COX6C (cytochrome c oxidase subunit 6C)

Gene

• Entrez ID: 1345
• Gene name: Cytochrome c oxidase subunit 6C
• Gene symbol: COX6C
• Synonyms (NCBI Gene): -
• Chromosome: 8
• Chromosome location: 8q22.2
• Summary: Cytochrome c oxidase, the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multip

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT905493	hsa-miR-2053	CLIP-seq
MIRT905494	hsa-miR-3125	CLIP-seq
MIRT905495	hsa-miR-3185	CLIP-seq
MIRT905496	hsa-miR-335	CLIP-seq
MIRT905497	hsa-miR-3607-5p	CLIP-seq
MIRT905498	hsa-miR-3916	CLIP-seq
MIRT905499	hsa-miR-3928	CLIP-seq
MIRT905500	hsa-miR-4272	CLIP-seq
MIRT905501	hsa-miR-4276	CLIP-seq
MIRT905502	hsa-miR-4504	CLIP-seq
MIRT905503	hsa-miR-4697-3p	CLIP-seq
MIRT905504	hsa-miR-4714-3p	CLIP-seq
MIRT905505	hsa-miR-4731-3p	CLIP-seq
MIRT905506	hsa-miR-4760-3p	CLIP-seq
MIRT905507	hsa-miR-4801	CLIP-seq
MIRT905508	hsa-miR-569	CLIP-seq
MIRT905509	hsa-miR-592	CLIP-seq
MIRT905510	hsa-miR-597	CLIP-seq
MIRT905511	hsa-miR-664	CLIP-seq
MIRT905512	hsa-miR-873	CLIP-seq
MIRT905494	hsa-miR-3125	CLIP-seq
MIRT905496	hsa-miR-335	CLIP-seq
MIRT905498	hsa-miR-3916	CLIP-seq
MIRT905499	hsa-miR-3928	CLIP-seq
MIRT905494	hsa-miR-3125	CLIP-seq
MIRT905496	hsa-miR-335	CLIP-seq
MIRT905497	hsa-miR-3607-5p	CLIP-seq
MIRT905498	hsa-miR-3916	CLIP-seq
MIRT905499	hsa-miR-3928	CLIP-seq
MIRT1968511	hsa-miR-3973	CLIP-seq
MIRT905501	hsa-miR-4276	CLIP-seq
MIRT905502	hsa-miR-4504	CLIP-seq
MIRT1968512	hsa-miR-4693-5p	CLIP-seq
MIRT905503	hsa-miR-4697-3p	CLIP-seq
MIRT905505	hsa-miR-4731-3p	CLIP-seq
MIRT905507	hsa-miR-4801	CLIP-seq
MIRT1968513	hsa-miR-548l	CLIP-seq
MIRT905509	hsa-miR-592	CLIP-seq
MIRT905510	hsa-miR-597	CLIP-seq
MIRT905511	hsa-miR-664	CLIP-seq
MIRT905512	hsa-miR-873	CLIP-seq
MIRT905497	hsa-miR-3607-5p	CLIP-seq
MIRT905500	hsa-miR-4272	CLIP-seq
MIRT905501	hsa-miR-4276	CLIP-seq
MIRT905502	hsa-miR-4504	CLIP-seq
MIRT905503	hsa-miR-4697-3p	CLIP-seq
MIRT905504	hsa-miR-4714-3p	CLIP-seq
MIRT905505	hsa-miR-4731-3p	CLIP-seq
MIRT905506	hsa-miR-4760-3p	CLIP-seq
MIRT905507	hsa-miR-4801	CLIP-seq
MIRT905509	hsa-miR-592	CLIP-seq
MIRT905510	hsa-miR-597	CLIP-seq
MIRT905512	hsa-miR-873	CLIP-seq
MIRT905511	hsa-miR-664	CLIP-seq
MIRT905512	hsa-miR-873	CLIP-seq
MIRT905493	hsa-miR-2053	CLIP-seq
MIRT905495	hsa-miR-3185	CLIP-seq
MIRT1968511	hsa-miR-3973	CLIP-seq
MIRT905500	hsa-miR-4272	CLIP-seq
MIRT1968512	hsa-miR-4693-5p	CLIP-seq
MIRT905504	hsa-miR-4714-3p	CLIP-seq
MIRT905506	hsa-miR-4760-3p	CLIP-seq
MIRT2507897	hsa-miR-539	CLIP-seq
MIRT1968513	hsa-miR-548l	CLIP-seq
MIRT2507898	hsa-miR-548u	CLIP-seq
MIRT905508	hsa-miR-569	CLIP-seq
MIRT905495	hsa-miR-3185	CLIP-seq
MIRT1968511	hsa-miR-3973	CLIP-seq
MIRT905500	hsa-miR-4272	CLIP-seq
MIRT1968512	hsa-miR-4693-5p	CLIP-seq
MIRT905504	hsa-miR-4714-3p	CLIP-seq
MIRT905506	hsa-miR-4760-3p	CLIP-seq
MIRT2507897	hsa-miR-539	CLIP-seq
MIRT1968513	hsa-miR-548l	CLIP-seq
MIRT2507898	hsa-miR-548u	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004129	Function	Cytochrome-c oxidase activity	IEA
GO:0005515	Function	Protein binding	IPI	17500595, 32296183, 32814053
GO:0005739	Component	Mitochondrion	IDA
GO:0005743	Component	Mitochondrial inner membrane	TAS
GO:0006091	Process	Generation of precursor metabolites and energy	TAS	2849755
GO:0006123	Process	Mitochondrial electron transport, cytochrome c to oxygen	TAS
GO:0016021	Component	Integral component of membrane	IEA
GO:1902600	Process	Proton transmembrane transport	IEA

Other IDs

• MIM: 124090
• HGNC: 2285
• e!Ensembl: ENSG00000164919

Protein

• UniProt ID: P09669
• Protein name: Cytochrome c oxidase subunit 6C (Cytochrome c oxidase polypeptide VIc)
• Protein function: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiqu
• PDB: 5Z62
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF02937	COX6C	5 → 74	Cytochrome c oxidase subunit VIc	Family

• Sequence:

  MAPEVLPKPRMRGLLARRLRNHMAVAFVLSLGVAALYKFRVADQRKKAYADFYRNYDVMK
  DFEEMRKAGIFQSVK

• Sequence length: 75

Pathways

KEGG:

Oxidative phosphorylation
Metabolic pathways
Cardiac muscle contraction
Thermogenesis
Non-alcoholic fatty liver disease
Alzheimer disease
Parkinson disease
Amyotrophic lateral sclerosis
Huntington disease
Prion disease
Pathways of neurodegeneration - multiple diseases
Chemical carcinogenesis - reactive oxygen species
Diabetic cardiomyopathy

Reactome:

TP53 Regulates Metabolic Genes
Respiratory electron transport

Associated diseases

Causal
Disease term	Disease name	dbSNP ID	References
Cohen syndrome	Cohen syndrome	rs180177327, rs120074149, rs120074150, rs120074151, rs120074152, rs120074153, rs120074154, rs180177329, rs386834054, rs386834055, rs386834056, rs386834057, rs386834058, rs386834059, rs386834060, rs386834061, rs386834062, rs386834063, rs386834064, rs386834065, rs386834066, rs386834067, rs386834069, rs180177374, rs386834070, rs386834071, rs386834072, rs386834073, rs386834074, rs180177356, rs386834075, rs386834076, rs386834077, rs180177357, rs386834078, rs386834079, rs180177358, rs386834080, rs386834081, rs386834082, rs386834083, rs386834084, rs386834085, rs386834086, rs386834087, rs386834089, rs386834090, rs386834091, rs180177359, rs180177362, rs386834094, rs180177363, rs180177364, rs1554884838, rs386834096, rs386834097, rs386834098, rs386834099, rs386834100, rs386834101, rs386834102, rs180177366, rs386834103, rs386834105, rs386834106, rs386834107, rs386834108, rs386834109, rs386834110, rs386834111, rs386834112, rs386834113, rs386834114, rs386834115, rs386834116, rs386834117, rs386834119, rs386834120, rs386834121, rs386834122, rs386834093, rs180177371, rs180177354, rs180177355, rs180177360, rs180177365, rs140936527, rs140353201, rs587777382, rs727504219, rs786204533, rs786204456, rs748404277, rs797046098, rs869312923, rs753770252, rs875989882, rs764776104, rs371364257, rs886041184, rs886041586, rs755125969, rs886041587, rs886041323, rs146960401, rs886041185, rs777593389, rs1057517029, rs1057516857, rs1057516422, rs1057517295, rs1057517076, rs144539572, rs759536357, rs1057516324, rs1057516971, rs1057516274, rs1057517319, rs1057516923, rs1057517177, rs1057517283, rs1057517338, rs1057516532, rs1057516681, rs1057517255, rs141703746, rs1057516670, rs1057516834, rs1057516926, rs1057517447, rs764544747, rs1057516653, rs765998879, rs768342041, rs752429062, rs763909903, rs1057516633, rs754016783, rs1057516694, rs1057516841, rs1057516331, rs1057516489, rs1057516287, rs1057516494, rs1057517318, rs1057516663, rs1057516302, rs1057516840, rs1057516559, rs1057516660, rs763079458, rs1057517393, rs1057516484, rs765302278, rs1057517236, rs1057516845, rs1057516558, rs1057516276, rs1057516538, rs1057516789, rs1057516807, rs1057517168, rs941969577, rs759374475, rs768801125, rs774357106, rs1057516568, rs1057516614, rs1057517063, rs1057516437, rs1057517137, rs745404712, rs1057517202, rs1057517376, rs1057517441, rs1057516245, rs747363890, rs1057516284, rs747217399, rs1057516651, rs1057517438, rs1057517385, rs773094891, rs1057517328, rs1057518228, rs1057518939, rs1057520769, rs1057520768, rs1554565484, rs1357171752, rs1554948192, rs1554622647, rs1554645551, rs1554892040, rs1554565645, rs756013171, rs1554588353, rs1554560735, rs1554566596, rs1554911731, rs145741622, rs1554570388, rs767858119, rs1161589003, rs1554826615, rs1554922054, rs1554625632, rs1554625872, rs1554706114, rs1456528242, rs1554911481, rs1235993153, rs1554924412, rs1301330402, rs1347701279, rs1554588477, rs372327659, rs1554590314, rs1554561356, rs1554622718, rs1554625617, rs1554665974, rs1554622622, rs1554634091, rs1554652265, rs1554666009, rs1554706662, rs1554765140, rs1554706149, rs1034855385, rs1554706285, rs1554765173, rs1554793521, rs1554843814, rs1554807146, rs1554884932, rs750609612, rs1554952465, rs1554560668, rs1554565558, rs542757501, rs773945333, rs1554581267, rs1554581632, rs1554622608, rs1554625693, rs1554625838, rs1394681818, rs1408744761, rs1554767735, rs1554843942, rs1188811827, rs1554853676, rs1554788238, rs1554884575, rs750092574, rs1554911430, rs1554952467, rs1554814271, rs1554955952, rs753645306, rs1554566396, rs1554574028, rs1554575679, rs1554579522, rs1554822819, rs1554581156, rs1554581430, rs1554581676, rs1554586953, rs1554586994, rs1554826566, rs1554587021, rs1554588489, rs1554852945, rs1554853667, rs930144563, rs1554952554, rs1378196300, rs1554565537, rs1554569259, rs1554575693, rs1200459145, rs867112705, rs1554586972, rs933746831, rs1554612610, rs1554814266, rs1554581504, rs1554581821, rs764225649, rs761273297, rs1563908020, rs1563700205, rs1563497844, rs1563726973, rs1563509743, rs980463746, rs1563499381, rs1563700124, rs1354326532, rs1588810676, rs1588038976, rs1588491595, rs1434257397, rs1176397159, rs1588635717, rs1588743576, rs755996065, rs1588048848, rs202046738, rs1588410519, rs1588095580, rs767518464, rs1588810695, rs1588491546, rs1588038825, rs771308343, rs750003804, rs1588579347, rs1469729130, rs1205613982, rs1587912461, rs1810830776, rs761736983, rs1588811810, rs1813682416, rs752399634, rs1829386577, rs386834095, rs1833089251, rs1812158350, rs1451352816, rs1485428182, rs1817657601, rs1434569440	19006247, 15141358, 20461111, 27533158

Associations from Text Mining
Disease Name	Relationship Type	References
Adenocarcinoma Follicular	Associate	27283500
Adenocarcinoma of Lung	Associate	38242874
Breast Neoplasms	Stimulate	33318294
Breast Neoplasms	Associate	36594618, 37510369
Cognitive Dysfunction	Associate	38242874
COVID 19	Associate	34623759
Diabetes Mellitus Type 1	Associate	33083497
Esophageal Neoplasms	Associate	38196829
Fused Kidney	Associate	38242874
Intracranial Aneurysm	Associate	36451838
Metabolic Syndrome	Associate	34714849
Mitochondrial Diseases	Stimulate	38242874
Multiple Myeloma	Associate	34623759, 36551283
Neoplasms	Associate	27283500, 36594618
Peritonitis	Inhibit	24204994
Stomach Neoplasms	Associate	37482618