Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	135152
Gene name Gene Name - the full gene name approved by the HGNC.	Beta-1,3-glucuronyltransferase 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	B3GAT2
Synonyms (NCBI Gene) Gene synonyms aliases	GLCATS
Chromosome Chromosome number	6
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	6q13
Summary Summary of gene provided in NCBI Entrez Gene.	The product of this gene is a transmembrane protein belonging to the glucuronyltransferase family, and catalyzes the transfer of a beta-1,3 linked glucuronic acid to a terminal galactose in different glycoproteins or glycolipids containing a Gal-beta-1-4G

Show/Hide all(47)

miRTarBase ID	miRNA	Experiments	Reference
MIRT539000	hsa-miR-4310	PAR-CLIP	22012620
MIRT538999	hsa-miR-7157-5p	PAR-CLIP	22012620
MIRT538998	hsa-miR-4530	PAR-CLIP	22012620
MIRT538997	hsa-miR-338-3p	PAR-CLIP	22012620
MIRT538996	hsa-miR-766-3p	PAR-CLIP	22012620
MIRT538994	hsa-miR-4326	PAR-CLIP	22012620
MIRT538995	hsa-miR-4691-5p	PAR-CLIP	22012620
MIRT538993	hsa-miR-6792-3p	PAR-CLIP	22012620
MIRT538992	hsa-miR-6749-3p	PAR-CLIP	22012620
MIRT539000	hsa-miR-4310	PAR-CLIP	22012620
MIRT538999	hsa-miR-7157-5p	PAR-CLIP	22012620
MIRT538998	hsa-miR-4530	PAR-CLIP	22012620
MIRT538997	hsa-miR-338-3p	PAR-CLIP	22012620
MIRT538996	hsa-miR-766-3p	PAR-CLIP	22012620
MIRT538994	hsa-miR-4326	PAR-CLIP	22012620
MIRT538995	hsa-miR-4691-5p	PAR-CLIP	22012620
MIRT538993	hsa-miR-6792-3p	PAR-CLIP	22012620
MIRT538992	hsa-miR-6749-3p	PAR-CLIP	22012620
MIRT813139	hsa-miR-298	CLIP-seq
MIRT813140	hsa-miR-3123	CLIP-seq
MIRT813141	hsa-miR-3613-5p	CLIP-seq
MIRT813142	hsa-miR-3674	CLIP-seq
MIRT813143	hsa-miR-3925-5p	CLIP-seq
MIRT813144	hsa-miR-4732-5p	CLIP-seq
MIRT813145	hsa-miR-570	CLIP-seq
MIRT2444558	hsa-miR-1245b-3p	CLIP-seq
MIRT2444559	hsa-miR-136	CLIP-seq
MIRT2444560	hsa-miR-2964a-5p	CLIP-seq
MIRT2444561	hsa-miR-4718	CLIP-seq
MIRT2444558	hsa-miR-1245b-3p	CLIP-seq
MIRT2444559	hsa-miR-136	CLIP-seq
MIRT2444560	hsa-miR-2964a-5p	CLIP-seq
MIRT2482860	hsa-miR-3137	CLIP-seq
MIRT2482861	hsa-miR-3140-5p	CLIP-seq
MIRT2482862	hsa-miR-3194-3p	CLIP-seq
MIRT2444561	hsa-miR-4718	CLIP-seq
MIRT2482863	hsa-miR-4724-5p	CLIP-seq
MIRT2482864	hsa-miR-495	CLIP-seq
MIRT2444558	hsa-miR-1245b-3p	CLIP-seq
MIRT2444559	hsa-miR-136	CLIP-seq
MIRT2444560	hsa-miR-2964a-5p	CLIP-seq
MIRT2482860	hsa-miR-3137	CLIP-seq
MIRT2482861	hsa-miR-3140-5p	CLIP-seq
MIRT2482862	hsa-miR-3194-3p	CLIP-seq
MIRT2444561	hsa-miR-4718	CLIP-seq
MIRT2482863	hsa-miR-4724-5p	CLIP-seq
MIRT2482864	hsa-miR-495	CLIP-seq

Show/Hide all(10)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	IBA	21873635
GO:0000139	Component	Golgi membrane	TAS
GO:0005975	Process	Carbohydrate metabolic process	IBA	21873635
GO:0006486	Process	Protein glycosylation	IEA
GO:0015018	Function	Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity	IBA	21873635
GO:0015018	Function	Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity	ISS
GO:0016021	Component	Integral component of membrane	IEA
GO:0030203	Process	Glycosaminoglycan metabolic process	TAS
GO:0046872	Function	Metal ion binding	IEA
GO:0050650	Process	Chondroitin sulfate proteoglycan biosynthetic process	IBA	21873635

MIM	HGNC	e!Ensembl
607497	922	ENSG00000112309

Protein

UniProt ID

Q9NPZ5

Protein name

Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 2 (EC 2.4.1.135) (Beta-1,3-glucuronyltransferase 2) (GlcAT-D) (UDP-glucuronosyltransferase S) (GlcAT-S) (Glucuronosyltransferase S)

Protein function

Involved in the biosynthesis of L2/HNK-1 carbohydrate epitope on both glycolipids and glycoproteins.

PDB

2D0J

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF03360	Glyco_transf_43	101 → 304	Glycosyltransferase family 43	Family

Tissue specificity

TISSUE SPECIFICITY: Expressed in the trachea, retina, spinal cord, hippocampus and other brain regions, and, at lower levels, in testis and ovary.

Sequence

MKSALFTRFFILLPWILIVIIMLDVDTRRPVPPLTPRPYFSPYAVGRGGARLPLRRGGPA
HGTQKRNQSRPQPQPEPQLPTIYAITPTYSRPVQKAELTRLANTFRQVAQLHWILVEDAA
ARSELVSRFLARAGLPSTHLHVPTPRRYKRPGLPRATEQRNAGLAWLRQRHQHQRAQPGV
LFFADDDNTYSLELFQEMRTTRKVSVWPVGLVGGRRYERPLVENGKVVGWYTGWRADRPF
AIDMAGFAVSLQVILSNPKAVFKRRGSQPGMQESDFLKQITTVEELEPKANNCTKVLVWH
TRTEKVNLANEPKYHLDTVKIEV

Sequence length

323

Interactions

View interactions

	KEGG		Reactome
	Mannose type O-glycan biosynthesis Metabolic pathways		A tetrasaccharide linker sequence is required for GAG synthesis

Show/Hide Causal Diseases (1)

Disease term	Disease name	dbSNP ID	References
Causal
Schizophrenia	Schizophrenia	rs13447324, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346 View all (12 more)	20950796

Show/Hide Unknown Diseases (1)

Disease term	Disease name	Evidence	References	Source
Unknown
Insomnia	Insomnia			GWAS

Show/Hide Text Mining Associations (8)

Disease Name	Relationship Type	References
Associations from Text Mining
Barrett Esophagus	Associate	26545406
Colorectal Neoplasms	Associate	24244442
Lung Neoplasms	Associate	30867848
Melanoma	Associate	23110092
Neoplasms	Associate	23110092, 24244442
Polycystic Ovary Syndrome	Associate	32176075
Prostatic Neoplasms	Associate	28673330
Venous Thromboembolism	Associate	28011674

B3GAT2 (beta-1,3-glucuronyltransferase 2)