CPA2 (carboxypeptidase A2)

Gene
Gene Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
1358
Gene name Gene Name - the full gene name approved by the HGNC.
Carboxypeptidase A2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
CPA2
Synonyms (NCBI Gene) Gene synonyms aliases
-
Chromosome Chromosome number
7
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
7q32.2
Summary Summary of gene provided in NCBI Entrez Gene.
Three different forms of human pancreatic procarboxypeptidase A have been isolated. The encoded protein represents the A2 form, which is a monomeric protein with different biochemical properties from the A1 and A3 forms. The A2 form of pancreatic procarbo
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(9)
GO ID Ontology Definition Evidence Reference
GO:0004180 Function Carboxypeptidase activity IDA 2920728
GO:0004181 Function Metallocarboxypeptidase activity IBA 21873635
GO:0004181 Function Metallocarboxypeptidase activity IDA 2920728
GO:0005576 Component Extracellular region IDA 2920728
GO:0005615 Component Extracellular space IBA 21873635
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
600688 2297 ENSG00000158516
Protein
Gene Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID P48052
Protein name Carboxypeptidase A2 (EC 3.4.17.15)
Protein function Carboxypeptidase that catalyzes the release of a C-terminal amino acid, with a preference for large aromatic C-terminal residues.
PDB 1AYE , 1DTD , 1O6X
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF02244 Propep_M14 28 → 102 Carboxypeptidase activation peptide Domain
PF00246 Peptidase_M14 129 → 406 Zinc carboxypeptidase Domain
Sequence
Sequence length 419
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG  
  Pancreatic secretion
Protein digestion and absorption 		 
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Causal Diseases (1)
Causal
Disease term Disease name dbSNP ID References
Lymphoblastic leukemia Precursor Cell Lymphoblastic Leukemia Lymphoma rs387906351, rs104894562, rs398122513, rs398122840, rs1057524466, rs1064796115, rs1064795660, rs1064793129, rs1064796227, rs1567887558, rs1161194345, rs1597558200, rs1406320425, rs1597566470, rs1597566699
View all (13 more)		 27114598
Show/Hide Text Mining Associations (3)
Associations from Text Mining
Disease Name Relationship Type References
Pancreatic Neoplasms Associate 33099939
Pancreatitis Associate 27114598
Stomach Neoplasms Associate 37290894