Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
134510
Gene name Gene Name - the full gene name approved by the HGNC.
Ubiquitin like domain containing CTD phosphatase 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
UBLCP1
Synonyms (NCBI Gene) Gene synonyms aliases
CPUB1
Chromosome Chromosome number
5
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
5q33.3
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT019695 hsa-miR-375 Microarray 20215506
MIRT608049 hsa-miR-7106-5p HITS-CLIP 24906430
MIRT608048 hsa-miR-149-3p HITS-CLIP 24906430
MIRT608047 hsa-miR-4728-5p HITS-CLIP 24906430
MIRT608046 hsa-miR-6785-5p HITS-CLIP 24906430
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0004721 Function Phosphoprotein phosphatase activity IEA
GO:0004722 Function Protein serine/threonine phosphatase activity IBA
GO:0004722 Function Protein serine/threonine phosphatase activity IDA 21949367, 28539385
GO:0004722 Function Protein serine/threonine phosphatase activity IEA
GO:0005515 Function Protein binding IPI 16189514, 25416956, 27880917, 32296183, 33961781
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
609867 28110 ENSG00000164332
Protein
UniProt ID Q8WVY7
Protein name Ubiquitin-like domain-containing CTD phosphatase 1 (EC 3.1.3.16) (Nuclear proteasome inhibitor UBLCP1)
Protein function Dephosphorylates 26S nuclear proteasomes, thereby decreasing their proteolytic activity (PubMed:21949367, PubMed:28539385). Recruited to the 19S regulatory particle of the 26S proteasome through its interaction with 19S component PSMD2/RPN1 (Pub
PDB 2KX3 , 2LGD , 2M17
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00240 ubiquitin 5 79 Ubiquitin family Domain
PF03031 NIF 138 301 NLI interacting factor-like phosphatase Family
Tissue specificity TISSUE SPECIFICITY: Broadly expressed, with highest levels in placenta, lung, testis and ovary. Up-regulated in tumor tissues. {ECO:0000269|PubMed:15883030}.
Sequence
Sequence length 318
Interactions View interactions
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Psoriasis Psoriasis N/A N/A GWAS
Schizophrenia Schizophrenia N/A N/A GWAS
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Tuberculosis Associate 26942285