Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	135295
Gene name	Serine and arginine rich splicing factor 12
Gene symbol	SRSF12
Synonyms (NCBI Gene)	SFRS13BSFRS19SRrp35
Chromosome	6
Chromosome location	6q15

182

Show/Hide all (182)

miRTarBase ID	miRNA	Experiments	Reference
MIRT019116	hsa-miR-335-5p	Microarray	18185580
MIRT716237	hsa-miR-3606-3p	HITS-CLIP	19536157
MIRT716236	hsa-miR-513a-3p	HITS-CLIP	19536157
MIRT716235	hsa-miR-513c-3p	HITS-CLIP	19536157
MIRT716234	hsa-miR-4778-3p	HITS-CLIP	19536157
MIRT716233	hsa-miR-6875-3p	HITS-CLIP	19536157
MIRT716232	hsa-miR-4659a-3p	HITS-CLIP	19536157
MIRT716231	hsa-miR-4659b-3p	HITS-CLIP	19536157
MIRT716237	hsa-miR-3606-3p	HITS-CLIP	19536157
MIRT716236	hsa-miR-513a-3p	HITS-CLIP	19536157
MIRT716235	hsa-miR-513c-3p	HITS-CLIP	19536157
MIRT716234	hsa-miR-4778-3p	HITS-CLIP	19536157
MIRT716233	hsa-miR-6875-3p	HITS-CLIP	19536157
MIRT716232	hsa-miR-4659a-3p	HITS-CLIP	19536157
MIRT716231	hsa-miR-4659b-3p	HITS-CLIP	19536157
MIRT1390242	hsa-miR-106a	CLIP-seq
MIRT1390243	hsa-miR-106b	CLIP-seq
MIRT1390244	hsa-miR-1245b-3p	CLIP-seq
MIRT1390245	hsa-miR-150	CLIP-seq
MIRT1390246	hsa-miR-17	CLIP-seq
MIRT1390247	hsa-miR-186	CLIP-seq
MIRT1390248	hsa-miR-1913	CLIP-seq
MIRT1390249	hsa-miR-1976	CLIP-seq
MIRT1390250	hsa-miR-199a-3p	CLIP-seq
MIRT1390251	hsa-miR-199b-3p	CLIP-seq
MIRT1390252	hsa-miR-20a	CLIP-seq
MIRT1390253	hsa-miR-20b	CLIP-seq
MIRT1390254	hsa-miR-299-3p	CLIP-seq
MIRT1390255	hsa-miR-302a	CLIP-seq
MIRT1390256	hsa-miR-302b	CLIP-seq
MIRT1390257	hsa-miR-302c	CLIP-seq
MIRT1390258	hsa-miR-302d	CLIP-seq
MIRT1390259	hsa-miR-302e	CLIP-seq
MIRT1390260	hsa-miR-302f	CLIP-seq
MIRT1390261	hsa-miR-3129-3p	CLIP-seq
MIRT1390262	hsa-miR-3129-5p	CLIP-seq
MIRT1390263	hsa-miR-3133	CLIP-seq
MIRT1390264	hsa-miR-3159	CLIP-seq
MIRT1390265	hsa-miR-3176	CLIP-seq
MIRT1390266	hsa-miR-3183	CLIP-seq
MIRT1390267	hsa-miR-3190	CLIP-seq
MIRT1390268	hsa-miR-324-3p	CLIP-seq
MIRT1390269	hsa-miR-331-5p	CLIP-seq
MIRT1390270	hsa-miR-362-5p	CLIP-seq
MIRT1390271	hsa-miR-3675-3p	CLIP-seq
MIRT1390272	hsa-miR-371-5p	CLIP-seq
MIRT1390273	hsa-miR-371b-5p	CLIP-seq
MIRT1390274	hsa-miR-372	CLIP-seq
MIRT1390275	hsa-miR-373	CLIP-seq
MIRT1390276	hsa-miR-378g	CLIP-seq
MIRT1390277	hsa-miR-3922-3p	CLIP-seq
MIRT1390278	hsa-miR-3973	CLIP-seq
MIRT1390279	hsa-miR-4312	CLIP-seq
MIRT1390280	hsa-miR-4437	CLIP-seq
MIRT1390281	hsa-miR-4474-5p	CLIP-seq
MIRT1390282	hsa-miR-4491	CLIP-seq
MIRT1390283	hsa-miR-4517	CLIP-seq
MIRT1390284	hsa-miR-4657	CLIP-seq
MIRT1390285	hsa-miR-4666-5p	CLIP-seq
MIRT1390286	hsa-miR-4674	CLIP-seq
MIRT1390287	hsa-miR-4678	CLIP-seq
MIRT1390288	hsa-miR-4694-3p	CLIP-seq
MIRT1390289	hsa-miR-4707-3p	CLIP-seq
MIRT1390290	hsa-miR-4722-3p	CLIP-seq
MIRT1390291	hsa-miR-4723-3p	CLIP-seq
MIRT1390292	hsa-miR-4733-3p	CLIP-seq
MIRT1390293	hsa-miR-4757-5p	CLIP-seq
MIRT1390294	hsa-miR-4760-5p	CLIP-seq
MIRT1390295	hsa-miR-4789-5p	CLIP-seq
MIRT1390296	hsa-miR-4795-3p	CLIP-seq
MIRT1390297	hsa-miR-500b	CLIP-seq
MIRT1390298	hsa-miR-501-5p	CLIP-seq
MIRT1390299	hsa-miR-519d	CLIP-seq
MIRT1390300	hsa-miR-520a-3p	CLIP-seq
MIRT1390301	hsa-miR-520b	CLIP-seq
MIRT1390302	hsa-miR-520c-3p	CLIP-seq
MIRT1390303	hsa-miR-520d-3p	CLIP-seq
MIRT1390304	hsa-miR-520e	CLIP-seq
MIRT1390305	hsa-miR-520f	CLIP-seq
MIRT1390306	hsa-miR-520g	CLIP-seq
MIRT1390307	hsa-miR-520h	CLIP-seq
MIRT1390308	hsa-miR-522	CLIP-seq
MIRT1390309	hsa-miR-548a-5p	CLIP-seq
MIRT1390310	hsa-miR-548ab	CLIP-seq
MIRT1390311	hsa-miR-548ak	CLIP-seq
MIRT1390312	hsa-miR-548b-5p	CLIP-seq
MIRT1390313	hsa-miR-548c-5p	CLIP-seq
MIRT1390314	hsa-miR-548d-5p	CLIP-seq
MIRT1390315	hsa-miR-548h	CLIP-seq
MIRT1390316	hsa-miR-548i	CLIP-seq
MIRT1390317	hsa-miR-548j	CLIP-seq
MIRT1390318	hsa-miR-548l	CLIP-seq
MIRT1390319	hsa-miR-548n	CLIP-seq
MIRT1390320	hsa-miR-548w	CLIP-seq
MIRT1390321	hsa-miR-548y	CLIP-seq
MIRT1390322	hsa-miR-559	CLIP-seq
MIRT1390323	hsa-miR-889	CLIP-seq
MIRT1390324	hsa-miR-93	CLIP-seq
MIRT1390325	hsa-miR-936	CLIP-seq
MIRT1390242	hsa-miR-106a	CLIP-seq
MIRT1390243	hsa-miR-106b	CLIP-seq
MIRT1390245	hsa-miR-150	CLIP-seq
MIRT1390246	hsa-miR-17	CLIP-seq
MIRT1390248	hsa-miR-1913	CLIP-seq
MIRT1390252	hsa-miR-20a	CLIP-seq
MIRT1390253	hsa-miR-20b	CLIP-seq
MIRT1390255	hsa-miR-302a	CLIP-seq
MIRT1390256	hsa-miR-302b	CLIP-seq
MIRT1390257	hsa-miR-302c	CLIP-seq
MIRT1390258	hsa-miR-302d	CLIP-seq
MIRT1390259	hsa-miR-302e	CLIP-seq
MIRT1390268	hsa-miR-324-3p	CLIP-seq
MIRT1390272	hsa-miR-371-5p	CLIP-seq
MIRT1390273	hsa-miR-371b-5p	CLIP-seq
MIRT1390274	hsa-miR-372	CLIP-seq
MIRT1390275	hsa-miR-373	CLIP-seq
MIRT1390289	hsa-miR-4707-3p	CLIP-seq
MIRT1390299	hsa-miR-519d	CLIP-seq
MIRT1390300	hsa-miR-520a-3p	CLIP-seq
MIRT1390301	hsa-miR-520b	CLIP-seq
MIRT1390302	hsa-miR-520c-3p	CLIP-seq
MIRT1390303	hsa-miR-520d-3p	CLIP-seq
MIRT1390304	hsa-miR-520e	CLIP-seq
MIRT1390306	hsa-miR-520g	CLIP-seq
MIRT1390307	hsa-miR-520h	CLIP-seq
MIRT2116878	hsa-miR-587	CLIP-seq
MIRT2116879	hsa-miR-607	CLIP-seq
MIRT1390324	hsa-miR-93	CLIP-seq
MIRT1390242	hsa-miR-106a	CLIP-seq
MIRT1390243	hsa-miR-106b	CLIP-seq
MIRT2339266	hsa-miR-1264	CLIP-seq
MIRT2339267	hsa-miR-1343	CLIP-seq
MIRT1390245	hsa-miR-150	CLIP-seq
MIRT1390246	hsa-miR-17	CLIP-seq
MIRT1390248	hsa-miR-1913	CLIP-seq
MIRT1390249	hsa-miR-1976	CLIP-seq
MIRT1390252	hsa-miR-20a	CLIP-seq
MIRT1390253	hsa-miR-20b	CLIP-seq
MIRT1390255	hsa-miR-302a	CLIP-seq
MIRT1390256	hsa-miR-302b	CLIP-seq
MIRT1390257	hsa-miR-302c	CLIP-seq
MIRT1390258	hsa-miR-302d	CLIP-seq
MIRT1390259	hsa-miR-302e	CLIP-seq
MIRT1390264	hsa-miR-3159	CLIP-seq
MIRT2339268	hsa-miR-3179	CLIP-seq
MIRT1390268	hsa-miR-324-3p	CLIP-seq
MIRT2339269	hsa-miR-3646	CLIP-seq
MIRT1390272	hsa-miR-371-5p	CLIP-seq
MIRT1390273	hsa-miR-371b-5p	CLIP-seq
MIRT1390274	hsa-miR-372	CLIP-seq
MIRT1390275	hsa-miR-373	CLIP-seq
MIRT1390276	hsa-miR-378g	CLIP-seq
MIRT2339270	hsa-miR-4257	CLIP-seq
MIRT1390279	hsa-miR-4312	CLIP-seq
MIRT2339271	hsa-miR-4436b-3p	CLIP-seq
MIRT1390280	hsa-miR-4437	CLIP-seq
MIRT2339272	hsa-miR-4495	CLIP-seq
MIRT1390286	hsa-miR-4674	CLIP-seq
MIRT2339273	hsa-miR-4687-3p	CLIP-seq
MIRT2339274	hsa-miR-4700-3p	CLIP-seq
MIRT1390289	hsa-miR-4707-3p	CLIP-seq
MIRT2339275	hsa-miR-4720-3p	CLIP-seq
MIRT1390290	hsa-miR-4722-3p	CLIP-seq
MIRT2339276	hsa-miR-4731-5p	CLIP-seq
MIRT2339277	hsa-miR-5095	CLIP-seq
MIRT2339278	hsa-miR-512-3p	CLIP-seq
MIRT1390299	hsa-miR-519d	CLIP-seq
MIRT1390300	hsa-miR-520a-3p	CLIP-seq
MIRT1390301	hsa-miR-520b	CLIP-seq
MIRT1390302	hsa-miR-520c-3p	CLIP-seq
MIRT1390303	hsa-miR-520d-3p	CLIP-seq
MIRT1390304	hsa-miR-520e	CLIP-seq
MIRT1390306	hsa-miR-520g	CLIP-seq
MIRT1390307	hsa-miR-520h	CLIP-seq
MIRT2339279	hsa-miR-548k	CLIP-seq
MIRT1390324	hsa-miR-93	CLIP-seq
MIRT1390245	hsa-miR-150	CLIP-seq
MIRT1390248	hsa-miR-1913	CLIP-seq
MIRT1390268	hsa-miR-324-3p	CLIP-seq
MIRT1390289	hsa-miR-4707-3p	CLIP-seq
MIRT1390306	hsa-miR-520g	CLIP-seq
MIRT1390307	hsa-miR-520h	CLIP-seq

Show/Hide all (19)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000244	Process	Spliceosomal tri-snRNP complex assembly	NAS	11684676
GO:0000381	Process	Regulation of alternative mRNA splicing, via spliceosome	IBA
GO:0000381	Process	Regulation of alternative mRNA splicing, via spliceosome	IDA	11684676
GO:0000395	Process	MRNA 5'-splice site recognition	IDA	11684676
GO:0003676	Function	Nucleic acid binding	IEA
GO:0003723	Function	RNA binding	HDA	22681889
GO:0003723	Function	RNA binding	IEA
GO:0003723	Function	RNA binding	NAS	11684676
GO:0003729	Function	MRNA binding	IBA
GO:0005515	Function	Protein binding	IPI	23602568, 33961781
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	ISS	11684676
GO:0005654	Component	Nucleoplasm	TAS
GO:0006397	Process	MRNA processing	IEA
GO:0008380	Process	RNA splicing	IEA
GO:0016607	Component	Nuclear speck	IBA
GO:0048025	Process	Negative regulation of mRNA splicing, via spliceosome	ISS	11684676
GO:0050733	Function	RS domain binding	NAS	11684676
GO:0051082	Function	Unfolded protein binding	NAS	11684676

MIM	HGNC	e!Ensembl
HGNC	N/A	HGNC

Q8WXF0

Protein name

Serine/arginine-rich splicing factor 12 (35 kDa SR repressor protein) (SRrp35) (Splicing factor, arginine/serine-rich 13B) (Splicing factor, arginine/serine-rich 19)

Protein function

Splicing factor that seems to antagonize SR proteins in pre-mRNA splicing regulation.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00076	RRM_1	12 → 82	RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed in testis. {ECO:0000269|PubMed:11684676}.

Sequence

MSRYTRPPNTSLFIRNVADATRPEDLRREFGRYGPIVDVYIPLDFYTRRPRGFAYVQFED
VRDAEDALYNLNRKWVCGRQIEIQFAQGDRKTPGQMKSKERHPCSPSDHRRSRSPSQRRT
RSRSSSWGRNRRRSDSLKESRHRRFSYSQSKSRSKSLPRRSTSARQSRTPRRNFGSRGRS
RSKSLQKRSKSIGKSQSSSPQKQTSSGTKSRSHGRHSDSIARSPCKSPKGYTNSETKVQT
AKHSHFRSHSRSRSYRHKNSW

Sequence length

261

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (2)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ARTHRITIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LUNG CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (3)

Disease Name	Relationship Type	References	Evidence Score
Associations from Text MiningDisease associations identified through Pubtator
Colorectal Neoplasms	Associate	37359548	★★★★★ ★☆☆☆☆ Found in Text Mining only
Inflammation	Associate	37359548	★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia Myeloid Acute	Associate	39463061	★★★★★ ★☆☆☆☆ Found in Text Mining only

SRSF12 (serine and arginine rich splicing factor 12)