NCOA7 (nuclear receptor coactivator 7)

Gene

• Entrez ID: 135112
• Gene name: Nuclear receptor coactivator 7
• Gene symbol: NCOA7
• Synonyms (NCBI Gene): ERAP140, ESNA1, NCOA7-AS, Nbla00052, Nbla10993, TLDC4, dJ187J11.3
• Chromosome: 6
• Chromosome location: 6q22.31-q22.32

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT020066	hsa-miR-375	Microarray	20215506
MIRT543954	hsa-miR-543	PAR-CLIP	21572407
MIRT543953	hsa-miR-32-3p	PAR-CLIP	21572407
MIRT543952	hsa-miR-181a-5p	PAR-CLIP	21572407
MIRT543951	hsa-miR-181b-5p	PAR-CLIP	21572407
MIRT543950	hsa-miR-181c-5p	PAR-CLIP	21572407
MIRT543949	hsa-miR-181d-5p	PAR-CLIP	21572407
MIRT543948	hsa-miR-4262	PAR-CLIP	21572407
MIRT543947	hsa-miR-5680	PAR-CLIP	21572407
MIRT543946	hsa-let-7a-3p	PAR-CLIP	21572407
MIRT543945	hsa-let-7b-3p	PAR-CLIP	21572407
MIRT543944	hsa-let-7f-1-3p	PAR-CLIP	21572407
MIRT543943	hsa-miR-98-3p	PAR-CLIP	21572407
MIRT543942	hsa-miR-4789-5p	PAR-CLIP	21572407
MIRT543941	hsa-let-7f-2-3p	PAR-CLIP	21572407
MIRT543940	hsa-miR-1185-1-3p	PAR-CLIP	21572407
MIRT543939	hsa-miR-1185-2-3p	PAR-CLIP	21572407
MIRT543954	hsa-miR-543	PAR-CLIP	21572407
MIRT543953	hsa-miR-32-3p	PAR-CLIP	21572407
MIRT543952	hsa-miR-181a-5p	PAR-CLIP	21572407
MIRT543951	hsa-miR-181b-5p	PAR-CLIP	21572407
MIRT543950	hsa-miR-181c-5p	PAR-CLIP	21572407
MIRT543949	hsa-miR-181d-5p	PAR-CLIP	21572407
MIRT543948	hsa-miR-4262	PAR-CLIP	21572407
MIRT543947	hsa-miR-5680	PAR-CLIP	21572407
MIRT543946	hsa-let-7a-3p	PAR-CLIP	21572407
MIRT543945	hsa-let-7b-3p	PAR-CLIP	21572407
MIRT543944	hsa-let-7f-1-3p	PAR-CLIP	21572407
MIRT543943	hsa-miR-98-3p	PAR-CLIP	21572407
MIRT543942	hsa-miR-4789-5p	PAR-CLIP	21572407
MIRT543941	hsa-let-7f-2-3p	PAR-CLIP	21572407
MIRT543940	hsa-miR-1185-1-3p	PAR-CLIP	21572407
MIRT543939	hsa-miR-1185-2-3p	PAR-CLIP	21572407
MIRT1177354	hsa-miR-124	CLIP-seq
MIRT1177355	hsa-miR-128	CLIP-seq
MIRT1177356	hsa-miR-200b	CLIP-seq
MIRT1177357	hsa-miR-200c	CLIP-seq
MIRT1177358	hsa-miR-204	CLIP-seq
MIRT1177359	hsa-miR-208a	CLIP-seq
MIRT1177360	hsa-miR-208b	CLIP-seq
MIRT1177361	hsa-miR-211	CLIP-seq
MIRT1177362	hsa-miR-2681	CLIP-seq
MIRT1177363	hsa-miR-27a	CLIP-seq
MIRT1177364	hsa-miR-27b	CLIP-seq
MIRT1177365	hsa-miR-298	CLIP-seq
MIRT1177366	hsa-miR-300	CLIP-seq
MIRT1177367	hsa-miR-3123	CLIP-seq
MIRT1177368	hsa-miR-3133	CLIP-seq
MIRT1177369	hsa-miR-3148	CLIP-seq
MIRT1177370	hsa-miR-3186-5p	CLIP-seq
MIRT1177371	hsa-miR-3617	CLIP-seq
MIRT1177372	hsa-miR-3658	CLIP-seq
MIRT1177373	hsa-miR-376c	CLIP-seq
MIRT1177374	hsa-miR-381	CLIP-seq
MIRT1177375	hsa-miR-3925-5p	CLIP-seq
MIRT1177376	hsa-miR-3976	CLIP-seq
MIRT1177377	hsa-miR-3978	CLIP-seq
MIRT1177378	hsa-miR-4271	CLIP-seq
MIRT1177379	hsa-miR-429	CLIP-seq
MIRT1177380	hsa-miR-4427	CLIP-seq
MIRT1177381	hsa-miR-4453	CLIP-seq
MIRT1177382	hsa-miR-4464	CLIP-seq
MIRT1177383	hsa-miR-4495	CLIP-seq
MIRT1177384	hsa-miR-452	CLIP-seq
MIRT1177385	hsa-miR-4538	CLIP-seq
MIRT1177386	hsa-miR-4666-3p	CLIP-seq
MIRT1177387	hsa-miR-4676-3p	CLIP-seq
MIRT1177388	hsa-miR-4680-3p	CLIP-seq
MIRT1177389	hsa-miR-4708-3p	CLIP-seq
MIRT1177390	hsa-miR-4725-3p	CLIP-seq
MIRT1177391	hsa-miR-4748	CLIP-seq
MIRT1177392	hsa-miR-4762-3p	CLIP-seq
MIRT1177393	hsa-miR-4790-3p	CLIP-seq
MIRT1177394	hsa-miR-499-5p	CLIP-seq
MIRT1177395	hsa-miR-506	CLIP-seq
MIRT1177396	hsa-miR-5096	CLIP-seq
MIRT1177397	hsa-miR-513a-5p	CLIP-seq
MIRT1177398	hsa-miR-520d-5p	CLIP-seq
MIRT1177399	hsa-miR-524-5p	CLIP-seq
MIRT1177400	hsa-miR-548c-3p	CLIP-seq
MIRT1177401	hsa-miR-569	CLIP-seq
MIRT1177402	hsa-miR-583	CLIP-seq
MIRT1177403	hsa-miR-641	CLIP-seq
MIRT1177404	hsa-miR-873	CLIP-seq
MIRT1177405	hsa-miR-935	CLIP-seq
MIRT1177406	hsa-miR-1273f	CLIP-seq
MIRT1177355	hsa-miR-128	CLIP-seq
MIRT1177407	hsa-miR-23a	CLIP-seq
MIRT1177408	hsa-miR-23b	CLIP-seq
MIRT1177409	hsa-miR-23c	CLIP-seq
MIRT1177363	hsa-miR-27a	CLIP-seq
MIRT1177364	hsa-miR-27b	CLIP-seq
MIRT1177410	hsa-miR-3132	CLIP-seq
MIRT1177411	hsa-miR-3170	CLIP-seq
MIRT1177370	hsa-miR-3186-5p	CLIP-seq
MIRT1177412	hsa-miR-3652	CLIP-seq
MIRT1177413	hsa-miR-411	CLIP-seq
MIRT1177414	hsa-miR-4430	CLIP-seq
MIRT1177382	hsa-miR-4464	CLIP-seq
MIRT1177415	hsa-miR-4470	CLIP-seq
MIRT1177416	hsa-miR-4505	CLIP-seq
MIRT1177417	hsa-miR-4717-3p	CLIP-seq
MIRT1177418	hsa-miR-4718	CLIP-seq
MIRT1177391	hsa-miR-4748	CLIP-seq
MIRT1177396	hsa-miR-5096	CLIP-seq
MIRT1177400	hsa-miR-548c-3p	CLIP-seq
MIRT1177404	hsa-miR-873	CLIP-seq
MIRT1177354	hsa-miR-124	CLIP-seq
MIRT2051331	hsa-miR-1264	CLIP-seq
MIRT2051332	hsa-miR-3647-3p	CLIP-seq
MIRT1177395	hsa-miR-506	CLIP-seq
MIRT2051333	hsa-miR-9	CLIP-seq
MIRT2051334	hsa-miR-1283	CLIP-seq
MIRT2051335	hsa-miR-1324	CLIP-seq
MIRT1177356	hsa-miR-200b	CLIP-seq
MIRT1177357	hsa-miR-200c	CLIP-seq
MIRT1177407	hsa-miR-23a	CLIP-seq
MIRT1177408	hsa-miR-23b	CLIP-seq
MIRT1177409	hsa-miR-23c	CLIP-seq
MIRT2051336	hsa-miR-24	CLIP-seq
MIRT1177410	hsa-miR-3132	CLIP-seq
MIRT1177370	hsa-miR-3186-5p	CLIP-seq
MIRT2051337	hsa-miR-338-5p	CLIP-seq
MIRT1177412	hsa-miR-3652	CLIP-seq
MIRT2051338	hsa-miR-374a	CLIP-seq
MIRT2051339	hsa-miR-374b	CLIP-seq
MIRT2051340	hsa-miR-377	CLIP-seq
MIRT2051341	hsa-miR-3942-3p	CLIP-seq
MIRT2051342	hsa-miR-4284	CLIP-seq
MIRT1177379	hsa-miR-429	CLIP-seq
MIRT1177380	hsa-miR-4427	CLIP-seq
MIRT1177414	hsa-miR-4430	CLIP-seq
MIRT1177416	hsa-miR-4505	CLIP-seq
MIRT1177388	hsa-miR-4680-3p	CLIP-seq
MIRT1177417	hsa-miR-4717-3p	CLIP-seq
MIRT2051343	hsa-miR-4740-3p	CLIP-seq
MIRT1177392	hsa-miR-4762-3p	CLIP-seq
MIRT1177393	hsa-miR-4790-3p	CLIP-seq
MIRT2051344	hsa-miR-564	CLIP-seq
MIRT2051345	hsa-miR-642b	CLIP-seq
MIRT1177355	hsa-miR-128	CLIP-seq
MIRT1177363	hsa-miR-27a	CLIP-seq
MIRT1177364	hsa-miR-27b	CLIP-seq
MIRT1177396	hsa-miR-5096	CLIP-seq
MIRT2280459	hsa-miR-1275	CLIP-seq
MIRT2280460	hsa-miR-146a	CLIP-seq
MIRT2280461	hsa-miR-146b-5p	CLIP-seq
MIRT1177407	hsa-miR-23a	CLIP-seq
MIRT1177408	hsa-miR-23b	CLIP-seq
MIRT1177409	hsa-miR-23c	CLIP-seq
MIRT2051336	hsa-miR-24	CLIP-seq
MIRT1177362	hsa-miR-2681	CLIP-seq
MIRT1177365	hsa-miR-298	CLIP-seq
MIRT1177410	hsa-miR-3132	CLIP-seq
MIRT1177370	hsa-miR-3186-5p	CLIP-seq
MIRT1177412	hsa-miR-3652	CLIP-seq
MIRT2051342	hsa-miR-4284	CLIP-seq
MIRT1177414	hsa-miR-4430	CLIP-seq
MIRT1177416	hsa-miR-4505	CLIP-seq
MIRT2280462	hsa-miR-4525	CLIP-seq
MIRT2280463	hsa-miR-4665-5p	CLIP-seq
MIRT1177417	hsa-miR-4717-3p	CLIP-seq
MIRT2280464	hsa-miR-4723-5p	CLIP-seq
MIRT2280465	hsa-miR-4773	CLIP-seq
MIRT2280466	hsa-miR-589	CLIP-seq
MIRT2280467	hsa-miR-625	CLIP-seq
MIRT2280459	hsa-miR-1275	CLIP-seq
MIRT2280460	hsa-miR-146a	CLIP-seq
MIRT2280461	hsa-miR-146b-5p	CLIP-seq
MIRT2454960	hsa-miR-2115	CLIP-seq
MIRT1177362	hsa-miR-2681	CLIP-seq
MIRT2280462	hsa-miR-4525	CLIP-seq
MIRT2280463	hsa-miR-4665-5p	CLIP-seq
MIRT2280464	hsa-miR-4723-5p	CLIP-seq
MIRT2280465	hsa-miR-4773	CLIP-seq
MIRT2280466	hsa-miR-589	CLIP-seq
MIRT2280467	hsa-miR-625	CLIP-seq
MIRT2051333	hsa-miR-9	CLIP-seq
MIRT2051345	hsa-miR-642b	CLIP-seq
MIRT2051333	hsa-miR-9	CLIP-seq
MIRT2578894	hsa-miR-4728-3p	CLIP-seq
MIRT2051333	hsa-miR-9	CLIP-seq
MIRT2685936	hsa-miR-1179	CLIP-seq
MIRT2685937	hsa-miR-1228	CLIP-seq
MIRT2051331	hsa-miR-1264	CLIP-seq
MIRT2685938	hsa-miR-1278	CLIP-seq
MIRT2685939	hsa-miR-18a	CLIP-seq
MIRT2685940	hsa-miR-18b	CLIP-seq
MIRT2685941	hsa-miR-190	CLIP-seq
MIRT2685942	hsa-miR-190b	CLIP-seq
MIRT2685943	hsa-miR-203	CLIP-seq
MIRT1177358	hsa-miR-204	CLIP-seq
MIRT1177359	hsa-miR-208a	CLIP-seq
MIRT1177360	hsa-miR-208b	CLIP-seq
MIRT1177361	hsa-miR-211	CLIP-seq
MIRT2685944	hsa-miR-2114	CLIP-seq
MIRT2454960	hsa-miR-2115	CLIP-seq
MIRT2685945	hsa-miR-2117	CLIP-seq
MIRT2051336	hsa-miR-24	CLIP-seq
MIRT2685946	hsa-miR-2964a-3p	CLIP-seq
MIRT2685947	hsa-miR-302f	CLIP-seq
MIRT2685948	hsa-miR-3119	CLIP-seq
MIRT2685949	hsa-miR-3121-3p	CLIP-seq
MIRT2685950	hsa-miR-3140-3p	CLIP-seq
MIRT2685951	hsa-miR-3173-3p	CLIP-seq
MIRT2685952	hsa-miR-335	CLIP-seq
MIRT1177371	hsa-miR-3617	CLIP-seq
MIRT2685953	hsa-miR-3654	CLIP-seq
MIRT1177372	hsa-miR-3658	CLIP-seq
MIRT2685954	hsa-miR-3660	CLIP-seq
MIRT2685955	hsa-miR-3685	CLIP-seq
MIRT2685956	hsa-miR-369-3p	CLIP-seq
MIRT2051338	hsa-miR-374a	CLIP-seq
MIRT2051339	hsa-miR-374b	CLIP-seq
MIRT2685957	hsa-miR-380	CLIP-seq
MIRT2685958	hsa-miR-384	CLIP-seq
MIRT2685959	hsa-miR-4252	CLIP-seq
MIRT2685960	hsa-miR-4263	CLIP-seq
MIRT2685961	hsa-miR-4273	CLIP-seq
MIRT2685962	hsa-miR-4274	CLIP-seq
MIRT2685963	hsa-miR-4282	CLIP-seq
MIRT2051342	hsa-miR-4284	CLIP-seq
MIRT2685964	hsa-miR-4428	CLIP-seq
MIRT2685965	hsa-miR-4459	CLIP-seq
MIRT2685966	hsa-miR-4477b	CLIP-seq
MIRT2685967	hsa-miR-4490	CLIP-seq
MIRT1177383	hsa-miR-4495	CLIP-seq
MIRT2685968	hsa-miR-451b	CLIP-seq
MIRT2685969	hsa-miR-4526	CLIP-seq
MIRT2685970	hsa-miR-4638-3p	CLIP-seq
MIRT2685971	hsa-miR-4654	CLIP-seq
MIRT2685972	hsa-miR-4661-5p	CLIP-seq
MIRT2685973	hsa-miR-4677-5p	CLIP-seq
MIRT2685974	hsa-miR-4695-5p	CLIP-seq
MIRT2685975	hsa-miR-4698	CLIP-seq
MIRT2685976	hsa-miR-4717-5p	CLIP-seq
MIRT2685977	hsa-miR-4719	CLIP-seq
MIRT2578894	hsa-miR-4728-3p	CLIP-seq
MIRT2685978	hsa-miR-4729	CLIP-seq
MIRT2685979	hsa-miR-4735-3p	CLIP-seq
MIRT2685980	hsa-miR-4738-3p	CLIP-seq
MIRT2051343	hsa-miR-4740-3p	CLIP-seq
MIRT2685981	hsa-miR-4753-3p	CLIP-seq
MIRT2685982	hsa-miR-4769-5p	CLIP-seq
MIRT2685983	hsa-miR-4774-5p	CLIP-seq
MIRT2685984	hsa-miR-4795-3p	CLIP-seq
MIRT1177394	hsa-miR-499-5p	CLIP-seq
MIRT2685985	hsa-miR-513a-3p	CLIP-seq
MIRT2685986	hsa-miR-513b	CLIP-seq
MIRT2685987	hsa-miR-548n	CLIP-seq
MIRT2685988	hsa-miR-548t	CLIP-seq
MIRT2685989	hsa-miR-548v	CLIP-seq
MIRT2051344	hsa-miR-564	CLIP-seq
MIRT1177401	hsa-miR-569	CLIP-seq
MIRT2685990	hsa-miR-579	CLIP-seq
MIRT2685991	hsa-miR-590-3p	CLIP-seq
MIRT2685992	hsa-miR-630	CLIP-seq
MIRT1177403	hsa-miR-641	CLIP-seq
MIRT2685993	hsa-miR-653	CLIP-seq
MIRT2685994	hsa-miR-657	CLIP-seq
MIRT2685995	hsa-miR-659	CLIP-seq
MIRT2685996	hsa-miR-664	CLIP-seq
MIRT2051333	hsa-miR-9	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003713	Function	Transcription coactivator activity	IBA
GO:0003713	Function	Transcription coactivator activity	IDA	11971969
GO:0005515	Function	Protein binding	IPI	10395741, 20562859, 33961781, 34524948
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA
GO:0006979	Process	Response to oxidative stress	IBA
GO:0016922	Function	Nuclear receptor binding	IDA	11971969
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IDA	11971969
GO:1900408	Process	Negative regulation of cellular response to oxidative stress	IEA

Other IDs

• MIM: 609752
• HGNC: 21081
• e!Ensembl: ENSG00000111912

Protein

• UniProt ID: Q8NI08
• Protein name: Nuclear receptor coactivator 7 (140 kDa estrogen receptor-associated protein) (Estrogen nuclear receptor coactivator 1)
• Protein function: Enhances the transcriptional activities of several nuclear receptors. Involved in the coactivation of different nuclear receptors, such as ESR1, THRB, PPARG and RARA.
• PDB: 7OBP, 8AR6, 8AR9
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01476	LysM	116 → 158	LysM domain	Domain
  PF07534	TLD	806 → 942	TLD	Domain

• Tissue specificity: TISSUE SPECIFICITY: Highly expressed in brain. Weakly expressed in mammary gland, ovary, uterus, prostate, stomach, bladder, spinal cord and pancreas. Expressed in cancer cell line. {ECO:0000269|PubMed:11971969}.
• Sequence:

  MDTKEEKKERKQSYFARLKKKKQAKQNAETASAVATRTHTGKEDNNTVVLEPDKCNIAVE
  EEYMTDEKKKRKSNQLKEIRRTELKRYYSIDDNQNKTHDKKEKKMVVQKPHGTMEYTAGN
  QDTLNSIALKFNITPNKLVELNKLFTHTIVPGQVLFVPDANSPSSTLRLSSSSPGATVSP
  SSSDAEYDKLPDADLARKALKPIERVLSSTSEEDEPGVVKFLKMNCRYFTDGKGVVGGVM
  IVTPNNIMFDPHKSDPLVIENGCEEYGLICPMEEVVSIALYNDISHMKIKDALPSDLPQD
  LCPLYRPGEWEDLASEKDINPFSKFKSINKEKRQQNGEKIMTSDSRPIVPLEKSTGHTPT
  KPSGSSVSEKLKKLDSSRETSHGSPTVTKLSKEPSDTSSAFESTAKENFLGEDDDFVDLE
  ELSSQTGGGMHKKDTLKECLSLDPEERKKAESQINNSAVEMQVQSALAFLGTENDVELKG
  ALDLETCEKQDIMPEVDKQSGSPESRVENTLNIHEDLDKVKLIEYYLTKNKEGPQVSENL
  QKTELSDGKSIEPGGIDITLSSSLSQAGDPITEGNKEPDKTWVKKGEPLPVKLNSSTEAN
  VIKEALDSSLESTLDNSCQGAQMDNKSEVQLWLLKRIQVPIEDILPSKEEKSKTPPMFLC
  IKVGKPMRKSFATHTAAMVQQYGKRRKQPEYWFAVPRERVDHLYTFFVQWSPDVYGKDAK
  EQGFVVVEKEELNMIDNFFSEPTTKSWEIITVEEAKRRKSTCSYYEDEDEEVLPVLRPHS
  ALLENMHIEQLARRLPARVQGYPWRLAYSTLEHGTSLKTLYRKSASLDSPVLLVIKDMDN
  QIFGAYATHPFKFSDHYYGTGETFLYTFSPHFKVFKWSGENSYFINGDISSLELGGGGGR
  FGLWLDADLYHGRSNSCSTFNNDILSKKEDFIVQDLEVWAFD

• Sequence length: 942

Pathways

KEGG:

Lysosome