Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	134728
Gene name Gene Name - the full gene name approved by the HGNC.	Interleukin 1 receptor associated kinase 1 binding protein 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	IRAK1BP1
Synonyms (NCBI Gene) Gene synonyms aliases	AIP70, SIMPL
Chromosome Chromosome number	6
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	6q14.1

Show/Hide all(103)

miRTarBase ID	miRNA	Experiments	Reference
MIRT689153	hsa-miR-508-5p	HITS-CLIP	23313552
MIRT689152	hsa-miR-1273g-3p	HITS-CLIP	23313552
MIRT689151	hsa-miR-6849-3p	HITS-CLIP	23313552
MIRT689150	hsa-miR-939-3p	HITS-CLIP	23313552
MIRT689149	hsa-miR-766-3p	HITS-CLIP	23313552
MIRT689148	hsa-miR-4793-3p	HITS-CLIP	23313552
MIRT689147	hsa-miR-1285-3p	HITS-CLIP	23313552
MIRT689146	hsa-miR-3187-5p	HITS-CLIP	23313552
MIRT689145	hsa-miR-5189-5p	HITS-CLIP	23313552
MIRT689144	hsa-miR-612	HITS-CLIP	23313552
MIRT689143	hsa-miR-6860	HITS-CLIP	23313552
MIRT689142	hsa-miR-4537	HITS-CLIP	23313552
MIRT689141	hsa-miR-377-5p	HITS-CLIP	23313552
MIRT689140	hsa-miR-6086	HITS-CLIP	23313552
MIRT689139	hsa-miR-6499-3p	HITS-CLIP	23313552
MIRT689138	hsa-miR-661	HITS-CLIP	23313552
MIRT689137	hsa-miR-658	HITS-CLIP	23313552
MIRT689136	hsa-miR-196a-3p	HITS-CLIP	23313552
MIRT689135	hsa-miR-25-5p	HITS-CLIP	23313552
MIRT689134	hsa-miR-7703	HITS-CLIP	23313552
MIRT689133	hsa-miR-455-3p	HITS-CLIP	23313552
MIRT689132	hsa-miR-6516-5p	HITS-CLIP	23313552
MIRT568682	hsa-miR-181a-5p	PAR-CLIP	20371350
MIRT568681	hsa-miR-181b-5p	PAR-CLIP	20371350
MIRT568680	hsa-miR-181c-5p	PAR-CLIP	20371350
MIRT568679	hsa-miR-181d-5p	PAR-CLIP	20371350
MIRT568678	hsa-miR-4262	PAR-CLIP	20371350
MIRT568677	hsa-miR-892c-5p	PAR-CLIP	20371350
MIRT568676	hsa-miR-759	PAR-CLIP	20371350
MIRT568682	hsa-miR-181a-5p	PAR-CLIP	20371350
MIRT568681	hsa-miR-181b-5p	PAR-CLIP	20371350
MIRT568680	hsa-miR-181c-5p	PAR-CLIP	20371350
MIRT568679	hsa-miR-181d-5p	PAR-CLIP	20371350
MIRT568678	hsa-miR-4262	PAR-CLIP	20371350
MIRT568677	hsa-miR-892c-5p	PAR-CLIP	20371350
MIRT568676	hsa-miR-759	PAR-CLIP	20371350
MIRT727426	hsa-miR-15a-5p	HITS-CLIP	22473208
MIRT727425	hsa-miR-15b-5p	HITS-CLIP	22473208
MIRT727424	hsa-miR-16-5p	HITS-CLIP	22473208
MIRT727423	hsa-miR-195-5p	HITS-CLIP	22473208
MIRT689147	hsa-miR-1285-3p	PAR-CLIP	27292025
MIRT568682	hsa-miR-181a-5p	PAR-CLIP	27292025
MIRT568681	hsa-miR-181b-5p	PAR-CLIP	27292025
MIRT568680	hsa-miR-181c-5p	PAR-CLIP	27292025
MIRT568679	hsa-miR-181d-5p	PAR-CLIP	27292025
MIRT689136	hsa-miR-196a-3p	PAR-CLIP	27292025
MIRT689146	hsa-miR-3187-5p	PAR-CLIP	27292025
MIRT568678	hsa-miR-4262	PAR-CLIP	27292025
MIRT689142	hsa-miR-4537	PAR-CLIP	27292025
MIRT689133	hsa-miR-455-3p	PAR-CLIP	27292025
MIRT689153	hsa-miR-508-5p	PAR-CLIP	27292025
MIRT689145	hsa-miR-5189-5p	PAR-CLIP	27292025
MIRT689144	hsa-miR-612	PAR-CLIP	27292025
MIRT689139	hsa-miR-6499-3p	PAR-CLIP	27292025
MIRT689132	hsa-miR-6516-5p	PAR-CLIP	27292025
MIRT689138	hsa-miR-661	PAR-CLIP	27292025
MIRT689151	hsa-miR-6849-3p	PAR-CLIP	27292025
MIRT689143	hsa-miR-6860	PAR-CLIP	27292025
MIRT568676	hsa-miR-759	PAR-CLIP	27292025
MIRT689149	hsa-miR-766-3p	PAR-CLIP	27292025
MIRT568677	hsa-miR-892c-5p	PAR-CLIP	27292025
MIRT689150	hsa-miR-939-3p	PAR-CLIP	27292025
MIRT689153	hsa-miR-508-5p	HITS-CLIP	23313552
MIRT689152	hsa-miR-1273g-3p	HITS-CLIP	23313552
MIRT689151	hsa-miR-6849-3p	HITS-CLIP	23313552
MIRT689150	hsa-miR-939-3p	HITS-CLIP	23313552
MIRT689149	hsa-miR-766-3p	HITS-CLIP	23313552
MIRT689148	hsa-miR-4793-3p	HITS-CLIP	23313552
MIRT689147	hsa-miR-1285-3p	HITS-CLIP	23313552
MIRT689146	hsa-miR-3187-5p	HITS-CLIP	23313552
MIRT689145	hsa-miR-5189-5p	HITS-CLIP	23313552
MIRT689144	hsa-miR-612	HITS-CLIP	23313552
MIRT689143	hsa-miR-6860	HITS-CLIP	23313552
MIRT689142	hsa-miR-4537	HITS-CLIP	23313552
MIRT689141	hsa-miR-377-5p	HITS-CLIP	23313552
MIRT689140	hsa-miR-6086	HITS-CLIP	23313552
MIRT689139	hsa-miR-6499-3p	HITS-CLIP	23313552
MIRT689138	hsa-miR-661	HITS-CLIP	23313552
MIRT689137	hsa-miR-658	HITS-CLIP	23313552
MIRT689136	hsa-miR-196a-3p	HITS-CLIP	23313552
MIRT689135	hsa-miR-25-5p	HITS-CLIP	23313552
MIRT689134	hsa-miR-7703	HITS-CLIP	23313552
MIRT689133	hsa-miR-455-3p	HITS-CLIP	23313552
MIRT689132	hsa-miR-6516-5p	HITS-CLIP	23313552
MIRT568682	hsa-miR-181a-5p	PAR-CLIP	20371350
MIRT568681	hsa-miR-181b-5p	PAR-CLIP	20371350
MIRT568680	hsa-miR-181c-5p	PAR-CLIP	20371350
MIRT568679	hsa-miR-181d-5p	PAR-CLIP	20371350
MIRT568678	hsa-miR-4262	PAR-CLIP	20371350
MIRT568677	hsa-miR-892c-5p	PAR-CLIP	20371350
MIRT568676	hsa-miR-759	PAR-CLIP	20371350
MIRT568682	hsa-miR-181a-5p	PAR-CLIP	20371350
MIRT568681	hsa-miR-181b-5p	PAR-CLIP	20371350
MIRT568680	hsa-miR-181c-5p	PAR-CLIP	20371350
MIRT568679	hsa-miR-181d-5p	PAR-CLIP	20371350
MIRT568678	hsa-miR-4262	PAR-CLIP	20371350
MIRT568677	hsa-miR-892c-5p	PAR-CLIP	20371350
MIRT568676	hsa-miR-759	PAR-CLIP	20371350
MIRT1070419	hsa-miR-3121-3p	CLIP-seq
MIRT1070420	hsa-miR-3609	CLIP-seq
MIRT1070421	hsa-miR-4803	CLIP-seq
MIRT1070422	hsa-miR-548ah	CLIP-seq
MIRT1070423	hsa-miR-548c-3p	CLIP-seq

Show/Hide all(6)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	25416956, 32296183
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0006955	Process	Immune response	IEA
GO:0007249	Process	I-kappaB kinase/NF-kappaB signaling	IBA	21873635
GO:0007249	Process	I-kappaB kinase/NF-kappaB signaling	ISS

MIM	HGNC	e!Ensembl
615375	17368	ENSG00000146243

Protein

UniProt ID

Q5VVH5

Protein name

Interleukin-1 receptor-associated kinase 1-binding protein 1 (IRAK1-binding protein 1)

Protein function

Component of the IRAK1-dependent TNFRSF1A signaling pathway that leads to NF-kappa-B activation and is required for cell survival. Acts by enhancing RELA transcriptional activity (By similarity).

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF04402	SIMPL	53 → 253	Protein of unknown function (DUF541)	Family

Sequence

MSLQKTPPTRVFVELVPWADRSRENNLASGRETLPGLRHPLSSTQAQTATREVQVSGTSE
VSAGPDRAQVVVRVSSTKEAAAEAKKSVCRRLDYITQSLQQQGVQAENITVTKDFRRVEN
AYHMEAEVCITFTEFGKMQNICNFLVEKLDSSVVISPPQFYHTPGSVENLRRQACLVAVE
NAWRKAQEVCNLVGQTLGKPLLIKEEETKEWEGQIDDHQSSRLSSSLTVQQKIKSATIHA
ASKVFITFEVKGKEKRKKHL

Sequence length

260

Interactions

View interactions

Show/Hide Causal Diseases (4)

Disease term	Disease name	dbSNP ID
Causal
Attention deficit hyperactivity disorder	Attention deficit hyperactivity disorder	rs786205019
Autism	Autistic Disorder	rs121964908, rs62643608, rs181327458, rs797046134, rs869312704, rs1555013332, rs876657679, rs1057518999, rs1057518658, rs771827120, rs1555187899, rs773080572, rs753871454, rs1684130791, rs1684180699 View all (8 more)
Mental retardation	Mild Mental Retardation	rs5742905, rs267607136, rs267607137, rs2131714307, rs267607038, rs267607042, rs80338685, rs137853127, rs80338815, rs28940893, rs387906309, rs121908096, rs121908099, rs587784365, rs121918315 View all (1024 more)
Hypotonia	Neonatal Hypotonia	rs141138948, rs397517172, rs869312824, rs1583169151

Show/Hide Unknown Diseases (6)

Disease term	Disease name	Source
Unknown
Metabolic Syndrome	Metabolic Syndrome	GWAS
Sjogren-Larsson Syndrome	Sjogren-Larsson Syndrome	GWAS
Drusen	Drusen	GWAS
Hypertension	Hypertension	GWAS
Dermatitis	Dermatitis	GWAS
Heart Failure	Heart Failure	GWAS

Show/Hide Text Mining Associations (4)

Disease Name	Relationship Type	References
Associations from Text Mining
Arthritis	Associate	17079333
Diabetes Mellitus	Associate	17079333
Hypertension	Associate	24165912
Sjogren's Syndrome	Associate	24097067

IRAK1BP1 (interleukin 1 receptor associated kinase 1 binding protein 1)