CLVS2 (clavesin 2)

Gene

• Entrez ID: 134829
• Gene name: Clavesin 2
• Gene symbol: CLVS2
• Synonyms (NCBI Gene): C6orf212, C6orf213, RLBP1L2, bA160A10.4
• Chromosome: 6
• Chromosome location: 6q22.31
• Summary: This gene encodes a protein that belongs to the SEC14/CRAL-TRIO family of proteins. A similar protein in rat is thought to function in the endosomal pathway between early endosomes and mature lysosomes. [provided by RefSeq, Aug 2013]

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT518665	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT518664	hsa-miR-5003-3p	HITS-CLIP	21572407
MIRT518663	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT707560	hsa-miR-511-3p	HITS-CLIP	21572407
MIRT518662	hsa-miR-1257	HITS-CLIP	21572407
MIRT518661	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT518660	hsa-miR-6818-5p	HITS-CLIP	21572407
MIRT707559	hsa-miR-552-5p	HITS-CLIP	21572407
MIRT564190	hsa-miR-548aj-5p	PAR-CLIP	20371350
MIRT564189	hsa-miR-548f-5p	PAR-CLIP	20371350
MIRT564188	hsa-miR-548g-5p	PAR-CLIP	20371350
MIRT564187	hsa-miR-548x-5p	PAR-CLIP	20371350
MIRT564186	hsa-miR-1468-3p	PAR-CLIP	20371350
MIRT564185	hsa-miR-19a-3p	PAR-CLIP	20371350
MIRT564184	hsa-miR-19b-3p	PAR-CLIP	20371350
MIRT564183	hsa-miR-548aw	PAR-CLIP	20371350
MIRT564182	hsa-miR-568	PAR-CLIP	20371350
MIRT518665	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT518664	hsa-miR-5003-3p	PAR-CLIP	23446348
MIRT518663	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT518662	hsa-miR-1257	PAR-CLIP	23446348
MIRT518661	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT518660	hsa-miR-6818-5p	PAR-CLIP	23446348
MIRT442388	hsa-miR-3921	PAR-CLIP	22100165
MIRT442387	hsa-miR-4653-5p	PAR-CLIP	22100165
MIRT442386	hsa-miR-4682	PAR-CLIP	22100165
MIRT442385	hsa-miR-6780a-3p	PAR-CLIP	22100165
MIRT442384	hsa-miR-6807-5p	PAR-CLIP	22100165
MIRT442382	hsa-miR-8055	PAR-CLIP	22100165
MIRT518665	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT518664	hsa-miR-5003-3p	HITS-CLIP	21572407
MIRT518663	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT707560	hsa-miR-511-3p	HITS-CLIP	21572407
MIRT518662	hsa-miR-1257	HITS-CLIP	21572407
MIRT518661	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT518660	hsa-miR-6818-5p	HITS-CLIP	21572407
MIRT707559	hsa-miR-552-5p	HITS-CLIP	21572407
MIRT564190	hsa-miR-548aj-5p	PAR-CLIP	20371350
MIRT564189	hsa-miR-548f-5p	PAR-CLIP	20371350
MIRT564188	hsa-miR-548g-5p	PAR-CLIP	20371350
MIRT564187	hsa-miR-548x-5p	PAR-CLIP	20371350
MIRT564186	hsa-miR-1468-3p	PAR-CLIP	20371350
MIRT564185	hsa-miR-19a-3p	PAR-CLIP	20371350
MIRT564184	hsa-miR-19b-3p	PAR-CLIP	20371350
MIRT564183	hsa-miR-548aw	PAR-CLIP	20371350
MIRT564182	hsa-miR-568	PAR-CLIP	20371350
MIRT518665	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT518664	hsa-miR-5003-3p	PAR-CLIP	23446348
MIRT518663	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT518662	hsa-miR-1257	PAR-CLIP	23446348
MIRT518661	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT518660	hsa-miR-6818-5p	PAR-CLIP	23446348
MIRT442388	hsa-miR-3921	PAR-CLIP	22100165
MIRT442387	hsa-miR-4653-5p	PAR-CLIP	22100165
MIRT442386	hsa-miR-4682	PAR-CLIP	22100165
MIRT442385	hsa-miR-6780a-3p	PAR-CLIP	22100165
MIRT442384	hsa-miR-6807-5p	PAR-CLIP	22100165
MIRT442382	hsa-miR-8055	PAR-CLIP	22100165

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005768	Component	Endosome	IBA
GO:0005768	Component	Endosome	IDA	19651769
GO:0005768	Component	Endosome	IEA
GO:0005794	Component	Golgi apparatus	IEA
GO:0005802	Component	Trans-Golgi network	IBA
GO:0005802	Component	Trans-Golgi network	ISS
GO:0007040	Process	Lysosome organization	IBA
GO:0007040	Process	Lysosome organization	ISS
GO:0008289	Function	Lipid binding	IEA
GO:0016020	Component	Membrane	IEA
GO:0030136	Component	Clathrin-coated vesicle	IBA
GO:0030136	Component	Clathrin-coated vesicle	IEA
GO:0030136	Component	Clathrin-coated vesicle	ISS
GO:0031410	Component	Cytoplasmic vesicle	IEA
GO:0031901	Component	Early endosome membrane	IEA
GO:0032588	Component	Trans-Golgi network membrane	IEA
GO:0032588	Component	Trans-Golgi network membrane	TAS
GO:0080025	Function	Phosphatidylinositol-3,5-bisphosphate binding	IDA	19651769
GO:0080025	Function	Phosphatidylinositol-3,5-bisphosphate binding	IEA
GO:1902936	Function	Phosphatidylinositol bisphosphate binding	IBA

Other IDs

• MIM: 616945
• HGNC: 23046
• e!Ensembl: ENSG00000146352

Protein

• UniProt ID: Q5SYC1
• Protein name: Clavesin-2 (Retinaldehyde-binding protein 1-like 2) (clathrin vesicle-associated Sec14 protein 2)
• Protein function: Required for normal morphology of late endosomes and/or lysosomes in neurons (By similarity). Binds phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2).
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF03765	CRAL_TRIO_N	3 → 74	CRAL/TRIO, N-terminal domain	Domain
  PF00650	CRAL_TRIO	98 → 252	CRAL/TRIO domain	Domain

• Sequence:

  MTHLQAGLSPETLEKARLELNENPDTLHQDIQEVRDMVITRPDIGFLRTDDAFILRFLRA
  RKFHHFEAFRLLAQYFEYRQQNLDMFKSFKATDPGIKQALKDGFPGGLANLDHYGRKILV
  LFAANWDQSRYTLVDILRAILLSLEAMIEDPELQVNGFVLIIDWSNFTFKQASKLTPSML
  RLAIEGLQDSFPARFGGIHFVNQPWYIHALYTVIRPFLKEKTRKRIFLHGNNLNSLHQLI
  HPEILPSEFGGMLPPYDMGTWARTLLDHEYDDDSEYNVDSYSMPVKEVEKELSPKSMKRS
  QSVVDPTVLKRMDKNEEENMQPLLSLD

• Sequence length: 327

Pathways

Reactome:

Lysosome Vesicle Biogenesis