SDHAF4 (succinate dehydrogenase complex assembly factor 4)

Gene

• Entrez ID: 135154
• Gene name: Succinate dehydrogenase complex assembly factor 4
• Gene symbol: SDHAF4
• Synonyms (NCBI Gene): C6orf57, Sdh8
• Chromosome: 6
• Chromosome location: 6q13

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT740307	hsa-miR-3155a	HITS-CLIP	19536157
MIRT740308	hsa-miR-3155b	HITS-CLIP	19536157
MIRT740309	hsa-miR-484	HITS-CLIP	19536157
MIRT740310	hsa-miR-6832-3p	HITS-CLIP	19536157
MIRT740311	hsa-miR-4469	HITS-CLIP	19536157
MIRT740312	hsa-miR-7113-3p	HITS-CLIP	19536157
MIRT740313	hsa-miR-4287	HITS-CLIP	19536157
MIRT740314	hsa-miR-4685-3p	HITS-CLIP	19536157
MIRT740315	hsa-miR-3663-5p	HITS-CLIP	19536157
MIRT740316	hsa-miR-3124-3p	HITS-CLIP	19536157
MIRT740317	hsa-miR-6131	HITS-CLIP	19536157
MIRT740318	hsa-miR-6801-5p	HITS-CLIP	19536157
MIRT740319	hsa-miR-204-5p	HITS-CLIP	19536157
MIRT740320	hsa-miR-211-5p	HITS-CLIP	19536157
MIRT740321	hsa-miR-6867-3p	HITS-CLIP	19536157
MIRT740322	hsa-miR-5587-5p	HITS-CLIP	19536157
MIRT740323	hsa-miR-6843-3p	HITS-CLIP	19536157
MIRT740324	hsa-miR-6848-3p	HITS-CLIP	19536157
MIRT740320	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT740319	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT740310	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT741908	hsa-miR-3927-5p	HITS-CLIP	23824327
MIRT740316	hsa-miR-3124-3p	HITS-CLIP	23824327
MIRT741909	hsa-miR-623	HITS-CLIP	23824327
MIRT741910	hsa-miR-337-3p	HITS-CLIP	23824327
MIRT741911	hsa-miR-202-5p	HITS-CLIP	23824327
MIRT741912	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT741913	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT741914	hsa-miR-3685	HITS-CLIP	23824327
MIRT741915	hsa-miR-384	HITS-CLIP	23824327
MIRT741916	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT742356	hsa-miR-6736-3p	HITS-CLIP	23824327
MIRT742357	hsa-miR-6787-3p	HITS-CLIP	23824327
MIRT742358	hsa-miR-4634	HITS-CLIP	23824327

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003674	Function	Molecular_function	ND
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005575	Component	Cellular_component	ND
GO:0005739	Component	Mitochondrion	IBA	21873635
GO:0005749	Component	Mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)	ISS	24954416
GO:0005759	Component	Mitochondrial matrix	IEA
GO:0008177	Function	Succinate dehydrogenase (ubiquinone) activity	ISS	24954416
GO:0034553	Process	Mitochondrial respiratory chain complex II assembly	IBA	21873635
GO:0034553	Process	Mitochondrial respiratory chain complex II assembly	IGI	24954416
GO:0045087	Process	Innate immune response	IEA
GO:0045333	Process	Cellular respiration	IGI	24954416

Other IDs

• MIM: 619198
• HGNC: 20957
• e!Ensembl: ENSG00000154079

Protein

• UniProt ID: Q5VUM1
• Protein name: Succinate dehydrogenase assembly factor 4, mitochondrial (SDH assembly factor 4) (SDHAF4)
• Protein function: Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chai
• PDB: 8DYD, 8DYE
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF07896	DUF1674	59 → 108	Protein of unknown function (DUF1674)	Family

• Sequence:

  MTPSRLPWLLSWVSATAWRAARSPLLCHSLRKTSSSQGGKSELVKQSLKKPKLPEGRFDA
  PEDSHLEKEPLEKFPDDVNPVTKEKGGPRGPEPTRYGDWERKGRCIDF

• Sequence length: 108

Associated diseases

Causal
Disease term	Disease name	dbSNP ID	References
Diabetes mellitus	Diabetes Mellitus, Non-Insulin-Dependent	rs587776515, rs61730328, rs606231121, rs606231122, rs79020217, rs77625743, rs78378398, rs606231123, rs1362648752, rs104893649, rs80356624, rs80356616, rs80356625, rs80356611, rs104894237, rs80356613, rs387906407, rs151344623, rs28938469, rs28936371, rs137852672, rs80356637, rs80356642, rs80356653, rs137852673, rs137852674, rs80356634, rs80356651, rs193929360, rs137853334, rs137853335, rs137853336, rs1600731198, rs137853338, rs121964882, rs121964883, rs387906511, rs121964884, rs121964885, rs2147483647, rs387906512, rs121964887, rs121964888, rs121964889, rs121964890, rs121964891, rs28934878, rs74315383, rs121964893, rs886037620, rs886037621, rs121434593, rs121913150, rs587776825, rs137853236, rs2135842335, rs137853237, rs137853238, rs2135818776, rs1566092470, rs1463923467, rs137853243, rs137853244, rs2135839114, rs137853245, rs2135847417, rs121918407, rs104894005, rs104894006, rs80356655, rs104894008, rs104894009, rs104894010, rs104894011, rs80356654, rs104894016, rs193929376, rs193929374, rs193929375, rs193929373, rs80356669, rs80356664, rs193929366, rs1048095, rs193929355, rs193929356, rs1259467443, rs104893642, rs387906777, rs193922396, rs193922400, rs193922401, rs137852676, rs193922407, rs193922638, rs193922257, rs193922258, rs193922259, rs193922260, rs193922261, rs193922262, rs193922263, rs193922264, rs193922265, rs193922268, rs193921338, rs193922269, rs193922272, rs193922273, rs193922275, rs193922278, rs193922279, rs193922280, rs193922281, rs193922282, rs193922283, rs193922284, rs193922286, rs193922287, rs193922289, rs193922291, rs193922295, rs193922297, rs193922300, rs193922302, rs193922303, rs193922308, rs193922313, rs193922314, rs144723656, rs193922315, rs193922316, rs193922317, rs148311934, rs193922319, rs193922320, rs193922326, rs193922329, rs193922330, rs193922331, rs193922335, rs193922336, rs193922338, rs193922340, rs193922341, rs193922471, rs193922475, rs193922476, rs193922479, rs80356663, rs193922355, rs193922356, rs193922576, rs193922578, rs193922582, rs193922588, rs193922592, rs193922594, rs193922596, rs386134267, rs193922598, rs193922599, rs193922600, rs193922604, rs193922605, rs397514580, rs397515519, rs267601516, rs587780343, rs587780345, rs587780346, rs587780347, rs587780357, rs148954387, rs587783672, rs587783669, rs786204676, rs794727236, rs151344624, rs794727775, rs794727839, rs199946797, rs869320673, rs796065047, rs759072800, rs797045595, rs797045209, rs797045207, rs797045213, rs863225280, rs149703259, rs864321656, rs139964066, rs777870079, rs878853246, rs769268803, rs886039380, rs886041392, rs886041391, rs886042610, rs143064649, rs1057516192, rs746480424, rs1057516281, rs576684889, rs754728827, rs1057520291, rs1057520779, rs893256143, rs1057520504, rs1057524790, rs1057524902, rs1057524904, rs1057524905, rs764232985, rs1064793998, rs1064794268, rs769086289, rs369429452, rs1085307913, rs1131691416, rs765432081, rs1131692182, rs748749585, rs1554335441, rs762263694, rs1312678560, rs767565869, rs1375656631, rs1554335391, rs1360415315, rs1554335616, rs1554335752, rs1554909277, rs769518471, rs757171524, rs768951263, rs762703502, rs1555212248, rs1555212359, rs1555813319, rs1555816654, rs371977235, rs1415041911, rs1554334894, rs1260178539, rs1554335421, rs1555211904, rs779184183, rs1554335564, rs200670692, rs1400535021, rs1554334872, rs1555212749, rs1553876668, rs1553878211, rs954727530, rs1554924035, rs372307320, rs925231098, rs1554913069, rs1554933565, rs766431403, rs746714109, rs751279984, rs770664202, rs1008906426, rs758844607, rs1554924540, rs1566092307, rs753998395, rs1565885935, rs1167124132, rs1376796469, rs556436603, rs1562715657, rs1486280029, rs1564869850, rs755259997, rs769569410, rs1172328722, rs1286294151, rs1375557127, rs1568731279, rs1562715426, rs556581174, rs1564865302, rs1565886545, rs1568724014, rs1392795567, rs781260712, rs1562719705, rs1382448285, rs1564977373, rs750586210, rs1598842892, rs1583592247, rs780612692, rs1593060859, rs1476637197, rs751279776, rs1593060890, rs1191912908, rs1167675604, rs1583601110, rs1593058932, rs778611627, rs753296261	21490949

Unknown
Disease term	Disease name	Evidence	References	Source
Diabetes	Diabetes			GWAS
Prostate cancer	Prostate cancer	Together, these results show that PRRX2 is an oncogene and might play a role in the aggressiveness of PC within the DNPC population.		GWAS, CBGDA

Associations from Text Mining
Disease Name	Relationship Type	References
Diabetes Gestational	Associate	36672824
Paraganglioma	Associate	32948195
Thyroid Neoplasms	Associate	36672824