Gene Gene information from NCBI Gene database.
Entrez ID 133
Gene name Adrenomedullin
Gene symbol ADM
Synonyms (NCBI Gene)
AMPAMP
Chromosome 11
Chromosome location 11p15.4
Summary The protein encoded by this gene is a preprohormone which is cleaved to form two biologically active peptides, adrenomedullin and proadrenomedullin N-terminal 20 peptide. Adrenomedullin is a 52 aa peptide with several functions, including vasodilation, re
miRNA miRNA information provided by mirtarbase database.
956
miRTarBase ID miRNA Experiments Reference
MIRT029565 hsa-miR-26b-5p Sequencing 20371350
MIRT050138 hsa-miR-26a-5p CLASH 23622248
MIRT045894 hsa-miR-125b-5p CLASH 23622248
MIRT438600 hsa-miR-126-3p Luciferase reporter assay 24037526
MIRT438600 hsa-miR-126-3p Luciferase reporter assay 24037526
Transcription factors Transcription factors information provided by TRRUST V2 database.
4
Transcription factor Regulation Reference
CEBPB Activation 9480831
CEBPB Unknown 12630823
GTF3A Unknown 12630823
TFAP2A Unknown 10848972
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
48
GO ID Ontology Definition Evidence Reference
GO:0001570 Process Vasculogenesis IDA 16964401
GO:0001843 Process Neural tube closure IEA
GO:0001878 Process Response to yeast IDA 10225288
GO:0002031 Process G protein-coupled receptor internalization IDA 10882736
GO:0003073 Process Regulation of systemic arterial blood pressure IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
103275 259 ENSG00000148926
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P35318
Protein name Pro-adrenomedullin [Cleaved into: Adrenomedullin (AM); Proadrenomedullin N-20 terminal peptide (ProAM N-terminal 20 peptide) (PAMP) (ProAM-N20)]
Protein function Adrenomedullin/ADM and proadrenomedullin N-20 terminal peptide/PAMP are peptide hormones that act as potent hypotensive and vasodilatator agents (PubMed:8387282, PubMed:9620797). Numerous actions have been reported most related to the physiologi
PDB 2FLY , 2L7S , 4RWF , 5V6Y , 6UUN , 6UUS , 6V2E , 7VV0
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00214 Calc_CGRP_IAPP 1 151 Calcitonin / CGRP / IAPP family Family
Tissue specificity TISSUE SPECIFICITY: Highest levels found in pheochromocytoma and adrenal medulla. Also found in lung, ventricle and kidney tissues. {ECO:0000269|PubMed:8387282}.
Sequence
Sequence length 185
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Neuroactive ligand-receptor interaction
Vascular smooth muscle contraction
  G alpha (s) signalling events
Calcitonin-like ligand receptors
ADORA2B mediated anti-inflammatory cytokines production