COX6B1 (cytochrome c oxidase subunit 6B1)

Gene

• Entrez ID: 1340
• Gene name: Cytochrome c oxidase subunit 6B1
• Gene symbol: COX6B1
• Synonyms (NCBI Gene): COX6B, COXG, COXVIb1, MC4DN7
• Chromosome: 19
• Chromosome location: 19q13.12
• Summary: Cytochrome c oxidase (COX), the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs121909602	G>A	Pathogenic	Coding sequence variant, missense variant
rs778740017	C>T	Pathogenic	Missense variant, coding sequence variant

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT044502	hsa-miR-320a	CLASH	23622248
MIRT038293	hsa-miR-130b-5p	CLASH	23622248
MIRT036188	hsa-miR-320b	CLASH	23622248
MIRT711874	hsa-miR-3146	HITS-CLIP	19536157
MIRT711873	hsa-miR-621	HITS-CLIP	19536157
MIRT711872	hsa-miR-6131	HITS-CLIP	19536157
MIRT711871	hsa-miR-1180-3p	HITS-CLIP	19536157
MIRT711870	hsa-miR-4474-3p	HITS-CLIP	19536157
MIRT696503	hsa-miR-141-3p	HITS-CLIP	23313552
MIRT696502	hsa-miR-200a-3p	HITS-CLIP	23313552
MIRT696501	hsa-miR-6757-3p	HITS-CLIP	23313552
MIRT696500	hsa-miR-6134	HITS-CLIP	23313552
MIRT696499	hsa-miR-377-5p	HITS-CLIP	23313552
MIRT696498	hsa-miR-6086	HITS-CLIP	23313552
MIRT696497	hsa-miR-3689d	HITS-CLIP	23313552
MIRT696496	hsa-miR-6851-5p	HITS-CLIP	23313552
MIRT696494	hsa-miR-6880-5p	HITS-CLIP	23313552
MIRT696495	hsa-miR-7847-3p	HITS-CLIP	23313552
MIRT696493	hsa-miR-455-3p	HITS-CLIP	23313552
MIRT696492	hsa-miR-6516-5p	HITS-CLIP	23313552
MIRT696491	hsa-miR-1207-3p	HITS-CLIP	23313552
MIRT696490	hsa-miR-378g	HITS-CLIP	23313552
MIRT696489	hsa-miR-6776-5p	HITS-CLIP	23313552
MIRT696488	hsa-miR-214-5p	HITS-CLIP	23313552
MIRT696487	hsa-miR-6811-3p	HITS-CLIP	23313552
MIRT696486	hsa-miR-6847-3p	HITS-CLIP	23313552
MIRT696485	hsa-miR-5589-5p	HITS-CLIP	23313552
MIRT696484	hsa-miR-4284	HITS-CLIP	23313552
MIRT696483	hsa-miR-24-3p	HITS-CLIP	23313552
MIRT696482	hsa-miR-4505	HITS-CLIP	23313552
MIRT696481	hsa-miR-5787	HITS-CLIP	23313552
MIRT696480	hsa-miR-4656	HITS-CLIP	23313552
MIRT696479	hsa-miR-6829-5p	HITS-CLIP	23313552
MIRT696478	hsa-miR-4492	HITS-CLIP	23313552
MIRT696477	hsa-miR-4498	HITS-CLIP	23313552
MIRT696476	hsa-miR-5001-5p	HITS-CLIP	23313552
MIRT696475	hsa-miR-762	HITS-CLIP	23313552
MIRT696474	hsa-miR-4675	HITS-CLIP	23313552
MIRT696473	hsa-miR-4741	HITS-CLIP	23313552
MIRT696472	hsa-miR-6772-5p	HITS-CLIP	23313552
MIRT696471	hsa-miR-4455	HITS-CLIP	23313552
MIRT696470	hsa-miR-609	HITS-CLIP	23313552
MIRT524392	hsa-miR-7977	HITS-CLIP	23313552
MIRT696469	hsa-miR-6514-3p	HITS-CLIP	23313552
MIRT696468	hsa-miR-1587	HITS-CLIP	23313552
MIRT696467	hsa-miR-3620-5p	HITS-CLIP	23313552
MIRT682652	hsa-miR-890	HITS-CLIP	23706177
MIRT682651	hsa-miR-4695-5p	HITS-CLIP	23706177
MIRT682650	hsa-miR-4779	HITS-CLIP	23706177
MIRT367242	hsa-miR-2392	HITS-CLIP	23706177
MIRT562459	hsa-miR-3929	HITS-CLIP	23706177
MIRT562460	hsa-miR-4419b	HITS-CLIP	23706177
MIRT562458	hsa-miR-4478	HITS-CLIP	23706177
MIRT682649	hsa-miR-135a-5p	HITS-CLIP	23706177
MIRT682648	hsa-miR-135b-5p	HITS-CLIP	23706177
MIRT682647	hsa-miR-3605-5p	HITS-CLIP	23706177
MIRT682646	hsa-miR-485-5p	HITS-CLIP	23706177
MIRT682645	hsa-miR-6884-5p	HITS-CLIP	23706177
MIRT682644	hsa-let-7a-5p	HITS-CLIP	23706177
MIRT682643	hsa-let-7b-5p	HITS-CLIP	23706177
MIRT682642	hsa-let-7c-5p	HITS-CLIP	23706177
MIRT682641	hsa-let-7d-5p	HITS-CLIP	23706177
MIRT682640	hsa-let-7e-5p	HITS-CLIP	23706177
MIRT682639	hsa-let-7f-5p	HITS-CLIP	23706177
MIRT682638	hsa-let-7g-5p	HITS-CLIP	23706177
MIRT682637	hsa-let-7i-5p	HITS-CLIP	23706177
MIRT682636	hsa-miR-4458	HITS-CLIP	23706177
MIRT682635	hsa-miR-4500	HITS-CLIP	23706177
MIRT682634	hsa-miR-98-5p	HITS-CLIP	23706177
MIRT682633	hsa-miR-202-3p	HITS-CLIP	23706177
MIRT682632	hsa-miR-924	HITS-CLIP	23706177
MIRT562457	hsa-miR-7160-5p	HITS-CLIP	23706177
MIRT682631	hsa-miR-6894-5p	HITS-CLIP	23706177
MIRT682630	hsa-miR-7106-5p	HITS-CLIP	23706177
MIRT682629	hsa-miR-149-3p	HITS-CLIP	23706177
MIRT682628	hsa-miR-4728-5p	HITS-CLIP	23706177
MIRT682627	hsa-miR-6785-5p	HITS-CLIP	23706177
MIRT682626	hsa-miR-6883-5p	HITS-CLIP	23706177
MIRT682625	hsa-miR-6799-5p	HITS-CLIP	23706177
MIRT682624	hsa-miR-4266	HITS-CLIP	23706177
MIRT682623	hsa-miR-937-5p	HITS-CLIP	23706177
MIRT682622	hsa-miR-627-5p	HITS-CLIP	23706177
MIRT682621	hsa-miR-30c-1-3p	HITS-CLIP	23706177
MIRT682620	hsa-miR-30c-2-3p	HITS-CLIP	23706177
MIRT682619	hsa-miR-6788-5p	HITS-CLIP	23706177
MIRT682618	hsa-miR-1273h-5p	HITS-CLIP	23706177
MIRT682617	hsa-miR-30b-3p	HITS-CLIP	23706177
MIRT682616	hsa-miR-3689a-3p	HITS-CLIP	23706177
MIRT682615	hsa-miR-3689b-3p	HITS-CLIP	23706177
MIRT682614	hsa-miR-3689c	HITS-CLIP	23706177
MIRT682613	hsa-miR-6779-5p	HITS-CLIP	23706177
MIRT682612	hsa-miR-6780a-5p	HITS-CLIP	23706177
MIRT682611	hsa-miR-8081	HITS-CLIP	23706177
MIRT682610	hsa-miR-887-5p	HITS-CLIP	23706177
MIRT682609	hsa-miR-665	HITS-CLIP	23706177
MIRT367239	hsa-miR-3125	PAR-CLIP	20371350
MIRT367240	hsa-miR-3916	PAR-CLIP	20371350
MIRT367250	hsa-miR-6859-5p	PAR-CLIP	20371350
MIRT367249	hsa-miR-6847-5p	PAR-CLIP	20371350
MIRT367246	hsa-miR-5004-5p	PAR-CLIP	20371350
MIRT367252	hsa-miR-7154-3p	PAR-CLIP	20371350
MIRT082022	hsa-miR-433-3p	PAR-CLIP	20371350
MIRT082021	hsa-miR-224-5p	PAR-CLIP	20371350
MIRT082026	hsa-miR-6165	PAR-CLIP	20371350
MIRT082025	hsa-miR-4690-5p	PAR-CLIP	20371350
MIRT082027	hsa-miR-6510-5p	PAR-CLIP	20371350
MIRT558610	hsa-miR-4524a-5p	PAR-CLIP	20371350
MIRT558609	hsa-miR-4524b-5p	PAR-CLIP	20371350
MIRT082024	hsa-miR-374b-3p	PAR-CLIP	20371350
MIRT562459	hsa-miR-3929	PAR-CLIP	20371350
MIRT562460	hsa-miR-4419b	PAR-CLIP	20371350
MIRT562458	hsa-miR-4478	PAR-CLIP	20371350
MIRT562457	hsa-miR-7160-5p	PAR-CLIP	20371350
MIRT524393	hsa-miR-4533	PAR-CLIP	20371350
MIRT524394	hsa-miR-3202	PAR-CLIP	20371350
MIRT524392	hsa-miR-7977	PAR-CLIP	20371350
MIRT524391	hsa-miR-6079	PAR-CLIP	20371350
MIRT524390	hsa-miR-7850-5p	PAR-CLIP	20371350
MIRT567999	hsa-miR-106a-5p	PAR-CLIP	20371350
MIRT567998	hsa-miR-106b-5p	PAR-CLIP	20371350
MIRT567997	hsa-miR-17-5p	PAR-CLIP	20371350
MIRT567996	hsa-miR-20a-5p	PAR-CLIP	20371350
MIRT567995	hsa-miR-20b-5p	PAR-CLIP	20371350
MIRT567994	hsa-miR-519d-3p	PAR-CLIP	20371350
MIRT567993	hsa-miR-526b-3p	PAR-CLIP	20371350
MIRT567992	hsa-miR-93-5p	PAR-CLIP	20371350
MIRT567991	hsa-miR-302a-3p	PAR-CLIP	20371350
MIRT567990	hsa-miR-302b-3p	PAR-CLIP	20371350
MIRT567989	hsa-miR-302c-3p	PAR-CLIP	20371350
MIRT567988	hsa-miR-302d-3p	PAR-CLIP	20371350
MIRT567987	hsa-miR-302e	PAR-CLIP	20371350
MIRT567986	hsa-miR-372-3p	PAR-CLIP	20371350
MIRT567985	hsa-miR-373-3p	PAR-CLIP	20371350
MIRT567984	hsa-miR-520a-3p	PAR-CLIP	20371350
MIRT567983	hsa-miR-520b	PAR-CLIP	20371350
MIRT567982	hsa-miR-520c-3p	PAR-CLIP	20371350
MIRT567981	hsa-miR-520d-3p	PAR-CLIP	20371350
MIRT567980	hsa-miR-520e	PAR-CLIP	20371350
MIRT567979	hsa-miR-552-3p	PAR-CLIP	20371350
MIRT567978	hsa-miR-296-3p	PAR-CLIP	20371350
MIRT567977	hsa-miR-3934-5p	PAR-CLIP	20371350
MIRT567976	hsa-miR-5095	PAR-CLIP	20371350
MIRT567975	hsa-miR-7151-3p	PAR-CLIP	20371350
MIRT512138	hsa-miR-6807-5p	PAR-CLIP	20371350
MIRT512137	hsa-miR-4701-5p	PAR-CLIP	20371350
MIRT562459	hsa-miR-3929	PAR-CLIP	20371350
MIRT562460	hsa-miR-4419b	PAR-CLIP	20371350
MIRT562458	hsa-miR-4478	PAR-CLIP	20371350
MIRT562457	hsa-miR-7160-5p	PAR-CLIP	20371350
MIRT524393	hsa-miR-4533	PAR-CLIP	20371350
MIRT524394	hsa-miR-3202	PAR-CLIP	20371350
MIRT524392	hsa-miR-7977	PAR-CLIP	20371350
MIRT524391	hsa-miR-6079	PAR-CLIP	20371350
MIRT524390	hsa-miR-7850-5p	PAR-CLIP	20371350
MIRT562459	hsa-miR-3929	PAR-CLIP	20371350
MIRT562460	hsa-miR-4419b	PAR-CLIP	20371350
MIRT562458	hsa-miR-4478	PAR-CLIP	20371350
MIRT562457	hsa-miR-7160-5p	PAR-CLIP	20371350
MIRT524393	hsa-miR-4533	PAR-CLIP	20371350
MIRT524394	hsa-miR-3202	PAR-CLIP	20371350
MIRT524392	hsa-miR-7977	PAR-CLIP	20371350
MIRT524391	hsa-miR-6079	PAR-CLIP	20371350
MIRT524390	hsa-miR-7850-5p	PAR-CLIP	20371350
MIRT082022	hsa-miR-433-3p	PAR-CLIP	21572407
MIRT082021	hsa-miR-224-5p	PAR-CLIP	21572407
MIRT082026	hsa-miR-6165	PAR-CLIP	21572407
MIRT082025	hsa-miR-4690-5p	PAR-CLIP	21572407
MIRT082027	hsa-miR-6510-5p	PAR-CLIP	21572407
MIRT558614	hsa-miR-4661-3p	PAR-CLIP	21572407
MIRT558613	hsa-miR-939-3p	PAR-CLIP	21572407
MIRT558612	hsa-miR-6852-5p	PAR-CLIP	21572407
MIRT558611	hsa-miR-6742-3p	PAR-CLIP	21572407
MIRT558610	hsa-miR-4524a-5p	PAR-CLIP	21572407
MIRT558609	hsa-miR-4524b-5p	PAR-CLIP	21572407
MIRT558608	hsa-miR-1343-3p	PAR-CLIP	21572407
MIRT558607	hsa-miR-6783-3p	PAR-CLIP	21572407
MIRT082024	hsa-miR-374b-3p	PAR-CLIP	21572407
MIRT082023	hsa-miR-651-5p	PAR-CLIP	21572407
MIRT512139	hsa-miR-4707-5p	PAR-CLIP	23446348
MIRT512138	hsa-miR-6807-5p	PAR-CLIP	23446348
MIRT512137	hsa-miR-4701-5p	PAR-CLIP	23446348
MIRT524393	hsa-miR-4533	PAR-CLIP	23446348
MIRT524394	hsa-miR-3202	PAR-CLIP	23446348
MIRT524392	hsa-miR-7977	PAR-CLIP	23446348
MIRT524391	hsa-miR-6079	PAR-CLIP	23446348
MIRT524390	hsa-miR-7850-5p	PAR-CLIP	23446348
MIRT512149	hsa-miR-548aa	PAR-CLIP	23446348
MIRT512148	hsa-miR-548ap-3p	PAR-CLIP	23446348
MIRT512147	hsa-miR-548t-3p	PAR-CLIP	23446348
MIRT512146	hsa-miR-548as-3p	PAR-CLIP	23446348
MIRT512145	hsa-miR-548at-3p	PAR-CLIP	23446348
MIRT512144	hsa-miR-548ay-3p	PAR-CLIP	23446348
MIRT512143	hsa-miR-6771-3p	PAR-CLIP	23446348
MIRT512142	hsa-miR-6849-3p	PAR-CLIP	23446348
MIRT512141	hsa-miR-4786-5p	PAR-CLIP	23446348
MIRT512140	hsa-miR-769-5p	PAR-CLIP	23446348
MIRT512139	hsa-miR-4707-5p	PAR-CLIP	23446348
MIRT512138	hsa-miR-6807-5p	PAR-CLIP	23446348
MIRT512137	hsa-miR-4701-5p	PAR-CLIP	23446348
MIRT512142	hsa-miR-6849-3p	HITS-CLIP	27418678
MIRT711874	hsa-miR-3146	HITS-CLIP	19536157
MIRT711873	hsa-miR-621	HITS-CLIP	19536157
MIRT711872	hsa-miR-6131	HITS-CLIP	19536157
MIRT711871	hsa-miR-1180-3p	HITS-CLIP	19536157
MIRT711870	hsa-miR-4474-3p	HITS-CLIP	19536157
MIRT696503	hsa-miR-141-3p	HITS-CLIP	23313552
MIRT696502	hsa-miR-200a-3p	HITS-CLIP	23313552
MIRT696501	hsa-miR-6757-3p	HITS-CLIP	23313552
MIRT696500	hsa-miR-6134	HITS-CLIP	23313552
MIRT696499	hsa-miR-377-5p	HITS-CLIP	23313552
MIRT696498	hsa-miR-6086	HITS-CLIP	23313552
MIRT696497	hsa-miR-3689d	HITS-CLIP	23313552
MIRT696496	hsa-miR-6851-5p	HITS-CLIP	23313552
MIRT696494	hsa-miR-6880-5p	HITS-CLIP	23313552
MIRT696495	hsa-miR-7847-3p	HITS-CLIP	23313552
MIRT696493	hsa-miR-455-3p	HITS-CLIP	23313552
MIRT696492	hsa-miR-6516-5p	HITS-CLIP	23313552
MIRT696491	hsa-miR-1207-3p	HITS-CLIP	23313552
MIRT696490	hsa-miR-378g	HITS-CLIP	23313552
MIRT696489	hsa-miR-6776-5p	HITS-CLIP	23313552
MIRT696488	hsa-miR-214-5p	HITS-CLIP	23313552
MIRT696487	hsa-miR-6811-3p	HITS-CLIP	23313552
MIRT696486	hsa-miR-6847-3p	HITS-CLIP	23313552
MIRT696485	hsa-miR-5589-5p	HITS-CLIP	23313552
MIRT696484	hsa-miR-4284	HITS-CLIP	23313552
MIRT696483	hsa-miR-24-3p	HITS-CLIP	23313552
MIRT696482	hsa-miR-4505	HITS-CLIP	23313552
MIRT696481	hsa-miR-5787	HITS-CLIP	23313552
MIRT696480	hsa-miR-4656	HITS-CLIP	23313552
MIRT696479	hsa-miR-6829-5p	HITS-CLIP	23313552
MIRT696478	hsa-miR-4492	HITS-CLIP	23313552
MIRT696477	hsa-miR-4498	HITS-CLIP	23313552
MIRT696476	hsa-miR-5001-5p	HITS-CLIP	23313552
MIRT696475	hsa-miR-762	HITS-CLIP	23313552
MIRT696474	hsa-miR-4675	HITS-CLIP	23313552
MIRT696473	hsa-miR-4741	HITS-CLIP	23313552
MIRT696472	hsa-miR-6772-5p	HITS-CLIP	23313552
MIRT696471	hsa-miR-4455	HITS-CLIP	23313552
MIRT696470	hsa-miR-609	HITS-CLIP	23313552
MIRT524392	hsa-miR-7977	HITS-CLIP	23313552
MIRT696469	hsa-miR-6514-3p	HITS-CLIP	23313552
MIRT696468	hsa-miR-1587	HITS-CLIP	23313552
MIRT696467	hsa-miR-3620-5p	HITS-CLIP	23313552
MIRT682652	hsa-miR-890	HITS-CLIP	23706177
MIRT682651	hsa-miR-4695-5p	HITS-CLIP	23706177
MIRT682650	hsa-miR-4779	HITS-CLIP	23706177
MIRT367242	hsa-miR-2392	HITS-CLIP	23706177
MIRT562459	hsa-miR-3929	HITS-CLIP	23706177
MIRT562460	hsa-miR-4419b	HITS-CLIP	23706177
MIRT562458	hsa-miR-4478	HITS-CLIP	23706177
MIRT682649	hsa-miR-135a-5p	HITS-CLIP	23706177
MIRT682648	hsa-miR-135b-5p	HITS-CLIP	23706177
MIRT682647	hsa-miR-3605-5p	HITS-CLIP	23706177
MIRT682646	hsa-miR-485-5p	HITS-CLIP	23706177
MIRT682645	hsa-miR-6884-5p	HITS-CLIP	23706177
MIRT682644	hsa-let-7a-5p	HITS-CLIP	23706177
MIRT682643	hsa-let-7b-5p	HITS-CLIP	23706177
MIRT682642	hsa-let-7c-5p	HITS-CLIP	23706177
MIRT682641	hsa-let-7d-5p	HITS-CLIP	23706177
MIRT682640	hsa-let-7e-5p	HITS-CLIP	23706177
MIRT682639	hsa-let-7f-5p	HITS-CLIP	23706177
MIRT682638	hsa-let-7g-5p	HITS-CLIP	23706177
MIRT682637	hsa-let-7i-5p	HITS-CLIP	23706177
MIRT682636	hsa-miR-4458	HITS-CLIP	23706177
MIRT682635	hsa-miR-4500	HITS-CLIP	23706177
MIRT682634	hsa-miR-98-5p	HITS-CLIP	23706177
MIRT682633	hsa-miR-202-3p	HITS-CLIP	23706177
MIRT682632	hsa-miR-924	HITS-CLIP	23706177
MIRT562457	hsa-miR-7160-5p	HITS-CLIP	23706177
MIRT682631	hsa-miR-6894-5p	HITS-CLIP	23706177
MIRT682630	hsa-miR-7106-5p	HITS-CLIP	23706177
MIRT682629	hsa-miR-149-3p	HITS-CLIP	23706177
MIRT682628	hsa-miR-4728-5p	HITS-CLIP	23706177
MIRT682627	hsa-miR-6785-5p	HITS-CLIP	23706177
MIRT682626	hsa-miR-6883-5p	HITS-CLIP	23706177
MIRT682625	hsa-miR-6799-5p	HITS-CLIP	23706177
MIRT682624	hsa-miR-4266	HITS-CLIP	23706177
MIRT682623	hsa-miR-937-5p	HITS-CLIP	23706177
MIRT682622	hsa-miR-627-5p	HITS-CLIP	23706177
MIRT682621	hsa-miR-30c-1-3p	HITS-CLIP	23706177
MIRT682620	hsa-miR-30c-2-3p	HITS-CLIP	23706177
MIRT682619	hsa-miR-6788-5p	HITS-CLIP	23706177
MIRT682618	hsa-miR-1273h-5p	HITS-CLIP	23706177
MIRT682617	hsa-miR-30b-3p	HITS-CLIP	23706177
MIRT682616	hsa-miR-3689a-3p	HITS-CLIP	23706177
MIRT682615	hsa-miR-3689b-3p	HITS-CLIP	23706177
MIRT682614	hsa-miR-3689c	HITS-CLIP	23706177
MIRT682613	hsa-miR-6779-5p	HITS-CLIP	23706177
MIRT682612	hsa-miR-6780a-5p	HITS-CLIP	23706177
MIRT682611	hsa-miR-8081	HITS-CLIP	23706177
MIRT682610	hsa-miR-887-5p	HITS-CLIP	23706177
MIRT682609	hsa-miR-665	HITS-CLIP	23706177
MIRT367239	hsa-miR-3125	PAR-CLIP	20371350
MIRT367240	hsa-miR-3916	PAR-CLIP	20371350
MIRT367250	hsa-miR-6859-5p	PAR-CLIP	20371350
MIRT367249	hsa-miR-6847-5p	PAR-CLIP	20371350
MIRT367246	hsa-miR-5004-5p	PAR-CLIP	20371350
MIRT367252	hsa-miR-7154-3p	PAR-CLIP	20371350
MIRT082022	hsa-miR-433-3p	PAR-CLIP	20371350
MIRT082021	hsa-miR-224-5p	PAR-CLIP	20371350
MIRT082026	hsa-miR-6165	PAR-CLIP	20371350
MIRT082025	hsa-miR-4690-5p	PAR-CLIP	20371350
MIRT082027	hsa-miR-6510-5p	PAR-CLIP	20371350
MIRT558610	hsa-miR-4524a-5p	PAR-CLIP	20371350
MIRT558609	hsa-miR-4524b-5p	PAR-CLIP	20371350
MIRT082024	hsa-miR-374b-3p	PAR-CLIP	20371350
MIRT562459	hsa-miR-3929	PAR-CLIP	20371350
MIRT562460	hsa-miR-4419b	PAR-CLIP	20371350
MIRT562458	hsa-miR-4478	PAR-CLIP	20371350
MIRT562457	hsa-miR-7160-5p	PAR-CLIP	20371350
MIRT524393	hsa-miR-4533	PAR-CLIP	20371350
MIRT524394	hsa-miR-3202	PAR-CLIP	20371350
MIRT524392	hsa-miR-7977	PAR-CLIP	20371350
MIRT524391	hsa-miR-6079	PAR-CLIP	20371350
MIRT524390	hsa-miR-7850-5p	PAR-CLIP	20371350
MIRT567999	hsa-miR-106a-5p	PAR-CLIP	20371350
MIRT567998	hsa-miR-106b-5p	PAR-CLIP	20371350
MIRT567997	hsa-miR-17-5p	PAR-CLIP	20371350
MIRT567996	hsa-miR-20a-5p	PAR-CLIP	20371350
MIRT567995	hsa-miR-20b-5p	PAR-CLIP	20371350
MIRT567994	hsa-miR-519d-3p	PAR-CLIP	20371350
MIRT567993	hsa-miR-526b-3p	PAR-CLIP	20371350
MIRT567992	hsa-miR-93-5p	PAR-CLIP	20371350
MIRT567991	hsa-miR-302a-3p	PAR-CLIP	20371350
MIRT567990	hsa-miR-302b-3p	PAR-CLIP	20371350
MIRT567989	hsa-miR-302c-3p	PAR-CLIP	20371350
MIRT567988	hsa-miR-302d-3p	PAR-CLIP	20371350
MIRT567987	hsa-miR-302e	PAR-CLIP	20371350
MIRT567986	hsa-miR-372-3p	PAR-CLIP	20371350
MIRT567985	hsa-miR-373-3p	PAR-CLIP	20371350
MIRT567984	hsa-miR-520a-3p	PAR-CLIP	20371350
MIRT567983	hsa-miR-520b	PAR-CLIP	20371350
MIRT567982	hsa-miR-520c-3p	PAR-CLIP	20371350
MIRT567981	hsa-miR-520d-3p	PAR-CLIP	20371350
MIRT567980	hsa-miR-520e	PAR-CLIP	20371350
MIRT567979	hsa-miR-552-3p	PAR-CLIP	20371350
MIRT567978	hsa-miR-296-3p	PAR-CLIP	20371350
MIRT567977	hsa-miR-3934-5p	PAR-CLIP	20371350
MIRT567976	hsa-miR-5095	PAR-CLIP	20371350
MIRT567975	hsa-miR-7151-3p	PAR-CLIP	20371350
MIRT512138	hsa-miR-6807-5p	PAR-CLIP	20371350
MIRT512137	hsa-miR-4701-5p	PAR-CLIP	20371350
MIRT562459	hsa-miR-3929	PAR-CLIP	20371350
MIRT562460	hsa-miR-4419b	PAR-CLIP	20371350
MIRT562458	hsa-miR-4478	PAR-CLIP	20371350
MIRT562457	hsa-miR-7160-5p	PAR-CLIP	20371350
MIRT524393	hsa-miR-4533	PAR-CLIP	20371350
MIRT524394	hsa-miR-3202	PAR-CLIP	20371350
MIRT524392	hsa-miR-7977	PAR-CLIP	20371350
MIRT524391	hsa-miR-6079	PAR-CLIP	20371350
MIRT524390	hsa-miR-7850-5p	PAR-CLIP	20371350
MIRT562459	hsa-miR-3929	PAR-CLIP	20371350
MIRT562460	hsa-miR-4419b	PAR-CLIP	20371350
MIRT562458	hsa-miR-4478	PAR-CLIP	20371350
MIRT562457	hsa-miR-7160-5p	PAR-CLIP	20371350
MIRT524393	hsa-miR-4533	PAR-CLIP	20371350
MIRT524394	hsa-miR-3202	PAR-CLIP	20371350
MIRT524392	hsa-miR-7977	PAR-CLIP	20371350
MIRT524391	hsa-miR-6079	PAR-CLIP	20371350
MIRT524390	hsa-miR-7850-5p	PAR-CLIP	20371350
MIRT082022	hsa-miR-433-3p	PAR-CLIP	21572407
MIRT082021	hsa-miR-224-5p	PAR-CLIP	21572407
MIRT082026	hsa-miR-6165	PAR-CLIP	21572407
MIRT082025	hsa-miR-4690-5p	PAR-CLIP	21572407
MIRT082027	hsa-miR-6510-5p	PAR-CLIP	21572407
MIRT558614	hsa-miR-4661-3p	PAR-CLIP	21572407
MIRT558613	hsa-miR-939-3p	PAR-CLIP	21572407
MIRT558612	hsa-miR-6852-5p	PAR-CLIP	21572407
MIRT558611	hsa-miR-6742-3p	PAR-CLIP	21572407
MIRT558610	hsa-miR-4524a-5p	PAR-CLIP	21572407
MIRT558609	hsa-miR-4524b-5p	PAR-CLIP	21572407
MIRT558608	hsa-miR-1343-3p	PAR-CLIP	21572407
MIRT558607	hsa-miR-6783-3p	PAR-CLIP	21572407
MIRT082024	hsa-miR-374b-3p	PAR-CLIP	21572407
MIRT082023	hsa-miR-651-5p	PAR-CLIP	21572407
MIRT512139	hsa-miR-4707-5p	PAR-CLIP	23446348
MIRT512138	hsa-miR-6807-5p	PAR-CLIP	23446348
MIRT512137	hsa-miR-4701-5p	PAR-CLIP	23446348
MIRT524393	hsa-miR-4533	PAR-CLIP	23446348
MIRT524394	hsa-miR-3202	PAR-CLIP	23446348
MIRT524392	hsa-miR-7977	PAR-CLIP	23446348
MIRT524391	hsa-miR-6079	PAR-CLIP	23446348
MIRT524390	hsa-miR-7850-5p	PAR-CLIP	23446348
MIRT512149	hsa-miR-548aa	PAR-CLIP	23446348
MIRT512148	hsa-miR-548ap-3p	PAR-CLIP	23446348
MIRT512147	hsa-miR-548t-3p	PAR-CLIP	23446348
MIRT512146	hsa-miR-548as-3p	PAR-CLIP	23446348
MIRT512145	hsa-miR-548at-3p	PAR-CLIP	23446348
MIRT512144	hsa-miR-548ay-3p	PAR-CLIP	23446348
MIRT512143	hsa-miR-6771-3p	PAR-CLIP	23446348
MIRT512142	hsa-miR-6849-3p	PAR-CLIP	23446348
MIRT512141	hsa-miR-4786-5p	PAR-CLIP	23446348
MIRT512140	hsa-miR-769-5p	PAR-CLIP	23446348
MIRT512139	hsa-miR-4707-5p	PAR-CLIP	23446348
MIRT512138	hsa-miR-6807-5p	PAR-CLIP	23446348
MIRT512137	hsa-miR-4701-5p	PAR-CLIP	23446348
MIRT905435	hsa-miR-1225-5p	CLIP-seq
MIRT905436	hsa-miR-1343	CLIP-seq
MIRT905437	hsa-miR-197	CLIP-seq
MIRT905438	hsa-miR-224	CLIP-seq
MIRT905439	hsa-miR-3192	CLIP-seq
MIRT905440	hsa-miR-342-5p	CLIP-seq
MIRT905441	hsa-miR-412	CLIP-seq
MIRT905442	hsa-miR-433	CLIP-seq
MIRT905443	hsa-miR-4434	CLIP-seq
MIRT905444	hsa-miR-4450	CLIP-seq
MIRT905445	hsa-miR-4516	CLIP-seq
MIRT905446	hsa-miR-4524	CLIP-seq
MIRT905447	hsa-miR-4534	CLIP-seq
MIRT905448	hsa-miR-4651	CLIP-seq
MIRT905449	hsa-miR-4664-5p	CLIP-seq
MIRT905450	hsa-miR-4793-5p	CLIP-seq
MIRT905451	hsa-miR-4802-5p	CLIP-seq
MIRT905452	hsa-miR-491-5p	CLIP-seq
MIRT905453	hsa-miR-608	CLIP-seq
MIRT905454	hsa-miR-651	CLIP-seq
MIRT905455	hsa-miR-765	CLIP-seq
MIRT905435	hsa-miR-1225-5p	CLIP-seq
MIRT905436	hsa-miR-1343	CLIP-seq
MIRT905438	hsa-miR-224	CLIP-seq
MIRT905440	hsa-miR-342-5p	CLIP-seq
MIRT905442	hsa-miR-433	CLIP-seq
MIRT905444	hsa-miR-4450	CLIP-seq
MIRT905446	hsa-miR-4524	CLIP-seq
MIRT905448	hsa-miR-4651	CLIP-seq
MIRT905449	hsa-miR-4664-5p	CLIP-seq
MIRT905452	hsa-miR-491-5p	CLIP-seq
MIRT905453	hsa-miR-608	CLIP-seq
MIRT905454	hsa-miR-651	CLIP-seq
MIRT905436	hsa-miR-1343	CLIP-seq
MIRT905438	hsa-miR-224	CLIP-seq
MIRT905442	hsa-miR-433	CLIP-seq
MIRT905446	hsa-miR-4524	CLIP-seq
MIRT905454	hsa-miR-651	CLIP-seq
MIRT905438	hsa-miR-224	CLIP-seq
MIRT905442	hsa-miR-433	CLIP-seq
MIRT905446	hsa-miR-4524	CLIP-seq
MIRT2507889	hsa-miR-4676-5p	CLIP-seq
MIRT2507890	hsa-miR-575	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004129	Function	Cytochrome-c oxidase activity	NAS	2172092
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005739	Component	Mitochondrion	IBA
GO:0005739	Component	Mitochondrion	IDA
GO:0005739	Component	Mitochondrion	IEA
GO:0005743	Component	Mitochondrial inner membrane	IBA
GO:0005743	Component	Mitochondrial inner membrane	IEA
GO:0005743	Component	Mitochondrial inner membrane	IEA
GO:0005743	Component	Mitochondrial inner membrane	TAS
GO:0006119	Process	Oxidative phosphorylation	IEA
GO:0006123	Process	Mitochondrial electron transport, cytochrome c to oxygen	NAS	30030519
GO:0016020	Component	Membrane	IEA
GO:0021762	Process	Substantia nigra development	HEP	22926577
GO:0031966	Component	Mitochondrial membrane	IDA	30030519
GO:0045277	Component	Respiratory chain complex IV	IBA
GO:0045277	Component	Respiratory chain complex IV	IEA
GO:0045333	Process	Cellular respiration	NAS	30030519
GO:1902600	Process	Proton transmembrane transport	IEA

Other IDs

• MIM: 124089
• HGNC: 2280
• e!Ensembl: ENSG00000126267

Protein

• UniProt ID: P14854
• Protein name: Cytochrome c oxidase subunit 6B1 (Cytochrome c oxidase subunit VIb isoform 1) (COX VIb-1)
• Protein function: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiqu
• PDB: 5Z62
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF02297	COX6B	19 → 83	Cytochrome oxidase c subunit VIb	Domain

• Sequence:

  MAEDMETKIKNYKTAPFDSRFPNQNQTRNCWQNYLDFHRCQKAMTAKGGDISVCEWYQRV
  YQSLCPTSWVTDWDEQRAEGTFPGKI

• Sequence length: 86

Pathways

KEGG:

Oxidative phosphorylation
Metabolic pathways
Cardiac muscle contraction
Thermogenesis
Non-alcoholic fatty liver disease
Alzheimer disease
Parkinson disease
Amyotrophic lateral sclerosis
Huntington disease
Prion disease
Pathways of neurodegeneration - multiple diseases
Chemical carcinogenesis - reactive oxygen species
Diabetic cardiomyopathy

Reactome:

TP53 Regulates Metabolic Genes
Respiratory electron transport

Associated diseases

Causal
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Mitochondrial complex IV deficiency, nuclear type 1	Likely pathogenic	rs778740017, rs121909602	RCV000201789 RCV000018371
Mitochondrial complex IV deficiency, nuclear type 7	Likely pathogenic	rs121909602	RCV005025068

Unknown
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
COX6B1-related disorder	Benign	rs7991	RCV003975101

Associations from Text Mining
Disease Name	Relationship Type	References
Cardiomyopathies	Associate	24781756
Colorectal Neoplasms	Associate	22545919
COVID 19	Associate	38259479
Cytochrome c Oxidase Deficiency	Associate	24781756
Heart Diseases	Associate	24781756
Hydrocephalus	Associate	24781756
Leukemia Lymphocytic Chronic B Cell	Associate	16083281
Lymphatic Metastasis	Associate	22545919
Mitochondrial Diseases	Associate	26669719
Mitochondrial Encephalomyopathies	Associate	18499082, 24781756
Neoplasm Metastasis	Associate	22545919
Non alcoholic Fatty Liver Disease	Associate	33194991
Pre Eclampsia	Associate	38259479
Squamous Cell Carcinoma of Head and Neck	Associate	33194991