Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	1356
Gene name Gene Name - the full gene name approved by the HGNC.	Ceruloplasmin
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	CP
Synonyms (NCBI Gene) Gene synonyms aliases	AB073614, CP-2
Chromosome Chromosome number	3
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	3q24-q25.1
Summary Summary of gene provided in NCBI Entrez Gene.	The protein encoded by this gene is a metalloprotein that binds most of the copper in plasma and is involved in the peroxidation of Fe(II)transferrin to Fe(III) transferrin. Mutations in this gene cause aceruloplasminemia, which results in iron accumulati

Show/Hide all(63)

SNP ID	Visualize variation	Clinical significance	Consequence
rs34386552	G>A	Conflicting-interpretations-of-pathogenicity	Non coding transcript variant, coding sequence variant, missense variant
rs34394958	A>C,G	Benign-likely-benign, likely-benign, pathogenic, benign	Non coding transcript variant, coding sequence variant, synonymous variant, missense variant
rs34987997	T>A,C	Conflicting-interpretations-of-pathogenicity, likely-benign	Non coding transcript variant, coding sequence variant, synonymous variant, missense variant
rs56033670	G>C	Conflicting-interpretations-of-pathogenicity, benign	Non coding transcript variant, coding sequence variant, missense variant
rs121909579	C>T	Pathogenic	Non coding transcript variant, stop gained, coding sequence variant
rs139633388	C>G	Conflicting-interpretations-of-pathogenicity, uncertain-significance	Missense variant, non coding transcript variant, coding sequence variant
rs151304828	G>A	Conflicting-interpretations-of-pathogenicity, likely-benign	Coding sequence variant, synonymous variant, non coding transcript variant
rs200683433	C>G	Pathogenic	Coding sequence variant, non coding transcript variant, missense variant
rs369900671	G>C	Pathogenic	Coding sequence variant, non coding transcript variant, stop gained
rs386134121	T>A	Pathogenic	Missense variant, non coding transcript variant, coding sequence variant
rs386134122	G>C	Pathogenic	Missense variant, non coding transcript variant, coding sequence variant
rs386134123	A>C,G	Pathogenic	Missense variant, non coding transcript variant, coding sequence variant
rs386134124	G>A,C,T	Pathogenic	Missense variant, non coding transcript variant, coding sequence variant
rs386134125	A>G	Pathogenic	Missense variant, non coding transcript variant, coding sequence variant
rs386134126	C>G	Pathogenic	Missense variant, non coding transcript variant, coding sequence variant
rs386134127	G>T	Pathogenic	Missense variant, non coding transcript variant, coding sequence variant
rs386134128	A>G,T	Pathogenic	Missense variant, non coding transcript variant, coding sequence variant
rs386134129	C>T	Pathogenic	Missense variant, non coding transcript variant, coding sequence variant, intron variant
rs386134130	G>T	Pathogenic	Missense variant, non coding transcript variant, coding sequence variant
rs386134131	C>T	Pathogenic	Missense variant, non coding transcript variant, coding sequence variant
rs386134132	T>C	Pathogenic	Missense variant, non coding transcript variant, coding sequence variant
rs386134133	C>T	Pathogenic	Missense variant, non coding transcript variant, coding sequence variant
rs386134134	C>A,T	Pathogenic	Splice donor variant
rs386134135	C>T	Pathogenic	Splice acceptor variant
rs386134136	C>T	Pathogenic	Splice donor variant
rs386134137	T>C	Pathogenic	Splice acceptor variant
rs386134138	->AC	Pathogenic	Non coding transcript variant, coding sequence variant, splice acceptor variant
rs386134139	C>T	Pathogenic	Splice acceptor variant, intron variant
rs386134140	C>A	Pathogenic	Splice donor variant
rs386134141	C>A,T	Likely-pathogenic, pathogenic	Splice acceptor variant
rs386134142	C>T	Pathogenic	Splice acceptor variant, intron variant
rs386134143	->T	Pathogenic	Non coding transcript variant, coding sequence variant, frameshift variant
rs386134144	AA>-	Pathogenic	Non coding transcript variant, coding sequence variant, frameshift variant
rs386134145	->GTGTA	Pathogenic	Non coding transcript variant, coding sequence variant, frameshift variant
rs386134146	C>-	Pathogenic	Non coding transcript variant, coding sequence variant, frameshift variant, intron variant
rs386134147	G>-	Pathogenic	Non coding transcript variant, coding sequence variant, frameshift variant, intron variant
rs386134148	C>-	Pathogenic	Non coding transcript variant, coding sequence variant, frameshift variant, intron variant
rs386134149	C>-	Pathogenic	Non coding transcript variant, coding sequence variant, frameshift variant
rs386134150	C>-	Pathogenic	Non coding transcript variant, coding sequence variant, frameshift variant
rs386134151	->A	Pathogenic	Non coding transcript variant, coding sequence variant, frameshift variant
rs386134152	C>-	Pathogenic	Non coding transcript variant, coding sequence variant, frameshift variant
rs386134153	AG>-	Pathogenic	Non coding transcript variant, coding sequence variant, frameshift variant
rs386134154	->T	Pathogenic	Non coding transcript variant, coding sequence variant, frameshift variant
rs386134155	G>A	Pathogenic	Non coding transcript variant, coding sequence variant, stop gained
rs386134156	G>A	Pathogenic	Non coding transcript variant, coding sequence variant, stop gained
rs529607771	C>T	Conflicting-interpretations-of-pathogenicity, uncertain-significance	Missense variant, non coding transcript variant, coding sequence variant
rs587777922	G>-	Pathogenic	Coding sequence variant, non coding transcript variant, frameshift variant
rs750451693	C>T	Likely-pathogenic, uncertain-significance	Non coding transcript variant, coding sequence variant, missense variant
rs753254095	C>-	Likely-pathogenic	Non coding transcript variant, coding sequence variant, splice donor variant
rs767161351	G>A,C,T	Likely-pathogenic	Coding sequence variant, non coding transcript variant, missense variant
rs769313989	A>T	Pathogenic	Coding sequence variant, non coding transcript variant, missense variant
rs776936158	C>T	Likely-pathogenic, pathogenic-likely-pathogenic	Non coding transcript variant, coding sequence variant, intron variant, missense variant
rs1057518247	T>C	Pathogenic	Splice acceptor variant
rs1064797073	C>A	Likely-pathogenic	Missense variant, non coding transcript variant, coding sequence variant
rs1135401784	A>G	Likely-pathogenic	Missense variant, non coding transcript variant, coding sequence variant
rs1553759167	TGGGGAATAATCCCATTCCACCTCCACTGCTGCGATATAGTATGTCCTCTCTCCCAGGTAGAAGGTGGAATCCTCAGACTGCCGCCTGCATTGGTTCACAGTATATTTTTGCTTCATGCCGCCTGTGTAATGATCAGTTGTAAGGCATTCAACATTAAAAGTCCCTGGAGTGGTAAATAAGAAAACATGTCACTTCTTTGCTAGTGCCCTCTGGGGCTCTCCACCTTCCTCAGAATTA>-	Pathogenic	Splice acceptor variant, non coding transcript variant, intron variant, coding sequence variant
rs1553759338	GAAAAGTTTAGGTGCAGAATATTTATGGGAGTCATTCCCCTTCTAGTCTGATTTTCCAGCTATCTTTAAAAGGACCATAATCTAAAAAGGGATCATCTTGAGGAGCCTATGGAAGTGGAGAAAACCACACCATGTTCTTTTACTCCACATTGTCCTCAGTAACTAGGAAACAGACCTATCTGGTACATACTTCAGCTGATAGTGGCCTAGACTTGCTCTTTCAAAGATAGGAAGGGCACTTCAGAGGCTTGGGGA	Pathogenic	Splice donor variant, non coding transcript variant, intron variant, splice acceptor variant, coding sequence variant
rs1553761391	->AC	Pathogenic	Frameshift variant, non coding transcript variant, coding sequence variant
rs1553762556	C>T	Pathogenic	Splice donor variant
rs1553765380	T>-	Likely-pathogenic	Frameshift variant, non coding transcript variant, coding sequence variant
rs1559935542	->C	Pathogenic	Non coding transcript variant, frameshift variant, coding sequence variant
rs1559940237	C>T	Pathogenic	Non coding transcript variant, stop gained, coding sequence variant
rs1576759850	A>-	Pathogenic	Frameshift variant, non coding transcript variant, coding sequence variant

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miRTarBase ID	miRNA	Experiments	Reference
MIRT735517	hsa-miR-145-5p	Immunohistochemistry (IHC), RNA-seq, qRT-PCR	32708433
MIRT905614	hsa-miR-23a	CLIP-seq
MIRT905615	hsa-miR-23b	CLIP-seq
MIRT905616	hsa-miR-23c	CLIP-seq
MIRT1968537	hsa-miR-409-3p	CLIP-seq
MIRT1968538	hsa-miR-4659a-3p	CLIP-seq
MIRT1968539	hsa-miR-4659b-3p	CLIP-seq
MIRT1968540	hsa-miR-4778-3p	CLIP-seq
MIRT2204401	hsa-miR-1285	CLIP-seq
MIRT2204402	hsa-miR-129-5p	CLIP-seq
MIRT2204403	hsa-miR-1323	CLIP-seq
MIRT2204404	hsa-miR-145	CLIP-seq
MIRT2204405	hsa-miR-3127-5p	CLIP-seq
MIRT2204406	hsa-miR-3187-5p	CLIP-seq
MIRT2204407	hsa-miR-375	CLIP-seq
MIRT2204408	hsa-miR-4261	CLIP-seq
MIRT2204409	hsa-miR-4326	CLIP-seq
MIRT2204410	hsa-miR-4477b	CLIP-seq
MIRT2204411	hsa-miR-4496	CLIP-seq
MIRT2204412	hsa-miR-4505	CLIP-seq
MIRT2204413	hsa-miR-4719	CLIP-seq
MIRT2204414	hsa-miR-4733-5p	CLIP-seq
MIRT2204415	hsa-miR-513b	CLIP-seq
MIRT2204416	hsa-miR-548o	CLIP-seq
MIRT2204417	hsa-miR-578	CLIP-seq
MIRT2204418	hsa-miR-612	CLIP-seq

Show/Hide all(31)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004322	Function	Ferroxidase activity	IDA	14623105
GO:0004322	Function	Ferroxidase activity	IEA
GO:0004322	Function	Ferroxidase activity	IMP	16150804, 29183916
GO:0004322	Function	Ferroxidase activity	TAS	7708681
GO:0004602	Function	Glutathione peroxidase activity	IDA	10481051, 10508415
GO:0004602	Function	Glutathione peroxidase activity	IEA
GO:0005507	Function	Copper ion binding	IEA
GO:0005576	Component	Extracellular region	IEA
GO:0005576	Component	Extracellular region	NAS	14718574
GO:0005576	Component	Extracellular region	TAS
GO:0005615	Component	Extracellular space	HDA	16502470, 20551380
GO:0005615	Component	Extracellular space	IDA	16150804, 19996109
GO:0005615	Component	Extracellular space	IEA
GO:0005615	Component	Extracellular space	TAS	7708681
GO:0005765	Component	Lysosomal membrane	HDA	17897319
GO:0005788	Component	Endoplasmic reticulum lumen	TAS
GO:0005886	Component	Plasma membrane	IBA
GO:0006878	Process	Intracellular copper ion homeostasis	IDA	14623105
GO:0006879	Process	Intracellular iron ion homeostasis	IDA	14623105
GO:0006879	Process	Intracellular iron ion homeostasis	IMP	16150804, 29183916
GO:0006879	Process	Intracellular iron ion homeostasis	TAS	9445478
GO:0016491	Function	Oxidoreductase activity	IBA
GO:0016491	Function	Oxidoreductase activity	IEA
GO:0016722	Function	Oxidoreductase activity, acting on metal ions	IEA
GO:0016724	Function	Oxidoreductase activity, acting on metal ions, oxygen as acceptor	IDA	14623105
GO:0046872	Function	Metal ion binding	IEA
GO:0047066	Function	Phospholipid-hydroperoxide glutathione peroxidase activity	IDA	10481051, 10508415
GO:0051087	Function	Protein-folding chaperone binding	IPI	19996109
GO:0070062	Component	Extracellular exosome	HDA	19056867, 23533145
GO:0072562	Component	Blood microparticle	HDA	22516433
GO:0098869	Process	Cellular oxidant detoxification	IEA

MIM	HGNC	e!Ensembl
117700	2295	ENSG00000047457

Protein

UniProt ID

P00450

Protein name

Ceruloplasmin (Cuproxidase ceruloplasmin) (EC 1.16.3.4) (Ferroxidase ceruloplasmin) (EC 1.16.3.1) (Glutathione peroxidase ceruloplasmin) (EC 1.11.1.9) (Glutathione-dependent peroxiredoxin ceruloplasmin) (EC 1.11.1.27)

Protein function

Multifunctional blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has ferroxidase activity oxidizing Fe(2+) to Fe(3+) without releasing radical oxygen species. It is involved in iron transport across the cell membrane (PubMed:161508

PDB

1KCW , 2J5W , 4EJX , 4ENZ

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF07732	Cu-oxidase_3	74 → 204	Multicopper oxidase	Domain
PF00394	Cu-oxidase	221 → 358	Multicopper oxidase	Domain
PF07732	Cu-oxidase_3	801 → 903	Multicopper oxidase	Domain
PF07731	Cu-oxidase_2	937 → 1060	Multicopper oxidase	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed by the liver and secreted in plasma. {ECO:0000305|PubMed:12055353}.

Sequence

MKILILGIFLFLCSTPAWAKEKHYYIGIIETTWDYASDHGEKKLISVDTEHSNIYLQNGP
DRIGRLYKKALYLQYTDETFRTTIEKPVWLGFLGPIIKAETGDKVYVHLKNLASRPYTFH
SHGITYYKEHEGAIYPDNTTDFQRADDKVYPGEQYTYMLLATEEQSPGEGDGNCVTRIYH
SHIDAPKDIASGLIGPLIICKKDSLDKEKEKHIDREFVVMFSVVDENFSWYLEDNIKTYC
SEPEKVDKDNEDFQESNRMYSVNGYTFGSLPGLSMCAEDRVKWYLFGMGNEVDVHAAFFH
GQALTNKNYRIDTINLFPATLFDAYMVAQNPGEWMLSCQNLNHLKAGLQAFFQVQECNKS
SSKDNIRGKHVRHYYIAAEEIIWNYAPSGIDIFTKENLTAPGSDSAVFFEQGTTRIGGSY
KKLVYREYTDASFTNRKERGPEEEHLGILGPVIWAEVGDTIRVTFHNKGAYPLSIEPIGV
RFNKNNEGTYYSPNYNPQSRSVPPSASHVAPTETFTYEWTVPKEVGPTNADPVCLAKMYY
SAVDPTKDIFTGLIGPMKICKKGSLHANGRQKDVDKEFYLFPTVFDENESLLLEDNIRMF
TTAPDQVDKEDEDFQESNKMHSMNGFMYGNQPGLTMCKGDSVVWYLFSAGNEADVHGIYF
SGNTYLWRGERRDTANLFPQTSLTLHMWPDTEGTFNVECLTTDHYTGGMKQKYTVNQCRR
QSEDSTFYLGERTYYIAAVEVEWDYSPQREWEKELHHLQEQNVSNAFLDKGEFYIGSKYK
KVVYRQYTDSTFRVPVERKAEEEHLGILGPQLHADVGDKVKIIFKNMATRPYSIHAHGVQ
TESSTVTPTLPGETLTYVWKIPERSGAGTEDSACIPWAYYSTVDQVKDLYSGLIGPLIVC
RRPYLKVFNPRRKLEFALLFLVFDENESWYLDDNIKTYSDHPEKVNKDDEEFIESNKMHA
INGRMFGNLQGLTMHVGDEVNWYLMGMGNEIDLHTVHFHGHSFQYKHRGVYSSDVFDIFP
GTYQTLEMFPRTPGIWLLHCHVTDHIHAGMETTYTVLQNEDTKSG

Sequence length

1065

Interactions

View interactions

	KEGG		Reactome
	Porphyrin metabolism Ferroptosis		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Metal ion SLC transporters Defective SLC40A1 causes hemochromatosis 4 (HFE4) (macrophages) Defective CP causes aceruloplasminemia (ACERULOP) Post-translational protein phosphorylation Iron uptake and transport

Show/Hide Causal Diseases (1)

Disease merge term	Disease name	dbSNP ID	References
Causal Diseases caused by PATHOGENIC or LIKELY PATHOGENIC variants from ClinVar only
neurodegeneration with brain iron accumulation	Neurodegeneration with brain iron accumulation	rs386134127, rs386134147, rs776936158, rs1135401784	N/A

Show/Hide Text Mining Associations (146)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Abnormalities Multiple	Associate	30170966
Acute Coronary Syndrome	Associate	22075249, 24311705
Adenocarcinoma of Lung	Associate	32708433
Aggressive Periodontitis	Associate	19656030
Alcohol Related Disorders	Associate	24799124
Alzheimer Disease	Associate	11283204, 16272261, 20796026, 24366863, 32087292
Anemia	Associate	12200392, 32235485
Anemia Hemolytic	Associate	15082597, 32264837
Ascites	Associate	27500424, 39337685
Atrial Fibrillation	Associate	24118451, 28427851
Behcet Syndrome	Inhibit	17334044
Bile Duct Neoplasms	Associate	28423673
Brain Diseases	Associate	22739732
Breast Neoplasms	Associate	21871081, 26446998
Breast Neoplasms	Inhibit	34413268, 34477121
Burkitt Lymphoma	Associate	11044091, 21865378, 7856099, 9261362, 9454768
Calcinosis	Inhibit	19423691, 19821764
Carcinoma Hepatocellular	Associate	12079511, 19307463, 24799124, 25609232, 25789864, 28561948
Carcinoma Pancreatic Ductal	Associate	26850699
Carcinoma Renal Cell	Associate	11720477, 25168455, 31431624, 34449964, 36973268
Carcinoma Renal Cell	Stimulate	19695674
Cardiomegaly	Stimulate	32087292
Cardiovascular Diseases	Associate	23861484
Chemical and Drug Induced Liver Injury	Associate	20453399
Chronic Kidney Disease Mineral and Bone Disorder	Associate	24311705
Cleft Palate	Associate	29377571
Cognition Disorders	Associate	23812204, 32087292
Colonic Neoplasms	Associate	34564978
Colorectal Neoplasms	Associate	15682479
Copper deficiency familial benign	Inhibit	25224196
Copper deficiency familial benign	Associate	29434149
Crohn Disease	Associate	25250685
Cystic Fibrosis	Associate	33927050
Cytochrome c Oxidase Deficiency	Associate	4308098
Depressive Disorder Major	Associate	32427278
Diabetes Mellitus	Associate	34669152, 34670377
Diabetes Mellitus Type 1	Associate	12879954
Diabetes Mellitus Type 2	Associate	29079528
Disease	Associate	14742624
Down Syndrome	Associate	22678011
Dry Eye Syndromes	Associate	29234088
Dyskeratosis Congenita	Associate	27013236
Epstein Barr Virus Infections	Associate	21628990, 22046134, 2549539, 25540367
Familial apoceruloplasmin deficiency	Associate	11929178, 12200392, 12879954, 1544429, 20655381, 20801540, 21720062, 22084216, 22243965, 23812204, 24607334, 25168455, 27175663, 29434149, 29709961 View all (4 more)
Familial apoceruloplasmin deficiency	Inhibit	12200392, 20686294, 32235485, 8894739
Fatty Liver Alcoholic	Associate	32935743
Fibrosis	Associate	24799124
Fragile X Tremor Ataxia Syndrome	Associate	25498860, 28233916
Fusariosis	Associate	32005944
Genetic Diseases Inborn	Associate	22243965
Glaucoma Open Angle	Associate	16862071
Glioblastoma	Associate	35918659
Glomerulonephritis Membranous	Stimulate	32427278
Graft vs Host Disease	Stimulate	23505556
Graves Ophthalmopathy	Associate	38130930
Heart Defects Congenital	Associate	33836056
Heart Diseases	Stimulate	24311705
Heart Failure	Associate	23861484, 24311705
Hematologic Diseases	Associate	29434149
Hemolytic Uremic Syndrome	Associate	15327386
Hemophilia A	Associate	10886198, 9292523
Hepatitis B	Associate	35137191
Hepatitis C	Associate	25789864
Hepatitis Chronic	Associate	20417464
Hepatolenticular Degeneration	Associate	1544429, 20082719, 20417464, 20739809, 22243965, 22688476, 28922444, 29979436, 30936772, 31547461, 31804371, 32264837, 34470610, 35296237, 35388883, 39178787, 4308098, 9311736 View all (3 more)
Hepatolenticular Degeneration	Inhibit	18809982, 29649982, 3654978
Hodgkin Disease	Associate	9261362
Hypoalphalipoproteinemias	Associate	32541515
Hypoxia	Stimulate	19656030
Infections	Associate	25540367
Inflammation	Associate	19656030, 22075249, 24118451
Inflammatory Bowel Diseases	Associate	35029158, 36155972
Intestinal Obstruction	Associate	21915437
Iron Deficiencies	Associate	35029158
Iron Overload	Stimulate	11472372
Iron Overload	Associate	12200392, 15082597, 22084216, 34048062, 35868289
Kidney Calculi	Associate	21474797
Kidney Diseases	Associate	25224196
Kidney Neoplasms	Associate	34449964
Leptospirosis	Associate	22554907
Leukemia Myeloid Acute	Associate	20670477
Liver Cirrhosis	Associate	28922444
Liver Diseases	Associate	34470610
Liver Failure	Associate	31568522
Lung Neoplasms	Stimulate	32708433
Lupus Erythematosus Systemic	Associate	30170966
Melanoma Cutaneous Malignant	Associate	35232428
Menkes Kinky Hair Syndrome	Associate	22243965
Mesothelioma Malignant	Associate	38013118
Metabolic Syndrome	Associate	25758665
Microphthalmia Syndromic 10	Associate	32087292
Mouth Neoplasms	Stimulate	30987719
Multiple Sclerosis	Stimulate	23762311
Myelodysplastic Syndromes	Associate	29434149
Nasopharyngeal Carcinoma	Stimulate	16537992
Nasopharyngeal Carcinoma	Associate	22590638, 32541515
Nasopharyngeal Diseases	Associate	16537992
Neoplasm Metastasis	Associate	15682479
Neoplasms	Associate	17032174, 17121795, 19307463, 19884712, 23912491, 24676332, 27600027, 28423673, 34413268, 36973268
Neoplasms	Stimulate	20585448
Neoplastic Syndromes Hereditary	Inhibit	11472372
Neoplastic Syndromes Hereditary	Associate	34670377
Nephrotic Syndrome	Associate	25224196
Nerve Degeneration	Associate	20796026
Neural Tube Defects	Associate	28397206
Neurodegenerative Diseases	Associate	24366863, 34360993, 35868289
Neuroferritinopathy	Associate	35180557, 35868289
Neuroinflammatory Diseases	Associate	32087292
Neurologic Manifestations	Associate	29709961
Non alcoholic Fatty Liver Disease	Associate	32935743
Obesity	Associate	24676332, 32264837
Oral Submucous Fibrosis	Associate	19884712
Osteogenesis imperfecta type 3	Associate	29976663
Ovarian Neoplasms	Associate	21923952, 38186569, 39337685
Pain	Associate	34608709
Pancreatic Neoplasms	Stimulate	35954297
Pancreatic Neoplasms	Associate	36812168
Pancytopenia	Associate	29434149
Pantothenate Kinase Associated Neurodegeneration	Associate	28821231, 35868289, 39419454
Parkinson Disease	Associate	25758665, 25943368
Peripheral Nervous System Diseases	Associate	25943368
Periventricular Nodular Heterotopia	Associate	33836056
Plaque Atherosclerotic	Inhibit	27040361
Platelet Signal Processing Defect	Associate	36768728
Pleural Effusion	Associate	29047238
Porphyria Erythropoietic	Associate	11254675
Pre Eclampsia	Associate	25031267
Pre Eclampsia	Stimulate	25463281
Renal cell carcinoma 1	Associate	22243965
Retinal Degeneration	Associate	32264837
Retinal Dysplasia	Associate	29434149
Sepsis	Associate	31568522
Siderosis	Associate	24607334
Soft Tissue Injuries	Associate	19656030
Spinocerebellar Ataxias	Associate	32264837
ST Elevation Myocardial Infarction	Associate	34360827
Subarachnoid Hemorrhage	Associate	32246437
Tarlov Cysts	Associate	28423673
Tourette Syndrome	Associate	22139323
Trauma Nervous System	Associate	32264837
Urolithiasis	Associate	21474797
Uterine Cervical Neoplasms	Associate	23925487
Varicose Ulcer	Associate	30803124
Vascular Malformations	Associate	33836056
Venous Thromboembolism	Associate	30803124
Vitamin K Deficiency	Associate	39178787

CP (ceruloplasmin)