndrome	Mammary Ductal Carcinoma, Mammary Carcinoma, Human	rs137854456, rs137854457, rs267606796, rs137854458, rs137854459, rs137854460, rs137854470, rs137854471, rs267606797, rs137854461, rs137854462, rs137854463, rs869025419, rs137854464, rs137854465 View all (942 more)	19142967

Show/Hide Text Mining Associations (101)

Disease Name	Relationship Type	References
Associations from Text Mining
Acute Disease	Stimulate	18711353
Adenocarcinoma	Inhibit	17585317
Adenocarcinoma	Associate	21102412, 27687058, 36037134, 38384059
Ameloblastoma	Associate	31473941
Ascites	Associate	21541062
Bile Duct Neoplasms	Associate	18854598
Biliary Tract Neoplasms	Associate	16439986, 18854598
Bloom Syndrome	Inhibit	36293204
Breast Carcinoma In Situ	Associate	18954444
Breast Neoplasms	Associate	15743508, 18752049, 20086175, 21883696, 22464177, 25417118, 25871476, 26919310, 36412441, 36412442, 36691073, 37059993, 37465316
Breast Neoplasms	Stimulate	33714203
Carcinogenesis	Associate	15743508, 15800679, 17291259
Carcinoma	Associate	28084340, 29671892
Carcinoma Basal Cell	Associate	18752049
Carcinoma Hepatocellular	Associate	16439986, 23385421
Carcinoma Non Small Cell Lung	Associate	33006362
Carcinoma Ovarian Epithelial	Associate	17653889, 30606772
Carcinoma Pancreatic Ductal	Stimulate	21102412
Carcinoma Pancreatic Ductal	Associate	29045505
Carcinoma Papillary	Associate	18313739
Carcinoma Papillary	Inhibit	38415551
Carcinoma Renal Cell	Associate	31751681, 37653791, 37762031
Carcinoma Squamous Cell	Associate	17585317, 33045147
Cell Transformation Neoplastic	Associate	25778318
Cerebral Intraventricular Hemorrhage	Associate	36293204
Cholangiocarcinoma	Associate	24586698
Clear cell metastatic renal cell carcinoma	Associate	33045147
Colitis Ulcerative	Stimulate	32164249
Colonic Neoplasms	Associate	23385421
Colorectal Neoplasms	Associate	16253248, 25038829, 28381183
Cystitis Interstitial	Associate	21352500
Darier Disease	Associate	37496039
Dermatitis Atopic	Associate	26319240
Dermatitis Atopic	Inhibit	37734479
Diabetes Mellitus Type 2	Associate	23552671
Ectodermal Dysplasia	Associate	37621953
Ectrodactyly Ectodermal Dysplasia And Cleft Lip Palate Syndrome 1	Stimulate	17291259
Endometrial Neoplasms	Associate	18313739, 18384777, 18850381, 23095775, 29671892
Endometriosis	Associate	18384777
Enterocolitis Necrotizing	Inhibit	29276042
Esophageal Squamous Cell Carcinoma	Associate	36070895
Fetal Growth Retardation	Associate	36293204
Gallbladder Neoplasms	Associate	18854598, 40527859
Gastroesophageal Reflux	Associate	29558791
Glioblastoma	Associate	35418179
Glioma	Stimulate	35418179
Hypothyroidism Congenital Nongoitrous 2	Associate	18384777
Hypotrichosis	Stimulate	17291259
Idiopathic Pulmonary Fibrosis	Associate	18955738, 32001212
Inflammation	Associate	16007110
Inflammation	Stimulate	31144425
Inflammatory Bowel Diseases	Associate	18711353, 23946598
Intestinal Diseases	Associate	23822740
Intestinal Pseudo Obstruction	Associate	31144425
Intracranial Embolism	Associate	38415551
Irritable Bowel Syndrome	Associate	27445342
Leukemia Lymphocytic Chronic B Cell	Associate	21832144
Lung Injury	Associate	21741940
Malignant mesenchymal tumor	Associate	26919310
Mesothelioma	Associate	16505274
Mesothelioma Malignant	Associate	16505274
Metaplasia	Inhibit	15743508
Mouth Diseases	Associate	23822740
Muscle Neoplasms	Associate	38415551
Nasopharyngeal Carcinoma	Associate	25778318
Neoplasm Invasiveness	Associate	17291259
Neoplasm Metastasis	Associate	23097631, 25038829, 25417118, 36412442
Neoplasms	Associate	15277215, 15475928, 15750830, 15800679, 16319398, 16439986, 16836752, 17060315, 17585317, 18827820, 21541062, 22043024, 23390516, 23563899, 23822740 View all (13 more)
Neoplasms	Stimulate	21102412
Neoplasms	Inhibit	23097631
Neoplasms Basal Cell	Associate	22043024
Neoplasms Squamous Cell	Associate	23856835
Neuroendocrine Tumors	Associate	17709988
NOG Related Symphalangism Spectrum Disorder	Associate	32360491
Non Muscle Invasive Bladder Neoplasms	Inhibit	38415551
Odontoma	Associate	31473941
Oncocytoma renal	Associate	31998788
Ovarian Diseases	Associate	16714763, 20053926
Ovarian Neoplasms	Associate	15277215, 15905176, 16714763, 17653889, 17678893, 17986852, 19619303, 20053926, 21541062, 23097631, 28084340, 28481779, 30606772, 32779991, 35373300, 37057131, 38238671 View all (2 more)
Pancreatic Intraductal Neoplasms	Associate	14982844, 21102412, 27591765
Pancreatic Neoplasms	Associate	12000726, 16836752, 21102412, 21573709, 26028104
Polycystic Ovary Syndrome	Associate	21411543
Prostatic Neoplasms	Associate	18648369, 23686669, 36749655
Prostatitis	Associate	37518873
Sarcoidosis	Associate	18955738
Sarcoma	Associate	28084340
Sarcoma Synovial	Associate	17060315, 28084340
Skin Diseases	Inhibit	37734479
Skin Neoplasms	Associate	24294371
Squamous Cell Carcinoma of Head and Neck	Stimulate	23563899
Squamous Cell Carcinoma of Head and Neck	Associate	23856835, 36232536
Stomach Neoplasms	Associate	17459057, 21844869, 23822740, 25755790, 28534362, 32816956
Thyroiditis	Associate	16836752
Tooth Erosion	Associate	29558791
Triple Negative Breast Neoplasms	Associate	22638807, 23443971, 24390667
Urethral Neoplasms	Associate	38415551
Urinary Bladder Diseases	Associate	16836752
Urinary Bladder Neoplasms	Stimulate	35742959
Urinary Bladder Neoplasms	Associate	38415551
Urticaria Solar	Associate	24294371
Uterine Neoplasms	Associate	15785748

CLDN4 (claudin 4)