Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID	1329
Gene name	Cytochrome c oxidase subunit 5B
Gene symbol	COX5B
Synonyms (NCBI Gene)	COXVB
Chromosome	2
Chromosome location	2q11.2
Summary	Cytochrome C oxidase (COX) is the terminal enzyme of the mitochondrial respiratory chain. It is a multi-subunit enzyme complex that couples the transfer of electrons from cytochrome c to molecular oxygen and contributes to a proton electrochemical gradien

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miRTarBase ID	miRNA	Experiments	Reference
MIRT564388	hsa-miR-3120-3p	PAR-CLIP	20371350
MIRT564387	hsa-miR-6869-5p	PAR-CLIP	20371350
MIRT564386	hsa-miR-8081	PAR-CLIP	20371350
MIRT207609	hsa-miR-8055	PAR-CLIP	20371350
MIRT564388	hsa-miR-3120-3p	PAR-CLIP	20371350
MIRT564387	hsa-miR-6869-5p	PAR-CLIP	20371350
MIRT564386	hsa-miR-8081	PAR-CLIP	20371350
MIRT207609	hsa-miR-8055	PAR-CLIP	20371350
MIRT905399	hsa-miR-1243	CLIP-seq
MIRT905400	hsa-miR-130a	CLIP-seq
MIRT905401	hsa-miR-130b	CLIP-seq
MIRT905402	hsa-miR-301a	CLIP-seq
MIRT905403	hsa-miR-301b	CLIP-seq
MIRT905404	hsa-miR-3591-5p	CLIP-seq
MIRT905405	hsa-miR-3654	CLIP-seq
MIRT905406	hsa-miR-3666	CLIP-seq
MIRT905407	hsa-miR-3978	CLIP-seq
MIRT905408	hsa-miR-4295	CLIP-seq
MIRT905409	hsa-miR-4434	CLIP-seq
MIRT905410	hsa-miR-4473	CLIP-seq
MIRT905411	hsa-miR-4516	CLIP-seq
MIRT905412	hsa-miR-454	CLIP-seq
MIRT905413	hsa-miR-4671-3p	CLIP-seq
MIRT905414	hsa-miR-875-3p	CLIP-seq
MIRT905399	hsa-miR-1243	CLIP-seq
MIRT905400	hsa-miR-130a	CLIP-seq
MIRT905401	hsa-miR-130b	CLIP-seq
MIRT905402	hsa-miR-301a	CLIP-seq
MIRT905403	hsa-miR-301b	CLIP-seq
MIRT905404	hsa-miR-3591-5p	CLIP-seq
MIRT905405	hsa-miR-3654	CLIP-seq
MIRT905406	hsa-miR-3666	CLIP-seq
MIRT905407	hsa-miR-3978	CLIP-seq
MIRT905408	hsa-miR-4295	CLIP-seq
MIRT905409	hsa-miR-4434	CLIP-seq
MIRT905410	hsa-miR-4473	CLIP-seq
MIRT905411	hsa-miR-4516	CLIP-seq
MIRT905412	hsa-miR-454	CLIP-seq
MIRT905413	hsa-miR-4671-3p	CLIP-seq
MIRT905414	hsa-miR-875-3p	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0004129	Function	Cytochrome-c oxidase activity	TAS	1646156
GO:0005515	Function	Protein binding	IPI	17500595, 21516116, 25416956, 31170524, 31515488, 32296183, 32814053, 34446781
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005739	Component	Mitochondrion	IBA
GO:0005739	Component	Mitochondrion	IDA
GO:0005739	Component	Mitochondrion	IEA
GO:0005740	Component	Mitochondrial envelope	IEA
GO:0005743	Component	Mitochondrial inner membrane	IEA
GO:0005743	Component	Mitochondrial inner membrane	TAS
GO:0006119	Process	Oxidative phosphorylation	IEA
GO:0006123	Process	Mitochondrial electron transport, cytochrome c to oxygen	IBA
GO:0006123	Process	Mitochondrial electron transport, cytochrome c to oxygen	IEA
GO:0006123	Process	Mitochondrial electron transport, cytochrome c to oxygen	NAS	30030519
GO:0007585	Process	Respiratory gaseous exchange by respiratory system	TAS	1646156
GO:0016020	Component	Membrane	IEA
GO:0031966	Component	Mitochondrial membrane	IDA	30030519
GO:0045277	Component	Respiratory chain complex IV	IEA
GO:0045333	Process	Cellular respiration	NAS	30030519
GO:0046872	Function	Metal ion binding	IEA
GO:1902600	Process	Proton transmembrane transport	IEA

MIM	HGNC	e!Ensembl
123866	2269	ENSG00000135940

P10606

Protein name

Cytochrome c oxidase subunit 5B, mitochondrial (Cytochrome c oxidase polypeptide Vb)

Protein function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiqu

PDB

5Z62

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01215	COX5B	8 → 128	Cytochrome c oxidase subunit Vb	Domain

Sequence

MASRLLRGAGTLAAQALRARGPSGAAAMRSMASGGGVPTDEEQATGLEREIMLAAKKGLD
PYNVLAPKGASGTREDPNLVPSISNKRIVGCICEEDNTSVVWFWLHKGEAQRCPRCGAHY
KLVPQQLAH

Sequence length

129

Interactions

View interactions

	KEGG		Reactome
	Oxidative phosphorylation Metabolic pathways Cardiac muscle contraction Thermogenesis Non-alcoholic fatty liver disease Alzheimer disease Parkinson disease Amyotrophic lateral sclerosis Huntington disease Prion disease Pathways of neurodegeneration - multiple diseases Chemical carcinogenesis - reactive oxygen species Diabetic cardiomyopathy		TP53 Regulates Metabolic Genes Respiratory electron transport

COX5B (cytochrome c oxidase subunit 5B)