AFAP1L1 (actin filament associated protein 1 like 1)

Gene

• Entrez ID: 134265
• Gene name: Actin filament associated protein 1 like 1
• Gene symbol: AFAP1L1
• Synonyms (NCBI Gene): -
• Chromosome: 5
• Chromosome location: 5q32

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT022265	hsa-miR-124-3p	Microarray	18668037
MIRT026274	hsa-miR-192-5p	Microarray	19074876
MIRT770884	hsa-miR-1252	CLIP-seq
MIRT770885	hsa-miR-1343	CLIP-seq
MIRT770886	hsa-miR-139-5p	CLIP-seq
MIRT770887	hsa-miR-140-5p	CLIP-seq
MIRT770888	hsa-miR-1911	CLIP-seq
MIRT770889	hsa-miR-27a	CLIP-seq
MIRT770890	hsa-miR-27b	CLIP-seq
MIRT770891	hsa-miR-3199	CLIP-seq
MIRT770892	hsa-miR-3202	CLIP-seq
MIRT770893	hsa-miR-371-5p	CLIP-seq
MIRT770894	hsa-miR-371b-5p	CLIP-seq
MIRT770895	hsa-miR-378g	CLIP-seq
MIRT770896	hsa-miR-4437	CLIP-seq
MIRT770897	hsa-miR-4438	CLIP-seq
MIRT770898	hsa-miR-4533	CLIP-seq
MIRT770899	hsa-miR-4674	CLIP-seq
MIRT770900	hsa-miR-5095	CLIP-seq
MIRT770901	hsa-miR-513a-5p	CLIP-seq
MIRT770902	hsa-miR-633	CLIP-seq
MIRT1545176	hsa-miR-3130-3p	CLIP-seq
MIRT1545177	hsa-miR-3977	CLIP-seq
MIRT1545178	hsa-miR-767-5p	CLIP-seq
MIRT1927399	hsa-miR-122	CLIP-seq
MIRT770884	hsa-miR-1252	CLIP-seq
MIRT770885	hsa-miR-1343	CLIP-seq
MIRT770887	hsa-miR-140-5p	CLIP-seq
MIRT1545176	hsa-miR-3130-3p	CLIP-seq
MIRT1927400	hsa-miR-3135b	CLIP-seq
MIRT770892	hsa-miR-3202	CLIP-seq
MIRT1927401	hsa-miR-3652	CLIP-seq
MIRT1927402	hsa-miR-3688-5p	CLIP-seq
MIRT770895	hsa-miR-378g	CLIP-seq
MIRT1927403	hsa-miR-3929	CLIP-seq
MIRT1545177	hsa-miR-3977	CLIP-seq
MIRT1927404	hsa-miR-4419b	CLIP-seq
MIRT1927405	hsa-miR-4430	CLIP-seq
MIRT770896	hsa-miR-4437	CLIP-seq
MIRT1927406	hsa-miR-4478	CLIP-seq
MIRT770898	hsa-miR-4533	CLIP-seq
MIRT770899	hsa-miR-4674	CLIP-seq
MIRT1927407	hsa-miR-4755-5p	CLIP-seq
MIRT1545178	hsa-miR-767-5p	CLIP-seq
MIRT1927399	hsa-miR-122	CLIP-seq
MIRT2168165	hsa-miR-1245b-3p	CLIP-seq
MIRT770884	hsa-miR-1252	CLIP-seq
MIRT2168166	hsa-miR-1271	CLIP-seq
MIRT770887	hsa-miR-140-5p	CLIP-seq
MIRT1927400	hsa-miR-3135b	CLIP-seq
MIRT770892	hsa-miR-3202	CLIP-seq
MIRT1927401	hsa-miR-3652	CLIP-seq
MIRT1927402	hsa-miR-3688-5p	CLIP-seq
MIRT2168167	hsa-miR-383	CLIP-seq
MIRT1927403	hsa-miR-3929	CLIP-seq
MIRT1927404	hsa-miR-4419b	CLIP-seq
MIRT1927405	hsa-miR-4430	CLIP-seq
MIRT1927406	hsa-miR-4478	CLIP-seq
MIRT770898	hsa-miR-4533	CLIP-seq
MIRT2168168	hsa-miR-4715-5p	CLIP-seq
MIRT2168169	hsa-miR-4772-5p	CLIP-seq
MIRT2168170	hsa-miR-595	CLIP-seq
MIRT2168171	hsa-miR-96	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001725	Component	Stress fiber	IEA
GO:0002102	Component	Podosome	IEA
GO:0005515	Function	Protein binding	IPI	25416956, 31515488, 32296183
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IBA
GO:0005856	Component	Cytoskeleton	IEA
GO:0042995	Component	Cell projection	IEA
GO:0070161	Component	Anchoring junction	IEA

Other IDs

• MIM: 614410
• HGNC: 26714
• e!Ensembl: ENSG00000157510

Protein

• UniProt ID: Q8TED9
• Protein name: Actin filament-associated protein 1-like 1 (AFAP1-like protein 1)
• Protein function: May be involved in podosome and invadosome formation.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00169	PH	222 → 316	PH domain	Domain
  PF00169	PH	414 → 507	PH domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Expressed in breast, colon and brain. In all 3 tissues, expressed in the microvasculature (at protein level). In addition, in the breast, found in the contractile myoepithelial cell layer which surrounds the breast ducts (at protein le
• Sequence:

  MDRGQVLEQLLPELTGLLSLLDHEYLSDTTLEKKMAVASILQSLQPLPAKEVSYLYVNTA
  DLHSGPSFVESLFEEFDCDLSDLRDMPEDDGEPSKGASPELAKSPRLRNAADLPPPLPNK
  PPPEDYYEEALPLGPGKSPEYISSHNGCSPSHSIVDGYYEDADSSYPATRVNGELKSSYN
  DSDAMSSSYESYDEEEEEGKSPQPRHQWPSEEASMHLVRECRICAFLLRKKRFGQWAKQL
  TVIREDQLLCYKSSKDRQPHLRLALDTCSIIYVPKDSRHKRHELRFTQGATEVLVLALQS
  REQAEEWLKVIREVSKPVGGAEGVEVPRSPVLLCKLDLDKRLSQEKQTSDSDSVGVGDNC
  STLGRRETCDHGKGKKSSLAELKGSMSRAAGRKITRIIGFSKKKTLADDLQTSSTEEEVP
  CCGYLNVLVNQGWKERWCRLKCNTLYFHKDHMDLRTHVNAIALQGCEVAPGFGPRHPFAF
  RILRNRQEVAILEASCSEDMGRWLGLLLVEMGSRVTPEALHYDYVDVETLTSIVSAGRNS
  FLYARSCQNQWPEPRVYDDVPYEKMQDEEPERPTGAQVKRHASSCSEKSHRVDPQVKVKR
  HASSANQYKYGKNRAEEDARRYLVEKEKLEKEKETIRTELIALRQEKRELKEAIRSSPGA
  KLKALEEAVATLEAQCRAKEERRIDLELKLVAVKERLQQSLAGGPALGLSVSSKPKSGET
  ANKPQNSVPEQPLPVNCVSELRKRSPSIVASNQGRVLQKAKEWEMKKT

• Sequence length: 768