Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
133
Gene name Gene Name - the full gene name approved by the HGNC.
Adrenomedullin
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
ADM
Synonyms (NCBI Gene) Gene synonyms aliases
AM, PAMP
Chromosome Chromosome number
11
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
11p15.4
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is a preprohormone which is cleaved to form two biologically active peptides, adrenomedullin and proadrenomedullin N-terminal 20 peptide. Adrenomedullin is a 52 aa peptide with several functions, including vasodilation, re
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT029565 hsa-miR-26b-5p Sequencing 20371350
MIRT050138 hsa-miR-26a-5p CLASH 23622248
MIRT045894 hsa-miR-125b-5p CLASH 23622248
MIRT438600 hsa-miR-126-3p Luciferase reporter assay 24037526
MIRT438600 hsa-miR-126-3p Luciferase reporter assay 24037526
Transcription factors
Transcription factor Regulation Reference
CEBPB Activation 9480831
CEBPB Unknown 12630823
GTF3A Unknown 12630823
TFAP2A Unknown 10848972
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0001570 Process Vasculogenesis IDA 16964401
GO:0001843 Process Neural tube closure IEA
GO:0001878 Process Response to yeast IDA 10225288
GO:0002031 Process G protein-coupled receptor internalization IDA 10882736
GO:0003073 Process Regulation of systemic arterial blood pressure IBA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
103275 259 ENSG00000148926
Protein
UniProt ID P35318
Protein name Pro-adrenomedullin [Cleaved into: Adrenomedullin (AM); Proadrenomedullin N-20 terminal peptide (ProAM N-terminal 20 peptide) (PAMP) (ProAM-N20)]
Protein function Adrenomedullin/ADM and proadrenomedullin N-20 terminal peptide/PAMP are peptide hormones that act as potent hypotensive and vasodilatator agents (PubMed:8387282, PubMed:9620797). Numerous actions have been reported most related to the physiologi
PDB 2FLY , 2L7S , 4RWF , 5V6Y , 6UUN , 6UUS , 6V2E , 7VV0
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00214 Calc_CGRP_IAPP 1 151 Calcitonin / CGRP / IAPP family Family
Tissue specificity TISSUE SPECIFICITY: Highest levels found in pheochromocytoma and adrenal medulla. Also found in lung, ventricle and kidney tissues. {ECO:0000269|PubMed:8387282}.
Sequence
Sequence length 185
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Neuroactive ligand-receptor interaction
Vascular smooth muscle contraction
  G alpha (s) signalling events
Calcitonin-like ligand receptors
ADORA2B mediated anti-inflammatory cytokines production
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Breast Cancer Breast cancer N/A N/A GWAS
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Abortion Habitual Associate 24260517
Albuminuria Associate 19424162
Angina Unstable Stimulate 15367525
Angioedemas Hereditary Stimulate 29729940
Arthritis Rheumatoid Associate 20942979
Arthritis Rheumatoid Stimulate 37470226
Astrocytoma Associate 25246098
Atherosclerosis Associate 15367525, 19247278
Bipolar Disorder Associate 20713499
Bone Diseases Associate 17900349