TAAR1 (trace amine associated receptor 1)

Gene
Gene Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
134864
Gene name Gene Name - the full gene name approved by the HGNC.
Trace amine associated receptor 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
TAAR1
Synonyms (NCBI Gene) Gene synonyms aliases
TA1, TAR1, TRAR1
Chromosome Chromosome number
6
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
6q23.2
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is a G-protein coupled receptor activated by trace amines. The encoded protein responds little or not at all to dopamine, serotonin, epinephrine, or histamine, but responds well to beta-phenylethylamine, p-tyramine, octopa
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(5)
GO ID Ontology Definition Evidence Reference
GO:0001594 Function Trace-amine receptor activity IBA 21873635
GO:0004930 Function G protein-coupled receptor activity IDA 11723224
GO:0005886 Component Plasma membrane TAS
GO:0007186 Process G protein-coupled receptor signaling pathway TAS
GO:0016021 Component Integral component of membrane IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
609333 17734 ENSG00000146399
Protein
Gene Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Q96RJ0
Protein name Trace amine-associated receptor 1 (TaR-1) (Trace amine receptor 1)
Protein function Intracellular G-protein coupled receptor for trace amines, which recognizes endogenous amine-containing metabolites such as beta-phenylethylamine (beta-PEA), 3-iodothyronamine (T1AM), isoamylamine (IAA), cadaverine (CAD), cyclohexylamine (CHA),
PDB 8JLN , 8JLO , 8JLP , 8JLQ , 8JLR , 8JSO , 8UHB , 8W87 , 8W88 , 8W89 , 8W8A , 8WC8 , 8WCA , 8ZSJ , 8ZSP , 8ZSS , 9JKQ
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00001 7tm_1 40 → 304 7 transmembrane receptor (rhodopsin family) Family
Tissue specificity TISSUE SPECIFICITY: Expressed at low level in both the central and peripheral nervous system (PubMed:11459929). Moderately expressed in stomach (PubMed:11459929). Low levels in amygdala, kidney, and lung, and small intestine (PubMed:11459929). Trace amoun
Sequence
Sequence length 339
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG   Reactome
  Neuroactive ligand-receptor interaction   Amine ligand-binding receptors
G alpha (s) signalling events
ADORA2B mediated anti-inflammatory cytokines production
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Causal Diseases (1)
Causal
Disease term Disease name dbSNP ID References
Schizophrenia Schizophrenia rs13447324, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346
View all (12 more)		 22641180
Show/Hide Text Mining Associations (20)
Associations from Text Mining
Disease Name Relationship Type References
Breast Neoplasms Associate 28409272
Carcinoma Ovarian Epithelial Associate 34445181
Carcinoma Renal Cell Associate 34445181
Communicable Diseases Inhibit 23797159
COVID 19 Associate 32442287
Cystic Fibrosis Associate 29415893
Fibromyalgia Associate 21905019
HIV Infections Associate 26302754
Inflammation Inhibit 29415893
Inflammation Associate 34769007