Gene Gene information from NCBI Gene database.
Entrez ID 136319
Gene name Myotrophin
Gene symbol MTPN
Synonyms (NCBI Gene)
GCDPV-1
Chromosome 7
Chromosome location 7q33
Summary The transcript produced from this gene is bi-cistronic and can encode both myotrophin and leucine zipper protein 6. The myotrophin protein is associated with cardiac hypertrophy, where it is involved in the conversion of NFkappa B p50-p65 heterodimers to
miRNA miRNA information provided by mirtarbase database.
1222
miRTarBase ID miRNA Experiments Reference
MIRT000054 hsa-miR-375 Reporter assay;Other 15538371
MIRT001834 hsa-miR-124-3p Reporter assay 15806104
MIRT023322 hsa-miR-122-5p Microarray 17612493
MIRT030848 hsa-miR-21-5p Microarray 18591254
MIRT001850 hsa-let-7b-5p Reporter assay 15806104
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
20
GO ID Ontology Definition Evidence Reference
GO:0005634 Component Nucleus IBA
GO:0005634 Component Nucleus IEA
GO:0005634 Component Nucleus ISS
GO:0005737 Component Cytoplasm IBA
GO:0005737 Component Cytoplasm IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
606484 15667 ENSG00000105887
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P58546
Protein name Myotrophin (Protein V-1)
Protein function Promotes dimerization of NF-kappa-B subunits and regulates NF-kappa-B transcription factor activity (By similarity). Plays a role in the regulation of the growth of actin filaments. Inhibits the activity of the F-actin-capping protein complex fo
PDB 3AAA , 7DF7 , 7DSA , 7DSB
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF12796 Ank_2 6 98 Ankyrin repeats (3 copies) Repeat
Tissue specificity TISSUE SPECIFICITY: Ubiquitous. {ECO:0000269|PubMed:10329199}.
Sequence
Sequence length 118
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
7
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
BONE DISEASE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CARTILAGE DISEASE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
DEMENTIA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
DRY EYE SYNDROME GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References Evidence Score
Cardiomegaly Associate 9194197
★☆☆☆☆
Found in Text Mining only
Cardiomyopathy Hypertrophic Associate 9194197
★☆☆☆☆
Found in Text Mining only
Glioma Associate 17453002
★☆☆☆☆
Found in Text Mining only
Heart Diseases Associate 12932609
★☆☆☆☆
Found in Text Mining only
Heart Failure Stimulate 12932609
★☆☆☆☆
Found in Text Mining only
Heart Failure Associate 33518662
★☆☆☆☆
Found in Text Mining only
Hypertension Associate 9194197
★☆☆☆☆
Found in Text Mining only
Hypertrophy Stimulate 12932609
★☆☆☆☆
Found in Text Mining only
Neoplasms Stimulate 16982933
★☆☆☆☆
Found in Text Mining only
Postural Orthostatic Tachycardia Syndrome Associate 40022872
★☆☆☆☆
Found in Text Mining only