CLDN4 (claudin 4)

Gene

• Entrez ID: 1364
• Gene name: Claudin 4
• Gene symbol: CLDN4
• Synonyms (NCBI Gene): CPE-R, CPER, CPETR, CPETR1, WBSCR8, hCPE-R
• Chromosome: 7
• Chromosome location: 7q11.23
• Summary: The protein encoded by this intronless gene belongs to the claudin family. Claudins are integral membrane proteins that are components of the epithelial cell tight junctions, which regulate movement of solutes and ions through the paracellular space. This

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT017395	hsa-miR-335-5p	Microarray	18185580
MIRT051675	hsa-let-7e-5p	CLASH	23622248
MIRT895415	hsa-miR-124	CLIP-seq
MIRT895416	hsa-miR-1252	CLIP-seq
MIRT895417	hsa-miR-1254	CLIP-seq
MIRT895418	hsa-miR-127-5p	CLIP-seq
MIRT895419	hsa-miR-1291	CLIP-seq
MIRT895420	hsa-miR-1910	CLIP-seq
MIRT895421	hsa-miR-1914	CLIP-seq
MIRT895422	hsa-miR-1915	CLIP-seq
MIRT895423	hsa-miR-2116	CLIP-seq
MIRT895424	hsa-miR-298	CLIP-seq
MIRT895425	hsa-miR-3074-5p	CLIP-seq
MIRT895426	hsa-miR-3116	CLIP-seq
MIRT895427	hsa-miR-3150b-3p	CLIP-seq
MIRT895428	hsa-miR-3155	CLIP-seq
MIRT895429	hsa-miR-3155b	CLIP-seq
MIRT895430	hsa-miR-3179	CLIP-seq
MIRT895431	hsa-miR-3189-3p	CLIP-seq
MIRT895432	hsa-miR-3202	CLIP-seq
MIRT895433	hsa-miR-3591-5p	CLIP-seq
MIRT895434	hsa-miR-3664-5p	CLIP-seq
MIRT895435	hsa-miR-3667-3p	CLIP-seq
MIRT895436	hsa-miR-3674	CLIP-seq
MIRT895437	hsa-miR-3689a-5p	CLIP-seq
MIRT895438	hsa-miR-3689b	CLIP-seq
MIRT895439	hsa-miR-3689e	CLIP-seq
MIRT895440	hsa-miR-3689f	CLIP-seq
MIRT895441	hsa-miR-382	CLIP-seq
MIRT895442	hsa-miR-3922-5p	CLIP-seq
MIRT895443	hsa-miR-3925-3p	CLIP-seq
MIRT895444	hsa-miR-3928	CLIP-seq
MIRT895445	hsa-miR-4257	CLIP-seq
MIRT895446	hsa-miR-4264	CLIP-seq
MIRT895447	hsa-miR-4292	CLIP-seq
MIRT895448	hsa-miR-4297	CLIP-seq
MIRT895449	hsa-miR-4435	CLIP-seq
MIRT895450	hsa-miR-4459	CLIP-seq
MIRT895451	hsa-miR-4493	CLIP-seq
MIRT895452	hsa-miR-4522	CLIP-seq
MIRT895453	hsa-miR-4530	CLIP-seq
MIRT895454	hsa-miR-4533	CLIP-seq
MIRT895455	hsa-miR-455-3p	CLIP-seq
MIRT895456	hsa-miR-4640-5p	CLIP-seq
MIRT895457	hsa-miR-4677-5p	CLIP-seq
MIRT895458	hsa-miR-4685-5p	CLIP-seq
MIRT895459	hsa-miR-4688	CLIP-seq
MIRT895460	hsa-miR-4690-5p	CLIP-seq
MIRT895461	hsa-miR-4695-5p	CLIP-seq
MIRT895462	hsa-miR-4708-3p	CLIP-seq
MIRT895463	hsa-miR-4708-5p	CLIP-seq
MIRT895464	hsa-miR-4715-3p	CLIP-seq
MIRT895465	hsa-miR-4722-3p	CLIP-seq
MIRT895466	hsa-miR-4722-5p	CLIP-seq
MIRT895467	hsa-miR-4726-3p	CLIP-seq
MIRT895468	hsa-miR-4726-5p	CLIP-seq
MIRT895469	hsa-miR-4729	CLIP-seq
MIRT895470	hsa-miR-4733-5p	CLIP-seq
MIRT895471	hsa-miR-4747-5p	CLIP-seq
MIRT895472	hsa-miR-4778-3p	CLIP-seq
MIRT895473	hsa-miR-4779	CLIP-seq
MIRT895474	hsa-miR-4784	CLIP-seq
MIRT895475	hsa-miR-4786-3p	CLIP-seq
MIRT895476	hsa-miR-4792	CLIP-seq
MIRT895477	hsa-miR-484	CLIP-seq
MIRT895478	hsa-miR-486-3p	CLIP-seq
MIRT895479	hsa-miR-506	CLIP-seq
MIRT895480	hsa-miR-520a-5p	CLIP-seq
MIRT895481	hsa-miR-520d-5p	CLIP-seq
MIRT895482	hsa-miR-524-5p	CLIP-seq
MIRT895483	hsa-miR-525-5p	CLIP-seq
MIRT895484	hsa-miR-582-5p	CLIP-seq
MIRT895485	hsa-miR-617	CLIP-seq
MIRT895486	hsa-miR-621	CLIP-seq
MIRT895487	hsa-miR-622	CLIP-seq
MIRT895488	hsa-miR-661	CLIP-seq
MIRT895489	hsa-miR-766	CLIP-seq
MIRT895490	hsa-miR-922	CLIP-seq
MIRT895491	hsa-miR-941	CLIP-seq
MIRT1965495	hsa-miR-10a	CLIP-seq
MIRT1965496	hsa-miR-10b	CLIP-seq
MIRT895415	hsa-miR-124	CLIP-seq
MIRT895416	hsa-miR-1252	CLIP-seq
MIRT895417	hsa-miR-1254	CLIP-seq
MIRT1965497	hsa-miR-1285	CLIP-seq
MIRT895419	hsa-miR-1291	CLIP-seq
MIRT1965498	hsa-miR-1343	CLIP-seq
MIRT895420	hsa-miR-1910	CLIP-seq
MIRT895421	hsa-miR-1914	CLIP-seq
MIRT1965499	hsa-miR-2277-5p	CLIP-seq
MIRT895424	hsa-miR-298	CLIP-seq
MIRT895425	hsa-miR-3074-5p	CLIP-seq
MIRT895426	hsa-miR-3116	CLIP-seq
MIRT1965500	hsa-miR-3148	CLIP-seq
MIRT895427	hsa-miR-3150b-3p	CLIP-seq
MIRT1965501	hsa-miR-3176	CLIP-seq
MIRT1965502	hsa-miR-3178	CLIP-seq
MIRT895430	hsa-miR-3179	CLIP-seq
MIRT1965503	hsa-miR-3183	CLIP-seq
MIRT1965504	hsa-miR-3191	CLIP-seq
MIRT895432	hsa-miR-3202	CLIP-seq
MIRT1965505	hsa-miR-326	CLIP-seq
MIRT1965506	hsa-miR-330-5p	CLIP-seq
MIRT1965507	hsa-miR-339-5p	CLIP-seq
MIRT1965508	hsa-miR-3620	CLIP-seq
MIRT895435	hsa-miR-3667-3p	CLIP-seq
MIRT895436	hsa-miR-3674	CLIP-seq
MIRT895437	hsa-miR-3689a-5p	CLIP-seq
MIRT895438	hsa-miR-3689b	CLIP-seq
MIRT895439	hsa-miR-3689e	CLIP-seq
MIRT895440	hsa-miR-3689f	CLIP-seq
MIRT1965509	hsa-miR-3922-3p	CLIP-seq
MIRT895442	hsa-miR-3922-5p	CLIP-seq
MIRT895443	hsa-miR-3925-3p	CLIP-seq
MIRT895444	hsa-miR-3928	CLIP-seq
MIRT895445	hsa-miR-4257	CLIP-seq
MIRT895446	hsa-miR-4264	CLIP-seq
MIRT1965510	hsa-miR-4267	CLIP-seq
MIRT1965511	hsa-miR-4286	CLIP-seq
MIRT895447	hsa-miR-4292	CLIP-seq
MIRT895448	hsa-miR-4297	CLIP-seq
MIRT895449	hsa-miR-4435	CLIP-seq
MIRT1965512	hsa-miR-4486	CLIP-seq
MIRT895451	hsa-miR-4493	CLIP-seq
MIRT895453	hsa-miR-4530	CLIP-seq
MIRT895454	hsa-miR-4533	CLIP-seq
MIRT1965513	hsa-miR-4537	CLIP-seq
MIRT895455	hsa-miR-455-3p	CLIP-seq
MIRT895458	hsa-miR-4685-5p	CLIP-seq
MIRT895459	hsa-miR-4688	CLIP-seq
MIRT895462	hsa-miR-4708-3p	CLIP-seq
MIRT895463	hsa-miR-4708-5p	CLIP-seq
MIRT895465	hsa-miR-4722-3p	CLIP-seq
MIRT1965514	hsa-miR-4723-3p	CLIP-seq
MIRT895469	hsa-miR-4729	CLIP-seq
MIRT895470	hsa-miR-4733-5p	CLIP-seq
MIRT1965515	hsa-miR-4736	CLIP-seq
MIRT895472	hsa-miR-4778-3p	CLIP-seq
MIRT895474	hsa-miR-4784	CLIP-seq
MIRT895475	hsa-miR-4786-3p	CLIP-seq
MIRT895476	hsa-miR-4792	CLIP-seq
MIRT895478	hsa-miR-486-3p	CLIP-seq
MIRT895479	hsa-miR-506	CLIP-seq
MIRT895481	hsa-miR-520d-5p	CLIP-seq
MIRT1965516	hsa-miR-522	CLIP-seq
MIRT895482	hsa-miR-524-5p	CLIP-seq
MIRT895484	hsa-miR-582-5p	CLIP-seq
MIRT895487	hsa-miR-622	CLIP-seq
MIRT895488	hsa-miR-661	CLIP-seq
MIRT1965517	hsa-miR-668	CLIP-seq
MIRT895489	hsa-miR-766	CLIP-seq
MIRT895490	hsa-miR-922	CLIP-seq
MIRT895491	hsa-miR-941	CLIP-seq
MIRT1965495	hsa-miR-10a	CLIP-seq
MIRT1965496	hsa-miR-10b	CLIP-seq
MIRT2201449	hsa-miR-1207-5p	CLIP-seq
MIRT895415	hsa-miR-124	CLIP-seq
MIRT2201450	hsa-miR-1247	CLIP-seq
MIRT895418	hsa-miR-127-5p	CLIP-seq
MIRT1965497	hsa-miR-1285	CLIP-seq
MIRT2201451	hsa-miR-1293	CLIP-seq
MIRT1965498	hsa-miR-1343	CLIP-seq
MIRT2201452	hsa-miR-1470	CLIP-seq
MIRT2201453	hsa-miR-1539	CLIP-seq
MIRT895420	hsa-miR-1910	CLIP-seq
MIRT2201454	hsa-miR-1913	CLIP-seq
MIRT895422	hsa-miR-1915	CLIP-seq
MIRT895423	hsa-miR-2116	CLIP-seq
MIRT1965499	hsa-miR-2277-5p	CLIP-seq
MIRT2201455	hsa-miR-2355-5p	CLIP-seq
MIRT895424	hsa-miR-298	CLIP-seq
MIRT2201456	hsa-miR-3065-3p	CLIP-seq
MIRT2201457	hsa-miR-3130-3p	CLIP-seq
MIRT895427	hsa-miR-3150b-3p	CLIP-seq
MIRT895428	hsa-miR-3155	CLIP-seq
MIRT895429	hsa-miR-3155b	CLIP-seq
MIRT1965501	hsa-miR-3176	CLIP-seq
MIRT1965502	hsa-miR-3178	CLIP-seq
MIRT1965503	hsa-miR-3183	CLIP-seq
MIRT895431	hsa-miR-3189-3p	CLIP-seq
MIRT2201458	hsa-miR-324-3p	CLIP-seq
MIRT1965505	hsa-miR-326	CLIP-seq
MIRT1965506	hsa-miR-330-5p	CLIP-seq
MIRT1965507	hsa-miR-339-5p	CLIP-seq
MIRT895433	hsa-miR-3591-5p	CLIP-seq
MIRT2201459	hsa-miR-361-3p	CLIP-seq
MIRT1965508	hsa-miR-3620	CLIP-seq
MIRT895434	hsa-miR-3664-5p	CLIP-seq
MIRT2201460	hsa-miR-3665	CLIP-seq
MIRT2201461	hsa-miR-3670	CLIP-seq
MIRT895437	hsa-miR-3689a-5p	CLIP-seq
MIRT895438	hsa-miR-3689b	CLIP-seq
MIRT895439	hsa-miR-3689e	CLIP-seq
MIRT895440	hsa-miR-3689f	CLIP-seq
MIRT895441	hsa-miR-382	CLIP-seq
MIRT2201462	hsa-miR-3918	CLIP-seq
MIRT1965509	hsa-miR-3922-3p	CLIP-seq
MIRT895442	hsa-miR-3922-5p	CLIP-seq
MIRT895444	hsa-miR-3928	CLIP-seq
MIRT895445	hsa-miR-4257	CLIP-seq
MIRT895446	hsa-miR-4264	CLIP-seq
MIRT1965510	hsa-miR-4267	CLIP-seq
MIRT1965511	hsa-miR-4286	CLIP-seq
MIRT2201463	hsa-miR-4290	CLIP-seq
MIRT895447	hsa-miR-4292	CLIP-seq
MIRT2201464	hsa-miR-4313	CLIP-seq
MIRT2201465	hsa-miR-4325	CLIP-seq
MIRT895449	hsa-miR-4435	CLIP-seq
MIRT895450	hsa-miR-4459	CLIP-seq
MIRT2201466	hsa-miR-4483	CLIP-seq
MIRT1965512	hsa-miR-4486	CLIP-seq
MIRT895451	hsa-miR-4493	CLIP-seq
MIRT895452	hsa-miR-4522	CLIP-seq
MIRT895453	hsa-miR-4530	CLIP-seq
MIRT895455	hsa-miR-455-3p	CLIP-seq
MIRT2201467	hsa-miR-4645-5p	CLIP-seq
MIRT2201468	hsa-miR-4663	CLIP-seq
MIRT2201469	hsa-miR-4667-3p	CLIP-seq
MIRT2201470	hsa-miR-4673	CLIP-seq
MIRT2201471	hsa-miR-4676-5p	CLIP-seq
MIRT895457	hsa-miR-4677-5p	CLIP-seq
MIRT895458	hsa-miR-4685-5p	CLIP-seq
MIRT895460	hsa-miR-4690-5p	CLIP-seq
MIRT895461	hsa-miR-4695-5p	CLIP-seq
MIRT895462	hsa-miR-4708-3p	CLIP-seq
MIRT895463	hsa-miR-4708-5p	CLIP-seq
MIRT895464	hsa-miR-4715-3p	CLIP-seq
MIRT895465	hsa-miR-4722-3p	CLIP-seq
MIRT895466	hsa-miR-4722-5p	CLIP-seq
MIRT1965514	hsa-miR-4723-3p	CLIP-seq
MIRT895467	hsa-miR-4726-3p	CLIP-seq
MIRT895469	hsa-miR-4729	CLIP-seq
MIRT895470	hsa-miR-4733-5p	CLIP-seq
MIRT1965515	hsa-miR-4736	CLIP-seq
MIRT895471	hsa-miR-4747-5p	CLIP-seq
MIRT2201472	hsa-miR-4749-3p	CLIP-seq
MIRT2201473	hsa-miR-4763-3p	CLIP-seq
MIRT895473	hsa-miR-4779	CLIP-seq
MIRT895474	hsa-miR-4784	CLIP-seq
MIRT895475	hsa-miR-4786-3p	CLIP-seq
MIRT895476	hsa-miR-4792	CLIP-seq
MIRT2201474	hsa-miR-4793-3p	CLIP-seq
MIRT895477	hsa-miR-484	CLIP-seq
MIRT895479	hsa-miR-506	CLIP-seq
MIRT895480	hsa-miR-520a-5p	CLIP-seq
MIRT895483	hsa-miR-525-5p	CLIP-seq
MIRT2201475	hsa-miR-541	CLIP-seq
MIRT2201476	hsa-miR-548ac	CLIP-seq
MIRT2201477	hsa-miR-548d-3p	CLIP-seq
MIRT2201478	hsa-miR-548z	CLIP-seq
MIRT2201479	hsa-miR-575	CLIP-seq
MIRT2201480	hsa-miR-593	CLIP-seq
MIRT2201481	hsa-miR-596	CLIP-seq
MIRT2201482	hsa-miR-615-5p	CLIP-seq
MIRT895485	hsa-miR-617	CLIP-seq
MIRT895486	hsa-miR-621	CLIP-seq
MIRT895487	hsa-miR-622	CLIP-seq
MIRT2201483	hsa-miR-654-5p	CLIP-seq
MIRT1965517	hsa-miR-668	CLIP-seq
MIRT895490	hsa-miR-922	CLIP-seq
MIRT2201484	hsa-miR-940	CLIP-seq
MIRT895491	hsa-miR-941	CLIP-seq
MIRT2201453	hsa-miR-1539	CLIP-seq
MIRT895420	hsa-miR-1910	CLIP-seq
MIRT895423	hsa-miR-2116	CLIP-seq
MIRT895434	hsa-miR-3664-5p	CLIP-seq
MIRT2201461	hsa-miR-3670	CLIP-seq
MIRT895444	hsa-miR-3928	CLIP-seq
MIRT895446	hsa-miR-4264	CLIP-seq
MIRT895452	hsa-miR-4522	CLIP-seq
MIRT895455	hsa-miR-455-3p	CLIP-seq
MIRT2201468	hsa-miR-4663	CLIP-seq
MIRT895457	hsa-miR-4677-5p	CLIP-seq
MIRT895458	hsa-miR-4685-5p	CLIP-seq
MIRT895486	hsa-miR-621	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004888	Function	Transmembrane signaling receptor activity	TAS	9334247
GO:0005198	Function	Structural molecule activity	IEA
GO:0005254	Function	Chloride channel activity	IEA
GO:0005515	Function	Protein binding	IPI	27647526, 32296183
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	20375010
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	IMP	23407391
GO:0005886	Component	Plasma membrane	TAS	9334247
GO:0005911	Component	Cell-cell junction	IDA	18774778
GO:0005923	Component	Bicellular tight junction	IBA
GO:0005923	Component	Bicellular tight junction	IDA	23407391
GO:0005923	Component	Bicellular tight junction	IEA
GO:0005923	Component	Bicellular tight junction	ISS
GO:0006811	Process	Monoatomic ion transport	IEA
GO:0006821	Process	Chloride transport	IEA
GO:0007155	Process	Cell adhesion	IBA
GO:0007565	Process	Female pregnancy	IEA
GO:0007623	Process	Circadian rhythm	IEA
GO:0009925	Component	Basal plasma membrane	IEA
GO:0016020	Component	Membrane	IEA
GO:0016324	Component	Apical plasma membrane	IEA
GO:0016327	Component	Apicolateral plasma membrane	IEA
GO:0016328	Component	Lateral plasma membrane	IEA
GO:0016338	Process	Calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules	ISS
GO:0022604	Process	Regulation of cell morphogenesis	IMP	16103090
GO:0030335	Process	Positive regulation of cell migration	IMP	16103090
GO:0032570	Process	Response to progesterone	IEA
GO:0034220	Process	Monoatomic ion transmembrane transport	IEA
GO:0034707	Component	Chloride channel complex	IEA
GO:0042802	Function	Identical protein binding	ISS
GO:0061436	Process	Establishment of skin barrier	IMP	23407391
GO:0070160	Component	Tight junction	IDA	30734065
GO:0070161	Component	Anchoring junction	IEA
GO:0070293	Process	Renal absorption	ISS
GO:0070830	Process	Bicellular tight junction assembly	IBA
GO:0090303	Process	Positive regulation of wound healing	IMP	16103090
GO:0160184	Process	Paracellular transport	ISS
GO:1902476	Process	Chloride transmembrane transport	IEA

Other IDs

• MIM: 602909
• HGNC: 2046
• e!Ensembl: ENSG00000189143

Protein

• UniProt ID: O14493
• Protein name: Claudin-4 (Clostridium perfringens enterotoxin receptor) (CPE-R) (CPE-receptor) (Williams-Beuren syndrome chromosomal region 8 protein)
• Protein function: Can associate with other claudins to regulate tight junction structural and functional strand dynamics (PubMed:35773259, PubMed:36008380). May coassemble with CLDN8 into tight junction strands containing anion-selective channels that convey para
• PDB: 5B2G, 7KP4, 7TDM, 7TDN, 8U4V, 8U5B, 9CMH, 9CMI
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00822	PMP22_Claudin	4 → 181	PMP-22/EMP/MP20/Claudin family	Family

• Sequence:

  MASMGLQVMGIALAVLGWLAVMLCCALPMWRVTAFIGSNIVTSQTIWEGLWMNCVVQSTG
  QMQCKVYDSLLALPQDLQAARALVIISIIVAALGVLLSVVGGKCTNCLEDESAKAKTMIV
  AGVVFLLAGLMVIVPVSWTAHNIIQDFYNPLVASGQKREMGASLYVGWAASGLLLLGGGL
  LCCNCPPRTDKPYSAKYSAARSAAASNYV

• Sequence length: 209

Pathways

KEGG:

Virion - Hepatitis viruses
Cell adhesion molecules
Tight junction
Leukocyte transendothelial migration
Pathogenic Escherichia coli infection
Hepatitis C