Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	136
Gene name	Adenosine A2b receptor
Gene symbol	ADORA2B
Synonyms (NCBI Gene)	ADORA2
Chromosome	17
Chromosome location	17p12
Summary	This gene encodes an adenosine receptor that is a member of the G protein-coupled receptor superfamily. This integral membrane protein stimulates adenylate cyclase activity in the presence of adenosine. This protein also interacts with netrin-1, which is

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Show/Hide all (229)

miRTarBase ID	miRNA	Experiments	Reference
MIRT004499	hsa-miR-27b-3p	qRT-PCRLuciferase reporter assay	20388705
MIRT559721	hsa-miR-3681-3p	PAR-CLIP	21572407
MIRT559720	hsa-miR-216a-3p	PAR-CLIP	21572407
MIRT004499	hsa-miR-27b-3p	PAR-CLIP	21572407
MIRT076088	hsa-miR-27a-3p	PAR-CLIP	21572407
MIRT035581	hsa-miR-128-3p	PAR-CLIP	21572407
MIRT076091	hsa-miR-452-5p	PAR-CLIP	21572407
MIRT076119	hsa-miR-4676-3p	PAR-CLIP	21572407
MIRT076127	hsa-miR-892c-3p	PAR-CLIP	21572407
MIRT559719	hsa-miR-216b-3p	PAR-CLIP	21572407
MIRT076103	hsa-miR-1208	PAR-CLIP	21572407
MIRT116052	hsa-miR-545-5p	PAR-CLIP	21572407
MIRT076090	hsa-miR-377-3p	PAR-CLIP	21572407
MIRT076092	hsa-miR-513a-5p	PAR-CLIP	21572407
MIRT559718	hsa-miR-222-5p	PAR-CLIP	21572407
MIRT116049	hsa-miR-30a-3p	PAR-CLIP	21572407
MIRT116050	hsa-miR-30d-3p	PAR-CLIP	21572407
MIRT116051	hsa-miR-30e-3p	PAR-CLIP	21572407
MIRT482422	hsa-miR-944	PAR-CLIP	23592263
MIRT482421	hsa-miR-552-3p	PAR-CLIP	23592263
MIRT482420	hsa-miR-5003-3p	PAR-CLIP	23592263
MIRT482419	hsa-miR-6504-3p	PAR-CLIP	23592263
MIRT482418	hsa-miR-3934-5p	PAR-CLIP	23592263
MIRT482417	hsa-miR-6872-3p	PAR-CLIP	23592263
MIRT482416	hsa-miR-6850-3p	PAR-CLIP	23592263
MIRT482415	hsa-miR-5095	PAR-CLIP	23592263
MIRT482414	hsa-miR-7151-3p	PAR-CLIP	23592263
MIRT482413	hsa-miR-6807-5p	PAR-CLIP	23592263
MIRT035581	hsa-miR-128-3p	Luciferase reporter assayqRT-PCRWestern blot	26478435
MIRT035581	hsa-miR-128-3p	Luciferase reporter assayqRT-PCRWestern blot	26478435
MIRT482418	hsa-miR-3934-5p	PAR-CLIP	26701625
MIRT482418	hsa-miR-3934-5p	PAR-CLIP	26701625
MIRT482420	hsa-miR-5003-3p	PAR-CLIP	26701625
MIRT482420	hsa-miR-5003-3p	PAR-CLIP	26701625
MIRT482415	hsa-miR-5095	PAR-CLIP	26701625
MIRT482415	hsa-miR-5095	PAR-CLIP	26701625
MIRT482421	hsa-miR-552-3p	PAR-CLIP	26701625
MIRT482421	hsa-miR-552-3p	PAR-CLIP	26701625
MIRT482419	hsa-miR-6504-3p	PAR-CLIP	26701625
MIRT482419	hsa-miR-6504-3p	PAR-CLIP	26701625
MIRT482413	hsa-miR-6807-5p	PAR-CLIP	26701625
MIRT482413	hsa-miR-6807-5p	PAR-CLIP	26701625
MIRT482416	hsa-miR-6850-3p	PAR-CLIP	26701625
MIRT482416	hsa-miR-6850-3p	PAR-CLIP	26701625
MIRT482417	hsa-miR-6872-3p	PAR-CLIP	26701625
MIRT482417	hsa-miR-6872-3p	PAR-CLIP	26701625
MIRT482414	hsa-miR-7151-3p	PAR-CLIP	26701625
MIRT482414	hsa-miR-7151-3p	PAR-CLIP	26701625
MIRT482422	hsa-miR-944	PAR-CLIP	26701625
MIRT482422	hsa-miR-944	PAR-CLIP	26701625
MIRT559721	hsa-miR-3681-3p	PAR-CLIP	21572407
MIRT559720	hsa-miR-216a-3p	PAR-CLIP	21572407
MIRT004499	hsa-miR-27b-3p	PAR-CLIP	21572407
MIRT076088	hsa-miR-27a-3p	PAR-CLIP	21572407
MIRT035581	hsa-miR-128-3p	PAR-CLIP	21572407
MIRT076091	hsa-miR-452-5p	PAR-CLIP	21572407
MIRT076119	hsa-miR-4676-3p	PAR-CLIP	21572407
MIRT076127	hsa-miR-892c-3p	PAR-CLIP	21572407
MIRT559719	hsa-miR-216b-3p	PAR-CLIP	21572407
MIRT076103	hsa-miR-1208	PAR-CLIP	21572407
MIRT116052	hsa-miR-545-5p	PAR-CLIP	21572407
MIRT076090	hsa-miR-377-3p	PAR-CLIP	21572407
MIRT076092	hsa-miR-513a-5p	PAR-CLIP	21572407
MIRT559718	hsa-miR-222-5p	PAR-CLIP	21572407
MIRT116049	hsa-miR-30a-3p	PAR-CLIP	21572407
MIRT116050	hsa-miR-30d-3p	PAR-CLIP	21572407
MIRT116051	hsa-miR-30e-3p	PAR-CLIP	21572407
MIRT482422	hsa-miR-944	PAR-CLIP	23592263
MIRT482421	hsa-miR-552-3p	PAR-CLIP	23592263
MIRT482420	hsa-miR-5003-3p	PAR-CLIP	23592263
MIRT482419	hsa-miR-6504-3p	PAR-CLIP	23592263
MIRT482418	hsa-miR-3934-5p	PAR-CLIP	23592263
MIRT482417	hsa-miR-6872-3p	PAR-CLIP	23592263
MIRT482416	hsa-miR-6850-3p	PAR-CLIP	23592263
MIRT482415	hsa-miR-5095	PAR-CLIP	23592263
MIRT482414	hsa-miR-7151-3p	PAR-CLIP	23592263
MIRT482413	hsa-miR-6807-5p	PAR-CLIP	23592263
MIRT769598	hsa-miR-128	CLIP-seq
MIRT769599	hsa-miR-2052	CLIP-seq
MIRT769600	hsa-miR-27a	CLIP-seq
MIRT769601	hsa-miR-27b	CLIP-seq
MIRT769602	hsa-miR-3189-3p	CLIP-seq
MIRT769603	hsa-miR-33a	CLIP-seq
MIRT769604	hsa-miR-33b	CLIP-seq
MIRT769605	hsa-miR-3545-3p	CLIP-seq
MIRT769606	hsa-miR-362-5p	CLIP-seq
MIRT769607	hsa-miR-369-3p	CLIP-seq
MIRT769608	hsa-miR-374a	CLIP-seq
MIRT769609	hsa-miR-374b	CLIP-seq
MIRT769610	hsa-miR-377	CLIP-seq
MIRT769611	hsa-miR-432	CLIP-seq
MIRT769612	hsa-miR-4454	CLIP-seq
MIRT769613	hsa-miR-452	CLIP-seq
MIRT769614	hsa-miR-4528	CLIP-seq
MIRT769615	hsa-miR-4680-5p	CLIP-seq
MIRT769616	hsa-miR-4763-5p	CLIP-seq
MIRT769617	hsa-miR-4775	CLIP-seq
MIRT769618	hsa-miR-4789-3p	CLIP-seq
MIRT769619	hsa-miR-500a	CLIP-seq
MIRT769620	hsa-miR-500b	CLIP-seq
MIRT769621	hsa-miR-548l	CLIP-seq
MIRT769622	hsa-miR-548n	CLIP-seq
MIRT769623	hsa-miR-590-3p	CLIP-seq
MIRT769624	hsa-miR-633	CLIP-seq
MIRT769625	hsa-miR-642b	CLIP-seq
MIRT1927039	hsa-miR-4536	CLIP-seq
MIRT769616	hsa-miR-4763-5p	CLIP-seq
MIRT769618	hsa-miR-4789-3p	CLIP-seq
MIRT769625	hsa-miR-642b	CLIP-seq
MIRT2167921	hsa-miR-106a	CLIP-seq
MIRT2167922	hsa-miR-106b	CLIP-seq
MIRT2167923	hsa-miR-17	CLIP-seq
MIRT2167924	hsa-miR-20a	CLIP-seq
MIRT2167925	hsa-miR-20b	CLIP-seq
MIRT2167926	hsa-miR-302a	CLIP-seq
MIRT2167927	hsa-miR-302b	CLIP-seq
MIRT2167928	hsa-miR-302c	CLIP-seq
MIRT2167929	hsa-miR-302d	CLIP-seq
MIRT2167930	hsa-miR-302e	CLIP-seq
MIRT2167931	hsa-miR-372	CLIP-seq
MIRT2167932	hsa-miR-373	CLIP-seq
MIRT2167933	hsa-miR-512-3p	CLIP-seq
MIRT2167934	hsa-miR-519d	CLIP-seq
MIRT2167935	hsa-miR-520a-3p	CLIP-seq
MIRT2167936	hsa-miR-520b	CLIP-seq
MIRT2167937	hsa-miR-520c-3p	CLIP-seq
MIRT2167938	hsa-miR-520d-3p	CLIP-seq
MIRT2167939	hsa-miR-520e	CLIP-seq
MIRT2167940	hsa-miR-520g	CLIP-seq
MIRT2167941	hsa-miR-520h	CLIP-seq
MIRT2167942	hsa-miR-93	CLIP-seq
MIRT2383956	hsa-miR-1827	CLIP-seq
MIRT2383957	hsa-miR-2682	CLIP-seq
MIRT2167926	hsa-miR-302a	CLIP-seq
MIRT2167927	hsa-miR-302b	CLIP-seq
MIRT2167928	hsa-miR-302c	CLIP-seq
MIRT2167929	hsa-miR-302d	CLIP-seq
MIRT2167930	hsa-miR-302e	CLIP-seq
MIRT2383958	hsa-miR-335	CLIP-seq
MIRT2167931	hsa-miR-372	CLIP-seq
MIRT2167932	hsa-miR-373	CLIP-seq
MIRT2383959	hsa-miR-449c	CLIP-seq
MIRT1927039	hsa-miR-4536	CLIP-seq
MIRT2383960	hsa-miR-455-3p	CLIP-seq
MIRT2383961	hsa-miR-4685-5p	CLIP-seq
MIRT769618	hsa-miR-4789-3p	CLIP-seq
MIRT2167935	hsa-miR-520a-3p	CLIP-seq
MIRT2167936	hsa-miR-520b	CLIP-seq
MIRT2167937	hsa-miR-520c-3p	CLIP-seq
MIRT2167938	hsa-miR-520d-3p	CLIP-seq
MIRT2167939	hsa-miR-520e	CLIP-seq
MIRT769625	hsa-miR-642b	CLIP-seq
MIRT2443276	hsa-miR-1976	CLIP-seq
MIRT2443277	hsa-miR-3690	CLIP-seq
MIRT2443278	hsa-miR-4254	CLIP-seq
MIRT2443279	hsa-miR-4279	CLIP-seq
MIRT2443280	hsa-miR-7	CLIP-seq
MIRT2167921	hsa-miR-106a	CLIP-seq
MIRT2167922	hsa-miR-106b	CLIP-seq
MIRT2470436	hsa-miR-1287	CLIP-seq
MIRT2470437	hsa-miR-1294	CLIP-seq
MIRT2470438	hsa-miR-150	CLIP-seq
MIRT2167923	hsa-miR-17	CLIP-seq
MIRT2383956	hsa-miR-1827	CLIP-seq
MIRT2167924	hsa-miR-20a	CLIP-seq
MIRT2167925	hsa-miR-20b	CLIP-seq
MIRT2383957	hsa-miR-2682	CLIP-seq
MIRT2167926	hsa-miR-302a	CLIP-seq
MIRT2167927	hsa-miR-302b	CLIP-seq
MIRT2167928	hsa-miR-302c	CLIP-seq
MIRT2167929	hsa-miR-302d	CLIP-seq
MIRT2167930	hsa-miR-302e	CLIP-seq
MIRT2470439	hsa-miR-3135b	CLIP-seq
MIRT2383958	hsa-miR-335	CLIP-seq
MIRT2167931	hsa-miR-372	CLIP-seq
MIRT2167932	hsa-miR-373	CLIP-seq
MIRT2470440	hsa-miR-3909	CLIP-seq
MIRT2470441	hsa-miR-4312	CLIP-seq
MIRT2470442	hsa-miR-4316	CLIP-seq
MIRT2383959	hsa-miR-449c	CLIP-seq
MIRT1927039	hsa-miR-4536	CLIP-seq
MIRT2383960	hsa-miR-455-3p	CLIP-seq
MIRT2383961	hsa-miR-4685-5p	CLIP-seq
MIRT2470443	hsa-miR-4757-5p	CLIP-seq
MIRT769618	hsa-miR-4789-3p	CLIP-seq
MIRT2470444	hsa-miR-502-5p	CLIP-seq
MIRT2167933	hsa-miR-512-3p	CLIP-seq
MIRT2470445	hsa-miR-513b	CLIP-seq
MIRT2167934	hsa-miR-519d	CLIP-seq
MIRT2167935	hsa-miR-520a-3p	CLIP-seq
MIRT2167936	hsa-miR-520b	CLIP-seq
MIRT2167937	hsa-miR-520c-3p	CLIP-seq
MIRT2167938	hsa-miR-520d-3p	CLIP-seq
MIRT2167939	hsa-miR-520e	CLIP-seq
MIRT2167940	hsa-miR-520g	CLIP-seq
MIRT2167941	hsa-miR-520h	CLIP-seq
MIRT2470446	hsa-miR-548aa	CLIP-seq
MIRT2470447	hsa-miR-552	CLIP-seq
MIRT2470448	hsa-miR-570	CLIP-seq
MIRT769625	hsa-miR-642b	CLIP-seq
MIRT2167942	hsa-miR-93	CLIP-seq
MIRT2470437	hsa-miR-1294	CLIP-seq
MIRT2383956	hsa-miR-1827	CLIP-seq
MIRT2383957	hsa-miR-2682	CLIP-seq
MIRT2167926	hsa-miR-302a	CLIP-seq
MIRT2167927	hsa-miR-302b	CLIP-seq
MIRT2167928	hsa-miR-302c	CLIP-seq
MIRT2167929	hsa-miR-302d	CLIP-seq
MIRT2167930	hsa-miR-302e	CLIP-seq
MIRT2383958	hsa-miR-335	CLIP-seq
MIRT2167931	hsa-miR-372	CLIP-seq
MIRT2167932	hsa-miR-373	CLIP-seq
MIRT2470440	hsa-miR-3909	CLIP-seq
MIRT2470442	hsa-miR-4316	CLIP-seq
MIRT2383959	hsa-miR-449c	CLIP-seq
MIRT1927039	hsa-miR-4536	CLIP-seq
MIRT2383960	hsa-miR-455-3p	CLIP-seq
MIRT2383961	hsa-miR-4685-5p	CLIP-seq
MIRT769618	hsa-miR-4789-3p	CLIP-seq
MIRT2470444	hsa-miR-502-5p	CLIP-seq
MIRT2470445	hsa-miR-513b	CLIP-seq
MIRT2167935	hsa-miR-520a-3p	CLIP-seq
MIRT2167936	hsa-miR-520b	CLIP-seq
MIRT2167937	hsa-miR-520c-3p	CLIP-seq
MIRT2167938	hsa-miR-520d-3p	CLIP-seq
MIRT2167939	hsa-miR-520e	CLIP-seq
MIRT2470446	hsa-miR-548aa	CLIP-seq
MIRT2470448	hsa-miR-570	CLIP-seq
MIRT769625	hsa-miR-642b	CLIP-seq

Show/Hide all (30)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001609	Function	G protein-coupled adenosine receptor activity	IBA
GO:0001609	Function	G protein-coupled adenosine receptor activity	IEA
GO:0001973	Process	G protein-coupled adenosine receptor signaling pathway	IEA
GO:0002882	Process	Positive regulation of chronic inflammatory response to non-antigenic stimulus	IEA
GO:0004930	Function	G protein-coupled receptor activity	IEA
GO:0005515	Function	Protein binding	IPI	29568380
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS	7558011
GO:0007165	Process	Signal transduction	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	TAS	7558011
GO:0007189	Process	Adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA
GO:0007189	Process	Adenylate cyclase-activating G protein-coupled receptor signaling pathway	IEA
GO:0007190	Process	Activation of adenylate cyclase activity	TAS	8022409
GO:0010575	Process	Positive regulation of vascular endothelial growth factor production	IEA
GO:0010753	Process	Positive regulation of cGMP-mediated signaling	IEA
GO:0016020	Component	Membrane	IEA
GO:0019934	Process	CGMP-mediated signaling	IEA
GO:0032722	Process	Positive regulation of chemokine production	IEA
GO:0032755	Process	Positive regulation of interleukin-6 production	IEA
GO:0042311	Process	Vasodilation	IBA
GO:0043303	Process	Mast cell degranulation	IEA
GO:0043306	Process	Positive regulation of mast cell degranulation	IEA
GO:0045202	Component	Synapse	IEA
GO:0060087	Process	Relaxation of vascular associated smooth muscle	IEA
GO:0098685	Component	Schaffer collateral - CA1 synapse	IEA
GO:0098793	Component	Presynapse	IEA
GO:0098978	Component	Glutamatergic synapse	IEA
GO:0099171	Process	Presynaptic modulation of chemical synaptic transmission	IEA

MIM	HGNC	e!Ensembl
600446	264	ENSG00000170425

P29275

Protein name

Adenosine receptor A2b

Protein function

Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

PDB

7XY6 , 7XY7 , 8HDO , 8HDP

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00001	7tm_1	24 → 290	7 transmembrane receptor (rhodopsin family)	Family

Sequence

MLLETQDALYVALELVIAALSVAGNVLVCAAVGTANTLQTPTNYFLVSLAAADVAVGLFA
IPFAITISLGFCTDFYGCLFLACFVLVLTQSSIFSLLAVAVDRYLAICVPLRYKSLVTGT
RARGVIAVLWVLAFGIGLTPFLGWNSKDSATNNCTEPWDGTTNESCCLVKCLFENVVPMS
YMVYFNFFGCVLPPLLIMLVIYIKIFLVACRQLQRTELMDHSRTTLQREIHAAKSLAMIV
GIFALCWLPVHAVNCVTLFQPAQGKNKPKWAMNMAILLSHANSVVNPIVYAYRNRDFRYT
FHKIISRYLLCQADVKSGNGQAGVQPALGVGL

Sequence length

332

Interactions

View interactions

	KEGG		Reactome
	Rap1 signaling pathway Calcium signaling pathway Neuroactive ligand-receptor interaction Vascular smooth muscle contraction Alcoholism		Adenosine P1 receptors G alpha (s) signalling events Surfactant metabolism ADORA2B mediated anti-inflammatory cytokines production

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Cervical cancer	Benign	rs61755963	RCV005913446

Show/Hide Text Mining Associations (26)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Anemia Sickle Cell	Associate	22679008
Asthma	Stimulate	26232643
Breast Neoplasms	Associate	28971320, 35401817
COVID 19	Stimulate	35091759
Dyslipidemias	Associate	32075205
Familial medullary thyroid carcinoma	Stimulate	35203352
Heart Failure	Associate	25629231
Hypoxia	Stimulate	26228921
Inflammation	Associate	26232643
Inflammatory Bowel Diseases	Associate	19253308
Inflammatory Bowel Diseases	Stimulate	22038827
Lung Neoplasms	Associate	31678144
Lymphatic Metastasis	Associate	36786018
Mouth Neoplasms	Associate	26228921
Neoplasm Metastasis	Associate	36786018
Neoplasms	Associate	22038827, 22119961, 32348778, 40221657
Neoplasms	Inhibit	28971320
Neuralgia	Associate	33494823
Ovarian Neoplasms	Associate	35562985, 37278400
Pain	Associate	33494823
Pancreatic Neoplasms	Associate	39639217
Pulmonary Disease Chronic Obstructive	Associate	33658578
Spinal Cord Injuries	Associate	33494823
Squamous Cell Carcinoma of Head and Neck	Stimulate	26228921
Squamous Cell Carcinoma of Head and Neck	Associate	40221657
Stomach Neoplasms	Associate	36786018

ADORA2B (adenosine A2b receptor)